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Raju VS Rajala

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentOphthalmology
AddressDMEI 409
608 Stanton L Young Blvd
Oklahoma City OK 73104
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    Collapse Research 
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    R01EY035282     (RAJALA, RAJU VS)Sep 1, 2023 - Jun 30, 2027
    NIH
    Regulators of Photoreceptor Aerobic Glycolysis in Retinal Health and Disease
    Role: Principal Investigator
    R01EY030024     (RAJALA, RAJU VS)Sep 30, 2019 - Jun 30, 2024
    NIH
    Neuroprotection Mechanism for Photoreceptors
    Role: Principal Investigator
    R01DK097092     (RAJALA, RAJU VS)Sep 1, 2013 - Jun 30, 2018
    NIH
    Mechanistic studies on obesity-deteriorated glucose and lipid metabolisms
    Role: Principal Investigator
    R01EY016507     (RAJALA, RAJU VS)Apr 1, 2005 - Aug 31, 2015
    NIH
    Light Activation of Retinal Insulin Receptor Signaling
    Role: Principal Investigator
    R01EY000871     (RAJALA, RAJU VS)Feb 1, 1978 - Mar 31, 2021
    NIH
    Second Messengers in the Retina
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Adele R, Hussein R, Tavares E, Ahmed K, Di Scipio M, Charish J, Liang M, Monis S, Tumber A, Chen X, Paton TA, Roslin NM, Eileen C, Ivakine E, Sunny NE, Wilson MD, Campos E, Rajala RV, Maynes JT, Monnier PP, Paterson AD, H?on E, Vincent A. Autosomal dominant macular dystrophy linked to a chromosome 17 tandem duplication. JCI Insight. 2024 Oct 22. PMID: 39436697.
      Citations:    
    2. Rajala A, Rajala R, Bhat MA, Eminhizer M, Hao J, Du J, Rajala RVS. Age-related retinal degeneration resulting from the deletion of Shp2 tyrosine phosphatase in photoreceptor neurons. Cell Death Dis. 2024 Aug 08; 15(8):577. PMID: 39117618; PMCID: PMC11310310.
      Citations:    Fields:    Translation:AnimalsCells
    3. Rajala A, Rajala RVS. Age-Related Changes in the Glycolytic Enzymes of M2-Isoform of Pyruvate Kinase and Fructose-1,6-Bisphosphate Aldolase: Implications to Age-Related Macular Degeneration. Aging Dis. 2024 04 22. PMID: 38739943.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Rajala RVS, Rajala A. From Insight to Eyesight: Unveiling the Secrets of the Insulin-Like Growth Factor Axis in Retinal Health. Aging Dis. 2024 Jan 30. PMID: 38300646.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Rajala RVS, Rajala A. Unlocking the role of lactate: metabolic pathways, signaling, and gene regulation in postmitotic retinal cells. Front Ophthalmol (Lausanne). 2023; 3:1296624. PMID: 38983010; PMCID: PMC11182115.
      Citations: 1     
    6. Rajala A, Rajala R, Gopinadhan Nair GK, Rajala RVS. Atlas of phosphoinositide signatures in the retina identifies heterogeneity between cell types. PNAS Nexus. 2023 Mar; 2(3):pgad063. PMID: 37007713; PMCID: PMC10062291.
      Citations: 2     
    7. Rajala A, Bhat MA, Teel K, Gopinadhan Nair GK, Purcell L, Rajala RVS. The function of lactate dehydrogenase A in retinal neurons: implications to retinal degenerative diseases. PNAS Nexus. 2023 Mar; 2(3):pgad038. PMID: 36896135; PMCID: PMC9991461.
      Citations: 5     
    8. Rajala A, Teel K, Bhat MA, Batushansky A, Griffin TM, Purcell L, Rajala RVS. Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection. Cell Death Dis. 2022 Jul 15; 13(7):613. PMID: 35840554.
