"Clioquinol" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
| Descriptor ID |
D007464
|
| MeSH Number(s) |
D03.633.100.810.350.625.400
|
| Concept/Terms |
Clioquinol- Clioquinol
- 5-Chloro-7-iodo-8-quinolinol
- 5 Chloro 7 iodo 8 quinolinol
- Iodochloroxyquinoline
- Chloroiodoquine
- Iodochlorhydroxyquin
|
Below are MeSH descriptors whose meaning is more general than "Clioquinol".
Below are MeSH descriptors whose meaning is more specific than "Clioquinol".
This graph shows the total number of publications written about "Clioquinol" by people in this website by year, and whether "Clioquinol" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 1 | 3 |
| 2011 | 2 | 0 | 2 |
| 2013 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Clioquinol" by people in Profiles.
-
Zinc at sub-cytotoxic concentrations induces heme oxygenase-1 expression in human cancer cells. Cell Physiol Biochem. 2013; 32(1):100-10.
-
Clioquinol suppresses cyclin D1 gene expression through transcriptional and post-transcriptional mechanisms. Anticancer Res. 2011 Sep; 31(9):2739-47.
-
Nitroxoline (8-hydroxy-5-nitroquinoline) is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline). Cancer Lett. 2011 Dec 15; 312(1):11-7.
-
Metal ionophores - an emerging class of anticancer drugs. IUBMB Life. 2009 Nov; 61(11):1013-8.
-
PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells. Biochem Pharmacol. 2009 May 01; 77(9):1480-6.
-
Clioquinol targets zinc to lysosomes in human cancer cells. Biochem J. 2009 Jan 01; 417(1):133-9.
-
Zinc-binding compounds induce cancer cell death via distinct modes of action. Cancer Lett. 2008 Nov 28; 271(2):251-9.
-
Clioquinol and docosahexaenoic acid act synergistically to kill tumor cells. Mol Cancer Ther. 2006 Jul; 5(7):1864-72.
-
Anticancer activity of the antibiotic clioquinol. Cancer Res. 2005 Apr 15; 65(8):3389-95.