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Matts, Robert

One or more keywords matched the following items that are connected to Matts, Robert

Item Type	Name
Concept	Heat-Shock Proteins
Concept	HSP70 Heat-Shock Proteins
Concept	HSP90 Heat-Shock Proteins
Concept	Heat-Shock Response
Concept	HSC70 Heat-Shock Proteins
Academic Article	Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates.
Academic Article	Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90.
Academic Article	Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase.
Academic Article	Differential inhibition of Hsc70 activities by two Hsc70-binding peptides.
Academic Article	High affinity binding of Hsp90 is triggered by multiple discrete segments of its kinase clients.
Academic Article	Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions.
Academic Article	Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37.
Academic Article	Assays for identification of Hsp90 inhibitors and biochemical methods for discriminating their mechanism of action.
Academic Article	Gambogic acid, a natural product inhibitor of Hsp90.
Academic Article	Elucidation of the Hsp90 C-terminal inhibitor binding site.
Academic Article	Approaches for defining the Hsp90-dependent proteome.
Academic Article	Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine.
Academic Article	Structure-guided design of an Hsp90ß N-terminal isoform-selective inhibitor.
Academic Article	Interactions of the heme-regulated eIF-2 alpha kinase with heat shock proteins in rabbit reticulocyte lysates.
Academic Article	The relationship between protein synthesis and heat shock proteins levels in rabbit reticulocyte lysates.
Academic Article	Evidence for the association of the heme-regulated eIF-2 alpha kinase with the 90-kDa heat shock protein in rabbit reticulocyte lysate in situ.
Academic Article	Changes in the expression of the heme-regulated eIF-2 alpha kinase and heat shock proteins in rabbit reticulocytes maturing during recovery from anemia.
Academic Article	Dual role for Hsc70 in the biogenesis and regulation of the heme-regulated kinase of the alpha subunit of eukaryotic translation initiation factor 2.
Academic Article	Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase.
Academic Article	High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase.
Academic Article	Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.
Academic Article	The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors.
Academic Article	Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors.
Academic Article	Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex.
Academic Article	Association of Hsp90 with cellular Src-family kinases in a cell-free system correlates with altered kinase structure and function.
Academic Article	Denatured proteins inhibit translation in hemin-supplemented rabbit reticulocyte lysate by inducing the activation of the heme-regulated eIF-2 alpha kinase.
Academic Article	Effect of geldanamycin on the kinetics of chaperone-mediated renaturation of firefly luciferase in rabbit reticulocyte lysate.
Academic Article	Hsp90-mediated folding of the lymphoid cell kinase p56lck.
Academic Article	Modular folding and evidence for phosphorylation-induced stabilization of an hsp90-dependent kinase.
Academic Article	Luciferase renaturation assays of chaperones and chaperone antagonists.
Academic Article	Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases.
Academic Article	The molecular chaperone Hsp90 is required for signal transduction by wild-type Hck and maintenance of its constitutively active counterpart.
Academic Article	Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.
Academic Article	Evidence for chaperone heterocomplexes containing both Hsp90 and VCP.
Academic Article	Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation.
Academic Article	Exposure of protein kinase motifs that trigger binding of Hsp90 and Cdc37.
Academic Article	Cdk2: a genuine protein kinase client of Hsp90 and Cdc37.
Academic Article	Derrubone, an inhibitor of the Hsp90 protein folding machinery.
Academic Article	Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold.
Academic Article	Identification and initial SAR of silybin: an Hsp90 inhibitor.
Academic Article	Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins.
Academic Article	A High-Throughput Screen for Inhibitors of the Hsp90-Chaperone Machine.
Academic Article	Proteomic Profiling of Hsp90 Inhibitors.
Academic Article	ATP-dependent chaperoning activity of reticulocyte lysate.
Academic Article	Hsp90 is obligatory for the heme-regulated eIF-2alpha kinase to acquire and maintain an activable conformation.
Academic Article	Evidence that Hsc70 negatively modulates the activation of the heme-regulated eIF-2alpha kinase in rabbit reticulocyte lysate.
Academic Article	p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules.
Academic Article	p50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck.
Academic Article	Hsp90 functions to balance the phosphorylation state of Akt during C2C12 myoblast differentiation.
Academic Article	Direct interaction of the cell division cycle 37 homolog inhibits endothelial nitric oxide synthase activity.
Academic Article	Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells.
Academic Article	KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells.
Academic Article	The role of the 90-kDa heat-shock protein and its associated cohorts in stabilizing the heme-regulated eIF-2alpha kinase in reticulocyte lysates during heat stress.
Grant	LCK TYROSINE KINASE/HEAT SHOCK PROTEIN INTERACTIONS
Grant	HEAVY METAL IONS--EUKARYOTIC PROTEIN SYNTHESIS
Grant	Structure/Function Studies of Anti-cancer Hsp90 Inhibitors that Target the C-terminal Domain
Grant	LCK TYROSINE KINASE/HEAT SHOCK PROTEIN INTERACTION
Academic Article	Selective Inhibition of the Hsp90a Isoform.
Academic Article	Crystal structure of the middle and C-terminal domains of Hsp90a labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target.

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