      Citations: 8     Fields:    Translation:AnimalsCells
    9. Fort PE, Losiewicz MK, Elghazi L, Kong D, Cras-Méneur C, Fingar DC, Kimball SR, Rajala RVS, Smith AJ, Ali RR, Abcouwer SF, Gardner TW. mTORC1 regulates high levels of protein synthesis in retinal ganglion cells of adult mice. J Biol Chem. 2022 06; 298(6):101944. PMID: 35447116.
      Citations: 3     Fields:    Translation:AnimalsCells
    10. Rajala A, Rajala R, Teel K, Rajala RVS. Ribosomal targeting strategy and nuclear labeling to analyze photoreceptor phosphoinositide signatures. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 08; 1867(8):159161. PMID: 35427794.
      Citations: 3     Fields:    Translation:AnimalsCells
    11. Shang P, Stepicheva N, Teel K, McCauley A, Fitting CS, Hose S, Grebe R, Yazdankhah M, Ghosh S, Liu H, Strizhakova A, Weiss J, Bhutto IA, Lutty GA, Jayagopal A, Qian J, Sahel JA, Samuel Zigler J, Handa JT, Sergeev Y, Rajala RVS, Watkins S, Sinha D. ßA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells. Commun Biol. 2021 07 08; 4(1):850. PMID: 34239035.
      Citations: 10     Translation:HumansAnimalsCells
    12. Rajala RVS, McCauley A, Rajala R, Teel K, Rajala A. Regulation of Phosphoinositide Levels in the Retina by Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14. Biomolecules. 2021 04 19; 11(4). PMID: 33921658.
      Citations:    Fields:    Translation:AnimalsCells
    13. Rajala RVS. Signaling roles of phosphoinositides in the retina. J Lipid Res. 2021; 62:100041. PMID: 32540927.
      Citations: 10     Fields:    
    14. Rajala A, He F, Anderson RE, Wensel TG, Rajala RVS. Loss of Class III Phosphoinositide 3-Kinase Vps34 Results in Cone Degeneration. Biology (Basel). 2020 Nov 07; 9(11). PMID: 33171845.
      Citations: 5     
    15. Losiewicz MK, Elghazi L, Fingar DC, Rajala RVS, Lentz SI, Fort PE, Abcouwer SF, Gardner TW. mTORC1 and mTORC2 expression in inner retinal neurons and glial cells. Exp Eye Res. 2020 08; 197:108131. PMID: 32622801.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    16. Rajala A, McCauley A, Brush RS, Nguyen K, Rajala RVS. Phosphoinositide Lipids in Ocular Tissues. Biology (Basel). 2020 Jun 12; 9(6). PMID: 32545642.
      Citations: 4     
    17. Lee SY, Surbeck JW, Drake M, Saunders A, Jin HD, Shah VA, Rajala RV. Increased Glial Fibrillary Acid Protein and Vimentin in Vitreous Fluid as a Biomarker for Proliferative Vitreoretinopathy. Invest Ophthalmol Vis Sci. 2020 05 11; 61(5):22. PMID: 32413125.
      Citations: 13     Fields:    Translation:Humans
    18. Rajala A, Soni K, Rajala RVS. Metabolic and Non-metabolic Roles of Pyruvate Kinase M2 Isoform in Diabetic Retinopathy. Sci Rep. 2020 05 04; 10(1):7456. PMID: 32366925.
      Citations: 7     Fields:    Translation:AnimalsCells
    19. Rajala RVS. Aerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms. Front Cell Dev Biol. 2020; 8:266. PMID: 32426353.
      Citations: 23     
    20. Rajala A, Rajala RVS. A non-canonical rhodopsin-mediated insulin receptor signaling pathway in retinal photoreceptor neurons. Cell Biol Int. 2020 Apr; 44(4):1020-1027. PMID: 31889373.
