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Zhizhuang Joe Zhao

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPathology
AddressBMSB 451
940 Stanton L Young Blvd
Oklahoma City OK 73104
Phone405/271-9344
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    Collapse Research 
    Collapse research activities and funding
    R01HL094591     (ZHAO, ZHIZHUANG JOE)Sep 15, 2009 - Aug 31, 2011
    NIH
    Tyrosine Kinase JAK2 and Myeloproliferative Disorders
    Role: Principal Investigator
    R01HL079441     (ZHAO, ZHIZHUANG JOE)Apr 1, 2006 - Mar 31, 2012
    NIH
    Tyrosine Phosphatase PTP-MEG2 and Hematopoiesis
    Role: Principal Investigator
    R01HL076309     (ZHAO, ZHIZHUANG JOE)Apr 1, 2004 - Mar 31, 2010
    NIH
    Tyrosine Phosphatase in Signal Transduction
    Role: Principal Investigator
    R01CA075218     (ZHAO, ZHIZHUANG J)Dec 7, 1998 - Nov 30, 2003
    NIH
    PROTEIN TYROSINE PHOSPHATASES IN POLYCYTHEMIA VERA
    Role: Principal Investigator
    R01HL057393     (ZHAO, ZHIZHUANG J)Aug 1, 1997 - Jun 30, 2002
    NIH
    TYROSINE PHOSPHATASES IN SIGNAL TRANSDUCTION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fuentes-Mattei E, Bayraktar R, Manshouri T, Silva AM, Ivan C, Gulei D, Fabris L, Soares do Amaral N, Mur P, Perez C, Torres-Claudio E, Dragomir MP, Badillo-Perez A, Knutsen E, Narayanan P, Golfman L, Shimizu M, Zhang X, Zhao W, Ho WT, Estecio MR, Bartholomeusz G, Tomuleasa C, Berindan-Neagoe I, Zweidler-McKay PA, Estrov Z, Zhao ZJ, Verstovsek S, Calin GA, Redis RS. miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2. JCI Insight. 2024 Feb 08; 9(3). PMID: 38329131.
      Citations:    Fields:    
    2. Fu Y, Li G, Fu X, Xing S, Zhao ZJ. RNA-Seq Analysis Reveals Altered Expression of Cell Adhesion-Related Genes Following PZR Knockout in Lung Cancer Cells. Appl Biochem Biotechnol. 2023 Jul 20. PMID: 37470934.
      Citations:    Fields:    
    3. Pei HZ, Peng Z, Zhuang X, Wang X, Lu B, Guo Y, Zhao Y, Zhang D, Xiao Y, Gao T, Yu L, He C, Wu S, Baek SH, Zhao ZJ, Xu X, Chen Y. miR-221/222 induce instability of p53 By downregulating deubiquitinase YOD1 in acute myeloid leukemia. Cell Death Discov. 2023 Jul 15; 9(1):249. PMID: 37454155; PMCID: PMC10349814.
      Citations: 1     
    4. Fu Y, Sui Y, Zhao Y, Jiang J, Wang X, Cui J, Fu X, Xing S, Zhao ZJ. PZR promotes tumorigenicity of lung cancer cells by regulating cell migration and invasion via modulating oxidative stress and cell adhesion. Aging (Albany NY). 2023 06 06; 15(11):4949-4962. PMID: 37279992; PMCID: PMC10292906.
      Citations:    Fields:    Translation:AnimalsCells
    5. He C, Peng Z, Zhang D, Guo Y, Liang T, Zhao Y, Yu L, Zhang Q, Chang Z, Xiao Y, Li N, Xue H, Wu S, Zhao ZJ, Zhang C, Chen Y. Sunitinib selectively targets leukemogenic signaling of mutant SHP2 in juvenile myelomonocytic leukemia. Biochem Pharmacol. 2023 May 13; 213:115588. PMID: 37187274.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Chen L, Zhao W, Li M, Yang Y, Tian C, Zhang D, Chang Z, Zhang Y, Zhao ZJ, Chen Y, Ma L. SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor. Reproduction. 2023 May 01. PMID: 37184079.
