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William H Hildebrand

TitleProf,George L Cross Rsrch
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMicrobiology & Immunology
AddressBRC 317A
975 NE 10th St
Oklahoma City OK 73104
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    Collapse Research 
    Collapse research activities and funding
    R01CA252713     (ZHAO, SHAYING)May 11, 2021 - Apr 30, 2026
    NIH
    Canine MHC-I genotyping and tumor specific neoantigen determination
    Role: Co-Principal Investigator
    R01AI147954     (ADAMS, ERIN JUNE)Jul 10, 2019 - Jun 30, 2025
    NIH
    T cell recognition of the MR1 presented microbial metabolome
    Role: Co-Principal Investigator
    R21AI108860     (LANIER, LEWIS L)Jun 16, 2014 - May 31, 2016
    NIH
    Human natural killer cell recognition of cytomegalovirus
    Role: Co-Principal Investigator
    U01FD004410     (HILDEBRAND, WILLIAM)Jun 15, 2012 - May 31, 2017
    NIH
    Direct Discovery of HLA-associated Influenza Epitopes
    Role: Principal Investigator
    R01AI090672     (HILDEBRAND, WILLIAM)Jul 7, 2010 - Jun 30, 2015
    NIH
    Discovery and Targeting of HIV-1 Associated Antigens
    Role: Principal Investigator
    U01AI082057     (HILDEBRAND, WILLIAM)Apr 9, 2009 - Mar 31, 2015
    NIH
    Discovery and Targeting of West Nile Virus Epitopes
    Role: Principal Investigator
    N01AI40027-9-0-1     (HILDEBRAND, WILLIAM)Mar 31, 2004 - Sep 30, 2009
    NIH
    Direct Epitope Identification and Validation
    Role: Principal Investigator
    N01AI095360     (HILDEBRAND, WILLIAM)May 1, 1999 - Apr 30, 2004
    NIH/NIAID
    BAA-APPLICATION OF HLA DATA TO DEVELOP &IMPROVE VACCINE
    Role: Principal Investigator
    N01AI045243     (HILDEBRAND, WILLIAM)Sep 30, 1994 - Sep 29, 2000
    NIH/NIAID
    FUNCTIONAL SIGNIFICANCE OF HLA CLASS I POLYMORPHISM
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kulicke CA, Swarbrick GM, Ladd NA, Cansler M, Null M, Worley A, Lemon C, Ahmed T, Bennett J, Lust TN, Heisler CM, Huber ME, Krawic JR, Ankley LM, McBride SK, Tafesse FG, Olive AJ, Hildebrand WH, Lewinsohn DA, Adams EJ, Lewinsohn DM, Harriff MJ. Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation. Commun Biol. 2024 Feb 24; 7(1):228. PMID: 38402309; PMCID: PMC10894271.
      Citations:    
    2. Krawic JR, Ladd NA, Cansler M, McMurtrey C, Devereaux J, Worley A, Ahmed T, Froyd C, Kulicke CA, Swarbrick G, Nilsen A, Lewinsohn DM, Adams EJ, Hildebrand W. Multiple Isomers of Photolumazine V Bind MR1 and Differentially Activate MAIT Cells. J Immunol. 2024 Jan 26. PMID: 38275935.
      Citations:    Fields:    Translation:HumansCells
    3. Knoche SM, Larson AC, Brumfield GL, Cate S, Hildebrand WH, Solheim JC. Correction: Major histocompatibility complex class I molecule expression by pancreatic cancer cells is regulated by activation and inhibition of the epidermal growth factor receptor. Immunol Res. 2023 Dec 05. PMID: 38051459.
      Citations:    Fields:    
    4. Nilsson JB, Kaabinejadian S, Yari H, Kester MGD, van Balen P, Hildebrand WH, Nielsen M. Accurate prediction of HLA class II antigen presentation across all loci using tailored data acquisition and refined machine learning. Sci Adv. 2023 11 24; 9(47):eadj6367. PMID: 38000035; PMCID: PMC10672173.
      Citations: 4     Fields:    Translation:Humans
    5. Feng Y, Hess PR, Tompkins SM, Hildebrand WH, Zhao S. A Kmer-based paired-end read de novo assembler and genotyper for canine MHC class I genotyping. iScience. 2023 Feb 17; 26(2):105996. PMID: 36798440; PMCID: PMC9926114.
      Citations: 1     
    6. Jin H, Ladd NA, Peev AM, Swarbrick GM, Cansler M, Null M, Boughter CT, McMurtrey C, Nilsen A, Dobos KM, Hildebrand WH, Lewinsohn DA, Adams EJ, Lewinsohn DM, Harriff MJ. Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells. Sci Rep. 2022 Dec 29; 12(1):22539. PMID: 36581641.
      Citations: 3     Fields:    Translation:Cells
    7. Hoover AR, Kaabinejadian S, Krawic JR, Sun XH, Naqash AR, Yin Q, Yang X, Christopher Garcia K, Davis MM, Hildebrand WH, Chen WR. Localized ablative immunotherapy drives de novo CD8+ T-cell responses to poorly immunogenic tumors. J Immunother Cancer. 2022 Oct; 10(10). PMID: 36253002; PMCID: PMC9577935.
      Citations: 2     Fields:    Translation:AnimalsCells
    8. Hoover AR, Liu K, DeVette CI, Krawic JR, Medcalf AD, West CL, Hode T, Lam SSK, Welm AL, Sun XH, Hildebrand WH, Chen WR. Single-cell RNA sequencing reveals localized tumour ablation and intratumoural immunostimulant delivery potentiate T cell mediated tumour killing. Clin Transl Med. 2022 07; 12(7):e937. PMID: 35808806.