      Citations: 1     Fields:    Translation:AnimalsCells
    21. Rajala RVS. Therapeutic Benefits from Nanoparticles: The Potential Significance of Nanoscience in Retinal Degenerative Diseases. J Mol Biol Ther. 2019; 1:44-55. PMID: 34528026.
      Citations:    
    22. Rajala A, Wang Y, Soni K, Rajala RVS. Pyruvate kinase M2 isoform deletion in cone photoreceptors results in age-related cone degeneration. Cell Death Dis. 2018 07 03; 9(7):737. PMID: 29970877.
      Citations: 20     Fields:    Translation:AnimalsCells
    23. Rajala A, Wang Y, Brush RS, Tsantilas K, Jankowski CSR, Lindsay KJ, Linton JD, Hurley JB, Anderson RE, Rajala RVS. Pyruvate kinase M2 regulates photoreceptor structure, function, and viability. Cell Death Dis. 2018 02 14; 9(2):240. PMID: 29445082.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    24. Wang Y, Rajala A, Rajala RVS. Nanoparticles as Delivery Vehicles for the Treatment of Retinal Degenerative Diseases. Adv Exp Med Biol. 2018; 1074:117-123. PMID: 29721935.
      Citations: 5     Fields:    Translation:HumansAnimals
    25. Rajala A, Wang Y, Rajala RVS. Constitutive Activation Mutant mTOR Promote Cone Survival in Retinitis Pigmentosa Mice. Adv Exp Med Biol. 2018; 1074:491-497. PMID: 29721981.
      Citations: 6     Fields:    Translation:AnimalsCells
    26. Rajala RVS, Rajala A. Redundant and Nonredundant Functions of Akt Isoforms in the Retina. Adv Exp Med Biol. 2018; 1074:585-591. PMID: 29721991.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    27. Rajala A, Wang Y, Abcouwer SF, Gardner TW, Rajala RVS. Developmental and light regulation of tumor suppressor protein PP2A in the retina. Oncotarget. 2018 Jan 05; 9(2):1505-1523. PMID: 29416710.
      Citations: 5     Fields:    
    28. Chen Q, Qiu F, Zhou K, Matlock HG, Takahashi Y, Rajala RVS, Yang Y, Moran E, Ma JX. Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARa. Diabetes. 2017 06; 66(6):1671-1682. PMID: 28270521.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    29. Rajala RV, Rajala A, Kooker C, Wang Y, Anderson RE. The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina. Sci Rep. 2016 11 24; 6:37727. PMID: 27883057.
      Citations: 38     Fields:    Translation:AnimalsCells
    30. Rajala A, Wang Y, Rajala RV. Activation of oncogenic tyrosine kinase signaling promotes insulin receptor-mediated cone photoreceptor survival. Oncotarget. 2016 Jul 26; 7(30):46924-46942. PMID: 27391439.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    31. Wang Y, Rajala A, Cao B, Ranjo-Bishop M, Agbaga MP, Mao C, Rajala RV. Cell-Specific Promoters Enable Lipid-Based Nanoparticles to Deliver Genes to Specific Cells of the Retina In Vivo. Theranostics. 2016; 6(10):1514-27. PMID: 27446487.
      Citations: 20     Fields:    Translation:AnimalsCells
    32. Rajala RV, Gardner TW. Burning fat fuels photoreceptors. Nat Med. 2016 Apr; 22(4):342-3. PMID: 27050587.
      Citations: 8     Fields:    Translation:Humans
    33. Rao KN, Li L, Zhang W, Brush RS, Rajala RV, Khanna H. Loss of human disease protein retinitis pigmentosa GTPase regulator (RPGR) differentially affects rod or cone-enriched retina. Hum Mol Genet. 2016 Apr 01; 25(7):1345-56. PMID: 26908598.
      Citations: 16     Fields:    Translation:AnimalsCells
    34. Azadi S, Brush RS, Anderson RE, Rajala RV. Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina. Adv Exp Med Biol. 2016; 854:363-9. PMID: 26427433.