      Citations:    Fields:    Translation:AnimalsCells
    7. Zhao Y, He C, Zhang D, Guo Y, Peng Z, Yu L, Li N, Chen C, Zhao ZJ, Chen Y. Leukemogenic SHP2 mutations lead to erythropoietin independency of HCD-57 cells: a novel model for preclinical research of SHP2-mutant JMML. Exp Hematol Oncol. 2023 Feb 20; 12(1):20. PMID: 36805832; PMCID: PMC9940371.
      Citations:    
    8. Sui Y, Li S, Fu XQ, Zhao ZJ, Xing S. Bioinformatics analyses of combined databases identify shared differentially expressed genes in cancer and autoimmune disease. J Transl Med. 2023 02 10; 21(1):109. PMID: 36765396; PMCID: PMC9921081.
      Citations: 1     Fields:    Translation:Humans
    9. He X, Kashyap MK, Zhao ZJ, Yu J, Shi H. Editorial: Linking cellular metabolism to hematological malignancies. Front Oncol. 2022; 12:1077358. PMID: 36439481; PMCID: PMC9693723.
      Citations:    
    10. Zhang D, He C, Guo Y, Li J, Li B, Zhao Y, Yu L, Chang Z, Pei H, Yang M, Li N, Zhang Q, He Y, Pan Y, Zhao ZJ, Zhang C, Chen Y. Efficacy of SCF drug conjugate targeting c-KIT in gastrointestinal stromal tumor. BMC Med. 2022 08 24; 20(1):257. PMID: 35999600; PMCID: PMC9400206.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    11. Li L, Kim JH, Lu W, Williams DM, Kim J, Cope L, Rampal RK, Koche RP, Xian L, Luo LZ, Vasiljevic M, Matson DR, Zhao ZJ, Rogers O, Stubbs MC, Reddy K, Romero AR, Psaila B, Spivak JL, Moliterno AR, Resar LMS. HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression. Blood. 2022 05 05; 139(18):2797-2815. PMID: 35286385.
      Citations: 13     Fields:    Translation:AnimalsCells
    12. Yu L, Guo Y, Chang Z, Zhang D, Zhang S, Pei H, Pang J, Zhao ZJ, Chen Y. Bidirectional Interaction Between Cancer Cells and Platelets Provides Potential Strategies for Cancer Therapies. Front Oncol. 2021; 11:764119. PMID: 34722319.
      Citations: 13     
    13. Zhao Y, Zhang D, Guo Y, Lu B, Zhao ZJ, Xu X, Chen Y. Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies. Front Oncol. 2021; 11:680834. PMID: 34123850.
      Citations: 22     
    14. Zhang D, Guo Y, Zhao Y, Yu L, Chang Z, Pei H, Huang J, Chen C, Xue H, Xu X, Pan Y, Li N, Zhu C, Zhao ZJ, Yu J, Chen Y. Expression of a recombinant FLT3 ligand and its emtansine conjugate as a therapeutic candidate against acute myeloid leukemia cells with FLT3 expression. Microb Cell Fact. 2021 Mar 10; 20(1):67. PMID: 33691697.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    15. Li S, Wang X, Zhao Y, Yang J, Cui T, Zhao ZJ, Chen Y, Zheng Z. Association of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-Analysis. Front Immunol. 2021; 12:592841. PMID: 33717071.
      Citations: 1     Fields:    Translation:HumansCells
    16. Hao Q, Kundu S, Kleam J, Zhao ZJ, Idell S, Tang H. Enhanced RIPK3 kinase activity-dependent lytic cell death in M1 but not M2 macrophages. Mol Immunol. 2021 01; 129:86-93. PMID: 33221042; PMCID: PMC7750277.
      Citations: 10     Fields:    Translation:AnimalsCells
    17. Guo Y, Sun H, Zhang D, Zhao Y, Shi M, Yang M, Xing S, Fu X, Bin T, Lu B, Wu S, Xu X, Xu X, Chen Y, Zhao ZJ. Development of a highly sensitive method for detection of FLT3D835Y. Biomark Res. 2020; 8:30. PMID: 32817792.
