Interleukin-18

"Interleukin-18" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

Descriptor ID	D020382
MeSH Number(s)	D12.644.276.374.465.518 D12.776.467.374.465.518 D23.529.374.465.518
Concept/Terms	Interleukin-18 Interleukin-18 Interleukin 18 IFN-gamma-Inducing Factor IL-18 Interferon-gamma Inducing Factor Inducing Factor, Interferon-gamma Interferon gamma Inducing Factor Interferon-gamma-Inducing Factor IFN-gamma Inducing Factor IFN gamma Inducing Factor Inducing Factor, IFN-gamma IL18

Below are MeSH descriptors whose meaning is more general than "Interleukin-18".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-18 [D12.644.276.374.465.518]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-18 [D12.776.467.374.465.518]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-18 [D23.529.374.465.518]

Below are MeSH descriptors whose meaning is related to "Interleukin-18".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-18".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-18" by people in this website by year, and whether "Interleukin-18" was a major or minor topic of these publications.

Bar chart showing 13 publications over 10 distinct years, with a maximum of 2 publications in 2007 and 2013 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	1	0	1
2005	1	0	1
2007	0	2	2
2009	0	1	1
2011	1	0	1
2012	0	1	1
2013	0	2	2
2015	1	1	2
2017	1	0	1
2019	1	0	1

Below are the most recent publications written about "Interleukin-18" by people in Profiles.

Umare V, Pradhan V, Nath S, Rajadhyaksha A, Ghosh K, Nadkarni AH. Impact of functional IL-18 polymorphisms on genetic predisposition and diverse clinical manifestations of the disease in Indian SLE patients. Lupus. 2019 Apr; 28(4):545-554.

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Deswaerte V, Nguyen P, West A, Browning AF, Yu L, Ruwanpura SM, Balic J, Livis T, Girard C, Preaudet A, Oshima H, Fung KY, Tye H, Najdovska M, Ernst M, Oshima M, Gabay C, Putoczki T, Jenkins BJ. Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism. Cancer Res. 2018 03 01; 78(5):1293-1307.

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Du M, Otalora L, Martin AA, Moiseyev G, Vanlandingham P, Wang Q, Farjo R, Yeganeh A, Quiambao A, Farjo KM. Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid-Independent Mechanism. Mol Cell Biol. 2015 Aug; 35(16):2771-89.

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Gandhapudi SK, Tan C, Marino JH, Taylor AA, Pack CC, Gaikwad J, Van De Wiele CJ, Wren JD, Teague TK. IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells. J Immunol. 2015 Apr 15; 194(8):3820-8.

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Lester S, Stokes L, Skarratt KK, Gu BJ, Sivils KL, Lessard CJ, Wiley JS, Rischmueller M. Epistasis with HLA DR3 implicates the P2X7 receptor in the pathogenesis of primary Sjögren's syndrome. Arthritis Res Ther. 2013 Jun 02; 15(4):R71.

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Bouwer AL, Saunderson SC, Dunn AC, Lester KL, Crowley LR, Jack RW, McLellan AD. Rapid interferon-gamma release from natural killer cells induced by a streptococcal commensal. J Interferon Cytokine Res. 2013 Aug; 33(8):459-66.

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Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 2012 Nov 08; 491(7423):259-63.

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Htoon J, Nadig A, Hughes T, Yavuz S, Direskeneli H, Saruhan-Direskeneli G, Sawalha AH. IL18 polymorphism is associated with Behçet's disease but not lupus in patients from Turkey. J Rheumatol. 2011 May; 38(5):962-3.

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Zhou X, Li F, Kong L, Chodosh J, Cao W. Anti-inflammatory effect of pigment epithelium-derived factor in DBA/2J mice. Mol Vis. 2009; 15:438-50.

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Li C, Huang Z, Kingsley R, Zhou X, Li F, Parke DW, Cao W. Biochemical alterations in the retinas of very low-density lipoprotein receptor knockout mice: an animal model of retinal angiomatous proliferation. Arch Ophthalmol. 2007 Jun; 125(6):795-803.

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