      Citations: 2     Fields:    Translation:AnimalsCells
    35. Rajala RV, Kanan Y, Anderson RE. Photoreceptor Neuroprotection: Regulation of Akt Activation Through Serine/Threonine Phosphatases, PHLPP and PHLPPL. Adv Exp Med Biol. 2016; 854:419-24. PMID: 26427440.
      Citations: 3     Fields:    Translation:HumansCells
    36. Wang Y, Rajala A, Rajala RV. Lipid Nanoparticles for Ocular Gene Delivery. J Funct Biomater. 2015 Jun 08; 6(2):379-94. PMID: 26062170.
      Citations: 25     
    37. Takahashi Y, Chen Q, Rajala RVS, Ma JX. MicroRNA-184 modulates canonical Wnt signaling through the regulation of frizzled-7 expression in the retina with ischemia-induced neovascularization. FEBS Lett. 2015 Apr 28; 589(10):1143-1149. PMID: 25796186.
      Citations: 40     Fields:    Translation:AnimalsCells
    38. Rajala RV, Ranjo-Bishop M, Wang Y, Rajala A, Anderson RE. The p110a isoform of phosphoinositide 3-kinase is essential for cone photoreceptor survival. Biochimie. 2015 May; 112:35-40. PMID: 25742742.
      Citations: 6     Fields:    Translation:AnimalsCells
    39. Gupta VK, Rajala A, Rajala RV. Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells. Cell Commun Signal. 2015 Feb 03; 13:7. PMID: 25644171.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    40. Woodruff ML, Rajala A, Fain GL, Rajala RV. Effect of knocking down the insulin receptor on mouse rod responses. Sci Rep. 2015 Jan 19; 5:7858. PMID: 25598343.
      Citations: 3     Fields:    Translation:AnimalsCells
    41. Zulliger R, Naash MI, Rajala RV, Molday RS, Azadi S. Impaired association of retinal degeneration-3 with guanylate cyclase-1 and guanylate cyclase-activating protein-1 leads to leber congenital amaurosis-1. J Biol Chem. 2015 Feb 06; 290(6):3488-99. PMID: 25477517.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    42. Rajala A, Wang Y, Zhu Y, Ranjo-Bishop M, Ma JX, Mao C, Rajala RV. Nanoparticle-assisted targeted delivery of eye-specific genes to eyes significantly improves the vision of blind mice in vivo. Nano Lett. 2014 Sep 10; 14(9):5257-63. PMID: 25115433.
      Citations: 46     Fields:    Translation:AnimalsCells
    43. Rajala RV, Rajala A, Morris AJ, Anderson RE. Phosphoinositides: minor lipids make a major impact on photoreceptor cell functions. Sci Rep. 2014 Jun 26; 4:5463. PMID: 24964953.
      Citations: 6     Fields:    Translation:AnimalsCells
    44. Rajala RV, Basavarajappa DK, Dighe R, Rajala A. Spatial and temporal aspects and the interplay of Grb14 and protein tyrosine phosphatase-1B on the insulin receptor phosphorylation. Cell Commun Signal. 2013 Dec 18; 11:96. PMID: 24350791.
      Citations: 6     Fields:    Translation:AnimalsCells
    45. Rajala RV, Rajala A. Neuroprotective role of protein tyrosine phosphatase-1B in rod photoreceptor neurons. Protein Cell. 2013 Dec; 4(12):890-2. PMID: 24203758.
      Citations: 5     Fields:    Translation:AnimalsCells
    46. Woodruff ML, Rajala A, Fain GL, Rajala RV. Modulation of mouse rod photoreceptor responses by Grb14 protein. J Biol Chem. 2014 Jan 03; 289(1):358-64. PMID: 24273167.
