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Darrin Randal Akins

TitleVc for Research Pres
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentResearch Administration Office
AddressRP865 450
800 Research Parkway
Oklahoma City OK 73104
Phone405/271-2133 ext 46640
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    R56AI059373     (AKINS, DARRIN R)Sep 27, 2011 - Mar 14, 2012
    NIH
    Outer membrane proteins of Borrelia burgdorferi
    Role: Principal Investigator
    R21AI085310     (AKINS, DARRIN R)May 24, 2010 - Apr 30, 2013
    NIH
    Surface Lipoproteins and Serum Resistance in Borrelia burgdorferi
    Role: Principal Investigator
    R21AI064629     (AKINS, DARRIN R)Apr 1, 2006 - Mar 31, 2009
    NIH
    Complement evasion by Borrelia burgdorferi
    Role: Principal Investigator
    R01AI059373     (AKINS, DARRIN R.)Apr 1, 2004 - Dec 31, 2023
    NIH
    Outer Membrane Proteins of Borrelia burgdorferi
    Role: Principal Investigator
    P20GM103447     (AKINS, DARRIN R.)Sep 6, 2001 - Apr 30, 2024
    NIH
    Oklahoma IDeA Network of Biomedical Research Excellence
    Role: Principal Investigator
    P20RR016478     (AKINS, DARRIN R)Sep 6, 2001 - Mar 31, 2014
    NIH
    Oklahoma IDeA Network of Biomedical Research Excellence
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bowen HG, Kenedy MR, Johnson DK, MacKerell AD, Akins DR. Identification of a novel transport system in Borrelia burgdorferi that links the inner and outer membranes. Pathog Dis. 2023 01 17; 81. PMID: 37385817; PMCID: PMC10353723.
      Citations:    Fields:    Translation:HumansCells
    2. Undi RB, Larabee JL, Filiberti A, Ulahannan S, Aravindan S, Stroberg E, Barton LM, Duval EJ, Mukhopadhyay S, Henthorn JC, Akins D, Houchen CW, Huycke MM, Ali N. Targeting Doublecortin-Like Kinase 1 (DCLK1)-Regulated SARS-CoV-2 Pathogenesis in COVID-19. J Virol. 2022 09 14; 96(17):e0096722. PMID: 35943255; PMCID: PMC9472619.
      Citations: 3     Fields:    Translation:HumansCells
    3. Chou AF, Hammon D, Akins DR. Impact of the Oklahoma IDeA Network of Biomedical Research Excellence research support and mentoring program for early-stage faculty. Adv Physiol Educ. 2022 Sep 01; 46(3):443-452. PMID: 35658613.
      Citations: 1     Fields:    Translation:Humans
    4. Kuhn HW, Lasseter AG, Adams PP, Avile CF, Stone BL, Akins DR, Jewett TJ, Jewett MW. BB0562 is a nutritional virulence determinant with lipase activity important for Borrelia burgdorferi infection and survival in fatty acid deficient environments. PLoS Pathog. 2021 08; 17(8):e1009869. PMID: 34415955.
      Citations: 6     Fields:    Translation:AnimalsCells
    5. Bista S, Singh P, Bernard Q, Yang X, Hart T, Lin YP, Kitsou C, Singh Rana V, Zhang F, Linhardt RJ, Zhnag K, Akins DR, Hritzo L, Kim Y, Grab DJ, Dumler JS, Pal U. A Novel Laminin-Binding Protein Mediates Microbial-Endothelial Cell Interactions and Facilitates Dissemination of Lyme Disease Pathogens. J Infect Dis. 2020 04 07; 221(9):1438-1447. PMID: 31758693.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    6. Chou AF, Hammon D, Akins DR. Impact and Outcomes of the Oklahoma IDeA Network of Biomedical Research Excellence Summer Undergraduate Research Program. J Microbiol Biol Educ. 2019; 20(3). PMID: 31768211.
      Citations: 8     
    7. Iqbal H, Akins DR, Kenedy MR. Co-immunoprecipitation for Identifying Protein-Protein Interactions in Borrelia burgdorferi. Methods Mol Biol. 2018; 1690:47-55. PMID: 29032535.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    8. Cole BK, Scott E, Ilikj M, Bard D, Akins DR, Dyer DW, Chavez-Bueno S. Route of infection alters virulence of neonatal septicemia Escherichia coli clinical isolates. PLoS One. 2017; 12(12):e0189032. PMID: 29236742.