      Citations: 2     
    18. Spivak JL, Merchant A, Williams DM, Rogers O, Zhao W, Duffield A, Resar LS, Moliterno AR, Zhao ZJ. Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera. PLoS One. 2020; 15(6):e0232801. PMID: 32479500.
      Citations: 6     Fields:    Translation:HumansAnimals
    19. Chen X, Fu X, Zhao W, Ho WT, Xing S, Zhao ZJ. Loss of tyrosine phosphatase SHP2 activity promotes growth of colorectal carcinoma HCT-116 cells. Signal Transduct Target Ther. 2020 05 29; 5(1):83. PMID: 32467571.
      Citations: 2     Fields:    Translation:HumansCells
    20. Chen Y, Guo Y, Pan Y, Zhao ZJ. Structure analysis of the receptor binding of 2019-nCoV. Biochem Biophys Res Commun. 2020 Feb 17. PMID: 32081428.
      Citations: 352     Fields:    
    21. Fuentes-Mattei E, Bayraktar R, Manshouri T, Silva AM, Ivan C, Gulei D, Fabris L, Soares do Amaral N, Mur P, Perez C, Torres-Claudio E, Dragomir MP, Badillo-Perez A, Knutsen E, Narayanan P, Golfman L, Shimizu M, Zhang X, Zhao W, Ho WT, Estecio MR, Bartholomeusz G, Tomuleasa C, Berindan-Neagoe I, Zweidler-McKay PA, Estrov Z, Zhao ZJ, Verstovsek S, Calin GA, Redis RS. miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2. JCI Insight. 2020 01 16; 5(1). PMID: 31941838.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    22. Pratap S, Zhao ZJ. Finding new lanes: Chimeric antigen receptor (CAR) T-cells for myeloid leukemia. Cancer Rep (Hoboken). 2020 04; 3(2):e1222. PMID: 32671999.
      Citations: 4     Fields:    Translation:Humans
    23. Zhang J, Zhao ZJ, Fu X, Niu H, Hu C, Dong Y, Cui MZ, Zhang F, Zeng L, Xu X. Proapoptotic Mitochondrial Carrier Homolog Protein PSAP Mediates Death Receptor 6 Induced Apoptosis. J Alzheimers Dis. 2020; 74(4):1097-1106. PMID: 32144986.
      Citations: 4     Fields:    Translation:HumansCells
    24. Zhang J, Niu H, Zhao ZJ, Fu X, Wang Y, Zhang X, Zhang F, Zeng L. CRISPR/Cas9 Knockout of Bak Mediates Bax Translocation to Mitochondria in response to TNFa/CHX-induced Apoptosis. Biomed Res Int. 2019; 2019:9071297. PMID: 31637258.
      Citations: 4     Fields:    Translation:HumansCells
    25. Yu L, Zhao ZJ. Engineered platelets with antithrombotic and antimetastatic properties. Stem Cell Investig. 2019; 6:27. PMID: 31620474.
      Citations: 1     
    26. Samant P, Burt TA, Zhao ZJ, Xiang L. Nanoscale photoacoustic tomography for label-free super-resolution imaging: simulation study (Erratum). J Biomed Opt. 2019 Sep; 24(9):1. PMID: 31571435.
      Citations:    Fields:    
    27. Guo Y, Zhou Y, Yamatomo S, Yang H, Zhang P, Chen S, Nimer SD, Zhao ZJ, Xu M, Bai J, Yang FC. ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis. Leukemia. 2019 05; 33(5):1287-1291. PMID: 30651633.
      Citations: 14     Fields:    Translation:Humans
    28. Samant P, Burt TA, Zhao ZJ, Xiang L. Nanoscale photoacoustic tomography for label-free super-resolution imaging: simulation study. J Biomed Opt. 2018 11; 23(11):1-10. PMID: 30411552.
