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Amanda L Sharpe

TitleProf,Asst
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPharmaceutical Sciences
AddressCPB 335
1110 N Stonewall Ave
Oklahoma City OK 73117
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    SC3GM121214     (SHARPE, AMANDA L)Feb 15, 2017 - Aug 31, 2017
    NIH
    Proopiomelanocortin neuronal involvement in feeding and reward learning mediated by projections from the arcuate nucleus to the nucleus accumbens
    Role: Principal Investigator
    F32AA014747     (SHARPE, AMANDA L)Dec 1, 2003 - Jun 10, 2005
    NIH
    Ethanol Intake and Hypothalamic CRH Receptor Type 2
    Role: Principal Investigator
    F31AA005566     (SHARPE, AMANDA L)Sep 1, 2000
    NIH
    EXAMINATION OF ALCOHOL AND NICOTINE COADMINISTRATION
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sharpe AL, Liter LR, Donohue D, Carter KA, Vangeneugden P, Weaver S, Stout MB, Beckstead MJ. Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake. bioRxiv. 2024 Sep 07. PMID: 39282417; PMCID: PMC11398421.
      Citations:    
    2. Iannitelli AF, Hassenein L, Mulvey B, Blankenship HE, Liles LC, Sharpe AL, Pare JF, Segal A, Sloan SA, Martinowich K, McCann KE, Dougherty JD, Smith Y, Beckstead MJ, Weinshenker D. Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus. bioRxiv. 2024 Aug 04. PMID: 36945637; PMCID: PMC10028911.
      Citations: 1     
    3. Blankenship HE, Carter KA, Cassidy NT, Markiewicz AN, Thellmann MI, Sharpe AL, Freeman WM, Beckstead MJ. VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction. bioRxiv. 2023 Nov 17. PMID: 38014232; PMCID: PMC10680865.
      Citations:    
    4. Kellogg CM, Pham K, Ko S, Cox JEJ, Machalinski AH, Stout MB, Sharpe AL, Beckstead MJ, Chucair-Elliott AJ, Oca?as SR, Freeman WM. Specificity and efficiency of tamoxifen-mediated Cre induction is equivalent regardless of age. iScience. 2023 Dec 15; 26(12):108413. PMID: 38058312; PMCID: PMC10696116.
      Citations: 1     
    5. Kellogg CM, Pham K, Ko S, Cox JEJ, Machalinski AH, Stout MB, Sharpe AL, Beckstead MJ, Chucair-Elliott AJ, Oca?as SR, Freeman WM. Consistent specificity and efficiency of tamoxifen-mediated cre induction across ages. bioRxiv. 2023 Sep 22. PMID: 37781585; PMCID: PMC10541132.
      Citations:    
    6. Kellogg CM, Pham K, Machalinski AH, Porter HL, Blankenship HE, Tooley KB, Stout MB, Rice HC, Sharpe AL, Beckstead MJ, Chucair-Elliott AJ, Oca?as SR, Freeman WM. Correction to: Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans. Geroscience. 2023 Aug 09. PMID: 37556087.
      Citations:    Fields:    
    7. Kellogg CM, Pham K, Machalinski AH, Porter HL, Blankenship HE, Tooley KB, Stout MB, Rice HC, Sharpe AL, Beckstead MJ, Chucair-Elliott AJ, Oca?as SR, Freeman WM. Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans. Geroscience. 2023 Jul 01. PMID: 37393197.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    8. Eliason NL, Sharpe AL. Proopiomelanocortin projections to the nucleus accumbens modulate acquisition and maintenance of operant palatable pellet administration in mice. Physiol Behav. 2023 Jun 01; 265:114176. PMID: 36965574.
      Citations:    Fields:    Translation:Animals
    9. Kellogg CM, Pham K, Machalinski AH, Porter HL, Blankenship HE, Stout MB, Rice HC, Sharpe AL, Beckstead MJ, Chucair-Elliott AJ, Oca?as SR, Freeman WM. Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans. bioRxiv. 2023 Mar 10. PMID: 36945372; PMCID: PMC10028873.
      Citations:    
    10. Eliason NL, Martin L, Low MJ, Sharpe AL. Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food. Neuropeptides. 2022 Dec; 96:102289. PMID: 36155088.
      Citations: 3     Fields:    Translation:Animals
    11. Sharpe AL, Trzeciak M, Eliason NL, Blankenship HE, Byrd BAM, Douglas PD, Freeman WM, Beckstead MJ. Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain. Addict Biol. 2022 03; 27(2):e13120. PMID: 34825430.
