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Rodney Kim Tweten

TitleProf,George L Cross Rsrch
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMicrobiology & Immunology
AddressBRC 313
975 NE 10th St
Oklahoma City OK 73104
Phone405/271-1205
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    Collapse Research 
    Collapse research activities and funding
    R01AI063444     (TWETEN, RODNEY K.)Jan 15, 2005 - Dec 31, 2009
    NIH
    A Novel Cholesterol-Dependent Cytolysin Receptor
    Role: Principal Investigator
    R37AI037657     (TWETEN, RODNEY K.)Apr 1, 1997 - Mar 31, 2026
    NIH
    Pore Formation by Cholesterol Dependent Cytolysins
    Role: Principal Investigator
    R01AI037657     (TWETEN, RODNEY K.)Apr 1, 1997 - Mar 31, 2016
    NIH
    Pore Formation by Cholesterol Dependent Cytolysins
    Role: Principal Investigator
    R01AI032097     (TWETEN, RODNEY K.)Jan 1, 1993 - Jun 30, 2005
    NIH
    STUDIES ON CLOSTRIDIUM SEPTICUM LETHAL TOXIN
    Role: Principal Investigator
    R01AI026895     (TWETEN, RODNEY K.)Jul 1, 1988 - Jun 30, 1992
    NIH
    STUDIES ON CLOSTRIDIUM DIFFICILE TOXIN B
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Xu S, Mo D, Rizvi FZ, Rosa JP, Ruiz J, Tan S, Tweten RK, Leong JM, Adams W. Pore-forming activity of S. pneumoniae pneumolysin disrupts the paracellular localization of the epithelial adherens junction protein E-cadherin. Infect Immun. 2023 09 14; 91(9):e0021323. PMID: 37607057; PMCID: PMC10501216.
      Citations: 1     Fields:    Translation:AnimalsCells
    2. Evans JC, McEneany VL, Coyne MJ, Caldwell EP, Sheahan ML, Von SS, Coyne EM, Tweten RK, Comstock LE. A proteolytically activated antimicrobial toxin encoded on a mobile plasmid of Bacteroidales induces a protective response. Nat Commun. 2022 07 23; 13(1):4258. PMID: 35871068.
      Citations: 4     Fields:    Translation:HumansCells
    3. Johnstone BA, Joseph R, Christie MP, Morton CJ, McGuiness C, Walsh JC, Böcking T, Tweten RK, Parker MW. Cholesterol-dependent cytolysins: The outstanding questions. IUBMB Life. 2022 Jul 14. PMID: 35836358.
      Citations: 6     Fields:    Translation:Cells
    4. Evans JC, Tweten RK. How protein engineering has revealed the molecular mechanisms of pore-forming toxins. Methods Enzymol. 2021; 649:47-70. PMID: 33712197.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Evans JC, Johnstone BA, Lawrence SL, Morton CJ, Christie MP, Parker MW, Tweten RK. A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins. mBio. 2020 09 29; 11(5). PMID: 32994330.
      Citations: 10     Fields:    Translation:AnimalsCells
    6. Phelps CC, Vadia S, Boyaka PN, Varikuti S, Attia Z, Dubey P, Satoskar AR, Tweten R, Seveau S. A listeriolysin O subunit vaccine is protective against Listeria monocytogenes. Vaccine. 2020 08 10; 38(36):5803-5813. PMID: 32684498.
      Citations: 6     Fields:    Translation:AnimalsCells
    7. Herrera AL, Van Hove C, Hanson M, Dale JB, Tweten RK, Huber VC, Diel D, Chaussee MS. Immunotherapy targeting the Streptococcus pyogenes M protein or streptolysin O to treat or prevent influenza A superinfection. PLoS One. 2020; 15(6):e0235139. PMID: 32574205.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    8. Thanawastien A, Joyce KE, Cartee RT, Haines LA, Pelton SI, Tweten RK, Killeen KP. Preclinical in vitro and in vivo profile of a highly-attenuated, broadly efficacious pneumolysin genetic toxoid. Vaccine. 2021 03 12; 39(11):1652-1660. PMID: 32532546.