      Citations: 1     Fields:    Translation:HumansCells
    29. Bastarache L, Hughey JJ, Hebbring S, Marlo J, Zhao W, Ho WT, Van Driest SL, McGregor TL, Mosley JD, Wells QS, Temple M, Ramirez AH, Carroll R, Osterman T, Edwards T, Ruderfer D, Velez Edwards DR, Hamid R, Cogan J, Glazer A, Wei WQ, Feng Q, Brilliant M, Zhao ZJ, Cox NJ, Roden DM, Denny JC. Phenotype risk scores identify patients with unrecognized Mendelian disease patterns. Science. 2018 03 16; 359(6381):1233-1239. PMID: 29590070.
      Citations: 89     Fields:    Translation:Humans
    30. Chen Y, Pan Y, Guo Y, Zhao W, Ho WT, Wang J, Xu M, Yang FC, Zhao ZJ. Tyrosine kinase inhibitors targeting FLT3 in the treatment of acute myeloid leukemia. Stem Cell Investig. 2017; 4:48. PMID: 28607922.
      Citations: 18     
    31. Shen T, Chen Z, Zhao ZJ, Wu J. Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer. Oncotarget. 2017 Sep 22; 8(37):60975-60986. PMID: 28977839.
      Citations: 8     Fields:    
    32. Yue L, Bartenstein M, Zhao W, Ho WT, Han Y, Murdun C, Mailloux AW, Zhang L, Wang X, Budhathoki A, Pradhan K, Rapaport F, Wang H, Shao Z, Ren X, Steidl U, Levine RL, Zhao ZJ, Verma A, Epling-Burnette PK. Efficacy of ALK5 inhibition in myelofibrosis. JCI Insight. 2017 04 06; 2(7):e90932. PMID: 28405618.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    33. Zhang D, Marlin MC, Liang Z, Ahmad M, Ashpole NM, Sonntag WE, Zhao ZJ, Li G. The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A. J Biol Chem. 2016 Nov 11; 291(46):23895-23905. PMID: 27655914.
      Citations: 15     Fields:    Translation:AnimalsCells
    34. Hannafon BN, Trigoso YD, Calloway CL, Zhao YD, Lum DH, Welm AL, Zhao ZJ, Blick KE, Dooley WC, Ding WQ. Plasma exosome microRNAs are indicative of breast cancer. Breast Cancer Res. 2016 09 08; 18(1):90. PMID: 27608715.
      Citations: 267     Fields:    Translation:HumansAnimalsCells
    35. Guo Y, Fu X, Huo B, Wang Y, Sun J, Meng L, Hao T, Zhao ZJ, Hu X. GATA2 regulates GATA1 expression through LSD1-mediated histone modification. Am J Transl Res. 2016; 8(5):2265-74. PMID: 27347333.
      Citations: 10     
    36. Agarwal A, Morrone K, Bartenstein M, Zhao ZJ, Verma A, Goel S. Bone marrow fibrosis in primary myelofibrosis: pathogenic mechanisms and the role of TGF-ß. Stem Cell Investig. 2016; 3:5. PMID: 27358897.
      Citations: 44     
    37. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
      Citations: 2808     Fields:    Translation:HumansAnimals
    38. Zhao W, Ho WT, Zhao ZJ. Quantitative analyses of myelofibrosis by determining hydroxyproline. Stem Cell Investig. 2015; 2:2. PMID: 27358870.
      Citations: 3     
    39. Li J, Liu X, Chu H, Fu X, Li T, Hu L, Xing S, Li G, Gu J, Zhao ZJ. Specific dephosphorylation of Janus Kinase 2 by protein tyrosine phosphatases. Proteomics. 2015 Jan; 15(1):68-76. PMID: 25354842.
      Citations: 7     Fields:    Translation:HumansCells
    40. Cherry M, Khawandanah M, Zhao ZJ, Srour S, Ozer H, Selby G, Ghabache B, Al-Kali A. Erlotinib is not effective in patients with JAK2V617F-positive polycythemia vera. Ann Hematol. 2015 Apr; 94(4):717-9. PMID: 25380996.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    41. Zhao BF, Zhao ZJ. Molecular cloning and characterization of a tyrosine phosphatase from Monosiga brevicollis. Biochem Biophys Res Commun. 2014 Oct 31; 453(4):761-6. PMID: 25445586.
