"Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
| Descriptor ID |
D007515
|
| MeSH Number(s) |
A03.734.414 A06.407.414
|
| Concept/Terms |
Islets of Langerhans- Islets of Langerhans
- Langerhans Islets
- Pancreatic Islets
- Islet, Pancreatic
- Islets, Pancreatic
- Pancreatic Islet
- Nesidioblasts
- Nesidioblast
- Pancreas, Endocrine
- Endocrine Pancreas
- Islands of Langerhans
- Langerhans Islands
- Islet Cells
- Cell, Islet
- Cells, Islet
- Islet Cell
|
Below are MeSH descriptors whose meaning is more general than "Islets of Langerhans".
Below are MeSH descriptors whose meaning is more specific than "Islets of Langerhans".
This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Islets of Langerhans" by people in Profiles.
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Pharmacological Inhibition of Inositol-Requiring Enzyme 1a RNase Activity Protects Pancreatic Beta Cell and Improves Diabetic Condition in Insulin Mutation-Induced Diabetes. Front Endocrinol (Lausanne). 2021; 12:749879.
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A fluorescent timer reporter enables sorting of insulin secretory granules by age. J Biol Chem. 2020 07 03; 295(27):8901-8911.
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Molecular subtyping in pancreatic neuroendocrine neoplasms: New insights into clinical, pathological unmet needs and challenges. Biochim Biophys Acta Rev Cancer. 2020 08; 1874(1):188367.
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Generation of islet-like cell aggregates from human non-pancreatic cancer cell lines. Biotechnol Lett. 2015 Jan; 37(1):227-33.
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Decreasing cx36 gap junction coupling compensates for overactive KATP channels to restore insulin secretion and prevent hyperglycemia in a mouse model of neonatal diabetes. Diabetes. 2014 May; 63(5):1685-97.
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Increasing the decrement in insulin secretion improves glucagon responses to hypoglycemia in advanced type 2 diabetes. Diabetes Care. 2005 Nov; 28(11):2691-6.
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Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans. J Biol Chem. 2005 Sep 16; 280(37):32413-8.
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Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans. Diabetes Care. 2005 May; 28(5):1124-31.
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Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells. J Endocrinol. 2005 Apr; 185(1):57-67.
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Adenoviral overexpression of the glutamylcysteine ligase catalytic subunit protects pancreatic islets against oxidative stress. J Biol Chem. 2004 Dec 24; 279(52):53988-93.