      Citations: 7     Fields:    Translation:AnimalsCells
    9. Adams W, Bhowmick R, Bou Ghanem EN, Wade K, Shchepetov M, Weiser JN, McCormick BA, Tweten RK, Leong JM. Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection. J Immunol. 2020 01 01; 204(1):101-111. PMID: 31776202.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    10. Burns JR, Morton CJ, Parker MW, Tweten RK. An Intermolecular p-Stacking Interaction Drives Conformational Changes Necessary to ß-Barrel Formation in a Pore-Forming Toxin. mBio. 2019 07 02; 10(4). PMID: 31266869.
      Citations: 6     Fields:    Translation:Cells
    11. Wade KR, Lawrence SL, Farrand AJ, Hotze EM, Kuiper MJ, Gorman MA, Christie MP, Panjikar S, Morton CJ, Parker MW, Tweten RK. The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin. mBio. 2019 04 23; 10(2). PMID: 31015325.
      Citations: 5     Fields:    Translation:Cells
    12. Christie MP, Johnstone BA, Tweten RK, Parker MW, Morton CJ. Cholesterol-dependent cytolysins: from water-soluble state to membrane pore. Biophys Rev. 2018 Oct; 10(5):1337-1348. PMID: 30117093.
      Citations: 22     
    13. Lawrence SL, Gorman MA, Feil SC, Mulhern TD, Kuiper MJ, Ratner AJ, Tweten RK, Morton CJ, Parker MW. Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins. Structure. 2016 09 06; 24(9):1488-98. PMID: 27499440.
      Citations: 24     Fields:    Translation:HumansCells
    14. Ellisdon AM, Reboul CF, Panjikar S, Huynh K, Oellig CA, Winter KL, Dunstone MA, Hodgson WC, Seymour J, Dearden PK, Tweten RK, Whisstock JC, McGowan S. Stonefish toxin defines an ancient branch of the perforin-like superfamily. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15360-5. PMID: 26627714.
      Citations: 23     Fields:    Translation:AnimalsCells
    15. Lawrence SL, Feil SC, Morton CJ, Farrand AJ, Mulhern TD, Gorman MA, Wade KR, Tweten RK, Parker MW. Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation. Sci Rep. 2015 Sep 25; 5:14352. PMID: 26403197.
      Citations: 33     Fields:    Translation:Cells
    16. Chen A, Mann B, Gao G, Heath R, King J, Maissoneuve J, Alderson M, Tate A, Hollingshead SK, Tweten RK, Briles DE, Tuomanen EI, Paton JC. Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection. Clin Vaccine Immunol. 2015 Oct; 22(10):1079-89. PMID: 26245351.
      Citations: 24     Fields:    Translation:AnimalsCellsPHPublic Health
    17. Farrand AJ, Hotze EM, Sato TK, Wade KR, Wimley WC, Johnson AE, Tweten RK. The Cholesterol-dependent Cytolysin Membrane-binding Interface Discriminates Lipid Environments of Cholesterol to Support ß-Barrel Pore Insertion. J Biol Chem. 2015 Jul 17; 290(29):17733-17744. PMID: 26032415.
      Citations: 24     Fields:    Translation:AnimalsCells
    18. Wade KR, Tweten RK. The Apicomplexan CDC/MACPF-like pore-forming proteins. Curr Opin Microbiol. 2015 Aug; 26:48-52. PMID: 26025132.
