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Robert Axtell

TitleAssistant Member
InstitutionOklahoma Medical Research Foundation
DepartmentArthritis and Clinical Immunology
Address825 N.E. 13th Street
Oklahoma City OK 73104
Phone405/271-2354
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    Collapse Research 
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    K99NS075099     (AXTELL, ROBERT C)May 5, 2011 - Apr 30, 2013
    NIH
    Molecular Stratification of Multiple Sclerosis and Associated Neuro-autoimmune Di
    Role: Principal Investigator

    R00NS075099     (AXTELL, ROBERT C)Sep 15, 2013 - Aug 31, 2016
    NIH
    Molecular Stratification of Multiple Sclerosis and Associated Neuro-autoimmune Di
    Role: Principal Investigator

    R56AI118787     (AXTELL, ROBERT C)Sep 1, 2016 - Aug 31, 2018
    NIH
    Functional Interaction Between T-cell and B-cell Immune Pathways in Neuro- inflammatory Disorders
    Role: Principal Investigator

    R01EY027346     (AXTELL, ROBERT C)Sep 30, 2017 - Jun 30, 2022
    NIH
    Pathogenic B cell and T helper cell interactions in Neuromyelitis Optica
    Role: Principal Investigator

    R01AI137047     (AXTELL, ROBERT C)Aug 1, 2018 - Jul 31, 2022
    NIH
    Understanding the roles type I Interferon and TH17 play in Neuromyelitis Optica and other autoimmune diseases.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Maria Z, Turner E, Agasing A, Kumar G, Axtell RC. Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE. Int J Mol Sci. 2021 Mar 13; 22(6). PMID: 33805762.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Kumar G, Maria Z, Kohli U, Agasing A, Quinn JL, Ko RM, Zamvil SS, Axtell RC. CNS Autoimmune Responses in BCMA-Deficient Mice Provide Insight for the Failure of Atacicept in MS. Neurol Neuroimmunol Neuroinflamm. 2021 05; 8(3). PMID: 33649164.
      Citations:    Fields:    
    3. Towner RA, Smith N, Zalles M, Morris S, Toliver M, Saunders D, Lerner M, Kumar G, Axtell RC. ELTD1 as a biomarker for multiple sclerosis: Pre-clinical molecular-targeted studies in a mouse experimental autoimmune encephalomyelitis model. Mult Scler Relat Disord. 2021 Apr; 49:102786. PMID: 33517175.
      Citations:    Fields:    Translation:Animals
    4. Chitrakar A, Budda SA, Henderson JG, Axtell RC, Zenewicz LA. E3 Ubiquitin Ligase Von Hippel-Lindau Protein Promotes Th17 Differentiation. J Immunol. 2020 08 15; 205(4):1009-1023. PMID: 32690659.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Agasing AM, Wu Q, Khatri B, Borisow N, Ruprecht K, Brandt AU, Gawde S, Kumar G, Quinn JL, Ko RM, Mao-Draayer Y, Lessard CJ, Paul F, Axtell RC. Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica. Nat Commun. 2020 06 05; 11(1):2856. PMID: 32503977.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    6. Agasing AM, Gawde S, Kumar G, Turner E, Axtell RC. B cell function impacts the efficacy of IFN-ß therapy in EAE. J Neuroimmunol. 2020 01 15; 338:577106. PMID: 31715458.
      Citations: 3     Fields:    Translation:AnimalsCells
    7. Jog NR, McClain MT, Heinlen LD, Gross T, Towner R, Guthridge JM, Axtell RC, Pardo G, Harley JB, James JA. Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model. J Autoimmun. 2020 01; 106:102332. PMID: 31515129.
      Citations: 4     Fields:    
    8. Lang GA, Amadou Amani S, Quinn JL, Axtell RC, Lang ML. Immunization-Expanded NKT Follicular Helper Cells Drive IgG1 Isotype Switch against an Exogenous T-Independent Polysaccharide but Do Not Promote Recall Responses. Immunohorizons. 2019 03; 3(3):88-93. PMID: 31342012.
      Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
    9. Quinn JL, Axtell RC. Emerging Role of Follicular T Helper Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Int J Mol Sci. 2018 Oct 19; 19(10). PMID: 30347676.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    10. Quinn JL, Kumar G, Agasing A, Ko RM, Axtell RC. Role of TFH Cells in Promoting T Helper 17-Induced Neuroinflammation. Front Immunol. 2018; 9:382. PMID: 29535739.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    11. Bhat R, Mahapatra S, Axtell RC, Steinman L. Amelioration of ongoing experimental autoimmune encephalomyelitis with fluoxetine. J Neuroimmunol. 2017 12 15; 313:77-81. PMID: 29153612.