      Citations: 11     Fields:    Translation:AnimalsCells
    47. Rajala A, Gupta VK, Anderson RE, Rajala RV. Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection. Mitochondrion. 2013 Nov; 13(6):566-76. PMID: 23993956.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    48. Rajala A, Dighe R, Agbaga MP, Anderson RE, Rajala RV. Insulin receptor signaling in cones. J Biol Chem. 2013 Jul 05; 288(27):19503-15. PMID: 23673657.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    49. Rajala A, Dilly AK, Rajala RV. Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina. Cell Commun Signal. 2013 Mar 22; 11(1):20. PMID: 23521888.
      Citations: 2     Fields:    
    50. Gupta VK, Rajala A, Rajala RV. Insulin receptor regulates photoreceptor CNG channel activity. Am J Physiol Endocrinol Metab. 2012 Dec 01; 303(11):E1363-72. PMID: 23032687.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    51. Rajala RV, Rajala A, Gupta VK. Conservation and divergence of Grb7 family of Ras-binding domains. Protein Cell. 2012 Jan; 3(1):60-70. PMID: 22271596.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    52. Gupta VK, Rajala A, Rajala RV. Ras-associating domain proteins: a new class of cyclic nucleotide-gated channel modulators. Adv Exp Med Biol. 2012; 723:777-82. PMID: 22183406.
      Citations:    Fields:    Translation:HumansCells
    53. Basavarajappa DK, Gupta VK, Rajala RV. Protein tyrosine phosphatase 1B: a novel molecular target for retinal degenerative diseases. Adv Exp Med Biol. 2012; 723:829-34. PMID: 22183413.
      Citations: 3     Fields:    Translation:HumansAnimals
    54. Gupta VK, Rajala A, Rodgers KK, Rajala RV. Mechanism involved in the modulation of photoreceptor-specific cyclic nucleotidegated channel by the tyrosine kinase adapter protein Grb14. Protein Cell. 2011 Nov; 2(11):906-17. PMID: 22180090.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    55. Ivanovic I, Allen DT, Dighe R, Le YZ, Anderson RE, Rajala RV. Phosphoinositide 3-kinase signaling in retinal rod photoreceptors. Invest Ophthalmol Vis Sci. 2011 Aug 11; 52(9):6355-62. PMID: 21730346.
      Citations: 17     Fields:    Translation:AnimalsCellsPHPublic Health
    56. Basavarajappa DK, Gupta VK, Dighe R, Rajala A, Rajala RV. Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14. Mol Cell Biol. 2011 Oct; 31(19):3975-87. PMID: 21791607.
      Citations: 18     Fields:    Translation:AnimalsCells
    57. Ivanovic I, Anderson RE, Le YZ, Fliesler SJ, Sherry DM, Rajala RV. Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3775-83. PMID: 21398281.
      Citations: 33     Fields:    Translation:AnimalsCells
    58. Gupta VK, Rajala A, Daly RJ, Rajala RV. Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel. EMBO Rep. 2010 Nov; 11(11):861-7. PMID: 20890309.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    59. Rajala RV, Anderson RE. Focus on molecules: phosphatidylinositol-4,5-bisphosphate (PIP2). Exp Eye Res. 2010 Sep; 91(3):324-5. PMID: 20457154.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    60. Rajala RV, Anderson RE. Rhodopsin-regulated insulin receptor signaling pathway in rod photoreceptor neurons. Mol Neurobiol. 2010 Aug; 42(1):39-47. PMID: 20407846.
      Citations: 17     Fields:    Translation:AnimalsCells
    61. Huang Z, Anderson RE, Cao W, Wiechmann AF, Rajala RV. Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II a phosphatidylinositol-5-phosphate 4-kinase. Neurochem Res. 2011 Apr; 36(4):627-35. PMID: 20204506.
      Citations: 4     Fields:    Translation:AnimalsCells
    62. Kanan Y, Matsumoto H, Song H, Sokolov M, Anderson RE, Rajala RV. Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL. J Neurochem. 2010 Apr; 113(2):477-88. PMID: 20089132.
      Citations: 10     Fields:    Translation:AnimalsCells
    63. Rajala RV, Tanito M, Neel BG, Rajala A. Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene. J Biol Chem. 2010 Mar 19; 285(12):8894-904. PMID: 20061388.