      Citations: 6     Fields:    Translation:AnimalsCells
    19. Verherstraeten S, Goossens E, Valgaeren B, Pardon B, Timbermont L, Haesebrouck F, Ducatelle R, Deprez P, Wade KR, Tweten R, Van Immerseel F. Perfringolysin O: The Underrated Clostridium perfringens Toxin? Toxins (Basel). 2015 May 14; 7(5):1702-21. PMID: 26008232.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    20. Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA. Conformational changes during pore formation by the perforin-related protein pleurotolysin. PLoS Biol. 2015 Feb; 13(2):e1002049. PMID: 25654333.
      Citations: 65     Fields:    Translation:AnimalsCells
    21. Wade KR, Hotze EM, Kuiper MJ, Morton CJ, Parker MW, Tweten RK. An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2204-9. PMID: 25646411.
      Citations: 23     Fields:    Translation:Cells
    22. Bolz DD, Li Z, McIndoo ER, Tweten RK, Bryant AE, Stevens DL. Cardiac myocyte dysfunction induced by streptolysin O is membrane pore and calcium dependent. Shock. 2015 Feb; 43(2):178-84. PMID: 25243426.
      Citations: 12     Fields:    Translation:AnimalsCells
    23. Tweten RK, Hotze EM, Wade KR. The Unique Molecular Choreography of Giant Pore Formation by the Cholesterol-Dependent Cytolysins of Gram-Positive Bacteria. Annu Rev Microbiol. 2015; 69:323-40. PMID: 26488276.
      Citations: 46     Fields:    Translation:HumansCells
    24. Wade KR, Hotze EM, Briles DE, Tweten RK. Mouse, but not human, ApoB-100 lipoprotein cholesterol is a potent innate inhibitor of Streptococcus pneumoniae pneumolysin. PLoS Pathog. 2014 Sep; 10(9):e1004353. PMID: 25188225.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    25. Harvey RM, Hughes CE, Paton AW, Trappetti C, Tweten RK, Paton JC. The impact of pneumolysin on the macrophage response to Streptococcus pneumoniae is strain-dependent. PLoS One. 2014; 9(8):e103625. PMID: 25105894.
      Citations: 23     Fields:    Translation:AnimalsCells
    26. Feil SC, Ascher DB, Kuiper MJ, Tweten RK, Parker MW. Structural studies of Streptococcus pyogenes streptolysin O provide insights into the early steps of membrane penetration. J Mol Biol. 2014 Feb 20; 426(4):785-92. PMID: 24316049.
      Citations: 32     Fields:    Translation:Cells
    27. Mann B, Thornton J, Heath R, Wade KR, Tweten RK, Gao G, El Kasmi K, Jordan JB, Mitrea DM, Kriwacki R, Maisonneuve J, Alderson M, Tuomanen EI. Broadly protective protein-based pneumococcal vaccine composed of pneumolysin toxoid-CbpA peptide recombinant fusion protein. J Infect Dis. 2014 Apr 01; 209(7):1116-25. PMID: 24041791.
      Citations: 42     Fields:    Translation:AnimalsCells
    28. Sato TK, Tweten RK, Johnson AE. Disulfide-bond scanning reveals assembly state and ß-strand tilt angle of the PFO ß-barrel. Nat Chem Biol. 2013 Jun; 9(6):383-9. PMID: 23563525.
      Citations: 26     Fields:    Translation:Cells
    29. Lawrence SL, Feil SC, Holien JK, Kuiper MJ, Doughty L, Dolezal O, Mulhern TD, Tweten RK, Parker MW. Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysin. Front Immunol. 2012; 3:330. PMID: 23181061.
      Citations: 3     Fields:    
    30. Hotze EM, Le HM, Sieber JR, Bruxvoort C, McInerney MJ, Tweten RK. Identification and characterization of the first cholesterol-dependent cytolysins from Gram-negative bacteria. Infect Immun. 2013 Jan; 81(1):216-25. PMID: 23115036.
      Citations: 38     Fields:    Translation:Cells
    31. Dowd KJ, Farrand AJ, Tweten RK. The cholesterol-dependent cytolysin signature motif: a critical element in the allosteric pathway that couples membrane binding to pore assembly. PLoS Pathog. 2012; 8(7):e1002787. PMID: 22792065.
