"Genistein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.
| Descriptor ID |
D019833
|
| MeSH Number(s) |
D03.383.663.283.266.450.400.375 D03.633.100.150.266.450.400.375
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Genistein".
Below are MeSH descriptors whose meaning is more specific than "Genistein".
This graph shows the total number of publications written about "Genistein" by people in this website by year, and whether "Genistein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Genistein" by people in Profiles.
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Targeting the Cancer Stem Cells in Endocrine Cancers with Phytochemicals. Curr Top Med Chem. 2022; 22(31):2589-2597.
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Characterization of an isoflavonoid-specific prenyltransferase from Lupinus albus. Plant Physiol. 2012 May; 159(1):70-80.
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Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus. J Neurophysiol. 2005 Jul; 94(1):247-54.
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Genistein alters methylation patterns in mice. J Nutr. 2002 08; 132(8 Suppl):2419S-2423S.
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Listeria monocytogenes infection and activation of human brain microvascular endothelial cells. J Infect Dis. 1998 Dec; 178(6):1658-66.
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L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle. Biochem Biophys Res Commun. 1997 Jun 27; 235(3):784-9.
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Activation of Src-family tyrosine kinases during Fas-induced apoptosis. J Leukoc Biol. 1996 Oct; 60(4):546-54.
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Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature. 1995 Jun 15; 375(6532):577-81.
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Unilateral nephrectomy selectively stimulates phospholipase D in the remaining kidney. Biochim Biophys Acta. 1993 May 08; 1177(1):87-92.
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Tyrosine phosphorylation is required for mast cell activation by Fc epsilon RI cross-linking. J Immunol. 1992 Jun 01; 148(11):3513-9.