"CD5 Antigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
| Descriptor ID |
D018956
|
| MeSH Number(s) |
D23.050.301.264.051.101 D23.050.301.264.894.101 D23.101.100.150.101 D23.101.100.894.101
|
| Concept/Terms |
CD5 Antigens- CD5 Antigens
- T1 Antigen
- Leu-1 Antigen
- Leu 1 Antigen
- CD5 Antigen
- Antigen, CD5
- Antigens, CD5
|
Below are MeSH descriptors whose meaning is more general than "CD5 Antigens".
- Chemicals and Drugs [D]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, Differentiation, B-Lymphocyte [D23.050.301.264.051]
- CD5 Antigens [D23.050.301.264.051.101]
- Antigens, Differentiation, T-Lymphocyte [D23.050.301.264.894]
- CD5 Antigens [D23.050.301.264.894.101]
- Biomarkers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, Differentiation, B-Lymphocyte [D23.101.100.150]
- CD5 Antigens [D23.101.100.150.101]
- Antigens, Differentiation, T-Lymphocyte [D23.101.100.894]
- CD5 Antigens [D23.101.100.894.101]
Below are MeSH descriptors whose meaning is more specific than "CD5 Antigens".
This graph shows the total number of publications written about "CD5 Antigens" by people in this website by year, and whether "CD5 Antigens" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "CD5 Antigens" by people in Profiles.
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Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responses. PLoS One. 2014; 9(1):e84895.
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CD5-dependent CK2 activation pathway regulates threshold for T cell anergy. J Immunol. 2012 Sep 15; 189(6):2918-30.
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CD5-CK2 binding/activation-deficient mice are resistant to experimental autoimmune encephalomyelitis: protection is associated with diminished populations of IL-17-expressing T cells in the central nervous system. J Immunol. 2006 Dec 15; 177(12):8542-9.
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Cutting edge: critical role for CD5 in experimental autoimmune encephalomyelitis: inhibition of engagement reverses disease in mice. J Immunol. 2004 Sep 01; 173(5):2928-32.
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AP2 adaptor complex-dependent internalization of CD5: differential regulation in T and B cells. J Immunol. 2002 Jun 01; 168(11):5612-20.
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Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice. J Immunol. 2001 Sep 15; 167(6):3033-42.
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Signaling through CD5 involves acidic sphingomyelinase, protein kinase C-zeta, mitogen-activated protein kinase kinase, and c-Jun NH2-terminal kinase. J Immunol. 1999 May 01; 162(9):5149-55.
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Association of an activation inducible serine kinase activity with CD5. J Immunol. 1993 Nov 01; 151(9):4423-30.
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Different mechanisms regulate the monoclonal antibody-induced modulation of CD2, CD3, and CD5 in human lymphocytes. Cell Immunol. 1993 Apr 01; 147(2):247-55.
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Intracellular events involved in CD5-induced human T cell activation and proliferation. J Immunol. 1992 Mar 01; 148(5):1287-93.