      Citations: 46     Fields:    Translation:HumansCells
    32. Dunstone MA, Tweten RK. Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins. Curr Opin Struct Biol. 2012 Jun; 22(3):342-9. PMID: 22658510.
      Citations: 47     Fields:    Translation:Cells
    33. Hotze EM, Wilson-Kubalek E, Farrand AJ, Bentsen L, Parker MW, Johnson AE, Tweten RK. Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins. J Biol Chem. 2012 Jul 13; 287(29):24534-43. PMID: 22645132.
      Citations: 32     Fields:    Translation:HumansCells
    34. Feil SC, Lawrence S, Mulhern TD, Holien JK, Hotze EM, Farrand S, Tweten RK, Parker MW. Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity. Structure. 2012 Feb 08; 20(2):248-58. PMID: 22325774.
      Citations: 23     Fields:    Translation:Cells
    35. Vadia S, Arnett E, Haghighat AC, Wilson-Kubalek EM, Tweten RK, Seveau S. The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes. PLoS Pathog. 2011 Nov; 7(11):e1002356. PMID: 22072970.
      Citations: 68     Fields:    Translation:HumansCells
    36. Lencer WI, Tweten RK. To translocate or not: that is the problem. Cell Host Microbe. 2011 Sep 15; 10(3):179-80. PMID: 21925105.
      Citations:    Fields:    
    37. Hotze EM, Tweten RK. Membrane assembly of the cholesterol-dependent cytolysin pore complex. Biochim Biophys Acta. 2012 Apr; 1818(4):1028-38. PMID: 21835159.
      Citations: 85     Fields:    Translation:HumansCells
    38. Wickham SE, Hotze EM, Farrand AJ, Polekhina G, Nero TL, Tomlinson S, Parker MW, Tweten RK. Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. J Biol Chem. 2011 Jun 10; 286(23):20952-62. PMID: 21507937.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    39. Farrand AJ, LaChapelle S, Hotze EM, Johnson AE, Tweten RK. Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4341-6. PMID: 20145114.
      Citations: 118     Fields:    Translation:HumansCells
    40. Flanagan JJ, Tweten RK, Johnson AE, Heuck AP. Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding. Biochemistry. 2009 May 12; 48(18):3977-87. PMID: 19292457.
      Citations: 71     Fields:    Translation:Cells
    41. LaChapelle S, Tweten RK, Hotze EM. Intermedilysin-receptor interactions during assembly of the pore complex: assembly intermediates increase host cell susceptibility to complement-mediated lysis. J Biol Chem. 2009 May 08; 284(19):12719-26. PMID: 19293153.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    42. Kennedy CL, Lyras D, Cordner LM, Melton-Witt J, Emmins JJ, Tweten RK, Rood JI. Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis. Infect Immun. 2009 Mar; 77(3):943-51. PMID: 19139192.
      Citations: 12     Fields:    Translation:AnimalsCells
    43. Farrand S, Hotze E, Friese P, Hollingshead SK, Smith DF, Cummings RD, Dale GL, Tweten RK. Characterization of a streptococcal cholesterol-dependent cytolysin with a lewis y and b specific lectin domain. Biochemistry. 2008 Jul 08; 47(27):7097-107. PMID: 18553932.
      Citations: 29     Fields:    Translation:HumansCells
    44. Miersch S, Espey MG, Chaube R, Akarca A, Tweten R, Ananvoranich S, Mutus B. Plasma membrane cholesterol content affects nitric oxide diffusion dynamics and signaling. J Biol Chem. 2008 Jul 04; 283(27):18513-21. PMID: 18445594.
      Citations: 21     Fields:    Translation:HumansCells
    45. Hu W, Ferris SP, Tweten RK, Wu G, Radaeva S, Gao B, Bronson RT, Halperin JA, Qin X. Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin. Nat Med. 2008 Jan; 14(1):98-103. PMID: 18157141.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    46. Soltani CE, Hotze EM, Johnson AE, Tweten RK. Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20226-31. PMID: 18077338.
