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Cyclin-Dependent Kinase Inhibitor p21
Downregulation of PCNA potentiates p21-mediated growth inhibition in response to hyperoxia.
PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of bax death.
p21(Cip1) protects against oxidative stress by suppressing ER-dependent activation of mitochondrial death pathways.
p21(Cip1/WAF1/Sdi1) does not affect expression of base excision DNA repair enzymes during chronic oxidative stress.
p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth.
p21(Cip1/Waf1/Sdi1) protects against hyperoxia by maintaining expression of Bcl-X(L).
Cyclin Dependent Kinase 5