"Genes, APC" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
| Descriptor ID |
D017491
|
| MeSH Number(s) |
G05.360.340.024.340.375.249.050 G05.360.340.024.340.415.400.050
|
| Concept/Terms |
Genes, APC- Genes, APC
- APC Gene
- APC Genes
- Gene, APC
- Genes, Adenomatous Polyposis Coli
|
Below are MeSH descriptors whose meaning is more general than "Genes, APC".
Below are MeSH descriptors whose meaning is more specific than "Genes, APC".
This graph shows the total number of publications written about "Genes, APC" by people in this website by year, and whether "Genes, APC" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genes, APC" by people in Profiles.
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Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. Mol Cancer. 2017 02 01; 16(1):30.
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Improved innate immune responses by Frondanol A5, a sea cucumber extract, prevent intestinal tumorigenesis. Cancer Prev Res (Phila). 2015 Apr; 8(4):327-37.
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Barrett's esophagus in the patients with familial adenomatous polyposis. Fam Cancer. 2014 Jun; 13(2):213-7.
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IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 2012 Nov 08; 491(7423):259-63.
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Anti-cancer activity of nitrones in the Apc(Min/+) model of colorectal cancer. Free Radic Res. 2010 Jan; 44(1):108-17.
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Suppression of familial adenomatous polyposis by CP-31398, a TP53 modulator, in APCmin/+ mice. Cancer Res. 2008 Sep 15; 68(18):7670-5.
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Microarray analysis reveals that leptin induces autocrine/paracrine cascades to promote survival and proliferation of colon epithelial cells in an Apc genotype-dependent fashion. Mol Carcinog. 2008 Jan; 47(1):9-21.
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Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes. Cancer Biol Ther. 2006 Dec; 5(12):1714-20.
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Leptin induces an Apc genotype-associated colon epithelial cell chemokine production pattern associated with macrophage chemotaxis and activation. Carcinogenesis. 2007 Feb; 28(2):455-64.
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The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer: clinical and pathologic features. Cancer Genet Cytogenet. 2006 Aug; 169(1):33-8.