      Citations: 71     Fields:    Translation:Cells
    47. Soltani CE, Hotze EM, Johnson AE, Tweten RK. Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin. J Biol Chem. 2007 May 25; 282(21):15709-16. PMID: 17412689.
      Citations: 42     Fields:    Translation:HumansCells
    48. Rossjohn J, Polekhina G, Feil SC, Morton CJ, Tweten RK, Parker MW. Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins. J Mol Biol. 2007 Apr 13; 367(5):1227-36. PMID: 17328912.
      Citations: 42     Fields:    Translation:Cells
    49. Melton-Witt JA, Bentsen LM, Tweten RK. Identification of functional domains of Clostridium septicum alpha toxin. Biochemistry. 2006 Dec 05; 45(48):14347-54. PMID: 17128973.
      Citations: 18     Fields:    Translation:Cells
    50. Salles II, Voth DE, Ward SC, Averette KM, Tweten RK, Bradley KA, Ballard JD. Cytotoxic activity of Bacillus anthracis protective antigen observed in a macrophage cell line overexpressing ANTXR1. Cell Microbiol. 2006 Aug; 8(8):1272-81. PMID: 16882031.
      Citations: 15     Fields:    Translation:AnimalsCells
    51. Tweten RK. Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins. Infect Immun. 2005 Oct; 73(10):6199-209. PMID: 16177291.
      Citations: 229     Fields:    Translation:Cells
    52. Dang TX, Milligan RA, Tweten RK, Wilson-Kubalek EM. Helical crystallization on nickel-lipid nanotubes: perfringolysin O as a model protein. J Struct Biol. 2005 Nov; 152(2):129-39. PMID: 16242343.
      Citations: 8     Fields:    Translation:Cells
    53. Schuerch DW, Wilson-Kubalek EM, Tweten RK. Molecular basis of listeriolysin O pH dependence. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12537-42. PMID: 16105950.
      Citations: 75     Fields:    Translation:HumansCells
    54. Ramachandran R, Tweten RK, Johnson AE. The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7139-44. PMID: 15878993.
      Citations: 50     Fields:    Translation:Cells
    55. Dang TX, Hotze EM, Rouiller I, Tweten RK, Wilson-Kubalek EM. Prepore to pore transition of a cholesterol-dependent cytolysin visualized by electron microscopy. J Struct Biol. 2005 Apr; 150(1):100-8. PMID: 15797734.
      Citations: 34     Fields:    Translation:Cells
    56. Zheng Z, Tweten RK, Mensa-Wilmot K. Intracellular glycosylphosphatidylinositols accumulate on endosomes: toxicity of alpha-toxin to Leishmania major. Eukaryot Cell. 2005 Mar; 4(3):556-66. PMID: 15755918.
      Citations: 6     Fields:    Translation:AnimalsCells
    57. Polekhina G, Giddings KS, Tweten RK, Parker MW. Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):600-5. PMID: 15637162.
      Citations: 67     Fields:    Translation:HumansCells
    58. Giddings KS, Zhao J, Sims PJ, Tweten RK. Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin. Nat Struct Mol Biol. 2004 Dec; 11(12):1173-8. PMID: 15543155.
      Citations: 120     Fields:    Translation:HumansAnimalsCells
    59. Czajkowsky DM, Hotze EM, Shao Z, Tweten RK. Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membrane. EMBO J. 2004 Aug 18; 23(16):3206-15. PMID: 15297878.
      Citations: 102     Fields:    Translation:Cells
    60. Zheng Z, Butler KD, Tweten RK, Mensa-Wilmot K. Endosomes, glycosomes, and glycosylphosphatidylinositol catabolism in Leishmania major. J Biol Chem. 2004 Oct 01; 279(40):42106-13. PMID: 15254033.