      Citations: 26     Fields:    Translation:AnimalsCells
    64. Rajala RV. Phosphoinositide 3-kinase signaling in the vertebrate retina. J Lipid Res. 2010 Jan; 51(1):4-22. PMID: 19638643.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    65. Rajala RV, Rajala A, Brush RS, Rotstein NP, Politi LE. Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors. J Neurochem. 2009 Sep; 110(5):1648-60. PMID: 19575708.
      Citations: 3     Fields:    Translation:AnimalsCells
    66. Rajala A, Daly RJ, Tanito M, Allen DT, Holt LJ, Lobanova ES, Arshavsky VY, Rajala RV. Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation. Biochemistry. 2009 Jun 23; 48(24):5563-72. PMID: 19438210.
      Citations: 20     Fields:    Translation:AnimalsCells
    67. Rajala RV, Rajala A. Cytoskeletal components enhance the autophosphorylation of retinal insulin receptor. Chem Biol Interact. 2009 Jul 15; 180(2):245-53. PMID: 19497423.
      Citations:    Fields:    Translation:AnimalsCells
    68. Rajala RV, Ivanovic I, Dilly AK. Retinal insulin receptor signaling in hyperosmotic stress. Vitam Horm. 2009; 80:583-612. PMID: 19251051.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    69. Rajala RV, Wiskur B, Tanito M, Callegan M, Rajala A. Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1033-40. PMID: 19029027.
      Citations: 34     Fields:    Translation:AnimalsCells
    70. Li G, Rajala A, Wiechmann AF, Anderson RE, Rajala RV. Activation and membrane binding of retinal protein kinase Balpha/Akt1 is regulated through light-dependent generation of phosphoinositides. J Neurochem. 2008 Dec; 107(5):1382-97. PMID: 18823366.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    71. Rajala RV. Phospho-Site-Specific Antibody Microarray to Study the State of Protein Phosphorylation in the Retina. J Proteomics Bioinform. 2008 Aug 13; 1:242. PMID: 20151040.
      Citations: 2     
    72. Dilly AK, Rajala RV. Insulin growth factor 1 receptor/PI3K/AKT survival pathway in outer segment membranes of rod photoreceptors. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):4765-73. PMID: 18566464.
      Citations: 14     Fields:    Translation:AnimalsCells
    73. Rajala A, Tanito M, Le YZ, Kahn CR, Rajala RV. Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. J Biol Chem. 2008 Jul 11; 283(28):19781-92. PMID: 18480052.
      Citations: 61     Fields:    Translation:AnimalsCells
    74. Rajaiya J, Xiao J, Rajala RV, Chodosh J. Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expression. Virol J. 2008 Jan 25; 5:17. PMID: 18221537.
      Citations: 26     Fields:    Translation:HumansCells
    75. Rajala A, Anderson RE, Ma JX, Lem J, Al-Ubaidi MR, Rajala RVS. G-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor. J Biol Chem. 2007 Mar 30; 282(13):9865-9873. PMID: 17272282.
      Citations: 33     Fields:    Translation:AnimalsCells
    76. Li G, Anderson RE, Tomita H, Adler R, Liu X, Zack DJ, Rajala RV. Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death. J Neurosci. 2007 Jan 03; 27(1):203-11. PMID: 17202487.
      Citations: 63     Fields:    Translation:AnimalsCells
    77. Rajala RV, Elliott MH, McClellan ME, Anderson RE. Localization of the insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments. Adv Exp Med Biol. 2006; 572:491-7. PMID: 17249614.
      Citations: 3     Fields:    Translation:AnimalsCells
    78. Rajala RV, Chan MD, Rajala A. Lipid-protein interactions of growth factor receptor-bound protein 14 in insulin receptor signaling. Biochemistry. 2005 Nov 29; 44(47):15461-71. PMID: 16300394.
