"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015536
|
| MeSH Number(s) |
G02.111.240 G05.308.200 G07.690.773.937
|
| Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 1 | 2 |
| 1995 | 0 | 1 | 1 |
| 1996 | 2 | 0 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2002 | 1 | 4 | 5 |
| 2003 | 1 | 5 | 6 |
| 2004 | 3 | 7 | 10 |
| 2005 | 1 | 1 | 2 |
| 2006 | 3 | 5 | 8 |
| 2007 | 1 | 6 | 7 |
| 2008 | 1 | 11 | 12 |
| 2009 | 0 | 7 | 7 |
| 2010 | 0 | 3 | 3 |
| 2011 | 1 | 5 | 6 |
| 2012 | 1 | 11 | 12 |
| 2013 | 0 | 6 | 6 |
| 2014 | 0 | 5 | 5 |
| 2015 | 0 | 7 | 7 |
| 2016 | 0 | 8 | 8 |
| 2017 | 0 | 9 | 9 |
| 2018 | 0 | 8 | 8 |
| 2019 | 0 | 2 | 2 |
| 2020 | 1 | 6 | 7 |
| 2021 | 0 | 4 | 4 |
| 2024 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Down-Regulation" by people in Profiles.
-
Palmitic Acid Induces Oxidative Stress and Senescence in Human Brainstem Astrocytes, Downregulating Glutamate Reuptake Transporters-Implications for Obesity-Related Sympathoexcitation. Nutrients. 2024 Aug 26; 16(17).
-
Resveratrol Contrasts LPA-Induced Ovarian Cancer Cell Migration and Platinum Resistance by Rescuing Hedgehog-Mediated Autophagy. Cells. 2021 11 17; 10(11).
-
Maternal plasma soluble neuropilin-1 is downregulated in fetal growth restriction complicated by abnormal umbilical artery Doppler: a pilot study. Ultrasound Obstet Gynecol. 2021 Nov; 58(5):716-721.
-
Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds. Commun Biol. 2021 06 18; 4(1):757.
-
Targeting PD-1 in CD8+ T Cells with a Biomimetic Bilirubin-5-fluoro-2-deoxyuridine-Bovine Serum Albumin Nanoconstruct for Effective Chemotherapy against Experimental Lymphoma. Mol Pharm. 2021 05 03; 18(5):2053-2065.
-
Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus. Genome Biol. 2020 11 19; 21(1):281.
-
Long non-coding RNA FENDRR regulates IFN?-induced M1 phenotype in macrophages. Sci Rep. 2020 08 13; 10(1):13672.
-
Synergistic therapy with tangeretin and 5-fluorouracil accelerates the ROS/JNK mediated apoptotic pathway in human colorectal cancer cell. Food Chem Toxicol. 2020 Sep; 143:111529.
-
Dual Activities of Receptor-Like Kinase OsWAKL21.2 Induce Immune Responses. Plant Physiol. 2020 07; 183(3):1345-1363.
-
Long Noncoding RNA FENDRR Exhibits Antifibrotic Activity in Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2020 04; 62(4):440-453.