      Citations: 4     Fields:    Translation:AnimalsCells
    12. Chucair-Elliott AJ, Ocañas SR, Stanford DR, Ansere VA, Buettner KB, Porter H, Eliason NL, Reid JJ, Sharpe AL, Stout MB, Beckstead MJ, Miller BF, Richardson A, Freeman WM. Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia. Commun Biol. 2020 11 19; 3(1):693. PMID: 33214681.
      Citations: 19     Translation:AnimalsCells
    13. Tschumi CW, Daszkowski AW, Sharpe AL, Trzeciak M, Beckstead MJ. A history of ethanol drinking increases locomotor stimulation and blunts enhancement of dendritic dopamine transmission by methamphetamine. Addict Biol. 2020 07; 25(4):e12763. PMID: 31062485.
      Citations: 4     Fields:    Translation:AnimalsCells
    14. Lynch WB, Tschumi CW, Sharpe AL, Branch SY, Chen C, Ge G, Li S, Beckstead MJ. Progressively disrupted somatodendritic morphology in dopamine neurons in a mouse Parkinson's model. Mov Disord. 2018 12; 33(12):1928-1937. PMID: 30440089.
      Citations: 5     Fields:    Translation:AnimalsCells
    15. Logan S, Owen D, Chen S, Chen WJ, Ungvari Z, Farley J, Csiszar A, Sharpe A, Loos M, Koopmans B, Richardson A, Sonntag WE. Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice. Geroscience. 2018 04; 40(2):123-137. PMID: 29687240.
      Citations: 23     Fields:    Translation:Animals
    16. Dominguez-Lopez S, Piccart E, Lynch WB, Wollet MB, Sharpe AL, Beckstead MJ. Antagonism of Neurotensin Receptors in the Ventral Tegmental Area Decreases Methamphetamine Self-Administration and Methamphetamine Seeking in Mice. Int J Neuropsychopharmacol. 2018 04 01; 21(4):361-370. PMID: 29272412.
      Citations: 9     Fields:    Translation:Animals
    17. Sharpe AL, Varela E, Beckstead MJ. Systemic PD149163, a neurotensin receptor 1 agonist, decreases methamphetamine self-administration in DBA/2J mice without causing excessive sedation. PLoS One. 2017; 12(7):e0180710. PMID: 28686721.
      Citations: 10     Fields:    Translation:HumansAnimals
    18. McCall NM, Kotecki L, Dominguez-Lopez S, Marron Fernandez de Velasco E, Carlblom N, Sharpe AL, Beckstead MJ, Wickman K. Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice. Neuropsychopharmacology. 2017 02; 42(3):707-715. PMID: 27468917.
      Citations: 26     Fields:    Translation:AnimalsCells
    19. Sharpe AL, Varela E, Bettinger L, Beckstead MJ. Methamphetamine self-administration in mice decreases GIRK channel-mediated currents in midbrain dopamine neurons. Int J Neuropsychopharmacol. 2014 Oct 31; 18(5). PMID: 25522412.
      Citations: 37     Fields:    Translation:AnimalsCells
    20. Bardgett ME, Sharpe AL, Toney GM. Activation of corticotropin-releasing factor receptors in the rostral ventrolateral medulla is required for glucose-induced sympathoexcitation. Am J Physiol Endocrinol Metab. 2014 Nov 15; 307(10):E944-53. PMID: 25269482.
      Citations: 14     Fields:    Translation:Animals
    21. Sharpe AL, Calderon AS, Andrade MA, Cunningham JT, Mifflin SW, Toney GM. Chronic intermittent hypoxia increases sympathetic control of blood pressure: role of neuronal activity in the hypothalamic paraventricular nucleus. Am J Physiol Heart Circ Physiol. 2013 Dec; 305(12):H1772-80. PMID: 24097432.
      Citations: 46     Fields:    Translation:AnimalsCells
    22. Branch SY, Goertz RB, Sharpe AL, Pierce J, Roy S, Ko D, Paladini CA, Beckstead MJ. Food restriction increases glutamate receptor-mediated burst firing of dopamine neurons. J Neurosci. 2013 Aug 21; 33(34):13861-72. PMID: 23966705.
      Citations: 45     Fields:    Translation:AnimalsCells
    23. Sharpe AL, Andrade MA, Herrera-Rosales M, Britton SL, Koch LG, Toney GM. Rats selectively bred for differences in aerobic capacity have similar hypertensive responses to chronic intermittent hypoxia. Am J Physiol Heart Circ Physiol. 2013 Aug 01; 305(3):H403-9. PMID: 23709603.
