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Christina Bourne

TitleAssistant Professor
InstitutionUniversity of Oklahoma, Norman
DepartmentChemistry/Biochemistry
Address620 Parrington Oval
Norman OK 73019
Phone405/325-4812
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Snead KJ, Moore LL, Bourne CR. ParD Antitoxin Hotspot Alters a Disorder-to-Order Transition upon Binding to Its Cognate ParE Toxin, Lessening Its Interaction Affinity and Increasing Its Protease Degradation Kinetics. Biochemistry. 2022 01 04; 61(1):34-45. PMID: 34914378.
      Citations:    Fields:    Translation:HumansCells
    2. Johnson BP, Kumar V, Scull EM, Thomas LM, Bourne CR, Singh S. Molecular Basis for the Substrate Promiscuity of Isopentenyl Phosphate Kinase from Candidatus methanomethylophilus alvus. ACS Chem Biol. 2022 01 21; 17(1):85-102. PMID: 34905349.
      Citations:    Fields:    Translation:Cells
    3. McGillick J, Ames JR, Murphy T, Bourne CR. A YoeB toxin cleaves both RNA and DNA. Sci Rep. 2021 02 11; 11(1):3592. PMID: 33574407.
      Citations: 1     Fields:    Translation:Cells
    4. Bourne CR. Bacterial Growth Mindset: Structural Plasticity in Defense Systems. Structure. 2021 02 04; 29(2):97-98. PMID: 33545061.
      Citations:    Fields:    Translation:Cells
    5. Tu CH, Holt M, Ruan S, Bourne C. Evaluating the Potential for Cross-Interactions of Antitoxins in Type II TA Systems. Toxins (Basel). 2020 06 26; 12(6). PMID: 32604745.
      Citations: 1     Fields:    Translation:Cells
    6. Ames JR, McGillick J, Murphy T, Reddem E, Bourne CR. Identifying a Molecular Mechanism That Imparts Species-Specific Toxicity to YoeB Toxins. Front Microbiol. 2020; 11:959. PMID: 32528435.
      Citations:    
    7. Muddala NP, White JC, Nammalwar B, Pratt I, Thomas LM, Bunce RA, Berlin KD, Bourne CR. Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur J Med Chem. 2020 Aug 15; 200:112412. PMID: 32502861.
      Citations:    Fields:    Translation:Cells
    8. Ames JR, Muthuramalingam M, Murphy T, Najar FZ, Bourne CR. Expression of different ParE toxins results in conserved phenotypes with distinguishable classes of toxicity. Microbiologyopen. 2019 10; 8(10):e902. PMID: 31309747.
      Citations: 6     Fields:    Translation:Cells
    9. Muthuramalingam M, White JC, Murphy T, Ames JR, Bourne CR. The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics. Mol Microbiol. 2019 02; 111(2):441-454. PMID: 30427086.
      Citations: 11     Fields:    Translation:Cells
    10. Muthuramalingam M, White JC, Bourne CR. Toxin-Antitoxin Modules Are Pliable Switches Activated by Multiple Protease Pathways. Toxins (Basel). 2016 07 09; 8(7). PMID: 27409636.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    11. Muddala NP, Nammalwar B, Selvaraju S, Bourne CR, Henry M, Bunce RA, Berlin KD, Barrow EW, Barrow WW. Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex. Molecules. 2015 Apr 21; 20(4):7222-44. PMID: 25905602.
      Citations: 1     Fields:    Translation:Cells
    12. Nammalwar B, Bourne CR, Wakeham N, Bourne PC, Barrow EW, Muddala NP, Bunce RA, Berlin KD, Barrow WW. Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis. Bioorg Med Chem. 2015 Jan 01; 23(1):203-11. PMID: 25435253.
      Citations: 6     Fields:    Translation:Cells
    13. Kobayashi M, Kinjo T, Koseki Y, Bourne CR, Barrow WW, Aoki S. Identification of novel potential antibiotics against Staphylococcus using structure-based drug screening targeting dihydrofolate reductase. J Chem Inf Model. 2014 Apr 28; 54(4):1242-53. PMID: 24655350.
      Citations: 6     Fields:    Translation:Cells
    14. Nammalwar B, Muddala NP, Bourne CR, Henry M, Bourne PC, Bunce RA, Barrow EW, Berlin KD, Barrow WW. Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis. Molecules. 2014 Mar 17; 19(3):3231-46. PMID: 24642909.
      Citations: 2     Fields:    Translation:Cells
    15. Bourne CR, Wakeham N, Webb N, Nammalwar B, Bunce RA, Berlin KD, Barrow WW. The structure and competitive substrate inhibition of dihydrofolate reductase from Enterococcus faecalis reveal restrictions to cofactor docking. Biochemistry. 2014 Feb 25; 53(7):1228-38. PMID: 24495113.
      Citations: 2     Fields:    Translation:Cells
    16. Bourne CR. Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery. Antibiotics (Basel). 2014 Jan 21; 3(1):1-28. PMID: 27025730.
      Citations:    
    17. Nammalwar B, Bunce RA, Berlin KD, Bourne CR, Bourne PC, Barrow EW, Barrow WW. Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of 2,4-Diaminopyrimidine-based Antibiotics. Org Prep Proced Int. 2013; 45(1):66-71. PMID: 23788820.
