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Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1.
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Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1.
Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. Mol Cancer. 2014 May 06; 13:103.
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PubMed
subject areas
Antineoplastic Agents
Antineoplastic Agents
Benzodiazepinones
Benzodiazepinones
Binding Sites
Binding Sites
Cell Line, Tumor
Cell Line, Tumor
Cell Movement
Cell Movement
Cell Proliferation
Cell Proliferation
Cell Survival
Cell Survival
Collagen
Collagen
Diffusion Chambers, Culture
Diffusion Chambers, Culture
Drug Combinations
Drug Combinations
Gene Expression
Gene Expression
Genetic Vectors
Genetic Vectors
Humans
Humans
Intracellular Signaling Peptides and Proteins
Intracellular Signaling Peptides and Proteins
Isoenzymes
Isoenzymes
Laminin
Laminin
Lentivirus
Lentivirus
Molecular Docking Simulation
Molecular Docking Simulation
Molecular Dynamics Simulation
Molecular Dynamics Simulation
Protein Binding
Protein Binding
Protein Kinase Inhibitors
Protein Kinase Inhibitors
Proteoglycans
Proteoglycans
Pyrimidines
Pyrimidines
authors with profiles
Naushad Ali
Courtney Wayne Houchen
Dongfeng Qu
Ralf Gregor Janknecht
William Lee Berry