      Citations: 6     Fields:    Translation:AnimalsCells
    12. Larabee CM, Desai S, Agasing A, Georgescu C, Wren JD, Axtell RC, Plafker SM. Loss of Nrf2 exacerbates the visual deficits and optic neuritis elicited by experimental autoimmune encephalomyelitis. Mol Vis. 2016; 22:1503-1513. PMID: 28050123.
      Citations: 17     Fields:    Translation:AnimalsCells
    13. Berkovich R, Bakshi R, Amezcua L, Axtell RC, Cen SY, Tauhid S, Neema M, Steinman L. Adrenocorticotropic hormone versus methylprednisolone added to interferon ß in patients with multiple sclerosis experiencing breakthrough disease: a randomized, rater-blinded trial. Ther Adv Neurol Disord. 2017 Jan; 10(1):3-17. PMID: 28450891.
      Citations:    
    14. Larabee CM, Hu Y, Desai S, Georgescu C, Wren JD, Axtell RC, Plafker SM. Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice. Mol Vis. 2016; 22:332-41. PMID: 27122964.
      Citations: 3     Fields:    Translation:AnimalsCells
    15. Hegen H, Adrianto I, Lessard CJ, Millonig A, Bertolotto A, Comabella M, Giovannoni G, Guger M, Hoelzl M, Khalil M, Fazekas F, Killestein J, Lindberg RL, Malucchi S, Mehling M, Montalban X, Rudzki D, Schautzer F, Sellebjerg F, Sorensen PS, Deisenhammer F, Steinman L, Axtell RC. Cytokine profiles show heterogeneity of interferon-ß response in multiple sclerosis patients. Neurol Neuroimmunol Neuroinflamm. 2016 Apr; 3(2):e202. PMID: 26894205.
      Citations: 12     Fields:    
    16. Schaffert SA, Loh C, Wang S, Arnold CP, Axtell RC, Newell EW, Nolan G, Ansel KM, Davis MM, Steinman L, Chen CZ. mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function. J Immunol. 2015 Aug 15; 195(4):1470-9. PMID: 26163591.
      Citations: 19     Fields:    Translation:AnimalsCellsPHPublic Health
    17. Doyle KP, Quach LN, Solé M, Axtell RC, Nguyen TV, Soler-Llavina GJ, Jurado S, Han J, Steinman L, Longo FM, Schneider JA, Malenka RC, Buckwalter MS. B-lymphocyte-mediated delayed cognitive impairment following stroke. J Neurosci. 2015 Feb 04; 35(5):2133-45. PMID: 25653369.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    18. Schubert RD, Hu Y, Kumar G, Szeto S, Abraham P, Winderl J, Guthridge JM, Pardo G, Dunn J, Steinman L, Axtell RC. IFN-ß treatment requires B cells for efficacy in neuroautoimmunity. J Immunol. 2015 Mar 01; 194(5):2110-6. PMID: 25646307.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    19. Cekanaviciute E, Dietrich HK, Axtell RC, Williams AM, Egusquiza R, Wai KM, Koshy AA, Buckwalter MS. Astrocytic TGF-ß signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection. J Immunol. 2014 Jul 01; 193(1):139-49. PMID: 24860191.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    20. Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, Hla T, Han MH. Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nat Immunol. 2013 Nov; 14(11):1166-72. PMID: 24076635.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    21. Naves R, Singh SP, Cashman KS, Rowse AL, Axtell RC, Steinman L, Mountz JD, Steele C, De Sarno P, Raman C. The interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis. J Immunol. 2013 Sep 15; 191(6):2967-77. PMID: 23960239.
      Citations: 18     Fields:    Translation:AnimalsCells
    22. Hartung HP, Steinman L, Goodin DS, Comi G, Cook S, Filippi M, O'Connor P, Jeffery DR, Kappos L, Axtell R, Knappertz V, Bogumil T, Schwenke S, Croze E, Sandbrink R, Pohl C. Interleukin 17F level and interferon ß response in patients with multiple sclerosis. JAMA Neurol. 2013 Aug; 70(8):1017-21. PMID: 23732754.
      Citations: 10     Fields:    Translation:Humans
    23. Davidson MG, Alonso MN, Yuan R, Axtell RC, Kenkel JA, Suhoski MM, González JC, Steinman L, Engleman EG. Th17 cells induce Th1-polarizing monocyte-derived dendritic cells. J Immunol. 2013 Aug 01; 191(3):1175-87. PMID: 23794631.
