Ubiquitin-Protein Ligase Complexes
"Ubiquitin-Protein Ligase Complexes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
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Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).
|Ubiquitin-Protein Ligase Complexes
- Ubiquitin-Protein Ligase Complexes
- Complexes, Ubiquitin-Protein Ligase
- Ligase Complexes, Ubiquitin-Protein
- Ubiquitin Protein Ligase Complexes
Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Protein Ligase Complexes".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Protein Ligase Complexes".
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Below are the most recent publications written about "Ubiquitin-Protein Ligase Complexes" by people in Profiles.
Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation. Mol Cell Biol. 2012 Feb; 32(3):590-605.
Sororin, the cell cycle and sister chromatid cohesion. Cell Cycle. 2005 Aug; 4(8):1039-42.
Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Mol Cell. 2005 Apr 15; 18(2):185-200.
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell. 2003 Apr 04; 113(1):101-13.
Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells. J Cell Biol. 2002 Sep 02; 158(5):841-7.
Elevating the level of Cdc34/Ubc3 ubiquitin-conjugating enzyme in mitosis inhibits association of CENP-E with kinetochores and blocks the metaphase alignment of chromosomes. J Cell Biol. 2001 Aug 20; 154(4):707-17.
The 3F3/2 anti-phosphoepitope antibody binds the mitotically phosphorylated anaphase-promoting complex/cyclosome. Curr Biol. 2000 Nov 30; 10(23):R850-2.
Protein dynamics at the kinetochore: cell cycle regulation of the metaphase to anaphase transition. FASEB J. 1999 Dec; 13 Suppl 2:S231-4.
Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. J Cell Biol. 1998 Jun 15; 141(6):1393-406.
Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast. J Cell Sci. 1997 Aug; 110 ( Pt 15):1793-804.