Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging.

Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging. J Gerontol A Biol Sci Med Sci. 2012 Apr; 67(4):313-29.

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subject areas

Aging
Aging
Animals
Animals
Aorta
Aorta
Apoptosis
Apoptosis
Disease Models, Animal
Disease Models, Animal
Female
Female
Gene Knockdown Techniques
Gene Knockdown Techniques
Glutamate-Cysteine Ligase
Glutamate-Cysteine Ligase
Heme Oxygenase-1
Heme Oxygenase-1
Hydrogen Peroxide
Hydrogen Peroxide
Hyperglycemia
Hyperglycemia
Insulin-Like Growth Factor I
Insulin-Like Growth Factor I
Lipoproteins, LDL
Lipoproteins, LDL
Liver
Liver
Male
Male
Membrane Proteins
Membrane Proteins
Mice
Mice
Mice, Inbred C57BL
Mice, Inbred C57BL
NAD(P)H Dehydrogenase (Quinone)
NAD(P)H Dehydrogenase (Quinone)
NF-E2-Related Factor 2
NF-E2-Related Factor 2
Oxidative Stress
Oxidative Stress
Tissue Culture Techniques
Tissue Culture Techniques

authors with profiles

Lora Celess Bailey-Downs
Anna Csiszar
Julie Ann Farley
William Edmund Sonntag
Zoltan Ungvari