      Citations: 11     Fields:    Translation:AnimalsCells
    24. Marabelle A, Kohrt H, Sagiv-Barfi I, Ajami B, Axtell RC, Zhou G, Rajapaksa R, Green MR, Torchia J, Brody J, Luong R, Rosenblum MD, Steinman L, Levitsky HI, Tse V, Levy R. Depleting tumor-specific Tregs at a single site eradicates disseminated tumors. J Clin Invest. 2013 Jun; 123(6):2447-63. PMID: 23728179.
      Citations: 142     Fields:    Translation:HumansAnimalsCells
    25. Axtell RC, Raman C, Steinman L. Type I interferons: beneficial in Th1 and detrimental in Th17 autoimmunity. Clin Rev Allergy Immunol. 2013 Apr; 44(2):114-20. PMID: 22231516.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    26. Steinman L, Axtell RC, Barbieri D, Bhat R, Brownell SE, de Jong BA, Dunn SE, Grant JL, Han MH, Ho PP, Kuipers HF, Kurnellas MP, Ousman SS, Rothbard JB. Piet Mondrian's trees and the evolution in understanding multiple sclerosis, Charcot Prize Lecture 2011. Mult Scler. 2013 Jan; 19(1):5-14. PMID: 23303879.
      Citations: 2     Fields:    Translation:Humans
    27. Sestero CM, McGuire DJ, De Sarno P, Brantley EC, Soldevila G, Axtell RC, Raman C. CD5-dependent CK2 activation pathway regulates threshold for T cell anergy. J Immunol. 2012 Sep 15; 189(6):2918-30. PMID: 22904299.
      Citations: 20     Fields:    Translation:AnimalsCells
    28. Grant JL, Ghosn EE, Axtell RC, Herges K, Kuipers HF, Woodling NS, Andreasson K, Herzenberg LA, Herzenberg LA, Steinman L. Reversal of paralysis and reduced inflammation from peripheral administration of ß-amyloid in TH1 and TH17 versions of experimental autoimmune encephalomyelitis. Sci Transl Med. 2012 Aug 01; 4(145):145ra105. PMID: 22855462.
      Citations: 40     Fields:    Translation:AnimalsCells
    29. Axtell RC, Raman C. Janus-like effects of type I interferon in autoimmune diseases. Immunol Rev. 2012 Jul; 248(1):23-35. PMID: 22725952.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    30. Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L. Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice. J Exp Med. 2012 Jul 02; 209(7):1325-34. PMID: 22734047.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    31. Bushnell SE, Zhao Z, Stebbins CC, Cadavid D, Buko AM, Whalley ET, Davis JA, Versage EM, Richert JR, Axtell RC, Steinman L, Medori R. Serum IL-17F does not predict poor response to IM IFNß-1a in relapsing-remitting MS. Neurology. 2012 Aug 07; 79(6):531-7. PMID: 22573631.
      Citations: 21     Fields:    Translation:Humans
    32. Herges K, de Jong BA, Kolkowitz I, Dunn C, Mandelbaum G, Ko RM, Maini A, Han MH, Killestein J, Polman C, Goodyear AL, Dunn J, Steinman L, Axtell RC. Protective effect of an elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin oligodendroglial glycoprotein. Mult Scler. 2012 Apr; 18(4):398-408. PMID: 22343184.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    33. Rothbard JB, Kurnellas MP, Brownell S, Adams CM, Su L, Axtell RC, Chen R, Fathman CG, Robinson WH, Steinman L. Therapeutic effects of systemic administration of chaperone aB-crystallin associated with binding proinflammatory plasma proteins. J Biol Chem. 2012 Mar 23; 287(13):9708-9721. PMID: 22308023.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    34. Kimura N, Itoh S, Nakae S, Axtell RC, Velotta JB, Bos EJ, Merk DR, Gong Y, Okamura H, Nagamine CM, Adachi H, Kornfeld H, Robbins RC, Fischbein MP. Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model. J Heart Lung Transplant. 2011 Dec; 30(12):1409-17. PMID: 22055099.
      Citations: 5     Fields:    Translation:Animals
    35. Itoh S, Kimura N, Axtell RC, Velotta JB, Gong Y, Wang X, Kajiwara N, Nambu A, Shimura E, Adachi H, Iwakura Y, Saito H, Okumura K, Sudo K, Steinman L, Robbins RC, Nakae S, Fischbein MP. Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion. Circulation. 2011 Sep 13; 124(11 Suppl):S187-96. PMID: 21911812.
      Citations: 31     Fields:    Translation:AnimalsCells
    36. Zhuang X, Xiang X, Grizzle W, Sun D, Zhang S, Axtell RC, Ju S, Mu J, Zhang L, Steinman L, Miller D, Zhang HG. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther. 2011 10; 19(10):1769-79. PMID: 21915101.
