Cyclin-Dependent Kinase 2
"Cyclin-Dependent Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE and also interacts with CYCLIN A to phosphorylate RETINOBLASTOMA PROTEIN. Its activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P27 and CYCLIN-DEPENDENT KINASE INHIBITOR P21.
| Descriptor ID |
D051357
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.646.500.750 D12.644.360.250.323 D12.776.167.200.323 D12.776.476.250.323
|
| Concept/Terms |
Cyclin-Dependent Kinase 2- Cyclin-Dependent Kinase 2
- Cyclin Dependent Kinase 2
- Cdk2 Protein Kinase
- Cdc2-Related Protein Kinase
- Cdc2 Related Protein Kinase
- p33cdk2 Kinase
- CDK2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase 2".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase 2".
This graph shows the total number of publications written about "Cyclin-Dependent Kinase 2" by people in this website by year, and whether "Cyclin-Dependent Kinase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cyclin-Dependent Kinase 2" by people in Profiles.
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The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase. Nucleic Acids Res. 2021 10 11; 49(18):10507-10523.
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Synthesis, inverse docking-assisted identification and in vitro biological characterization of Flavonol-based analogs of fisetin as c-Kit, CDK2 and mTOR inhibitors against melanoma and non-melanoma skin cancers. Bioorg Chem. 2021 02; 107:104595.
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Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Sci Rep. 2018 02 09; 8(1):2709.
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Differential Protein Expression in Small Intestinal Neuroendocrine Tumors and Liver Metastases. Pancreas. 2016 Apr; 45(4):528-32.
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Podophyllum hexandrum fraction (REC-2006) shows higher radioprotective efficacy in the p53-carrying hepatoma cell line: a role of cell cycle regulatory proteins. Integr Cancer Ther. 2009 Sep; 8(3):261-72.
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Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2. BMC Nephrol. 2008 Aug 25; 9:10.
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Identification of breast cancer peptide epitopes presented by HLA-A*0201. J Proteome Res. 2008 Apr; 7(4):1445-57.
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Cdk2: a genuine protein kinase client of Hsp90 and Cdc37. Biochemistry. 2005 Nov 22; 44(46):15287-95.