"Up-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015854
|
| MeSH Number(s) |
G02.111.905 G05.308.850 G07.690.773.998
|
| Concept/Terms |
Up-Regulation- Up-Regulation
- Up Regulation
- Upregulation
- Up-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Up-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Up-Regulation".
This graph shows the total number of publications written about "Up-Regulation" by people in this website by year, and whether "Up-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 4 | 5 |
| 2003 | 1 | 9 | 10 |
| 2004 | 1 | 7 | 8 |
| 2005 | 0 | 5 | 5 |
| 2006 | 2 | 3 | 5 |
| 2007 | 0 | 9 | 9 |
| 2008 | 2 | 9 | 11 |
| 2009 | 2 | 8 | 10 |
| 2010 | 2 | 4 | 6 |
| 2011 | 0 | 5 | 5 |
| 2012 | 0 | 13 | 13 |
| 2013 | 1 | 6 | 7 |
| 2014 | 2 | 7 | 9 |
| 2015 | 1 | 12 | 13 |
| 2016 | 0 | 10 | 10 |
| 2017 | 0 | 7 | 7 |
| 2018 | 2 | 6 | 8 |
| 2019 | 2 | 5 | 7 |
| 2020 | 3 | 5 | 8 |
| 2021 | 1 | 5 | 6 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Up-Regulation" by people in Profiles.
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Glycogen from spinal astrocytes dials up the pain. Nat Metab. 2024 Mar; 6(3):384-386.
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Increased interleukin-6/C-reactive protein levels are associated with the upregulation of the adenosine pathway and serve as potential markers of therapeutic resistance to immune checkpoint inhibitor-based therapies in non-small cell lung cancer. J Immunother Cancer. 2023 Oct; 11(10).
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Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism. Mol Cancer Res. 2022 09 02; 20(9):1391-1404.
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Resveratrol Contrasts LPA-Induced Ovarian Cancer Cell Migration and Platinum Resistance by Rescuing Hedgehog-Mediated Autophagy. Cells. 2021 11 17; 10(11).
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Tissue factor upregulation is associated with SARS-CoV-2 in the lungs of COVID-19 patients. J Thromb Haemost. 2021 09; 19(9):2268-2274.
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SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis. Blood Cancer J. 2021 05 17; 11(5):93.
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17a-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific Manner. J Gerontol A Biol Sci Med Sci. 2021 04 30; 76(5):778-785.
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Colony-stimulating factor 3 signaling in colon and rectal cancers: Immune response and CMS classification in TCGA data. PLoS One. 2021; 16(2):e0247233.
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Upregulation of AXL and ß-catenin in chronic lymphocytic leukemia cells cultured with bone marrow stroma cells is associated with enhanced drug resistance. Blood Cancer J. 2021 02 18; 11(2):37.
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The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors. Matrix Biol. 2021 03; 97:40-57.