"DNA Repair" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
| Descriptor ID |
D004260
|
| MeSH Number(s) |
G02.111.222 G05.219
|
| Concept/Terms |
Base Excision Repair- Base Excision Repair
- Base Excision Repairs
- Excision Repair, Base
- Repair, Base Excision
- Repairs, Base Excision
|
Below are MeSH descriptors whose meaning is more general than "DNA Repair".
Below are MeSH descriptors whose meaning is more specific than "DNA Repair".
This graph shows the total number of publications written about "DNA Repair" by people in this website by year, and whether "DNA Repair" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 2 | 0 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 3 | 0 | 3 |
| 2004 | 3 | 1 | 4 |
| 2005 | 2 | 2 | 4 |
| 2006 | 1 | 3 | 4 |
| 2007 | 3 | 1 | 4 |
| 2008 | 3 | 0 | 3 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 3 | 3 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 3 | 2 | 5 |
| 2015 | 2 | 2 | 4 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 2 | 3 |
| 2018 | 0 | 2 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 5 | 5 |
| 2021 | 0 | 3 | 3 |
| 2022 | 0 | 3 | 3 |
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Below are the most recent publications written about "DNA Repair" by people in Profiles.
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KRCC1, a modulator of the DNA damage response. Nucleic Acids Res. 2022 10 28; 50(19):11028-11039.
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Rare germline deleterious variants increase susceptibility for lung cancer. Hum Mol Genet. 2022 Oct 10; 31(20):3558-3565.
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Attenuating DNA damage response and immunosuppression radiosensitizes pancreatic cancer. EBioMedicine. 2022 Feb; 76:103822.
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The Timing and Duration of Folate Restriction Differentially Impacts Colon Carcinogenesis. Nutrients. 2021 Dec 21; 14(1).
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Preclinical Risk Evaluation of Normal Tissue Injury With Novel Radiosensitizers. Int J Radiat Oncol Biol Phys. 2021 12 01; 111(5):e54-e62.
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Full length RAG2 expression enhances the DNA damage response in pre-B cells. Immunobiology. 2021 05; 226(3):152089.
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Deregulated estrogen receptor signaling and DNA damage response in breast tumorigenesis. Biochim Biophys Acta Rev Cancer. 2021 01; 1875(1):188482.
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Reality CHEK: Understanding the biology and clinical potential of CHK1. Cancer Lett. 2021 01 28; 497:202-211.
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DNA Double-Strand Break Accumulation in Alzheimer's Disease: Evidence from Experimental Models and Postmortem Human Brains. Mol Neurobiol. 2021 Jan; 58(1):118-131.
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XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition. Sci Rep. 2020 08 28; 10(1):14253.