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One or more keywords matched the following items that are connected to Matts, Robert
Item TypeName
Concept Protein Biosynthesis
Concept Oncogene Protein pp60(v-src)
Concept Protein-Serine-Threonine Kinases
Concept Protein Structure, Secondary
Concept Protein Structure, Tertiary
Concept Protein Folding
Concept Protein Renaturation
Concept Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Concept Protein Isoforms
Concept Protein Binding
Concept Protein Conformation
Concept Protein Denaturation
Concept Protein Kinases
Concept Protein Processing, Post-Translational
Concept Protein Synthesis Inhibitors
Concept Protein-Tyrosine Kinases
Concept Ubiquitin-Protein Ligases
Concept Protein Refolding
Concept Protein Interaction Maps
Concept Protein Kinase Inhibitors
Concept Oncogene Protein v-cbl
Concept Protein Phosphatase 2
Academic Article Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates.
Academic Article Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase.
Academic Article Differential inhibition of Hsc70 activities by two Hsc70-binding peptides.
Academic Article High affinity binding of Hsp90 is triggered by multiple discrete segments of its kinase clients.
Academic Article Functional dissection of cdc37: characterization of domain structure and amino acid residues critical for protein kinase binding.
Academic Article Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions.
Academic Article Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37.
Academic Article Interdomain interactions regulate the activation of the heme-regulated eIF 2 alpha kinase.
Academic Article Gambogic acid, a natural product inhibitor of Hsp90.
Academic Article Elucidation of the Hsp90 C-terminal inhibitor binding site.
Academic Article Structure-guided design of an Hsp90ß N-terminal isoform-selective inhibitor.
Academic Article Interactions of the heme-regulated eIF-2 alpha kinase with heat shock proteins in rabbit reticulocyte lysates.
Academic Article The relationship between protein synthesis and heat shock proteins levels in rabbit reticulocyte lysates.
Academic Article Evidence for the association of the heme-regulated eIF-2 alpha kinase with the 90-kDa heat shock protein in rabbit reticulocyte lysate in situ.
Academic Article Effect of interferon on protein translation during growth stages of 3T3 cells.
Academic Article Dual role for Hsc70 in the biogenesis and regulation of the heme-regulated kinase of the alpha subunit of eukaryotic translation initiation factor 2.
Academic Article The heme-regulated eukaryotic initiation factor 2alpha kinase. A potential regulatory target for control of protein synthesis by diffusible gases.
Academic Article Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase.
Academic Article Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase.
Academic Article High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase.
Academic Article Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.
Academic Article The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors.
Academic Article Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors.
Academic Article Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex.
Academic Article Toxic heavy metal ions activate the heme-regulated eukaryotic initiation factor-2 alpha kinase by inhibiting the capacity of hemin-supplemented reticulocyte lysates to reduce disulfide bonds.
Academic Article Effect of phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 on the function of reversing factor in the initiation of protein synthesis.
Academic Article Distribution of reversing factor in reticulocyte lysates during active protein synthesis and on inhibition by heme deprivation or double-stranded RNA.
Academic Article The regulation of initiation of protein synthesis by phosphorylation of eIF-2(alpha) and the role of reversing factor in the recycling of eIF-2.
Academic Article Association of Hsp90 with cellular Src-family kinases in a cell-free system correlates with altered kinase structure and function.
Academic Article Denatured proteins inhibit translation in hemin-supplemented rabbit reticulocyte lysate by inducing the activation of the heme-regulated eIF-2 alpha kinase.
Academic Article Effect of geldanamycin on the kinetics of chaperone-mediated renaturation of firefly luciferase in rabbit reticulocyte lysate.
Academic Article Hsp90-mediated folding of the lymphoid cell kinase p56lck.
Academic Article Modular folding and evidence for phosphorylation-induced stabilization of an hsp90-dependent kinase.
Academic Article Luciferase renaturation assays of chaperones and chaperone antagonists.
Academic Article The N-terminal region of the heme-regulated eIF2alpha kinase is an autonomous heme binding domain.
Academic Article Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases.
Academic Article Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis.
Academic Article The molecular chaperone Hsp90 is required for signal transduction by wild-type Hck and maintenance of its constitutively active counterpart.
Academic Article Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.
Academic Article Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation.
Academic Article Exposure of protein kinase motifs that trigger binding of Hsp90 and Cdc37.
Academic Article Cdk2: a genuine protein kinase client of Hsp90 and Cdc37.
Academic Article Derrubone, an inhibitor of the Hsp90 protein folding machinery.
Academic Article Fate of reversing factor during restoration of protein synthesis by hemin or GTP in heme-deficient reticulocyte lysates.
Academic Article Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins.
Academic Article Phosphorothioated binary complex of eukaryotic initiation factor eIF-2 and GDP inhibits protein synthesis in hemin-supplemented reticulocyte lysates.
Academic Article ATP-dependent chaperoning activity of reticulocyte lysate.
Academic Article Hsp90 is obligatory for the heme-regulated eIF-2alpha kinase to acquire and maintain an activable conformation.
Academic Article Evidence that Hsc70 negatively modulates the activation of the heme-regulated eIF-2alpha kinase in rabbit reticulocyte lysate.
Academic Article p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules.
Academic Article p50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck.
Academic Article NO-induced activation mechanism of the heme-regulated eIF2alpha kinase.
Academic Article Hsp90 functions to balance the phosphorylation state of Akt during C2C12 myoblast differentiation.
Academic Article Direct ribosomal binding by a cellular inhibitor of translation.
Academic Article Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells.
Academic Article KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells.
Academic Article Identification of proteins associated with Aha1 in HeLa cells by quantitative proteomics.
Academic Article Inhibition of rabbit reticulocyte lysate protein synthesis by heavy metal ions involves the phosphorylation of the alpha-subunit of the eukaryotic initiation factor 2.
Academic Article The 60 S ribosomal subunit as a carrier of eukaryotic initiation factor 2 and the site of reversing factor activity during protein synthesis.
Academic Article The storage of globin mRNA during the inhibition of protein synthesis by heme deprivation.
Academic Article Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae.
Academic Article The role of the 90-kDa heat-shock protein and its associated cohorts in stabilizing the heme-regulated eIF-2alpha kinase in reticulocyte lysates during heat stress.
Academic Article Cisplatin inhibits protein synthesis in rabbit reticulocyte lysate by causing an arrest in elongation.
Grant Identification of Natural Product Inhibitors of Hsp90 as Chemotherapeutic Agents
Academic Article Selective Inhibition of the Hsp90a Isoform.
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