"tau Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).
| Descriptor ID |
D016875
|
| MeSH Number(s) |
D12.776.220.600.450.510 D12.776.631.560.510
|
| Concept/Terms |
tau Proteins- tau Proteins
- Proteins, tau
- tau Protein
- Protein, tau
|
Below are MeSH descriptors whose meaning is more general than "tau Proteins".
Below are MeSH descriptors whose meaning is more specific than "tau Proteins".
This graph shows the total number of publications written about "tau Proteins" by people in this website by year, and whether "tau Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "tau Proteins" by people in Profiles.
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Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy. Nat Commun. 2023 Apr 25; 14(1):2367.
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Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease. Neurology. 2021 02 02; 96(5):e671-e683.
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Tau Is Elevated in Pediatric Patients on Extracorporeal Membrane Oxygenation. ASAIO J. 2020 01; 66(1):91-96.
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Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability. Stem Cell Reports. 2017 12 12; 9(6):1868-1884.
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Caspase-Cleaved Tau Co-Localizes with Early Tangle Markers in the Human Vascular Dementia Brain. PLoS One. 2015; 10(7):e0132637.
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The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Hum Mol Genet. 2014 Jul 01; 23(13):3523-36.
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Neuroprotective Sirtuin ratio reversed by ApoE4. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18303-8.