In Situ Nick-End Labeling
"In Situ Nick-End Labeling" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
| Descriptor ID |
D020287
|
| MeSH Number(s) |
E05.393.475
|
| Concept/Terms |
In Situ Nick-End Labeling- In Situ Nick-End Labeling
- TUNEL
- Nick-End Labeling, In Situ
- In Situ Nick End Labelling
- In Situ Nick End Labeling
- In Situ Nick End-Labelling
- In Situ Nick-End Labelling
- Nick End-Labeling, In Situ
- Nick End Labeling, In Situ
- Nick End-Labelling, In Situ
- Nick End Labelling, In Situ
- Nick-End Labelling, In Situ
- In Situ Nick End-Labeling
|
Below are MeSH descriptors whose meaning is more general than "In Situ Nick-End Labeling".
Below are MeSH descriptors whose meaning is more specific than "In Situ Nick-End Labeling".
This graph shows the total number of publications written about "In Situ Nick-End Labeling" by people in this website by year, and whether "In Situ Nick-End Labeling" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 3 | 3 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 3 | 3 |
| 2012 | 0 | 4 | 4 |
| 2013 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "In Situ Nick-End Labeling" by people in Profiles.
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Interphotoreceptor Retinol-Binding Protein Ameliorates Diabetes-Induced Retinal Dysfunction and Neurodegeneration Through Rhodopsin. Diabetes. 2021 03; 70(3):788-799.
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Pyruvate kinase M2 regulates photoreceptor structure, function, and viability. Cell Death Dis. 2018 02 14; 9(2):240.
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High Energy Particle Radiation-associated Oncogenic Transformation in Normal Mice: Insight into the Connection between Activation of Oncotargets and Oncogene Addiction. Sci Rep. 2016 11 23; 6:37623.
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Protective and antioxidant effects of PPARa in the ischemic retina. Invest Ophthalmol Vis Sci. 2014 May 13; 55(7):4568-76.
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CD36, but not G2A, modulates efferocytosis, inflammation, and fibrosis following bleomycin-induced lung injury. J Lipid Res. 2013 Apr; 54(4):1114-23.
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Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells. Invest Ophthalmol Vis Sci. 2012 Jul 09; 53(8):4595-604.
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Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency. J Biol Chem. 2012 May 25; 287(22):18018-29.
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Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiation. Cytokine. 2012 Jun; 58(3):406-14.
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Defects in the outer limiting membrane are associated with rosette development in the Nrl-/- retina. PLoS One. 2012; 7(3):e32484.
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Radioprotective efficacy of tocopherol succinate is mediated through granulocyte-colony stimulating factor. Cytokine. 2011 Nov; 56(2):411-21.