      Citations: 7     Fields:    Translation:AnimalsCells
    9. Knoche SM, Larson AC, Brumfield GL, Cate S, Hildebrand WH, Solheim JC. Major histocompatibility complex class I molecule expression by pancreatic cancer cells is regulated by activation and inhibition of the epidermal growth factor receptor. Immunol Res. 2022 06; 70(3):371-391. PMID: 35303241.
      Citations:    Fields:    Translation:HumansCells
    10. Kaabinejadian S, Barra C, Alvarez B, Yari H, Hildebrand WH, Nielsen M. Accurate MHC Motif Deconvolution of Immunopeptidomics Data Reveals a Significant Contribution of DRB3, 4 and 5 to the Total DR Immunopeptidome. Front Immunol. 2022; 13:835454. PMID: 35154160.
      Citations: 17     Fields:    Translation:HumansCells
    11. Liu K, Hoover AR, Krawic JR, DeVette CI, Sun XH, Hildebrand WH, Lang ML, Axtell RC, Chen WR. Antigen presentation and interferon signatures in B cells driven by localized ablative cancer immunotherapy correlate with extended survival. Theranostics. 2022; 12(2):639-656. PMID: 34976205.
      Citations: 5     Fields:    Translation:AnimalsCells
    12. Puig M, Ananthula S, Venna R, Kumar Polumuri S, Mattson E, Walker LM, Cardone M, Takahashi M, Su S, Boyd LF, Natarajan K, Abdoulaeva G, Wu WW, Roderiquez G, Hildebrand WH, Beaucage SL, Li Z, Margulies DH, Norcross MA. Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides. Front Immunol. 2020; 11:629399. PMID: 33633747.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    13. Reynisson B, Barra C, Kaabinejadian S, Hildebrand WH, Peters B, Nielsen M. Improved Prediction of MHC II Antigen Presentation through Integration and Motif Deconvolution of Mass Spectrometry MHC Eluted Ligand Data. J Proteome Res. 2020 06 05; 19(6):2304-2315. PMID: 32308001.
      Citations: 169     Fields:    Translation:Cells
    14. Tanno H, Gould TM, McDaniel JR, Cao W, Tanno Y, Durrett RE, Park D, Cate SJ, Hildebrand WH, Dekker CL, Tian L, Weyand CM, Georgiou G, Goronzy JJ. Determinants governing T cell receptor a/ß-chain pairing in repertoire formation of identical twins. Proc Natl Acad Sci U S A. 2020 01 07; 117(1):532-540. PMID: 31879353.
      Citations: 27     Fields:    Translation:HumansCells
    15. DeVette CI, Gundlapalli H, Lai SA, McMurtrey CP, Hoover AR, Gurung HR, Chen WR, Welm AL, Hildebrand WH. A pipeline for identification and validation of tumor-specific antigens in a mouse model of metastatic breast cancer. Oncoimmunology. 2020; 9(1):1685300. PMID: 32002300.
      Citations: 7     Fields:    Translation:HumansAnimals
    16. Kim C, Jadhav RR, Gustafson CE, Smithey MJ, Hirsch AJ, Uhrlaub JL, Hildebrand WH, Nikolich-Žugich J, Weyand CM, Goronzy JJ. Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency. Cell Rep. 2019 11 19; 29(8):2202-2216.e5. PMID: 31747595.
      Citations: 27     Fields:    Translation:AnimalsCells
    17. Linette GP, Becker-Hapak M, Skidmore ZL, Baroja ML, Xu C, Hundal J, Spencer DH, Fu W, Cummins C, Robnett M, Kaabinejadian S, Hildebrand WH, Magrini V, Demeter R, Krupnick AS, Griffith OL, Griffith M, Mardis ER, Carreno BM. Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23662-23670. PMID: 31685621.
      Citations: 27     Fields:    Translation:HumansCellsPHPublic Health
    18. Wahl A, De C, Abad Fernandez M, Lenarcic EM, Xu Y, Cockrell AS, Cleary RA, Johnson CE, Schramm NJ, Rank LM, Newsome IG, Vincent HA, Sanders W, Aguilera-Sandoval CR, Boone A, Hildebrand WH, Dayton PA, Baric RS, Pickles RJ, Braunstein M, Moorman NJ, Goonetilleke N, Victor Garcia J. Precision mouse models with expanded tropism for human pathogens. Nat Biotechnol. 2019 10; 37(10):1163-1173. PMID: 31451733.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    19. Birrueta G, Frazier A, Pomés A, Glesner J, Filep S, Schal C, Jeong KY, McMurtrey C, Vander Schans T, Hildebrand WH, Busse P, Beigelman A, Bacharier LB, Peters B, Sette A, Schulten V. Variability in German Cockroach Extract Composition Greatly Impacts T Cell Potency in Cockroach-Allergic Donors. Front Immunol. 2019; 10:313. PMID: 30891032.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    20. Hartmann N, Harriff MJ, McMurtrey CP, Hildebrand WH, Lewinsohn DM, Kronenberg M. Role of MAIT cells in pulmonary bacterial infection. Mol Immunol. 2018 09; 101:155-159. PMID: 29940408.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    21. da Silva Antunes R, Pham J, McMurtrey C, Hildebrand WH, Phillips E, Mallal S, Sidney J, Busse P, Peters B, Schulten V, Sette A. Urinary Peptides As a Novel Source of T Cell Allergen Epitopes. Front Immunol. 2018; 9:886. PMID: 29755469.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    22. DeVette CI, Andreatta M, Bardet W, Cate SJ, Jurtz VI, Jackson KW, Welm AL, Nielsen M, Hildebrand WH. NetH2pan: A Computational Tool to Guide MHC Peptide Prediction on Murine Tumors. Cancer Immunol Res. 2018 06; 6(6):636-644. PMID: 29615400.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    23. McMurtrey C, Harriff MJ, Swarbrick GM, Duncan A, Cansler M, Null M, Bardet W, Jackson KW, Lewinsohn DA, Hildebrand W, Lewinsohn DM. T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells. PLoS One. 2017; 12(11):e0188288. PMID: 29176828.