      Citations: 8     Fields:    Translation:AnimalsCells
    79. Rajala MS, Rajala RV, Astley RA, Butt AL, Chodosh J. Corneal cell survival in adenovirus type 19 infection requires phosphoinositide 3-kinase/Akt activation. J Virol. 2005 Oct; 79(19):12332-41. PMID: 16160160.
      Citations: 30     Fields:    Translation:HumansCells
    80. Rajala RV. How does the biological function of N-myristoylation differ from that of N-palmitoylation? IUBMB Life. 2005 Aug; 57(8):597-8. PMID: 16118118.
      Citations:    Fields:    Translation:Cells
    81. Rajala RV, Chan MD. Identification of a NPXY motif in growth factor receptor-bound protein 14 (Grb14) and its interaction with the phosphotyrosine-binding (PTB) domain of IRS-1. Biochemistry. 2005 Jun 07; 44(22):7929-35. PMID: 15924411.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    82. Dumonceaux T, Rajala RV, Sharma R, Selvaraj G, Datla R. Molecular characterization of a gene encoding N-myristoyl transferase (NMT) from Triticum aestivum (bread wheat). Genome. 2004 Dec; 47(6):1036-42. PMID: 15644961.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    83. Rajala RV, McClellan ME, Chan MD, Tsiokas L, Anderson RE. Interaction of the retinal insulin receptor beta-subunit with the p85 subunit of phosphoinositide 3-kinase. Biochemistry. 2004 May 18; 43(19):5637-50. PMID: 15134438.
      Citations: 25     Fields:    Translation:AnimalsCells
    84. Rundle DR, Rajala RV, Alvarez RA, Anderson RE. Myristoyl-CoA:protein N-myristoyltransferases: isoform identification and gene expression in retina. Mol Vis. 2004 Mar 22; 10:177-85. PMID: 15041955.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    85. Yu X, Rajala RV, McGinnis JF, Li F, Anderson RE, Yan X, Li S, Elias RV, Knapp RR, Zhou X, Cao W. Involvement of insulin/phosphoinositide 3-kinase/Akt signal pathway in 17 beta-estradiol-mediated neuroprotection. J Biol Chem. 2004 Mar 26; 279(13):13086-94. PMID: 14711819.
      Citations: 48     Fields:    Translation:AnimalsCells
    86. Rajala RV, Anderson RE. Light regulation of the insulin receptor in the retina. Mol Neurobiol. 2003 Oct; 28(2):123-38. PMID: 14576451.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    87. Rajala RV, McClellan ME, Ash JD, Anderson RE. Regulation of retinal phosphoinositide 3-kinase activity in p85alpha-subunit knockout mice. Adv Exp Med Biol. 2003; 533:369-76. PMID: 15180287.
      Citations: 2     Fields:    Translation:Animals
    88. Cao W, Rajala RV, Li F, Anderson RE, Wei N, Soliman CE, McGinnis JF. Neuroprotective effect of estrogen upon retinal neurons in vitro. Adv Exp Med Biol. 2003; 533:395-402. PMID: 15180290.
      Citations: 5     Fields:    Translation:AnimalsCells
    89. Rajala RV, McClellan ME, Ash JD, Anderson RE. In vivo regulation of phosphoinositide 3-kinase in retina through light-induced tyrosine phosphorylation of the insulin receptor beta-subunit. J Biol Chem. 2002 Nov 08; 277(45):43319-26. PMID: 12213821.
      Citations: 48     Fields:    Translation:AnimalsCells
    90. Rundle DR, Rajala RV, Anderson RE. Characterization of Type I and Type II myristoyl-CoA:protein N-myristoyltransferases with the Acyl-CoAs found on heterogeneously acylated retinal proteins. Exp Eye Res. 2002 Jul; 75(1):87-97. PMID: 12123640.
