Item Type | Name |
Concept
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Protein Biosynthesis
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Concept
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Oncogene Protein pp60(v-src)
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Concept
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Protein Structure, Secondary
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Concept
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Protein Structure, Tertiary
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Concept
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Protein Folding
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Concept
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Protein Renaturation
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Concept
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Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
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Concept
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Protein Isoforms
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Concept
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Protein Binding
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Concept
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Protein Conformation
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Concept
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Protein Denaturation
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Concept
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Protein Kinases
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Concept
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Protein Processing, Post-Translational
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Concept
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Protein Synthesis Inhibitors
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Concept
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Protein-Tyrosine Kinases
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Concept
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Ubiquitin-Protein Ligases
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Concept
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Protein Refolding
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Concept
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Protein Interaction Maps
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Concept
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Protein Kinase Inhibitors
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Concept
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Oncogene Protein v-cbl
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Concept
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Protein Phosphatase 2
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Academic Article
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Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates.
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Academic Article
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Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase.
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Academic Article
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Differential inhibition of Hsc70 activities by two Hsc70-binding peptides.
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Academic Article
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High affinity binding of Hsp90 is triggered by multiple discrete segments of its kinase clients.
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Academic Article
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Functional dissection of cdc37: characterization of domain structure and amino acid residues critical for protein kinase binding.
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Academic Article
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Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions.
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Academic Article
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Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37.
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Academic Article
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Interdomain interactions regulate the activation of the heme-regulated eIF 2 alpha kinase.
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Academic Article
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Gambogic acid, a natural product inhibitor of Hsp90.
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Academic Article
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Elucidation of the Hsp90 C-terminal inhibitor binding site.
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Academic Article
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Structure-guided design of an Hsp90ß N-terminal isoform-selective inhibitor.
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Academic Article
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Interactions of the heme-regulated eIF-2 alpha kinase with heat shock proteins in rabbit reticulocyte lysates.
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Academic Article
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The relationship between protein synthesis and heat shock proteins levels in rabbit reticulocyte lysates.
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Academic Article
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Evidence for the association of the heme-regulated eIF-2 alpha kinase with the 90-kDa heat shock protein in rabbit reticulocyte lysate in situ.
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Academic Article
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Effect of interferon on protein translation during growth stages of 3T3 cells.
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Academic Article
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Dual role for Hsc70 in the biogenesis and regulation of the heme-regulated kinase of the alpha subunit of eukaryotic translation initiation factor 2.
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Academic Article
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The heme-regulated eukaryotic initiation factor 2alpha kinase. A potential regulatory target for control of protein synthesis by diffusible gases.
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Academic Article
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Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase.
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Academic Article
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Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase.
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Academic Article
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High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase.
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Academic Article
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Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.
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Academic Article
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The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors.
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Academic Article
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Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors.
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Academic Article
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Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex.
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Academic Article
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Toxic heavy metal ions activate the heme-regulated eukaryotic initiation factor-2 alpha kinase by inhibiting the capacity of hemin-supplemented reticulocyte lysates to reduce disulfide bonds.
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Academic Article
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Effect of phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 on the function of reversing factor in the initiation of protein synthesis.
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Academic Article
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Distribution of reversing factor in reticulocyte lysates during active protein synthesis and on inhibition by heme deprivation or double-stranded RNA.
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Academic Article
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The regulation of initiation of protein synthesis by phosphorylation of eIF-2(alpha) and the role of reversing factor in the recycling of eIF-2.
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Academic Article
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Association of Hsp90 with cellular Src-family kinases in a cell-free system correlates with altered kinase structure and function.
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Academic Article
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Denatured proteins inhibit translation in hemin-supplemented rabbit reticulocyte lysate by inducing the activation of the heme-regulated eIF-2 alpha kinase.
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Academic Article
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Effect of geldanamycin on the kinetics of chaperone-mediated renaturation of firefly luciferase in rabbit reticulocyte lysate.
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Academic Article
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Hsp90-mediated folding of the lymphoid cell kinase p56lck.
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Academic Article
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Modular folding and evidence for phosphorylation-induced stabilization of an hsp90-dependent kinase.
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Academic Article
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Luciferase renaturation assays of chaperones and chaperone antagonists.
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Academic Article
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The N-terminal region of the heme-regulated eIF2alpha kinase is an autonomous heme binding domain.
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Academic Article
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Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases.
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Academic Article
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Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis.
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Academic Article
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The molecular chaperone Hsp90 is required for signal transduction by wild-type Hck and maintenance of its constitutively active counterpart.
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Academic Article
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Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.
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Academic Article
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Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation.
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Academic Article
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Exposure of protein kinase motifs that trigger binding of Hsp90 and Cdc37.
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Academic Article
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Cdk2: a genuine protein kinase client of Hsp90 and Cdc37.
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Academic Article
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Derrubone, an inhibitor of the Hsp90 protein folding machinery.
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Academic Article
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Fate of reversing factor during restoration of protein synthesis by hemin or GTP in heme-deficient reticulocyte lysates.
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Academic Article
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Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins.
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Academic Article
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Phosphorothioated binary complex of eukaryotic initiation factor eIF-2 and GDP inhibits protein synthesis in hemin-supplemented reticulocyte lysates.
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Academic Article
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ATP-dependent chaperoning activity of reticulocyte lysate.
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Academic Article
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Hsp90 is obligatory for the heme-regulated eIF-2alpha kinase to acquire and maintain an activable conformation.
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Academic Article
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Evidence that Hsc70 negatively modulates the activation of the heme-regulated eIF-2alpha kinase in rabbit reticulocyte lysate.
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Academic Article
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p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules.
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Academic Article
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p50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck.
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Academic Article
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NO-induced activation mechanism of the heme-regulated eIF2alpha kinase.
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Academic Article
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Hsp90 functions to balance the phosphorylation state of Akt during C2C12 myoblast differentiation.
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Academic Article
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Direct ribosomal binding by a cellular inhibitor of translation.
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Academic Article
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Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells.
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Academic Article
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KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells.
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Academic Article
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Identification of proteins associated with Aha1 in HeLa cells by quantitative proteomics.
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Academic Article
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Inhibition of rabbit reticulocyte lysate protein synthesis by heavy metal ions involves the phosphorylation of the alpha-subunit of the eukaryotic initiation factor 2.
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Academic Article
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The 60 S ribosomal subunit as a carrier of eukaryotic initiation factor 2 and the site of reversing factor activity during protein synthesis.
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Academic Article
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The storage of globin mRNA during the inhibition of protein synthesis by heme deprivation.
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Academic Article
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Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae.
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Academic Article
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The role of the 90-kDa heat-shock protein and its associated cohorts in stabilizing the heme-regulated eIF-2alpha kinase in reticulocyte lysates during heat stress.
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Academic Article
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Cisplatin inhibits protein synthesis in rabbit reticulocyte lysate by causing an arrest in elongation.
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Grant
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LCK TYROSINE KINASE/HEAT SHOCK PROTEIN INTERACTIONS
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Grant
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Identification of Natural Product Inhibitors of Hsp90 as Chemotherapeutic Agents
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Grant
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HEAVY METAL IONS--EUKARYOTIC PROTEIN SYNTHESIS
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Grant
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LCK TYROSINE KINASE/HEAT SHOCK PROTEIN INTERACTION
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Grant
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EFFECT OF HEAVY METAL IONS--EUKARYOTIC PROTEIN SYNTHESIS
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Academic Article
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Selective Inhibition of the Hsp90a Isoform.
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Academic Article
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Crystal structure of the middle and C-terminal domains of Hsp90a labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target.
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