      Citations: 23     Fields:    Translation:HumansCells
    24. Marty R, Kaabinejadian S, Rossell D, Slifker MJ, van de Haar J, Engin HB, de Prisco N, Ideker T, Hildebrand WH, Font-Burgada J, Carter H. MHC-I Genotype Restricts the Oncogenic Mutational Landscape. Cell. 2017 Nov 30; 171(6):1272-1283.e15. PMID: 29107334.
      Citations: 174     Fields:    Translation:HumansCells
    25. Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, Dillon MB, Carpenter C, Weiskopf D, Phillips E, Mallal S, Peters B, Frazier A, Arlehamn CSL, Sette A. Erratum: T cells from patients with Parkinson's disease recognize a-synuclein peptides. Nature. 2017 09 13; 549(7671):292. PMID: 28905919.
      Citations: 9     Fields:    
    26. Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, Dillon MB, Carpenter C, Weiskopf D, Phillips E, Mallal S, Peters B, Frazier A, Lindestam Arlehamn CS, Sette A. T cells from patients with Parkinson's disease recognize a-synuclein peptides. Nature. 2017 06 29; 546(7660):656-661. PMID: 28636593.
      Citations: 379     Fields:    Translation:HumansCells
    27. Dulberger CL, McMurtrey CP, Hölzemer A, Neu KE, Liu V, Steinbach AM, Garcia-Beltran WF, Sulak M, Jabri B, Lynch VJ, Altfeld M, Hildebrand WH, Adams EJ. Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors. Immunity. 2017 06 20; 46(6):1018-1029.e7. PMID: 28636952.
      Citations: 60     Fields:    Translation:HumansCells
    28. Hilton HG, McMurtrey CP, Han AS, Djaoud Z, Guethlein LA, Blokhuis JH, Pugh JL, Goyos A, Horowitz A, Buchli R, Jackson KW, Bardet W, Bushnell DA, Robinson PJ, Mendoza JL, Birnbaum ME, Nielsen M, Garcia KC, Hildebrand WH, Parham P. The Intergenic Recombinant HLA-B*46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands. Cell Rep. 2017 05 16; 19(7):1394-1405. PMID: 28514659.
      Citations: 23     Fields:    Translation:HumansCells
    29. Kaabinejadian S, McMurtrey CP, Kim S, Jain R, Bardet W, Schafer FB, Davenport JL, Martin AD, Diamond MS, Weidanz JA, Hansen TH, Hildebrand WH. Immunodominant West Nile Virus T Cell Epitopes Are Fewer in Number and Fashionably Late. J Immunol. 2016 05 15; 196(10):4263-73. PMID: 27183642.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    30. McMurtrey C, Trolle T, Sansom T, Remesh SG, Kaever T, Bardet W, Jackson K, McLeod R, Sette A, Nielsen M, Zajonc DM, Blader IJ, Peters B, Hildebrand W. Toxoplasma gondii peptide ligands open the gate of the HLA class I binding groove. Elife. 2016 Jan 29; 5. PMID: 26824387.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    31. Trolle T, McMurtrey CP, Sidney J, Bardet W, Osborn SC, Kaever T, Sette A, Hildebrand WH, Nielsen M, Peters B. The Length Distribution of Class I-Restricted T Cell Epitopes Is Determined by Both Peptide Supply and MHC Allele-Specific Binding Preference. J Immunol. 2016 Feb 15; 196(4):1480-7. PMID: 26783342.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    32. Patterson AM, Kaabinejadian S, McMurtrey CP, Bardet W, Jackson KW, Zuna RE, Husain S, Adams GP, MacDonald G, Dillon RL, Ames H, Buchli R, Hawkins OE, Weidanz JA, Hildebrand WH. Human Leukocyte Antigen-Presented Macrophage Migration Inhibitory Factor Is a Surface Biomarker and Potential Therapeutic Target for Ovarian Cancer. Mol Cancer Ther. 2016 Feb; 15(2):313-22. PMID: 26719579.
      Citations: 2     Fields:    Translation:HumansCells
    33. Cram ED, Simmons RS, Palmer AL, Hildebrand WH, Rockey DD, Dolan BP. Enhanced Direct Major Histocompatibility Complex Class I Self-Antigen Presentation Induced by Chlamydia Infection. Infect Immun. 2016 02; 84(2):480-90. PMID: 26597986.
      Citations: 8     Fields:    Translation:HumansCells
    34. Abelin JG, Trantham PD, Penny SA, Patterson AM, Ward ST, Hildebrand WH, Cobbold M, Bai DL, Shabanowitz J, Hunt DF. Complementary IMAC enrichment methods for HLA-associated phosphopeptide identification by mass spectrometry. Nat Protoc. 2015 Sep; 10(9):1308-18. PMID: 26247297.
      Citations: 28     Fields:    
    35. Carreno BM, Magrini V, Becker-Hapak M, Kaabinejadian S, Hundal J, Petti AA, Ly A, Lie WR, Hildebrand WH, Mardis ER, Linette GP. Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells. Science. 2015 May 15; 348(6236):803-8. PMID: 25837513.