      Citations: 9     Fields:    Translation:HumansCells
    9. Shrestha B, Kenedy MR, Akins DR. Outer Membrane Proteins BB0405 and BB0406 Are Immunogenic, but Only BB0405 Is Required for Borrelia burgdorferi Infection. Infect Immun. 2017 02; 85(2). PMID: 27920211.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    10. Iqbal H, Kenedy MR, Lybecker M, Akins DR. The TamB ortholog of Borrelia burgdorferi interacts with the ß-barrel assembly machine (BAM) complex protein BamA. Mol Microbiol. 2016 12; 102(5):757-774. PMID: 27588694.
      Citations: 24     Fields:    Translation:Cells
    11. Kenedy MR, Scott EJ, Shrestha B, Anand A, Iqbal H, Radolf JD, Dyer DW, Akins DR. Consensus computational network analysis for identifying candidate outer membrane proteins from Borrelia spirochetes. BMC Microbiol. 2016 07 11; 16(1):141. PMID: 27400788.
      Citations: 13     Fields:    Translation:HumansCells
    12. Dunn JP, Kenedy MR, Iqbal H, Akins DR. Characterization of the ß-barrel assembly machine accessory lipoproteins from Borrelia burgdorferi. BMC Microbiol. 2015 Mar 24; 15:70. PMID: 25887384.
      Citations: 14     Fields:    Translation:Cells
    13. Dao HD, Kota P, James JA, Stoner JA, Akins DR. Assessment of Translational and Interdisciplinary Clinical Research at an Oklahoma Health Sciences Center. J Okla State Med Assoc. 2015 Mar; 108(3):93-101. PMID: 26242016.
      Citations: 4     Fields:    Translation:Humans
    14. Day MW, Jackson LA, Akins DR, Dyer DW, Chavez-Bueno S. Whole-Genome Sequences of the Archetypal K1 Escherichia coli Neonatal Isolate RS218 and Contemporary Neonatal Bacteremia Clinical Isolates SCB11, SCB12, and SCB15. Genome Announc. 2015 Feb 26; 3(1). PMID: 25720688.
      Citations: 8     
    15. Chavez-Bueno S, Day MW, Toby IT, Akins DR, Dyer DW. Genome Sequence of SCB34, a Sequence Type 131 Multidrug-Resistant Escherichia coli Isolate Causing Neonatal Early-Onset Sepsis. Genome Announc. 2014 Jun 12; 2(3). PMID: 24926049.
      Citations: 4     
    16. Kenedy MR, Luthra A, Anand A, Dunn JP, Radolf JD, Akins DR. Structural modeling and physicochemical characterization provide evidence that P66 forms a ß-barrel in the Borrelia burgdorferi outer membrane. J Bacteriol. 2014 Feb; 196(4):859-72. PMID: 24317399.
      Citations: 26     Fields:    Translation:Cells
    17. Kenedy MR, Lenhart TR, Akins DR. The role of Borrelia burgdorferi outer surface proteins. FEMS Immunol Med Microbiol. 2012 Oct; 66(1):1-19. PMID: 22540535.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    18. Lenhart TR, Kenedy MR, Yang X, Pal U, Akins DR. BB0324 and BB0028 are constituents of the Borrelia burgdorferi ß-barrel assembly machine (BAM) complex. BMC Microbiol. 2012 Apr 20; 12:60. PMID: 22519960.
      Citations: 18     Fields:    Translation:Cells
    19. Caimano MJ, Kenedy MR, Kairu T, Desrosiers DC, Harman M, Dunham-Ems S, Akins DR, Pal U, Radolf JD. The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks. Infect Immun. 2011 Aug; 79(8):3117-30. PMID: 21606185.
      Citations: 66     Fields:    Translation:AnimalsCells
    20. Kenedy MR, Akins DR. The OspE-related proteins inhibit complement deposition and enhance serum resistance of Borrelia burgdorferi, the lyme disease spirochete. Infect Immun. 2011 Apr; 79(4):1451-7. PMID: 21282413.
      Citations: 28     Fields:    Translation:HumansCells
    21. Yang X, Lenhart TR, Kariu T, Anguita J, Akins DR, Pal U. Characterization of unique regions of Borrelia burgdorferi surface-located membrane protein 1. Infect Immun. 2010 Nov; 78(11):4477-87. PMID: 20696833.