      Citations: 2     Fields:    Translation:AnimalsCells
    42. Zhao W, Zou K, Farasyn T, Ho WT, Zhao ZJ. Generation and characterization of a JAK2V617F-containing erythroleukemia cell line. PLoS One. 2014; 9(7):e99017. PMID: 25036984.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    43. Wang BY, Xu XS, Cui YX, Wang H, Liu G, Zhao ZJ, Ma JF, Fu XQ. Caenorhabditis elegans eyes absent ortholog EYA-1 is required for stress resistance. Biochemistry (Mosc). 2014 Jul; 79(7):653-62. PMID: 25108328.
      Citations: 2     Fields:    Translation:Animals
    44. Jin X, Zhao W, Kirabo A, Park SO, Ho WT, Sayeski PP, Zhao ZJ. Elevated levels of mast cells are involved in pruritus associated with polycythemia vera in JAK2V617F transgenic mice. J Immunol. 2014 Jul 15; 193(2):477-84. PMID: 24920845.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    45. Iida R, Welner RS, Zhao W, Alberola-lla J, Medina KL, Zhao ZJ, Kincade PW. Stem and progenitor cell subsets are affected by JAK2 signaling and can be monitored by flow cytometry. PLoS One. 2014; 9(4):e93643. PMID: 24699465.
      Citations: 3     Fields:    Translation:AnimalsCells
    46. Shi K, Zhao W, Chen Y, Ho WT, Yang P, Zhao ZJ. Cardiac hypertrophy associated with myeloproliferative neoplasms in JAK2V617F transgenic mice. J Hematol Oncol. 2014 Mar 19; 7:25. PMID: 24646493.
      Citations: 16     Fields:    Translation:Animals
    47. Zhao ZJ, Liu D. A new Stem Cell Investigation. Stem Cell Investig. 2014; 1:1. PMID: 27358849.
      Citations:    
    48. Jin X, Zhao W, Shi K, Ho WT, Zhao ZJ. Generation of a new congenic mouse strain with enhanced chymase expression in mast cells. PLoS One. 2013; 8(12):e84340. PMID: 24391943.
      Citations: 4     Fields:    Translation:AnimalsCells
    49. Tang JZ, Carmichael CL, Shi W, Metcalf D, Ng AP, Hyland CD, Jenkins NA, Copeland NG, Howell VM, Zhao ZJ, Smyth GK, Kile BT, Alexander WS. Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):6091-6. PMID: 23533276.
      Citations: 14     Fields:    Translation:AnimalsCells
    50. Chow A, Huggins M, Ahmed J, Hashimoto D, Lucas D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, Tanaka M, Zhao ZJ, Bergman A, Merad M, Frenette PS. CD169? macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat Med. 2013 Apr; 19(4):429-36. PMID: 23502962.
      Citations: 231     Fields:    Translation:HumansAnimalsCells
    51. Guo Y, Chen Y, Xu X, Fu X, Zhao ZJ. SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells. J Hematol Oncol. 2012 Dec 06; 5:72. PMID: 23216927.
      Citations: 9     Fields:    Translation:HumansCells
    52. Yu X, Ma J, Lin F, Zhao W, Fu X, Zhao ZJ. Myotubularin family phosphatase ceMTM3 is required for muscle maintenance by preventing excessive autophagy in Caenorhabditis elegans. BMC Cell Biol. 2012 Oct 31; 13:28. PMID: 23114011.
      Citations: 5     Fields:    Translation:Animals
    53. Hassed SJ, Wiley GB, Wang S, Lee JY, Li S, Xu W, Zhao ZJ, Mulvihill JJ, Robertson J, Warner J, Gaffney PM. RBPJ mutations identified in two families affected by Adams-Oliver syndrome. Am J Hum Genet. 2012 Aug 10; 91(2):391-5. PMID: 22883147.