      Citations: 668     Fields:    Translation:HumansCellsCTClinical Trials
    36. Olvera A, Pérez-Álvarez S, Ibarrondo J, Ganoza C, Lama JR, Lucchetti A, Cate S, Hildebrand W, Bernard N, Gomez L, Sanchez J, Brander C. The HLA-C*04: 01/KIR2DS4 gene combination and human leukocyte antigen alleles with high population frequency drive rate of HIV disease progression. AIDS. 2015 Mar 13; 29(5):507-17. PMID: 25715101.
      Citations: 19     Fields:    Translation:Humans
    37. Olvera A, Ganoza C, Pérez-Álvarez S, Hildebrand W, Sanchez J, Brander C. HLA-B*35-PX and HLA-B*35-PY subtype differentiation does not predict observed differences in level of HIV control in a Peruvian MSM cohort. AIDS. 2014 Sep 24; 28(15):2323-5. PMID: 25313587.
      Citations: 5     Fields:    Translation:HumansCells
    38. Yaciuk JC, Skaley M, Bardet W, Schafer F, Mojsilovic D, Cate S, Stewart CJ, McMurtrey C, Jackson KW, Buchli R, Olvera A, Cedeño S, Plana M, Mothe B, Brander C, West JT, Hildebrand WH. Direct interrogation of viral peptides presented by the class I HLA of HIV-infected T cells. J Virol. 2014 Nov; 88(22):12992-3004. PMID: 25165114.
      Citations: 32     Fields:    Translation:HumansCells
    39. Kim S, Pinto AK, Myers NB, Hawkins O, Doll K, Kaabinejadian S, Netland J, Bevan MJ, Weidanz JA, Hildebrand WH, Diamond MS, Hansen TH. A novel T-cell receptor mimic defines dendritic cells that present an immunodominant West Nile virus epitope in mice. Eur J Immunol. 2014 Jul; 44(7):1936-46. PMID: 24723377.
      Citations: 10     Fields:    Translation:AnimalsCells
    40. May NA, Wang Q, Balbo A, Konrad SL, Buchli R, Hildebrand WH, Schuck P, Hudson AW. Human herpesvirus 7 U21 tetramerizes to associate with class I major histocompatibility complex molecules. J Virol. 2014 Mar; 88(6):3298-308. PMID: 24390327.
      Citations: 9     Fields:    Translation:HumansCells
    41. McMurtrey C, Lowe D, Buchli R, Daga S, Royer D, Humphrey A, Cate S, Osborn S, Mojsilovic A, VanGundy R, Bardet W, Duty A, Mojsilovic D, Jackson K, Stastny P, Briggs D, Zehnder D, Higgins R, Hildebrand W. Profiling antibodies to class II HLA in transplant patient sera. Hum Immunol. 2014 Mar; 75(3):261-70. PMID: 24269696.
      Citations: 3     Fields:    Translation:HumansCells
    42. Kaabinejadian S, Piazza PA, McMurtrey CP, Vernon SR, Cate SJ, Bardet W, Schafer FB, Jackson KW, Campbell DM, Buchli R, Rinaldo CR, Hildebrand WH. Identification of class I HLA T cell control epitopes for West Nile virus. PLoS One. 2013; 8(6):e66298. PMID: 23762485.
      Citations: 8     Fields:    Translation:HumansCells
    43. Norcross MA, Luo S, Lu L, Boyne MT, Gomarteli M, Rennels AD, Woodcock J, Margulies DH, McMurtrey C, Vernon S, Hildebrand WH, Buchli R. Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity. AIDS. 2012 Jul 17; 26(11):F21-9. PMID: 22617051.
      Citations: 78     Fields:    Translation:HumansCells
    44. Hoof I, van Baarle D, Hildebrand WH, Kesmir C. Proteome sampling by the HLA class I antigen processing pathway. PLoS Comput Biol. 2012; 8(5):e1002517. PMID: 22615552.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    45. Sette A, Sidney J, Southwood S, Moore C, Berry J, Dow C, Bradley K, Hoof I, Lewis MG, Hildebrand WH, McMurtrey CP, Wilson NA, Watkins DI, Mothé BR. A shared MHC supertype motif emerges by convergent evolution in macaques and mice, but is totally absent in human MHC molecules. Immunogenetics. 2012 Jun; 64(6):421-34. PMID: 22322672.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    46. Mothe B, Llano A, Ibarrondo J, Daniels M, Miranda C, Zamarreño J, Bach V, Zuniga R, Pérez-Álvarez S, Berger CT, Puertas MC, Martinez-Picado J, Rolland M, Farfan M, Szinger JJ, Hildebrand WH, Yang OO, Sanchez-Merino V, Brumme CJ, Brumme ZL, Heckerman D, Allen TM, Mullins JI, Gómez G, Goulder PJ, Walker BD, Gatell JM, Clotet B, Korber BT, Sanchez J, Brander C. Definition of the viral targets of protective HIV-1-specific T cell responses. J Transl Med. 2011 Dec 07; 9:208. PMID: 22152067.
      Citations: 109     Fields:    Translation:HumansCells
    47. Weidanz JA, Hildebrand WH. Expanding the targets available to therapeutic antibodies via novel disease-specific markers. Int Rev Immunol. 2011 Oct-Dec; 30(5-6):312-27. PMID: 22053971.