      Citations: 35     Fields:    Translation:AnimalsCells
    22. Lenhart TR, Akins DR. Borrelia burgdorferi locus BB0795 encodes a BamA orthologue required for growth and efficient localization of outer membrane proteins. Mol Microbiol. 2010 Feb; 75(3):692-709. PMID: 20025662.
      Citations: 44     Fields:    Translation:Cells
    23. Kenedy MR, Vuppala SR, Siegel C, Kraiczy P, Akins DR. CspA-mediated binding of human factor H inhibits complement deposition and confers serum resistance in Borrelia burgdorferi. Infect Immun. 2009 Jul; 77(7):2773-82. PMID: 19451251.
      Citations: 55     Fields:    Translation:HumansCells
    24. Coleman AS, Yang X, Kumar M, Zhang X, Promnares K, Shroder D, Kenedy MR, Anderson JF, Akins DR, Pal U. Borrelia burgdorferi complement regulator-acquiring surface protein 2 does not contribute to complement resistance or host infectivity. PLoS One. 2008 Aug 20; 3(8):3010e. PMID: 18714378.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    25. Brooks CS, Vuppala SR, Jett AM, Akins DR. Identification of Borrelia burgdorferi outer surface proteins. Infect Immun. 2006 Jan; 74(1):296-304. PMID: 16368984.
      Citations: 57     Fields:    Translation:AnimalsCells
    26. Alitalo A, Meri T, Comstedt P, Jeffery L, Tornberg J, Strandin T, Lankinen H, Bergström S, Cinco M, Vuppala SR, Akins DR, Meri S. Expression of complement factor H binding immunoevasion proteins in Borrelia garinii isolated from patients with neuroborreliosis. Eur J Immunol. 2005 Oct; 35(10):3043-53. PMID: 16208765.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    27. Brooks CS, Vuppala SR, Jett AM, Alitalo A, Meri S, Akins DR. Complement regulator-acquiring surface protein 1 imparts resistance to human serum in Borrelia burgdorferi. J Immunol. 2005 Sep 01; 175(5):3299-308. PMID: 16116222.
      Citations: 68     Fields:    Translation:HumansCells
    28. Mashburn LM, Jett AM, Akins DR, Whiteley M. Staphylococcus aureus serves as an iron source for Pseudomonas aeruginosa during in vivo coculture. J Bacteriol. 2005 Jan; 187(2):554-66. PMID: 15629927.
      Citations: 151     Fields:    Translation:AnimalsCells
    29. Alitalo A, Meri T, Chen T, Lankinen H, Cheng ZZ, Jokiranta TS, Seppälä IJ, Lahdenne P, Hefty PS, Akins DR, Meri S. Lysine-dependent multipoint binding of the Borrelia burgdorferi virulence factor outer surface protein E to the C terminus of factor H. J Immunol. 2004 May 15; 172(10):6195-201. PMID: 15128807.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    30. Anderton JM, Tokarz R, Thill CD, Kuhlow CJ, Brooks CS, Akins DR, Katona LI, Benach JL. Whole-genome DNA array analysis of the response of Borrelia burgdorferi to a bactericidal monoclonal antibody. Infect Immun. 2004 Apr; 72(4):2035-44. PMID: 15039324.
      Citations: 12     Fields:    Translation:HumansCells
    31. Gilmore KS, Srinivas P, Akins DR, Hatter KL, Gilmore MS. Growth, development, and gene expression in a persistent Streptococcus gordonii biofilm. Infect Immun. 2003 Aug; 71(8):4759-66. PMID: 12874358.
      Citations: 27     Fields:    Translation:Cells
    32. Brooks CS, Hefty PS, Jolliff SE, Akins DR. Global analysis of Borrelia burgdorferi genes regulated by mammalian host-specific signals. Infect Immun. 2003 Jun; 71(6):3371-83. PMID: 12761121.
      Citations: 167     Fields:    Translation:Cells
    33. Ojaimi C, Brooks C, Casjens S, Rosa P, Elias A, Barbour A, Jasinskas A, Benach J, Katona L, Radolf J, Caimano M, Skare J, Swingle K, Akins D, Schwartz I. Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays. Infect Immun. 2003 Apr; 71(4):1689-705. PMID: 12654782.
