"Pyridoxal Phosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
| Descriptor ID |
D011732
|
| MeSH Number(s) |
D03.383.725.676.925.500.500 D08.211.740
|
| Concept/Terms |
Pyridoxal Phosphate- Pyridoxal Phosphate
- Phosphate, Pyridoxal
- Pyridoxal-P
- Pyridoxal P
- Pyridoxal 5-Phosphate
- Pyridoxal 5 Phosphate
|
Below are MeSH descriptors whose meaning is more general than "Pyridoxal Phosphate".
Below are MeSH descriptors whose meaning is more specific than "Pyridoxal Phosphate".
This graph shows the total number of publications written about "Pyridoxal Phosphate" by people in this website by year, and whether "Pyridoxal Phosphate" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 1 | 1 | 2 |
| 1996 | 1 | 1 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 1 | 2 |
| 2000 | 0 | 2 | 2 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pyridoxal Phosphate" by people in Profiles.
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SAR of non-hydrolysable analogs of pyridoxal 5'-phosphate against low molecular weight protein tyrosine phosphatase isoforms. Bioorg Med Chem Lett. 2020 08 15; 30(16):127342.
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Structural Basis for the Stereochemical Control of Amine Installation in Nucleotide Sugar Aminotransferases. ACS Chem Biol. 2015 Sep 18; 10(9):2048-56.
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The multifaceted pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase. Biochim Biophys Acta. 2011 Nov; 1814(11):1497-510.
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(31)P NMR spectroscopy senses the microenvironment of the 5'-phosphate group of enzyme-bound pyridoxal 5'-phosphate. Biochim Biophys Acta. 2011 Nov; 1814(11):1447-58.
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(31)P NMR studies of O-acetylserine sulfhydrylase-B from Salmonella typhimurium. Arch Biochem Biophys. 2009 Jul 15; 487(2):85-90.
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Role of Histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction. Arch Biochem Biophys. 2008 Apr 15; 472(2):115-25.
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Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes. Biochemistry. 2007 Jul 17; 46(28):8315-30.
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Interaction of serine acetyltransferase with O-acetylserine sulfhydrylase active site: evidence from fluorescence spectroscopy. Protein Sci. 2005 Aug; 14(8):2115-24.
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Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction. Biochemistry. 2003 Jan 14; 42(1):106-13.
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Detection of intermediates in reactions catalyzed by PLP-dependent enzymes: O-acetylserine sulfhydrylase and serine-glyoxalate aminotransferase. Methods Enzymol. 2002; 354:223-37.