      Citations:    Fields:    Translation:HumansCells
    48. Weidanz JA, Hawkins O, Verma B, Hildebrand WH. TCR-like biomolecules target peptide/MHC Class I complexes on the surface of infected and cancerous cells. Int Rev Immunol. 2011 Oct-Dec; 30(5-6):328-40. PMID: 22053972.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    49. Buranapraditkun S, Hempel U, Pitakpolrat P, Allgaier RL, Thantivorasit P, Lorenzen SI, Sirivichayakul S, Hildebrand WH, Altfeld M, Brander C, Walker BD, Phanuphak P, Hansasuta P, Rowland-Jones SL, Allen TM, Ruxrungtham K. A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais. PLoS One. 2011; 6(8):e23603. PMID: 21887282.
      Citations: 10     Fields:    Translation:HumansCells
    50. Greene JM, Wiseman RW, Lank SM, Bimber BN, Karl JA, Burwitz BJ, Lhost JJ, Hawkins OE, Kunstman KJ, Broman KW, Wolinsky SM, Hildebrand WH, O'Connor DH. Differential MHC class I expression in distinct leukocyte subsets. BMC Immunol. 2011 Jul 15; 12:39. PMID: 21762519.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    51. Reed JS, Sidney J, Piaskowski SM, Glidden CE, León EJ, Burwitz BJ, Kolar HL, Eernisse CM, Furlott JR, Maness NJ, Walsh AD, Rudersdorf RA, Bardet W, McMurtrey CP, O'Connor DH, Hildebrand WH, Sette A, Watkins DI, Wilson NA. The role of MHC class I allele Mamu-A*07 during SIV(mac)239 infection. Immunogenetics. 2011 Dec; 63(12):789-807. PMID: 21732180.
      Citations: 13     Fields:    Translation:AnimalsCells
    52. Hawkins O, Verma B, Lightfoot S, Jain R, Rawat A, McNair S, Caseltine S, Mojsilovic A, Gupta P, Neethling F, Almanza O, Dooley W, Hildebrand W, Weidanz J. An HLA-presented fragment of macrophage migration inhibitory factor is a therapeutic target for invasive breast cancer. J Immunol. 2011 Jun 01; 186(11):6607-16. PMID: 21515791.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    53. Gleimer M, Wahl AR, Hickman HD, Abi-Rached L, Norman PJ, Guethlein LA, Hammond JA, Draghi M, Adams EJ, Juo S, Jalili R, Gharizadeh B, Ronaghi M, Garcia KC, Hildebrand WH, Parham P. Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires. J Immunol. 2011 Feb 01; 186(3):1575-88. PMID: 21209280.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    54. Piazza P, McMurtrey CP, Lelic A, Cook RL, Hess R, Yablonsky E, Borowski L, Loeb MB, Bramson JL, Hildebrand WH, Rinaldo CR. Surface phenotype and functionality of WNV specific T cells differ with age and disease severity. PLoS One. 2010 Dec 13; 5(12):e15343. PMID: 21179445.
      Citations: 12     Fields:    Translation:HumansCells
    55. Augustine AD, Cassetti MC, Ennis FA, Harris E, Hildebrand WH, Repik PM. NIAID workshop on Flavivirus immunity. Viral Immunol. 2010 Jun; 23(3):235-40. PMID: 20565288.
      Citations: 2     Fields:    Translation:HumansCells
    56. Wang S, Buchli R, Schiller J, Gao J, VanGundy RS, Hildebrand WH, Eckels DD. Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity. World J Gastroenterol. 2010 Apr 28; 16(16):1953-69. PMID: 20419832.
      Citations: 7     Fields:    Translation:HumansCells
    57. Kim S, Li L, McMurtrey CP, Hildebrand WH, Weidanz JA, Gillanders WE, Diamond MS, Hansen TH. Single-chain HLA-A2 MHC trimers that incorporate an immundominant peptide elicit protective T cell immunity against lethal West Nile virus infection. J Immunol. 2010 Apr 15; 184(8):4423-30. PMID: 20212098.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    58. Wahl A, Schafer F, Bardet W, Hildebrand WH. HLA class I molecules reflect an altered host proteome after influenza virus infection. Hum Immunol. 2010 Jan; 71(1):14-22. PMID: 19748539.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    59. Fox LM, Cox DG, Lockridge JL, Wang X, Chen X, Scharf L, Trott DL, Ndonye RM, Veerapen N, Besra GS, Howell AR, Cook ME, Adams EJ, Hildebrand WH, Gumperz JE. Recognition of lyso-phospholipids by human natural killer T lymphocytes. PLoS Biol. 2009 Oct; 7(10):e1000228. PMID: 19859526.
      Citations: 138     Fields:    Translation:HumansCells
    60. Verma B, Hawkins OE, Neethling FA, Caseltine SL, Largo SR, Hildebrand WH, Weidanz JA. Direct discovery and validation of a peptide/MHC epitope expressed in primary human breast cancer cells using a TCRm monoclonal antibody with profound antitumor properties. Cancer Immunol Immunother. 2010 Apr; 59(4):563-73. PMID: 19779714.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    61. Wahl A, McCoy W, Schafer F, Bardet W, Buchli R, Fremont DH, Hildebrand WH. T-cell tolerance for variability in an HLA class I-presented influenza A virus epitope. J Virol. 2009 Sep; 83(18):9206-14. PMID: 19553306.
      Citations: 16     Fields:    Translation:Cells
    62. Loffredo JT, Sidney J, Bean AT, Beal DR, Bardet W, Wahl A, Hawkins OE, Piaskowski S, Wilson NA, Hildebrand WH, Watkins DI, Sette A. Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity. J Immunol. 2009 Jun 15; 182(12):7763-75. PMID: 19494300.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    63. Cox D, Fox L, Tian R, Bardet W, Skaley M, Mojsilovic D, Gumperz J, Hildebrand W. Determination of cellular lipids bound to human CD1d molecules. PLoS One. 2009; 4(5):e5325. PMID: 19415116.
