"Drug Tolerance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
| Descriptor ID |
D004361
|
| MeSH Number(s) |
G07.690.773.992
|
| Concept/Terms |
Drug Tolerance- Drug Tolerance
- Drug Tolerances
- Tolerance, Drug
- Tolerances, Drug
|
Below are MeSH descriptors whose meaning is more general than "Drug Tolerance".
Below are MeSH descriptors whose meaning is more specific than "Drug Tolerance".
This graph shows the total number of publications written about "Drug Tolerance" by people in this website by year, and whether "Drug Tolerance" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 5 | 5 |
| 1996 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 1 | 2 | 3 |
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Drug Tolerance" by people in Profiles.
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Analysis of fentanyl pharmacokinetics, and its sedative effects and tolerance in critically ill children. Pharmacotherapy. 2021 04; 41(4):359-369.
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Long-term safety of single-agent ibrutinib in patients with chronic lymphocytic leukemia in 3 pivotal studies. Blood Adv. 2019 06 25; 3(12):1799-1807.
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Two-year Efficacy and Safety of Subcutaneous Tocilizumab in Combination with Disease-modifying Antirheumatic Drugs Including Escalation to Weekly Dosing in Rheumatoid Arthritis. J Rheumatol. 2018 04; 45(4):456-464.
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Challenges with nitrate therapy and nitrate tolerance: prevalence, prevention, and clinical relevance. Am J Cardiovasc Drugs. 2014 Aug; 14(4):287-301.
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Severity and interference of chronic pain in methadone-maintained outpatients. Pain Med. 2014 Sep; 15(9):1540-8.
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Role for the epidermal growth factor receptor in chemotherapy-induced alopecia. PLoS One. 2013; 8(7):e69368.
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Sex differences in the Nociceptin/Orphanin FQ system in rat spinal cord following chronic morphine treatment. Neuropharmacology. 2012 Sep; 63(3):427-33.
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Resolution of chronic daily headache after acetaminophen discontinuation. Ann Pharmacother. 2009 Oct; 43(10):1727.
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Alpha2-receptor agonists for treatment and prevention of iatrogenic opioid abstinence syndrome in critically ill patients. Ann Pharmacother. 2009 Sep; 43(9):1506-11.
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Caffeine stimulation of cortisol secretion across the waking hours in relation to caffeine intake levels. Psychosom Med. 2005 Sep-Oct; 67(5):734-9.