Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
| Descriptor ID |
D013329
|
| MeSH Number(s) |
G02.111.830 G07.690.773.997
|
| Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
|
Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 0 | 3 | 3 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 5 | 5 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 5 | 5 |
| 2003 | 0 | 8 | 8 |
| 2004 | 0 | 8 | 8 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 4 | 4 |
| 2007 | 0 | 6 | 6 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 9 | 9 |
| 2010 | 0 | 8 | 8 |
| 2011 | 0 | 4 | 4 |
| 2012 | 0 | 3 | 3 |
| 2013 | 0 | 7 | 7 |
| 2014 | 0 | 9 | 9 |
| 2015 | 0 | 5 | 5 |
| 2016 | 0 | 11 | 11 |
| 2017 | 0 | 6 | 6 |
| 2018 | 0 | 13 | 13 |
| 2019 | 0 | 11 | 11 |
| 2020 | 0 | 10 | 10 |
| 2021 | 0 | 6 | 6 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 2 | 2 |
| 2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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Development of Novel Indole-Based Covalent Inhibitors of TEAD as Potential Antiliver Cancer Agents. J Med Chem. 2024 Sep 26; 67(18):16270-16295.
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Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer. Eur J Med Chem. 2024 Sep 05; 275:116598.
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Structure-Activity Relationships of Ligand Binding to Oxysterol-Binding Protein (OSBP) and OSBP-Related Protein 4. J Med Chem. 2023 03 23; 66(6):3866-3875.
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Carbohydrate-Small Molecule Hybrids as Lead Compounds Targeting IL-6 Signaling. Molecules. 2023 Jan 09; 28(2).
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Synthesis and Evaluation of Functionalized Aryl and Biaryl Isothiocyanates against Human MCF-7 Cells. ChemMedChem. 2022 07 19; 17(14):e202200250.
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Synthesis of 3-N-/O-/S-methyl-imidazo[1,2-a] pyridine derivatives for caspase-3 mediated apoptosis induced anticancer activity. Bioorg Chem. 2022 08; 125:105882.
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Distribution and history of extensional stresses on vWF surrogate molecules in turbulent flow. Sci Rep. 2022 01 07; 12(1):171.
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The role of distinct BRD4 isoforms and their contribution to high-grade serous ovarian carcinoma pathogenesis. Mol Cancer. 2021 11 10; 20(1):145.
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Investigation of indole functionalized pyrazoles and oxadiazoles as anti-inflammatory agents: Synthesis, in-vivo, in-vitro and in-silico analysis. Bioorg Chem. 2021 09; 114:105068.
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Piperazine, a Key Substructure for Antidepressants: Its Role in Developments and Structure-Activity Relationships. ChemMedChem. 2021 06 17; 16(12):1878-1901.