      Citations: 93     Fields:    Translation:HumansCells
    64. Tuli A, Sharma M, Wang X, Simone LC, Capek HL, Cate S, Hildebrand WH, Naslavsky N, Caplan S, Solheim JC. Amyloid precursor-like protein 2 association with HLA class I molecules. Cancer Immunol Immunother. 2009 Sep; 58(9):1419-31. PMID: 19184004.
      Citations: 15     Fields:    Translation:HumansCells
    65. Wahl A, Schafer F, Bardet W, Buchli R, Air GM, Hildebrand WH. HLA class I molecules consistently present internal influenza epitopes. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):540-5. PMID: 19122146.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    66. Hawkins OE, Vangundy RS, Eckerd AM, Bardet W, Buchli R, Weidanz JA, Hildebrand WH. Identification of breast cancer peptide epitopes presented by HLA-A*0201. J Proteome Res. 2008 Apr; 7(4):1445-57. PMID: 18345606.
      Citations: 31     Fields:    Translation:HumansCells
    67. McMurtrey CP, Lelic A, Piazza P, Chakrabarti AK, Yablonsky EJ, Wahl A, Bardet W, Eckerd A, Cook RL, Hess R, Buchli R, Loeb M, Rinaldo CR, Bramson J, Hildebrand WH. Epitope discovery in West Nile virus infection: Identification and immune recognition of viral epitopes. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):2981-6. PMID: 18299564.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    68. Wahl A, Weidanz J, Hildebrand W. Direct class I HLA antigen discovery to distinguish virus-infected and cancerous cells. Expert Rev Proteomics. 2006 Dec; 3(6):641-52. PMID: 17181478.
      Citations: 9     Fields:    Translation:HumansAnimals
    69. Hurley CK, Fernandez-Vina M, Hildebrand WH, Noreen HJ, Trachtenberg E, Williams TM, Baxter-Lowe LA, Begovich AB, Petersdorf E, Selvakumar A, Stastny P, Hegland J, Hartzman RJ, Carston M, Gandham S, Kollman C, Nelson G, Spellman S, Setterholm M. A high degree of HLA disparity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs. Hum Immunol. 2007 Jan; 68(1):30-40. PMID: 17207710.
      Citations: 17     Fields:    Translation:Humans
    70. Weidanz JA, Piazza P, Hickman-Miller H, Woodburn D, Nguyen T, Wahl A, Neethling F, Chiriva-Internati M, Rinaldo CR, Hildebrand WH. Development and implementation of a direct detection, quantitation and validation system for class I MHC self-peptide epitopes. J Immunol Methods. 2007 Jan 10; 318(1-2):47-58. PMID: 17134715.
      Citations: 12     Fields:    Translation:HumansCells
    71. Weidanz JA, Nguyen T, Woodburn T, Neethling FA, Chiriva-Internati M, Hildebrand WH, Lustgarten J. Levels of specific peptide-HLA class I complex predicts tumor cell susceptibility to CTL killing. J Immunol. 2006 Oct 15; 177(8):5088-97. PMID: 17015692.
      Citations: 22     Fields:    Translation:HumansCells
    72. Buchli R, Vangundy RS, Giberson CF, Hildebrand WH. Critical factors in the development of fluorescence polarization-based peptide binding assays: an equilibrium study monitoring specific peptide binding to soluble HLA-A*0201. J Immunol Methods. 2006 Jul 31; 314(1-2):38-53. PMID: 16844138.
      Citations: 5     Fields:    Translation:Cells
    73. Loffredo JT, Sidney J, Piaskowski S, Szymanski A, Furlott J, Rudersdorf R, Reed J, Peters B, Hickman-Miller HD, Bardet W, Rehrauer WM, O'Connor DH, Wilson NA, Hildebrand WH, Sette A, Watkins DI. The high frequency Indian rhesus macaque MHC class I molecule, Mamu-B*01, does not appear to be involved in CD8+ T lymphocyte responses to SIVmac239. J Immunol. 2005 Nov 01; 175(9):5986-97. PMID: 16237093.
      Citations: 27     Fields:    Translation:AnimalsCells
    74. Ellis NM, Li Y, Hildebrand W, Fischetti VA, Cunningham MW. T cell mimicry and epitope specificity of cross-reactive T cell clones from rheumatic heart disease. J Immunol. 2005 Oct 15; 175(8):5448-56. PMID: 16210652.
      Citations: 47     Fields:    Translation:HumansCells
    75. Buchli R, VanGundy RS, Hickman-Miller HD, Giberson CF, Bardet W, Hildebrand WH. Development and validation of a fluorescence polarization-based competitive peptide-binding assay for HLA-A*0201--a new tool for epitope discovery. Biochemistry. 2005 Sep 20; 44(37):12491-507. PMID: 16156661.
      Citations: 28     Fields:    Translation:HumansCells
    76. Wren JD, Hildebrand WH, Chandrasekaran S, Melcher U. Markov model recognition and classification of DNA/protein sequences within large text databases. Bioinformatics. 2005 Nov 01; 21(21):4046-53. PMID: 16159926.
      Citations: 6     Fields:    
    77. Hickman-Miller HD, Bardet W, Gilb A, Luis AD, Jackson KW, Watkins DI, Hildebrand WH. Rhesus macaque MHC class I molecules present HLA-B-like peptides. J Immunol. 2005 Jul 01; 175(1):367-75. PMID: 15972670.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    78. Huang XL, Fan Z, Colleton BA, Buchli R, Li H, Hildebrand WH, Rinaldo CR. Processing and presentation of exogenous HLA class I peptides by dendritic cells from human immunodeficiency virus type 1-infected persons. J Virol. 2005 Mar; 79(5):3052-62. PMID: 15709025.