      Citations: 327     Fields:    Translation:HumansAnimalsCells
    37. Lee LF, Axtell R, Tu GH, Logronio K, Dilley J, Yu J, Rickert M, Han B, Evering W, Walker MG, Shi J, de Jong BA, Killestein J, Polman CH, Steinman L, Lin JC. IL-7 promotes T(H)1 development and serum IL-7 predicts clinical response to interferon-ß in multiple sclerosis. Sci Transl Med. 2011 Jul 27; 3(93):93ra68. PMID: 21795588.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    38. Axtell RC, Raman C, Steinman L. Interferon-ß exacerbates Th17-mediated inflammatory disease. Trends Immunol. 2011 Jun; 32(6):272-7. PMID: 21530402.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    39. Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E. Common variants in P2RY11 are associated with narcolepsy. Nat Genet. 2011 Jan; 43(1):66-71. PMID: 21170044.
      Citations: 65     Fields:    Translation:Humans
    40. Dunn SE, Bhat R, Straus DS, Sobel RA, Axtell R, Johnson A, Nguyen K, Mukundan L, Moshkova M, Dugas JC, Chawla A, Steinman L. Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity. J Exp Med. 2010 Aug 02; 207(8):1599-608. PMID: 20624891.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    41. Lanz TV, Ding Z, Ho PP, Luo J, Agrawal AN, Srinagesh H, Axtell R, Zhang H, Platten M, Wyss-Coray T, Steinman L. Angiotensin II sustains brain inflammation in mice via TGF-beta. J Clin Invest. 2010 Aug; 120(8):2782-94. PMID: 20628203.
      Citations: 94     Fields:    Translation:AnimalsCells
    42. Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG, Mair R, Christakos A, Kolkowitz I, Katz L, Killestein J, Polman CH, de Waal Malefyt R, Steinman L, Raman C. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med. 2010 Apr; 16(4):406-12. PMID: 20348925.
      Citations: 226     Fields:    Translation:HumansAnimalsCells
    43. Itoh S, Nakae S, Axtell RC, Velotta JB, Kimura N, Kajiwara N, Iwakura Y, Saito H, Adachi H, Steinman L, Robbins RC, Fischbein MP. IL-17 contributes to the development of chronic rejection in a murine heart transplant model. J Clin Immunol. 2010 Mar; 30(2):235-40. PMID: 20130970.
      Citations: 22     Fields:    Translation:AnimalsCells
    44. Bhat R, Axtell R, Mitra A, Miranda M, Lock C, Tsien RW, Steinman L. Inhibitory role for GABA in autoimmune inflammation. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2580-5. PMID: 20133656.
      Citations: 129     Fields:    Translation:AnimalsCells
    45. Axtell RC, Steinman L. Gaining entry to an uninflamed brain. Nat Immunol. 2009 May; 10(5):453-5. PMID: 19381137.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    46. De Sarno P, Axtell RC, Raman C, Roth KA, Alessi DR, Jope RS. Lithium prevents and ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2008 Jul 01; 181(1):338-45. PMID: 18566399.
      Citations: 55     Fields:    Translation:AnimalsCells
    47. Axtell RC, Steinman L. Type 1 interferons cool the inflamed brain. Immunity. 2008 May; 28(5):600-2. PMID: 18482563.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    48. Axtell RC, Xu L, Barnum SR, Raman C. CD5-CK2 binding/activation-deficient mice are resistant to experimental autoimmune encephalomyelitis: protection is associated with diminished populations of IL-17-expressing T cells in the central nervous system. J Immunol. 2006 Dec 15; 177(12):8542-9. PMID: 17142752.
      Citations: 40     Fields:    Translation:AnimalsCells
    49. Bullard DC, Hu X, Schoeb TR, Axtell RC, Raman C, Barnum SR. Critical requirement of CD11b (Mac-1) on T cells and accessory cells for development of experimental autoimmune encephalomyelitis. J Immunol. 2005 Nov 15; 175(10):6327-33. PMID: 16272284.
      Citations: 34     Fields:    Translation:AnimalsCells
    50. Axtell RC, Webb MS, Barnum SR, Raman C. Cutting edge: critical role for CD5 in experimental autoimmune encephalomyelitis: inhibition of engagement reverses disease in mice. J Immunol. 2004 Sep 01; 173(5):2928-32. PMID: 15322150.
      Citations: 23     Fields:    Translation:AnimalsCells
    51. Lu X, Axtell RC, Collawn JF, Gibson A, Justement LB, Raman C. AP2 adaptor complex-dependent internalization of CD5: differential regulation in T and B cells. J Immunol. 2002 Jun 01; 168(11):5612-20. PMID: 12023358.
      Citations: 11     Fields:    Translation:AnimalsCells
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