"Genistein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.
| Descriptor ID |
D019833
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| MeSH Number(s) |
D03.383.663.283.266.450.400.375 D03.633.100.150.266.450.400.375
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Genistein".
Below are MeSH descriptors whose meaning is more specific than "Genistein".
This graph shows the total number of publications written about "Genistein" by people in this website by year, and whether "Genistein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 |
| 1993 | 0 | 1 | 1 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genistein" by people in Profiles.
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Shen G, Huhman D, Lei Z, Snyder J, Sumner LW, Dixon RA. Characterization of an isoflavonoid-specific prenyltransferase from Lupinus albus. Plant Physiol. 2012 May; 159(1):70-80.
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Ramsey MM, Adams MM, Ariwodola OJ, Sonntag WE, Weiner JL. Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus. J Neurophysiol. 2005 Jul; 94(1):247-54.
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Day JK, Bauer AM, DesBordes C, Zhuang Y, Kim BE, Newton LG, Nehra V, Forsee KM, MacDonald RS, Besch-Williford C, Huang TH, Lubahn DB. Genistein alters methylation patterns in mice. J Nutr. 2002 08; 132(8 Suppl):2419S-2423S.
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Wilson SL, Drevets DA. Listeria monocytogenes infection and activation of human brain microvascular endothelial cells. J Infect Dis. 1998 Dec; 178(6):1658-66.
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Renganathan M, Sonntag WE, Delbono O. L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle. Biochem Biophys Res Commun. 1997 Jun 27; 235(3):784-9.
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Schlottmann KE, Gulbins E, Lau SM, Coggeshall KM. Activation of Src-family tyrosine kinases during Fas-induced apoptosis. J Leukoc Biol. 1996 Oct; 60(4):546-54.
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Mukhopadhyay D, Tsiokas L, Zhou XM, Foster D, Brugge JS, Sukhatme VP. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature. 1995 Jun 15; 375(6532):577-81.
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Gatalica Z, Moehren G, Hoek JB. Unilateral nephrectomy selectively stimulates phospholipase D in the remaining kidney. Biochim Biophys Acta. 1993 May 08; 1177(1):87-92.
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Kawakami T, Inagaki N, Takei M, Fukamachi H, Coggeshall KM, Ishizaka K, Ishizaka T. Tyrosine phosphorylation is required for mast cell activation by Fc epsilon RI cross-linking. J Immunol. 1992 Jun 01; 148(11):3513-9.
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Mustelin T, Coggeshall KM, Isakov N, Altman A. T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation. Science. 1990 Mar 30; 247(4950):1584-7.