      Citations: 55     Fields:    Translation:HumansCells
    54. Chen Y, Guo Y, Han J, Ho WT, Li S, Fu X, Zhao ZJ. Generation and characterization of a highly effective protein substrate for analysis of FLT3 activity. J Hematol Oncol. 2012 Jul 16; 5:39. PMID: 22800464.
      Citations: 2     Fields:    Translation:HumansCells
    55. Kirabo A, Park SO, Wamsley HL, Gali M, Baskin R, Reinhard MK, Zhao ZJ, Bisht KS, Keseru GM, Cogle CR, Sayeski PP. The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis. Am J Pathol. 2012 Sep; 181(3):858-65. PMID: 22796437.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    56. Zhao W, Du Y, Ho WT, Fu X, Zhao ZJ. JAK2V617F and p53 mutations coexist in erythroleukemia and megakaryoblastic leukemic cell lines. Exp Hematol Oncol. 2012 Jun 21; 1(1):15. PMID: 23210734.
      Citations: 14     
    57. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
      Citations: 1822     Fields:    Translation:HumansAnimals
    58. Su F, Ren F, Rong Y, Wang Y, Geng Y, Wang Y, Feng M, Ju Y, Li Y, Zhao ZJ, Meng K, Chang Z. Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer. Breast Cancer Res. 2012 Mar 06; 14(2):R38. PMID: 22394684.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    59. Baskin R, Gali M, Park SO, Zhao ZJ, Keseru GM, Bisht KS, Sayeski PP. Identification of novel SAR properties of the Jak2 small molecule inhibitor G6: significance of the para-hydroxyl orientation. Bioorg Med Chem Lett. 2012 Feb 01; 22(3):1402-7. PMID: 22227213.
      Citations:    Fields:    Translation:AnimalsCells
    60. Kirabo A, Park SO, Majumder A, Gali M, Reinhard MK, Wamsley HL, Zhao ZJ, Cogle CR, Bisht KS, Keserü GM, Sayeski PP. The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow. Neoplasia. 2011 Nov; 13(11):1058-68. PMID: 22131881.
      Citations: 8     Fields:    Translation:AnimalsCells
    61. Majumder A, Magis AT, Park SO, Figueroa NC, Baskin R, Kirabo A, Allan RW, Zhao ZJ, Bisht KS, Keseru GM, Sayeski PP. A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growth. Exp Hematol. 2012 Jan; 40(1):22-34. PMID: 22019628.
      Citations:    Fields:    Translation:HumansAnimalsCells
    62. Zhao AH, Gao R, Zhao ZJ. Development of a highly sensitive method for detection of JAK2V617F. J Hematol Oncol. 2011 Oct 10; 4:40. PMID: 21985400.
      Citations: 8     Fields:    Translation:Humans
    63. Talbot AL, Bullock GC, Delehanty LL, Sattler M, Zhao ZJ, Goldfarb AN. Aconitase regulation of erythropoiesis correlates with a novel licensing function in erythropoietin-induced ERK signaling. PLoS One. 2011; 6(8):e23850. PMID: 21887333.
      Citations: 8     Fields:    Translation:AnimalsCells
    64. Yu X, Zhao W, Ma J, Fu X, Zhao ZJ. Beneficial and harmful effects of alcohol exposure on Caenorhabditis elegans worms. Biochem Biophys Res Commun. 2011 Sep 09; 412(4):757-62. PMID: 21871869.
      Citations: 6     Fields:    Translation:Animals
    65. Wang W, Liu L, Song X, Mo Y, Komma C, Bellamy HD, Zhao ZJ, Zhou GW. Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation. J Cell Biochem. 2011 Aug; 112(8):2062-71. PMID: 21465528.
      Citations: 44     Fields:    Translation:HumansCells
    66. Ma J, Li Z, Xing S, Ho WT, Fu X, Zhao ZJ. Tea contains potent inhibitors of tyrosine phosphatase PTP1B. Biochem Biophys Res Commun. 2011 Apr 01; 407(1):98-102. PMID: 21371422.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    67. Zhao W, Gao R, Lee J, Xing S, Ho WT, Fu X, Li S, Zhao ZJ. Relevance of JAK2V617F positivity to hematological diseases--survey of samples from a clinical genetics laboratory. J Hematol Oncol. 2011 Jan 14; 4:4. PMID: 21235771.