      Citations: 8     Fields:    Translation:Animals
    24. Sharpe AL, Klaus JD, Beckstead MJ. Meal schedule influences food restriction-induced locomotor sensitization to methamphetamine. Psychopharmacology (Berl). 2012 Feb; 219(3):795-803. PMID: 21750897.
      Citations: 6     Fields:    Translation:Animals
    25. Pastor R, Reed C, Burkhart-Kasch S, Li N, Sharpe AL, Coste SC, Stenzel-Poore MP, Phillips TJ. Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout mice. Psychopharmacology (Berl). 2011 Nov; 218(1):169-77. PMID: 21487655.
      Citations: 21     Fields:    Translation:Animals
    26. Sharpe AL, Phillips TJ. Central urocortin 3 administration decreases limited-access ethanol intake in nondependent mice. Behav Pharmacol. 2009 Jul; 20(4):346-51. PMID: 19581799.
      Citations: 22     Fields:    Translation:Animals
    27. Sharpe AL, Low MJ. Proopiomelanocortin peptides are not essential for development of ethanol-induced behavioral sensitization. Alcohol Clin Exp Res. 2009 Jul; 33(7):1202-7. PMID: 19389193.
      Citations:    Fields:    Translation:Animals
    28. Sharpe AL, Coste SC, Burkhart-Kasch S, Li N, Stenzel-Poore MP, Phillips TJ. Mice deficient in corticotropin-releasing factor receptor type 2 exhibit normal ethanol-associated behaviors. Alcohol Clin Exp Res. 2005 Sep; 29(9):1601-9. PMID: 16205360.
      Citations: 20     Fields:    Translation:Animals
    29. Sharpe AL, Tsivkovskaia NO, Ryabinin AE. Ataxia and c-Fos expression in mice drinking ethanol in a limited access session. Alcohol Clin Exp Res. 2005 Aug; 29(8):1419-26. PMID: 16131849.
      Citations: 36     Fields:    Translation:Animals
    30. Palmer AA, Sharpe AL, Burkhart-Kasch S, McKinnon CS, Coste SC, Stenzel-Poore MP, Phillips TJ. Corticotropin-releasing factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol. Psychopharmacology (Berl). 2004 Nov; 176(3-4):386-97. PMID: 15138758.
      Citations: 25     Fields:    Translation:Animals
    31. Sharpe AL, Samson HH. Ethanol and sucrose self-administration components: effects of drinking history. Alcohol. 2003 Jan; 29(1):31-8. PMID: 12657374.
      Citations: 6     Fields:    Translation:Animals
    32. Sharpe AL, Samson HH. Repeated nicotine injections decrease operant ethanol self-administration. Alcohol. 2002 Aug; 28(1):1-7. PMID: 12377355.
      Citations: 19     Fields:    Translation:Animals
    33. Sim-Selley LJ, Sharpe AL, Vogt LJ, Brunk LK, Selley DE, Samson HH. Effect of ethanol self-administration on mu- and delta-opioid receptor-mediated G-protein activity. Alcohol Clin Exp Res. 2002 May; 26(5):688-94. PMID: 12045478.
      Citations: 10     Fields:    Translation:Animals
    34. Sharpe AL, Samson HH. Effect of naloxone on appetitive and consummatory phases of ethanol self-administration. Alcohol Clin Exp Res. 2001 Jul; 25(7):1006-11. PMID: 11505025.
      Citations: 21     Fields:    Translation:Animals
    35. Freedland CS, Sharpe AL, Samson HH, Porrino LJ. Effects of SR141716A on ethanol and sucrose self-administration. Alcohol Clin Exp Res. 2001 Feb; 25(2):277-82. PMID: 11236843.
      Citations: 59     Fields:    Translation:Animals
    36. Samson HH, Sharpe AL, Denning C. Initiation of ethanol self-administration in the rat using sucrose substitution in a sipper-tube procedure. Psychopharmacology (Berl). 1999 Dec; 147(3):274-9. PMID: 10639685.
      Citations: 27     Fields:    Translation:Animals
    37. Samson HH, Slawecki CJ, Sharpe AL, Chappell A. Appetitive and consummatory behaviors in the control of ethanol consumption: a measure of ethanol seeking behavior. Alcohol Clin Exp Res. 1998 Nov; 22(8):1783-7. PMID: 9835295.
      Citations: 47     Fields:    Translation:Animals
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