"Receptors, Somatomedin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cell surface receptors that bind somatomedins and trigger intracellular changes which influence the behavior of cells. Studies have disclosed two types of receptors for this family of peptide hormones. The type I receptor is homologous to the insulin receptor and has tyrosine kinase activity. The type II receptor is identical to the mannose-6-phosphate receptor which is important in trafficking of lysosomal enzymes.
| Descriptor ID |
D017451
|
| MeSH Number(s) |
D12.776.543.750.750.400.780
|
| Concept/Terms |
Receptors, Somatomedin- Receptors, Somatomedin
- Insulin-Like Growth Factor Receptors
- Insulin Like Growth Factor Receptors
- Somatomedin Receptor
- Receptor, Somatomedin
- Somatomedin Receptors
- Insulin-Like Growth Factor Receptor
- Insulin Like Growth Factor Receptor
- Receptors, Insulin-Like Growth Factors
- Receptors, Insulin Like Growth Factors
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Somatomedin".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Somatomedin".
This graph shows the total number of publications written about "Receptors, Somatomedin" by people in this website by year, and whether "Receptors, Somatomedin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptors, Somatomedin" by people in Profiles.
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Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomography. J Nanobiotechnology. 2015 Dec 01; 13:90.
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Effect of in utero ethanol exposure on the postnatal ontogeny of insulin-like growth factor-1, and type-1 and type-2 insulin-like growth factor receptors in the rat brain. Neuroscience. 1994 Nov; 63(2):579-89.
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Insulin-like growth factor-I (IGF-I) enhanced proteolysis of IGF-binding protein-4 in conditioned medium from primary cultures of human decidua: independence from IGF receptor binding. Endocrinology. 1993 Oct; 133(4):1525-31.
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Distribution of insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) receptors in the hippocampal formation of rats and mice. Adv Exp Med Biol. 1991; 293:449-58.
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Acromegaloid patients with type A insulin resistance: parallel defects in insulin and insulin-like growth factor-I receptors and biological responses in cultured fibroblasts. J Clin Endocrinol Metab. 1989 Aug; 69(2):329-37.
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Actions of insulin-like growth factor-I on the B104 neuronal cell line: effects on cell replication, receptor characteristics, and influence of secreted binding protein on ligand binding. J Cell Physiol. 1989 Jun; 139(3):469-76.
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Demonstration of type I and type II somatomedin receptors on bovine growth plate chondrocytes. J Orthop Res. 1988; 6(6):817-26.
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Characteristics of hepatic receptors for somatomedin-C/insulin-like growth factor I and insulin in the developing human. J Clin Endocrinol Metab. 1987 Apr; 64(4):737-43.
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Structural similarities between human receptors for somatomedin C and insulin: analysis by affinity labeling. Biochemistry. 1981 Dec 22; 20(26):7345-50.