      Citations: 17     Fields:    Translation:HumansCells
    79. Petersen JL, Hickman-Miller HD, McIlhaney MM, Vargas SE, Purcell AW, Hildebrand WH, Solheim JC. A charged amino acid residue in the transmembrane/cytoplasmic region of tapasin influences MHC class I assembly and maturation. J Immunol. 2005 Jan 15; 174(2):962-9. PMID: 15634919.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    80. Buchli R, VanGundy RS, Hickman-Miller HD, Giberson CF, Bardet W, Hildebrand WH. Real-time measurement of in vitro peptide binding to soluble HLA-A*0201 by fluorescence polarization. Biochemistry. 2004 Nov 23; 43(46):14852-63. PMID: 15544356.
      Citations: 14     Fields:    Translation:HumansCells
    81. Hickman-Miller HD, Hildebrand WH. The immune response under stress: the role of HSP-derived peptides. Trends Immunol. 2004 Aug; 25(8):427-33. PMID: 15275642.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    82. Hickman HD, Luis AD, Buchli R, Few SR, Sathiamurthy M, VanGundy RS, Giberson CF, Hildebrand WH. Toward a definition of self: proteomic evaluation of the class I peptide repertoire. J Immunol. 2004 Mar 01; 172(5):2944-52. PMID: 14978097.
      Citations: 46     Fields:    Translation:HumansCells
    83. Leffell MS, Fallin MD, Hildebrand WH, Cavett JW, Iglehart BA, Zachary AA. HLA alleles and haplotypes among the Lakota Sioux: report of the ASHI minority workshops, part III. Hum Immunol. 2004 Jan; 65(1):78-89. PMID: 14700599.
      Citations: 12     Fields:    Translation:Humans
    84. Hickman HD, Luis AD, Bardet W, Buchli R, Battson CL, Shearer MH, Jackson KW, Kennedy RC, Hildebrand WH. Cutting edge: class I presentation of host peptides following HIV infection. J Immunol. 2003 Jul 01; 171(1):22-6. PMID: 12816978.
      Citations: 33     Fields:    Translation:HumansCells
    85. Ellerhorst JA, Hildebrand WH, Cavett JW, Fernandez-Vina MA, Hodges S, Poindexter N, Fischer H, Grimm EA. Heterozygosity or homozygosity for 2 HLA class II haplotypes predict favorable outcomes for renal cell carcinoma treated with cytokine therapy. J Urol. 2003 Jun; 169(6):2084-8. PMID: 12771724.
      Citations: 2     Fields:    Translation:Humans
    86. Sathiamurthy M, Hickman HD, Cavett JW, Zahoor A, Prilliman K, Metcalf S, Fernandez Vina M, Hildebrand WH. Population of the HLA ligand database. Tissue Antigens. 2003 Jan; 61(1):12-9. PMID: 12622773.
      Citations: 25     Fields:    Translation:Humans
    87. Huang XL, Fan Z, Zheng L, Borowski L, Li H, Thomas EK, Hildebrand WH, Zhao XQ, Rinaldo CR. Priming of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cell responses by dendritic cells loaded with HIV-1 proteins. J Infect Dis. 2003 Jan 15; 187(2):315-9. PMID: 12552458.
      Citations: 11     Fields:    Translation:HumansCells
    88. Leffell MS, Fallin MD, Erlich HA, Fernandez-Vina M, Hildebrand WH, Mack SJ, Zachary AA. HLA antigens, alleles and haplotypes among the Yup'ik Alaska natives: report of the ASHI Minority Workshops, Part II. Hum Immunol. 2002 Jul; 63(7):614-25. PMID: 12072196.
      Citations: 14     Fields:    Translation:Humans
    89. Wang QJ, Huang XL, Rappocciolo G, Jenkins FJ, Hildebrand WH, Fan Z, Thomas EK, Rinaldo CR. Identification of an HLA A*0201-restricted CD8(+) T-cell epitope for the glycoprotein B homolog of human herpesvirus 8. Blood. 2002 May 01; 99(9):3360-6. PMID: 11964304.
      Citations: 17     Fields:    Translation:HumansCells
    90. Hildebrand WH, Turnquist HR, Prilliman KR, Hickman HD, Schenk EL, McIlhaney MM, Solheim JC. HLA class I polymorphism has a dual impact on ligand binding and chaperone interaction. Hum Immunol. 2002 Apr; 63(4):248-55. PMID: 12039406.
      Citations: 7     Fields:    Translation:Humans
    91. Turnquist HR, Schenk EL, McIlhaney MM, Hickman HD, Hildebrand WH, Solheim JC. Disparate binding of chaperone proteins by HLA-A subtypes. Immunogenetics. 2002 Feb; 53(10-11):830-4. PMID: 11862383.
      Citations: 7     Fields:    Translation:HumansCells
    92. Ellexson-Turner ME, Leffell MS, Zachary AA, Turner S, Bennett T, Sidebottom DA, Cao K, Fernández-Viña M, Hildebrand WH. Sequence-based typing of HLA class I alleles in Alaskan Yupik Eskimo. Hum Immunol. 2001 Jun; 62(6):639-44. PMID: 11390039.
