"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
| Descriptor ID |
D017209
|
| MeSH Number(s) |
G04.146.160
|
| Concept/Terms |
Apoptosis- Apoptosis
- Programmed Cell Death, Type I
|
Below are MeSH descriptors whose meaning is more general than "Apoptosis".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis".
This graph shows the total number of publications written about "Apoptosis" by people in this website by year, and whether "Apoptosis" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 3 | 2 | 5 |
| 1998 | 1 | 0 | 1 |
| 1999 | 3 | 3 | 6 |
| 2000 | 6 | 2 | 8 |
| 2001 | 3 | 4 | 7 |
| 2002 | 8 | 7 | 15 |
| 2003 | 6 | 8 | 14 |
| 2004 | 4 | 8 | 12 |
| 2005 | 7 | 16 | 23 |
| 2006 | 11 | 15 | 26 |
| 2007 | 9 | 14 | 23 |
| 2008 | 11 | 20 | 31 |
| 2009 | 9 | 22 | 31 |
| 2010 | 4 | 18 | 22 |
| 2011 | 12 | 18 | 30 |
| 2012 | 10 | 22 | 32 |
| 2013 | 8 | 26 | 34 |
| 2014 | 8 | 22 | 30 |
| 2015 | 12 | 18 | 30 |
| 2016 | 7 | 21 | 28 |
| 2017 | 5 | 21 | 26 |
| 2018 | 2 | 15 | 17 |
| 2019 | 4 | 14 | 18 |
| 2020 | 5 | 17 | 22 |
| 2021 | 2 | 12 | 14 |
| 2022 | 0 | 5 | 5 |
| 2023 | 1 | 3 | 4 |
To return to the timeline,
click here.
Below are the most recent publications written about "Apoptosis" by people in Profiles.
-
Role of ERK1/2 Signaling in Cinnabarinic Acid-Driven Stanniocalcin 2-Mediated Protection against Alcohol-Induced Apoptosis. J Pharmacol Exp Ther. 2023 10; 387(1):111-120.
-
A protein bridge to death between the ER and mitochondria. J Biol Chem. 2023 Apr; 299(4):104581.
-
Niclosamide causes lysosome-dependent cell death in endometrial cancer cells and tumors. Biomed Pharmacother. 2023 May; 161:114422.
-
CopA3 peptide inhibits MDM2-p53 complex stability in colorectal cancers and activates p53 mediated cell death machinery. Life Sci. 2023 Apr 01; 318:121476.
-
Rhabdomyolysis-induced acute kidney injury and concomitant apoptosis induction via ROS-mediated ER stress is efficaciously counteracted by epigallocatechin gallate. J Nutr Biochem. 2022 Dec; 110:109134.
-
Annexin A5 as a targeting agent for cancer treatment. Cancer Lett. 2022 10 28; 547:215857.
-
Phosphodiesterase 5 inhibitor sildenafil potentiates the antitumor activity of cisplatin by ROS-mediated apoptosis: a role of deregulated glucose metabolism. Apoptosis. 2022 08; 27(7-8):606-618.
-
Hydroxybenzamide derivatives protect pancreatic ß cell by suppressing unfolded protein response activation. Chem Biol Drug Des. 2022 08; 100(2):155-168.
-
Synthesis of 3-N-/O-/S-methyl-imidazo[1,2-a] pyridine derivatives for caspase-3 mediated apoptosis induced anticancer activity. Bioorg Chem. 2022 08; 125:105882.
-
Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis. Environ Toxicol. 2022 Jun; 37(6):1445-1457.