Inhibitor of Apoptosis Proteins

"Inhibitor of Apoptosis Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity.

Descriptor ID	D051034
MeSH Number(s)	D08.811.464.938.750.210 D12.644.360.075.437 D12.776.476.075.437
Concept/Terms	Inhibitor of Apoptosis Proteins Inhibitor of Apoptosis Proteins Apoptosis Proteins Inhibitor Inhibitor-Of-Apoptosis Protein Inhibitor Of Apoptosis Protein Baculoviral Inhibitor Of Apoptosis Repeat Proteins IAP Repeat Containing Proteins IAP Protein (Apoptosis) Baculoviral IAP Repeat-Containing 2 Protein Baculoviral IAP Repeat-Containing 2 Protein Baculoviral IAP Repeat Containing 2 Protein Cellular Inhibitor of Apoptosis 1 Protein IAP2 Protein c-IAP1 Protein cIAP1 Protein Inhibitor of Apoptosis 2 Protein BIRC2 Protein Baculoviral IAP Repeat Containing Protein 2

Below are MeSH descriptors whose meaning is more general than "Inhibitor of Apoptosis Proteins".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
Ubiquitin-Protein Ligases [D08.811.464.938.750]
Inhibitor of Apoptosis Proteins [D08.811.464.938.750.210]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Inhibitor of Apoptosis Proteins [D12.644.360.075.437]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Inhibitor of Apoptosis Proteins [D12.776.476.075.437]

Below are MeSH descriptors whose meaning is related to "Inhibitor of Apoptosis Proteins".

Below are MeSH descriptors whose meaning is more specific than "Inhibitor of Apoptosis Proteins".

Inhibitor of Apoptosis Proteins
Baculoviral IAP Repeat-Containing 3 Protein
Neuronal Apoptosis-Inhibitory Protein
X-Linked Inhibitor of Apoptosis Protein

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Inhibitor of Apoptosis Proteins" by people in this website by year, and whether "Inhibitor of Apoptosis Proteins" was a major or minor topic of these publications.

Bar chart showing 14 publications over 9 distinct years, with a maximum of 3 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2004	0	1	1
2006	0	1	1
2008	0	2	2
2009	0	2	2
2010	0	2	2
2012	0	1	1
2014	0	1	1
2015	2	1	3

Below are the most recent publications written about "Inhibitor of Apoptosis Proteins" by people in Profiles.

Yeung BZ, Lu Z, Wientjes GM, Au JL. High Sensitivity RT-qPCR Assay of Nonlabeled siRNA in Small Blood Volume for Pharmacokinetic Studies: Application to Survivin siRNA. AAPS J. 2015 Nov; 17(6):1475-82.

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Wang J, Lu Z, Wang J, Cui M, Yeung BZ, Cole DJ, Wientjes MG, Au JL. Paclitaxel tumor priming promotes delivery and transfection of intravenous lipid-siRNA in pancreatic tumors. J Control Release. 2015 Oct 28; 216:103-10.

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Cui M, Au JL, Wientjes MG, O'Donnell MA, Loughlin KR, Lu Z. Intravenous siRNA Silencing of Survivin Enhances Activity of Mitomycin C in Human Bladder RT4 Xenografts. J Urol. 2015 Jul; 194(1):230-7.

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Wang J, Lu Z, Yeung BZ, Wientjes MG, Cole DJ, Au JL. Tumor priming enhances siRNA delivery and transfection in intraperitoneal tumors. J Control Release. 2014 Mar 28; 178:79-85.

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Lachenmayer A, Toffanin S, Cabellos L, Alsinet C, Hoshida Y, Villanueva A, Minguez B, Tsai HW, Ward SC, Thung S, Friedman SL, Llovet JM. Combination therapy for hepatocellular carcinoma: additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib. J Hepatol. 2012 Jun; 56(6):1343-50.

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Wang F, Dai J, Daum JR, Niedzialkowska E, Banerjee B, Stukenberg PT, Gorbsky GJ, Higgins JM. Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. Science. 2010 10 08; 330(6001):231-5.

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Madhusoodhanan R, Natarajan M, Singh JV, Jamgade A, Awasthi V, Anant S, Herman TS, Aravindan N. Effect of black raspberry extract in inhibiting NFkappa B dependent radioprotection in human breast cancer cells. Nutr Cancer. 2010; 62(1):93-104.

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Bishnupuri KS, Luo Q, Sainathan SK, Kikuchi K, Sureban SM, Sabarinathan M, Gross JH, Aden K, May R, Houchen CW, Anant S, Dieckgraefe BK. Reg IV regulates normal intestinal and colorectal cancer cell susceptibility to radiation-induced apoptosis. Gastroenterology. 2010 Feb; 138(2):616-26, 626.e1-2.

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Madhusoodhanan R, Natarajan M, Veeraraghavan J, Herman TS, Aravindan N. NFkappaB activity and transcriptional responses in human breast adenocarcinoma cells after single and fractionated irradiation. Cancer Biol Ther. 2009 May; 8(9):765-73.

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George RJ, Sturmoski MA, May R, Sureban SM, Dieckgraefe BK, Anant S, Houchen CW. Loss of p21Waf1/Cip1/Sdi1 enhances intestinal stem cell survival following radiation injury. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G245-54.

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