      Citations:    Fields:    Translation:HumansCells
    93. Sidebottom DA, Kennedy R, Hildebrand WH. Class I MHC expression in the yellow baboon. J Immunol. 2001 Mar 15; 166(6):3983-93. PMID: 11238644.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    94. Hickman HD, Cavett JW, Ellexson-Turner ME, Sparkman JN, Bennett TT, Turner S, Sidebottom DA, Trachtenberg EA, Confer DL, Hildebrand WH. Non-conservative substitutions distinguish previously uncharacterized HLA-A molecules. Tissue Antigens. 2001 Feb; 57(2):95-102. PMID: 11260503.
      Citations:    Fields:    Translation:Humans
    95. Ellexson-Turner M, Sidebottom D, Turner S, Bennett T, Hildebrand WH. Precision genotyping of human leukocyte antigen-A, -B and -C loci via direct DNA sequencing. Methods Mol Biol. 2001; 156:129-42. PMID: 11068755.
      Citations: 1     Fields:    Translation:HumansCells
    96. Hickman HD, Batson CL, Prilliman KR, Crawford DL, Jackson KL, Hildebrand WH. C-terminal epitope tagging facilitates comparative ligand mapping from MHC class I positive cells. Hum Immunol. 2000 Dec; 61(12):1339-46. PMID: 11163091.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    97. Prilliman KR, Crawford D, Hickman HD, Jackson KW, Wang J, Hildebrand WH. Alpha-2 domain polymorphism and HLA class I peptide loading. Tissue Antigens. 1999 Nov; 54(5):450-60. PMID: 10599884.
      Citations: 2     Fields:    Translation:HumansCells
    98. Prilliman KR, Jackson KW, Lindsey M, Wang J, Crawford D, Hildebrand WH. HLA-B15 peptide ligands are preferentially anchored at their C termini. J Immunol. 1999 Jun 15; 162(12):7277-84. PMID: 10358176.
      Citations: 15     Fields:    Translation:HumansCells
    99. Prilliman KR, Lindsey M, Wang J, Jackson KW, Hildebrand WH. Peptide motif of the class I molecule HLA-B*1503. Immunogenetics. 1999 Feb; 49(2):144-6. PMID: 9887352.
      Citations:    Fields:    Translation:HumansCells
    100. Turner S, Ellexson ME, Hickman HD, Sidebottom DA, Fernández-Viña M, Confer DL, Hildebrand WH. Sequence-based typing provides a new look at HLA-C diversity. J Immunol. 1998 Aug 01; 161(3):1406-13. PMID: 9686604.
      Citations: 16     Fields:    Translation:HumansCells
    101. Prilliman KR, Lindsey M, Jackson KW, Cole J, Bonner R, Hildebrand WH. Complexity among constituents of the HLA-B*1501 peptide motif. Immunogenetics. 1998 Jul; 48(2):89-97. PMID: 9634472.
      Citations: 1     Fields:    Translation:Cells
    102. Ellexson ME, Peck RL, Stewart D, Keller J, Hildebrand WH. Characterization of an HLA-A26 serologic variant. Immunogenetics. 1998 Jul; 48(2):152-5. PMID: 9634481.
      Citations:    Fields:    
    103. Kennedy RC, Shearer MH, Hildebrand W. Nonhuman primate models to evaluate vaccine safety and immunogenicity. Vaccine. 1997 Jun; 15(8):903-8. PMID: 9234544.
      Citations: 30     Fields:    Translation:HumansAnimals
    104. Ellexson M, Lai-Kwan P, Lau M, Muto K, Terasaki P, Cole J, Thompson C, Hildebrand W. Polymorphism at codons 114, 116, 145, and 163 muddle the typing of HLA-B*1304. Hum Immunol. 1997 Jun; 55(1):66-73. PMID: 9328792.
      Citations:    Fields:    Translation:HumansCells
    105. Prilliman K, Lindsey M, Zuo Y, Jackson KW, Zhang Y, Hildebrand W. Large-scale production of class I bound peptides: assigning a signature to HLA-B*1501. Immunogenetics. 1997; 45(6):379-85. PMID: 9089095.
      Citations: 24     Fields:    Translation:HumansCells
    106. Ellexson M, Stewart D, Chrétien P, Zhang L, Hildebrand W. Description of a modified sequencing strategy and the molecular characterization of HLA-B*8201. Tissue Antigens. 1996 May; 47(5):438-41. PMID: 8795148.
      Citations:    Fields:    Translation:HumansCells
    107. Prilliman K, Lawlor D, Ellexson M, McElwee N, Confer D, Cooper DK, Kennedy RC, Hildebrand W. Characterization of baboon class I major histocompatibility molecules. Implications for baboon-to-human xenotransplantation. Transplantation. 1996 Apr 15; 61(7):989-96. PMID: 8623205.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    108. Ellexson M, Lau M, Terasaki P, Hildebrand W. Molecular characterization of HLA-A*6803. Immunogenetics. 1996; 45(1):78-9. PMID: 8881043.
      Citations:    Fields:    Translation:HumansCells
    109. Prilliman K, Steiner N, Ellexson M, Stewart D, Lau M, Terasaki P, Hurley C, Hildebrand W. Novel alleles HLA-B*7802 and B*51022: evidence for convergency in the HLA-B5 family. Tissue Antigens. 1996 Jan; 47(1):49-57. PMID: 8929712.
      Citations:    Fields:    Translation:HumansCells
    110. Ellexson ME, Zhang G, Stewart D, Lau M, Teresi G, Terasaki P, Roe B, Hildebrand W. Nucleotide sequence analysis of HLA-B*1523 and B*8101. Dominant alpha-helical motifs produce complex serologic recognition patterns for the HLA-B"DT" and HLA-B"NM5" antigens. Hum Immunol. 1995 Oct; 44(2):103-10. PMID: 8847228.
      Citations: 1     Fields:    Translation:HumansCells
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