      Citations: 187     Fields:    Translation:AnimalsCells
    34. Hefty PS, Brooks CS, Jett AM, White GL, Wikel SK, Kennedy RC, Akins DR. OspE-related, OspF-related, and Elp lipoproteins are immunogenic in baboons experimentally infected with Borrelia burgdorferi and in human lyme disease patients. J Clin Microbiol. 2002 Nov; 40(11):4256-65. PMID: 12409407.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    35. Alitalo A, Meri T, Lankinen H, Seppälä I, Lahdenne P, Hefty PS, Akins D, Meri S. Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs. J Immunol. 2002 Oct 01; 169(7):3847-53. PMID: 12244181.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    36. Hefty PS, Jolliff SE, Caimano MJ, Wikel SK, Akins DR. Changes in temporal and spatial patterns of outer surface lipoprotein expression generate population heterogeneity and antigenic diversity in the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun. 2002 Jul; 70(7):3468-78. PMID: 12065486.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    37. Elias AF, Stewart PE, Grimm D, Caimano MJ, Eggers CH, Tilly K, Bono JL, Akins DR, Radolf JD, Schwan TG, Rosa P. Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background. Infect Immun. 2002 Apr; 70(4):2139-50. PMID: 11895980.
      Citations: 229     Fields:    Translation:AnimalsCells
    38. Ojaimi C, Brooks C, Akins D, Casjens S, Rosa P, Elias A, Barbour A, Jasinskas A, Benach J, Katonah L, Radolf J, Caimano M, Skare J, Swingle K, Sims S, Schwartz I. Borrelia burgdorferi gene expression profiling with membrane-based arrays. Methods Enzymol. 2002; 358:165-77. PMID: 12474386.
      Citations: 23     Fields:    Translation:Cells
    39. Hefty PS, Jolliff SE, Caimano MJ, Wikel SK, Radolf JD, Akins DR. Regulation of OspE-related, OspF-related, and Elp lipoproteins of Borrelia burgdorferi strain 297 by mammalian host-specific signals. Infect Immun. 2001 Jun; 69(6):3618-27. PMID: 11349022.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    40. Stevenson B, Zückert WR, Akins DR. Repetition, conservation, and variation: the multiple cp32 plasmids of Borrelia species. J Mol Microbiol Biotechnol. 2000 Oct; 2(4):411-22. PMID: 11075913.
      Citations: 29     Fields:    Translation:Cells
    41. Caimano MJ, Yang X, Popova TG, Clawson ML, Akins DR, Norgard MV, Radolf JD. Molecular and evolutionary characterization of the cp32/18 family of supercoiled plasmids in Borrelia burgdorferi 297. Infect Immun. 2000 Mar; 68(3):1574-86. PMID: 10678977.
      Citations: 36     Fields:    Translation:Cells
    42. Akins DR, Caimano MJ, Yang X, Cerna F, Norgard MV, Radolf JD. Molecular and evolutionary analysis of Borrelia burgdorferi 297 circular plasmid-encoded lipoproteins with OspE- and OspF-like leader peptides. Infect Immun. 1999 Mar; 67(3):1526-32. PMID: 10024606.
      Citations: 53     Fields:    Translation:Cells
    43. Hagman KE, Lahdenne P, Popova TG, Porcella SF, Akins DR, Radolf JD, Norgard MV. Decorin-binding protein of Borrelia burgdorferi is encoded within a two-gene operon and is protective in the murine model of Lyme borreliosis. Infect Immun. 1998 Jun; 66(6):2674-83. PMID: 9596733.
      Citations: 72     Fields:    Translation:AnimalsCellsPHPublic Health
    44. Akins DR, Bourell KW, Caimano MJ, Norgard MV, Radolf JD. A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state. J Clin Invest. 1998 May 15; 101(10):2240-50. PMID: 9593780.
      Citations: 145     Fields:    Translation:AnimalsCells
    45. Shevchenko DV, Akins DR, Robinson EJ, Li M, Shevchenko OV, Radolf JD. Identification of homologs for thioredoxin, peptidyl prolyl cis-trans isomerase, and glycerophosphodiester phosphodiesterase in outer membrane fractions from Treponema pallidum, the syphilis spirochete. Infect Immun. 1997 Oct; 65(10):4179-89. PMID: 9317025.
      Citations: 20     Fields:    Translation:Cells
    46. Akins DR, Robinson E, Shevchenko D, Elkins C, Cox DL, Radolf JD. Tromp1, a putative rare outer membrane protein, is anchored by an uncleaved signal sequence to the Treponema pallidum cytoplasmic membrane. J Bacteriol. 1997 Aug; 179(16):5076-86. PMID: 9260949.