      Citations:    
    18. Bourne CR, Wakeham N, Nammalwar B, Tseitin V, Bourne PC, Barrow EW, Mylvaganam S, Ramnarayan K, Bunce RA, Berlin KD, Barrow WW. Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase. Biochim Biophys Acta. 2013 Jan; 1834(1):46-52. PMID: 22999981.
      Citations: 5     Fields:    Translation:Cells
    19. Nammalwar B, Bourne CR, Bunce RA, Wakeham N, Bourne PC, Ramnarayan K, Mylvaganam S, Berlin KD, Barrow EW, Barrow WW. Inhibition of bacterial dihydrofolate reductase by 6-alkyl-2,4-diaminopyrimidines. ChemMedChem. 2012 Nov; 7(11):1974-82. PMID: 22930550.
      Citations: 5     Fields:    Translation:HumansCells
    20. Barrow EW, Clinkenbeard PA, Duncan-Decocq RA, Perteet RF, Hill KD, Bourne PC, Valderas MW, Bourne CR, Clarkson NL, Clinkenbeard KD, Barrow WW. High-throughput screening of a diversity collection using biodefense category A and B priority pathogens. J Biomol Screen. 2012 Aug; 17(7):946-56. PMID: 22653912.
      Citations: 2     Fields:    Translation:HumansCells
    21. Nammalwar B, Bunce RA, Berlin KD, Bourne CR, Bourne PC, Barrow EW, Barrow WW. Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis. Eur J Med Chem. 2012 Aug; 54:387-96. PMID: 22703705.
      Citations: 10     Fields:    Translation:Cells
    22. Bourne CR, Wakeham N, Bunce RA, Nammalwar B, Berlin KD, Barrow WW. Classifying compound mechanism of action for linking whole cell phenotypes to molecular targets. J Mol Recognit. 2012 Apr; 25(4):216-23. PMID: 22434711.
      Citations: 3     Fields:    Translation:Cells
    23. Nammalwar B, Bunce RA, Berlin KD, Bourne CR, Bourne PC, Barrow EW, Barrow WW. Approaches to Iodinated Derivatives of Vanillin and Isovanillin. Org Prep Proced Int. 2012; 44(2):146-152. PMID: 23805008.
      Citations:    
    24. Nammalwar B, Bunce RA, Berlin KD, Bourne CR, Bourne PC, Barrow EW, Barrow WW. Microwave-assisted Heck Synthesis of Substituted 2,4-Diaminopyrimidine-based Antibiotics. Org Prep Proced Int. 2012; 44(3):281-287. PMID: 23805009.
      Citations:    
    25. Bourne CR, Barrow EW, Bunce RA, Bourne PC, Berlin KD, Barrow WW. Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. Antimicrob Agents Chemother. 2010 Sep; 54(9):3825-33. PMID: 20606069.
      Citations: 15     Fields:    Translation:Cells
    26. Bourne CR, Bunce RA, Bourne PC, Berlin KD, Barrow EW, Barrow WW. Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity. Antimicrob Agents Chemother. 2009 Jul; 53(7):3065-73. PMID: 19364848.
      Citations: 16     Fields:    Translation:Cells
    27. Bourne CR, Katen SP, Fulz MR, Packianathan C, Zlotnick A. A mutant hepatitis B virus core protein mimics inhibitors of icosahedral capsid self-assembly. Biochemistry. 2009 Mar 03; 48(8):1736-42. PMID: 19196007.
      Citations: 39     Fields:    Translation:Cells
    28. Bourne C, Lee S, Venkataiah B, Lee A, Korba B, Finn MG, Zlotnick A. Small-molecule effectors of hepatitis B virus capsid assembly give insight into virus life cycle. J Virol. 2008 Oct; 82(20):10262-70. PMID: 18684823.
      Citations: 54     Fields:    Translation:HumansCells
    29. Zlotnick A, Lee A, Bourne CR, Johnson JM, Domanico PL, Stray SJ. In vitro screening for molecules that affect virus capsid assembly (and other protein association reactions). Nat Protoc. 2007; 2(3):490-8. PMID: 17406612.
      Citations: 28     Fields:    Translation:Cells
    30. Bourne CR, Finn MG, Zlotnick A. Global structural changes in hepatitis B virus capsids induced by the assembly effector HAP1. J Virol. 2006 Nov; 80(22):11055-61. PMID: 16943288.
      Citations: 84     Fields:    Translation:Cells
    31. Ramsland PA, Terzyan SS, Cloud G, Bourne CR, Farrugia W, Tribbick G, Geysen HM, Moomaw CR, Slaughter CA, Edmundson AB. Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody. Biochem J. 2006 May 01; 395(3):473-81. PMID: 16422668.
      Citations: 15     Fields:    Translation:HumansCells
    32. Stray SJ, Bourne CR, Punna S, Lewis WG, Finn MG, Zlotnick A. A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8138-43. PMID: 15928089.
      Citations: 110     Fields:    Translation:Cells
    33. Terzyan SS, Bourne CR, Ramsland PA, Bourne PC, Edmundson AB. Comparison of the three-dimensional structures of a human Bence-Jones dimer crystallized on Earth and aboard US Space Shuttle Mission STS-95. J Mol Recognit. 2003 Mar-Apr; 16(2):83-90. PMID: 12720277.
      Citations: 3     Fields:    Translation:HumansCells
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