Gene Targeting

"Gene Targeting" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.

Descriptor ID	D018390
MeSH Number(s)	E05.393.335
Concept/Terms	Gene Targeting Gene Targeting Gene Targetings Targeting, Gene Targetings, Gene

Below are MeSH descriptors whose meaning is more general than "Gene Targeting".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Gene Targeting [E05.393.335]

Below are MeSH descriptors whose meaning is more specific than "Gene Targeting".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Targeting" by people in this website by year, and whether "Gene Targeting" was a major or minor topic of these publications.

Bar chart showing 19 publications over 15 distinct years, with a maximum of 2 publications in 2002 and 2014 and 2015 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2002	0	2	2
2003	0	1	1
2004	0	1	1
2006	0	1	1
2007	1	0	1
2008	0	1	1
2010	1	0	1
2011	0	1	1
2014	1	1	2
2015	1	1	2
2016	1	0	1
2017	0	2	2
2019	1	0	1
2020	0	1	1

Below are the most recent publications written about "Gene Targeting" by people in Profiles.

Bista S, Singh P, Bernard Q, Yang X, Hart T, Lin YP, Kitsou C, Singh Rana V, Zhang F, Linhardt RJ, Zhnag K, Akins DR, Hritzo L, Kim Y, Grab DJ, Dumler JS, Pal U. A Novel Laminin-Binding Protein Mediates Microbial-Endothelial Cell Interactions and Facilitates Dissemination of Lyme Disease Pathogens. J Infect Dis. 2020 04 07; 221(9):1438-1447.

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Biswas I, Mettlach J. Targeted Gene Replacement in Acinetobacter baumannii. Methods Mol Biol. 2019; 1946:95-106.

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Shrestha B, Kenedy MR, Akins DR. Outer Membrane Proteins BB0405 and BB0406 Are Immunogenic, but Only BB0405 Is Required for Borrelia burgdorferi Infection. Infect Immun. 2017 02; 85(2).

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Ma K, Fu D, Yu D, Cui C, Wang L, Guo Z, Mao C. Targeted delivery of in situ PCR-amplified Sleeping Beauty transposon genes to cancer cells with lipid-based nanoparticle-like protocells. Biomaterials. 2017 03; 121:55-63.

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Le YZ, Zhu M, Anderson RE. Cre Recombinase: You Can't Live with It, and You Can't Live Without It. Adv Exp Med Biol. 2016; 854:725-30.

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Fuller KK, Chen S, Loros JJ, Dunlap JC. Development of the CRISPR/Cas9 System for Targeted Gene Disruption in Aspergillus fumigatus. Eukaryot Cell. 2015 Nov; 14(11):1073-80.

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Xu T, Li Y, Shi Z, Hemme CL, Li Y, Zhu Y, Van Nostrand JD, He Z, Zhou J. Efficient Genome Editing in Clostridium cellulolyticum via CRISPR-Cas9 Nickase. Appl Environ Microbiol. 2015 Jul; 81(13):4423-31.

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Shen B, Brown KM, Lee TD, Sibley LD. Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9. mBio. 2014 May 13; 5(3):e01114-14.

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Xu T, Li Y, Van Nostrand JD, He Z, Zhou J. Cas9-based tools for targeted genome editing and transcriptional control. Appl Environ Microbiol. 2014 Mar; 80(5):1544-52.

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Liskovykh M, Chuykin I, Ranjan A, Safina D, Popova E, Tolkunova E, Mosienko V, Minina JM, Zhdanova NS, Mullins JJ, Bader M, Alenina N, Tomilin A. Derivation, characterization, and stable transfection of induced pluripotent stem cells from Fischer344 rats. PLoS One. 2011; 6(11):e27345.

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