      Citations: 26     Fields:    Translation:Cells
    47. Shevchenko DV, Akins DR, Robinson E, Li M, Popova TG, Cox DL, Radolf JD. Molecular characterization and cellular localization of TpLRR, a processed leucine-rich repeat protein of Treponema pallidum, the syphilis spirochete. J Bacteriol. 1997 May; 179(10):3188-95. PMID: 9150213.
      Citations: 20     Fields:    Translation:Cells
    48. Lahdenne P, Porcella SF, Hagman KE, Akins DR, Popova TG, Cox DL, Katona LI, Radolf JD, Norgard MV. Molecular characterization of a 6.6-kilodalton Borrelia burgdorferi outer membrane-associated lipoprotein (lp6.6) which appears to be downregulated during mammalian infection. Infect Immun. 1997 Feb; 65(2):412-21. PMID: 9009290.
      Citations: 38     Fields:    Translation:AnimalsCellsPHPublic Health
    49. Norgard MV, Arndt LL, Akins DR, Curetty LL, Harrich DA, Radolf JD. Activation of human monocytic cells by Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides proceeds via a pathway distinct from that of lipopolysaccharide but involves the transcriptional activator NF-kappa B. Infect Immun. 1996 Sep; 64(9):3845-52. PMID: 8751937.
      Citations: 52     Fields:    Translation:HumansCells
    50. Cox DL, Akins DR, Bourell KW, Lahdenne P, Norgard MV, Radolf JD. Limited surface exposure of Borrelia burgdorferi outer surface lipoproteins. Proc Natl Acad Sci U S A. 1996 Jul 23; 93(15):7973-8. PMID: 8755587.
      Citations: 56     Fields:    Translation:AnimalsCells
    51. Porcella SF, Popova TG, Akins DR, Li M, Radolf JD, Norgard MV. Borrelia burgdorferi supercoiled plasmids encode multicopy tandem open reading frames and a lipoprotein gene family. J Bacteriol. 1996 Jun; 178(11):3293-307. PMID: 8655511.
      Citations: 56     Fields:    Translation:Cells
    52. Akins DR, Porcella SF, Popova TG, Shevchenko D, Baker SI, Li M, Norgard MV, Radolf JD. Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue. Mol Microbiol. 1995 Nov; 18(3):507-20. PMID: 8748034.
      Citations: 94     Fields:    Translation:Cells
    53. Radolf JD, Robinson EJ, Bourell KW, Akins DR, Porcella SF, Weigel LM, Jones JD, Norgard MV. Characterization of outer membranes isolated from Treponema pallidum, the syphilis spirochete. Infect Immun. 1995 Nov; 63(11):4244-52. PMID: 7591054.
      Citations: 48     Fields:    Translation:HumansCells
    54. Radolf JD, Arndt LL, Akins DR, Curetty LL, Levi ME, Shen Y, Davis LS, Norgard MV. Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytes/macrophages. J Immunol. 1995 Mar 15; 154(6):2866-77. PMID: 7876555.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    55. Cox DL, Akins DR, Porcella SF, Norgard MV, Radolf JD. Treponema pallidum in gel microdroplets: a novel strategy for investigation of treponemal molecular architecture. Mol Microbiol. 1995 Mar; 15(6):1151-64. PMID: 7623668.
      Citations: 44     Fields:    Translation:Cells
    56. Becker PS, Akins DR, Radolf JD, Norgard MV. Similarity between the 38-kilodalton lipoprotein of Treponema pallidum and the glucose/galactose-binding (MglB) protein of Escherichia coli. Infect Immun. 1994 Apr; 62(4):1381-91. PMID: 8132345.
      Citations: 17     Fields:    Translation:Cells
    57. Radolf JD, Bourell KW, Akins DR, Brusca JS, Norgard MV. Analysis of Borrelia burgdorferi membrane architecture by freeze-fracture electron microscopy. J Bacteriol. 1994 Jan; 176(1):21-31. PMID: 8282698.
      Citations: 56     Fields:    Translation:Cells
    58. Akins DR, Purcell BK, Mitra MM, Norgard MV, Radolf JD. Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphiphilicity. Infect Immun. 1993 Apr; 61(4):1202-10. PMID: 8454324.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
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