      Citations: 7     Fields:    Translation:Humans
    68. Wang S, Dong H, Han J, Ho WT, Fu X, Zhao ZJ. Identification of a variant form of tyrosine phosphatase LYP. BMC Mol Biol. 2010 Nov 02; 11:78. PMID: 21044313.
      Citations: 8     Fields:    Translation:HumansCells
    69. Yuan T, Wang Y, Zhao ZJ, Gu H. Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells. J Biol Chem. 2010 May 14; 285(20):14861-14870. PMID: 20335174; PMCID: PMC2865303.
      Citations: 40     Fields:    Translation:HumansCells
    70. Tophkhane C, Yang S, Zhao ZJ, Yang X. Cell density-dependent regulation of p73 in breast cancer cells. Int J Oncol. 2009 Dec; 35(6):1429-34. PMID: 19885566.
      Citations: 2     Fields:    Translation:HumansCells
    71. Ma J, Zeng F, Ho WT, Teng L, Li Q, Fu X, Zhao ZJ. Characterization and functional studies of a FYVE domain-containing phosphatase in C. elegans. J Cell Biochem. 2008 Aug 01; 104(5):1843-52. PMID: 18393358.
      Citations: 4     Fields:    Translation:AnimalsCells
    72. Xing S, Wanting TH, Zhao W, Ma J, Wang S, Xu X, Li Q, Fu X, Xu M, Zhao ZJ. Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice. Blood. 2008 May 15; 111(10):5109-17. PMID: 18334677.
      Citations: 107     Fields:    Translation:AnimalsCells
    73. Li Z, Xing S, Wang S, Ho WT, Zhao ZJ. Characterization of a highly effective protein substrate for analysis of JAK2(V617F) Activity. Exp Hematol. 2007 Nov; 35(11):1624-32. PMID: 17764811.
      Citations: 7     Fields:    Translation:HumansCells
    74. Sutton BC, Allen RA, Zhao ZJ, Dunn ST. Detection of the JAK2V617F mutation by asymmetric PCR and melt curve analysis. Cancer Biomark. 2007; 3(6):315-24. PMID: 18048969.
      Citations: 8     Fields:    Translation:HumansCells
    75. Li Z, Xu M, Xing S, Ho WT, Ishii T, Li Q, Fu X, Zhao ZJ. Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth. J Biol Chem. 2007 Feb 09; 282(6):3428-32. PMID: 17178722.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    76. Zheng C, Lin Z, Zhao ZJ, Yang Y, Niu H, Shen X. MAPK-activated protein kinase-2 (MK2)-mediated formation and phosphorylation-regulated dissociation of the signal complex consisting of p38, MK2, Akt, and Hsp27. J Biol Chem. 2006 Dec 01; 281(48):37215-26. PMID: 17015449.
      Citations: 52     Fields:    Translation:AnimalsCells
    77. Xu X, Zhang Q, Luo J, Xing S, Li Q, Krantz SB, Fu X, Zhao ZJ. JAK2(V617F): Prevalence in a large Chinese hospital population. Blood. 2007 Jan 01; 109(1):339-42. PMID: 16946305.
      Citations: 48     Fields:    Translation:HumansCells
    78. Wang N, Li Z, Ding R, Frank GD, Senbonmatsu T, Landon EJ, Inagami T, Zhao ZJ. Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling. J Biol Chem. 2006 Aug 04; 281(31):21878-21883. PMID: 16762922.
      Citations: 15     Fields:    Translation:HumansCells
    79. Yu Z, Maoui M, Zhao ZJ, Li Y, Shen SH. SHP-1 dephosphorylates 3BP2 and potentially downregulates 3BP2-mediated T cell antigen receptor signaling. FEBS J. 2006 May; 273(10):2195-205. PMID: 16649996.
      Citations: 7     Fields:    Translation:HumansCells
    80. Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch KA, Downey GP. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med. 2005 Dec 05; 202(11):1587-97. PMID: 16330817.