      Citations: 4     Fields:    Translation:AnimalsCells
    91. Kakkar R, Seitz DP, Kanthan R, Rajala RV, Radhi JM, Wang X, Pasha MK, Wang R, Sharma RK. Calmodulin-dependent cyclic nucleotide phosphodiesterase in an experimental rat model of cardiac ischemia-reperfusion. Can J Physiol Pharmacol. 2002 Jan; 80(1):59-66. PMID: 11926171.
      Citations:    Fields:    Translation:Animals
    92. Rajala RV, Kakkar R, Kanthan R, Radhi JM, Wang X, Wang R, Datla RS, Sharma RK. Altered expression and localization of N-myristoyltransferase in experimentally induced rat model of ischemia-reperfusion. J Cell Biochem. 2002; 86(3):509-19. PMID: 12210757.
      Citations: 2     Fields:    Translation:HumansAnimals
    93. Rajala RV, Anderson RE. Interaction of the insulin receptor beta-subunit with phosphatidylinositol 3-kinase in bovine ROS. Invest Ophthalmol Vis Sci. 2001 Dec; 42(13):3110-7. PMID: 11726610.
      Citations: 11     Fields:    Translation:AnimalsCells
    94. Rajala RV, Datla RS, Carlsen SA, Anderson DH, Qi Z, Wang JH, Sharma RK. Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members. Biochem Biophys Res Commun. 2001 Oct 19; 288(1):233-9. PMID: 11594778.
      Citations: 3     Fields:    Translation:HumansCells
    95. Kakkar R, Wang X, Radhi JM, Rajala RV, Wang R, Sharma RK. Decreased expression of high-molecular-weight calmodulin-binding protein and its correlation with apoptosis in ischemia-reperfused rat heart. Cell Calcium. 2001 Jan; 29(1):59-71. PMID: 11133356.
      Citations: 6     Fields:    Translation:Animals
    96. Rajala RV, Dehm S, Bi X, Bonham K, Sharma RK. Expression of N-myristoyltransferase inhibitor protein and its relationship to c-Src levels in human colon cancer cell lines. Biochem Biophys Res Commun. 2000 Jul 14; 273(3):1116-20. PMID: 10891381.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    97. Kakkar R, Radhi JM, Rajala RV, Sharma RK. Altered expression of high-molecular-weight calmodulin-binding protein in human ischaemic myocardium. J Pathol. 2000 Jun; 191(2):208-16. PMID: 10861583.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    98. Rajala RV, Radhi JM, Kakkar R, Datla RS, Sharma RK. Increased expression of N-myristoyltransferase in gallbladder carcinomas. Cancer. 2000 May 01; 88(9):1992-9. PMID: 10813869.
      Citations: 14     Fields:    Translation:HumansCells
    99. Xiang J, Srivamadan M, Rajala R, Jia Z. Study of B72.3 combining sites by molecular modeling and site-directed mutagenesis. Protein Eng. 2000 May; 13(5):339-44. PMID: 10835107.
      Citations:    Fields:    Translation:Cells
    100. Qi Q, Rajala RV, Anderson W, Jiang C, Rozwadowski K, Selvaraj G, Sharma R, Datla R. Molecular cloning, genomic organization, and biochemical characterization of myristoyl-CoA:protein N-myristoyltransferase from Arabidopsis thaliana. J Biol Chem. 2000 Mar 31; 275(13):9673-83. PMID: 10734119.
      Citations: 14     Fields:    Translation:AnimalsCells
    101. Rajala RV, Datla RS, Moyana TN, Kakkar R, Carlsen SA, Sharma RK. N-myristoyltransferase. Mol Cell Biochem. 2000 Jan; 204(1-2):135-55. PMID: 10718634.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    102. Rajala RV, Sharma RK. Myristoyl CoA:protein N-myristoyltransferase: subcellular localization, activation and kinetic behavior in the presence of organic solvents. Biochem Biophys Res Commun. 1995 Mar 17; 208(2):617-23. PMID: 7695615.
      Citations: 4     Fields:    Translation:AnimalsCells
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