      Citations: 26     Fields:    Translation:AnimalsCells
    81. Zhao ZJ, Vainchenker W, Krantz SB, Casadevall N, Constantinescu SN. Role of tyrosine kinases and phosphatases in polycythemia vera. Semin Hematol. 2005 Oct; 42(4):221-9. PMID: 16210035.
      Citations: 12     Fields:    Translation:HumansCells
    82. Ho WT, Xie Z, Zhao ZJ, Exton JH. Tyrosine phosphorylation of phospholipase D1 by v-Src does not per se result in activation. Cell Signal. 2005 Jun; 17(6):691-9. PMID: 15722193.
      Citations: 5     Fields:    Translation:AnimalsCells
    83. Zhao R, Xing S, Li Z, Fu X, Li Q, Krantz SB, Zhao ZJ. Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem. 2005 Jun 17; 280(24):22788-92. PMID: 15863514.
      Citations: 215     Fields:    Translation:HumansAnimalsCells
    84. Zhang MZ, Mai W, Li C, Cho SY, Hao C, Moeckel G, Zhao R, Kim I, Wang J, Xiong H, Wang H, Sato Y, Wu Y, Nakanuma Y, Lilova M, Pei Y, Harris RC, Li S, Coffey RJ, Sun L, Wu D, Chen XZ, Breyer MD, Zhao ZJ, McKanna JA, Wu G. PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2311-6. PMID: 14983006.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    85. Xu MJ, Sui X, Zhao R, Dai C, Krantz SB, Zhao ZJ. PTP-MEG2 is activated in polycythemia vera erythroid progenitor cells and is required for growth and expansion of erythroid cells. Blood. 2003 Dec 15; 102(13):4354-60. PMID: 12920026.
      Citations: 23     Fields:    Translation:HumansCells
    86. Zhao R, Fu X, Teng L, Li Q, Zhao ZJ. Blocking the function of tyrosine phosphatase SHP-2 by targeting its Src homology 2 domains. J Biol Chem. 2003 Oct 31; 278(44):42893-8. PMID: 12913007.
      Citations: 12     Fields:    Translation:AnimalsCells
    87. Zhao R, Zhao ZJ. Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs. Biochem Biophys Res Commun. 2003 Apr 18; 303(4):1028-33. PMID: 12684038.
      Citations: 5     Fields:    Translation:HumansCells
    88. Zhao R, Fu X, Li Q, Krantz SB, Zhao ZJ. Specific interaction of protein tyrosine phosphatase-MEG2 with phosphatidylserine. J Biol Chem. 2003 Jun 20; 278(25):22609-14. PMID: 12702726.
      Citations: 11     Fields:    Translation:HumansCells
    89. Yang J, Liu L, He D, Song X, Liang X, Zhao ZJ, Zhou GW. Crystal structure of human protein-tyrosine phosphatase SHP-1. J Biol Chem. 2003 Feb 21; 278(8):6516-20. PMID: 12482860.
      Citations: 67     Fields:    Translation:HumansCells
    90. Xu MJ, Zhao R, Cao H, Zhao ZJ. SPAP2, an Ig family receptor containing both ITIMs and ITAMs. Biochem Biophys Res Commun. 2002 May 10; 293(3):1037-46. PMID: 12051764.
      Citations: 13     Fields:    Translation:HumansCells
    91. Xu F, Xu MJ, Zhao R, Guerrah A, Zeng F, Zhao ZJ. Tyrosine phosphatases SHP-1 and SHP-2 are associated with distinct tyrosine-phosphorylated proteins. Exp Cell Res. 2002 Jan 01; 272(1):75-83. PMID: 11740867.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    92. Mishra AK, Zhang A, Niu T, Yang J, Liang X, Zhao ZJ, Zhou GW. Substrate specificity of protein tyrosine phosphatase: differential behavior of SHP-1 and SHP-2 towards signal regulation protein SIRPalpha1. J Cell Biochem. 2002; 84(4):840-6. PMID: 11835408.
      Citations: 2     Fields:    Translation:HumansCells
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