      Citations: 5     Fields:    Translation:AnimalsCells
    61. Ramachandran R, Tweten RK, Johnson AE. Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit beta-strand alignment. Nat Struct Mol Biol. 2004 Aug; 11(8):697-705. PMID: 15235590.
      Citations: 88     Fields:    Translation:Cells
    62. Polekhina G, Giddings KS, Tweten RK, Parker MW. Crystallization and preliminary X-ray analysis of the human-specific toxin intermedilysin. Acta Crystallogr D Biol Crystallogr. 2004 Feb; 60(Pt 2):347-9. PMID: 14747721.
      Citations: 6     Fields:    Translation:HumansCells
    63. Melton JA, Parker MW, Rossjohn J, Buckley JT, Tweten RK. The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin. J Biol Chem. 2004 Apr 02; 279(14):14315-22. PMID: 14715670.
      Citations: 29     Fields:    Translation:Cells
    64. Mourez M, Yan M, Lacy DB, Dillon L, Bentsen L, Marpoe A, Maurin C, Hotze E, Wigelsworth D, Pimental RA, Ballard JD, Collier RJ, Tweten RK. Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13803-8. PMID: 14623961.
      Citations: 38     Fields:    Translation:AnimalsCells
    65. Giddings KS, Johnson AE, Tweten RK. Redefining cholesterol's role in the mechanism of the cholesterol-dependent cytolysins. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11315-20. PMID: 14500900.
      Citations: 82     Fields:    Translation:Cells
    66. Heuck AP, Tweten RK, Johnson AE. Assembly and topography of the prepore complex in cholesterol-dependent cytolysins. J Biol Chem. 2003 Aug 15; 278(33):31218-25. PMID: 12777381.
      Citations: 50     Fields:    Translation:Cells
    67. Ramachandran R, Heuck AP, Tweten RK, Johnson AE. Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin. Nat Struct Biol. 2002 Nov; 9(11):823-7. PMID: 12368903.
      Citations: 76     Fields:    Translation:Cells
    68. Wichroski MJ, Melton JA, Donahue CG, Tweten RK, Ward GE. Clostridium septicum alpha-toxin is active against the parasitic protozoan Toxoplasma gondii and targets members of the SAG family of glycosylphosphatidylinositol-anchored surface proteins. Infect Immun. 2002 Aug; 70(8):4353-61. PMID: 12117945.
      Citations: 39     Fields:    Translation:AnimalsCells
    69. Hotze EM, Heuck AP, Czajkowsky DM, Shao Z, Johnson AE, Tweten RK. Monomer-monomer interactions drive the prepore to pore conversion of a beta-barrel-forming cholesterol-dependent cytolysin. J Biol Chem. 2002 Mar 29; 277(13):11597-605. PMID: 11799121.
      Citations: 50     Fields:    Translation:Cells
    70. Tweten RK. Clostridium perfringens beta toxin and Clostridium septicum alpha toxin: their mechanisms and possible role in pathogenesis. Vet Microbiol. 2001 Sep 03; 82(1):1-9. PMID: 11423190.
      Citations: 16     Fields:    Translation:Cells
    71. Heuck AP, Tweten RK, Johnson AE. Beta-barrel pore-forming toxins: intriguing dimorphic proteins. Biochemistry. 2001 Aug 07; 40(31):9065-73. PMID: 11478872.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    72. Tweten RK, Parker MW, Johnson AE. The cholesterol-dependent cytolysins. Curr Top Microbiol Immunol. 2001; 257:15-33. PMID: 11417120.
      Citations: 47     Fields:    Translation:Cells
    73. Hotze EM, Wilson-Kubalek EM, Rossjohn J, Parker MW, Johnson AE, Tweten RK. Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane beta-sheet from a prepore intermediate. J Biol Chem. 2001 Mar 16; 276(11):8261-8. PMID: 11102453.
      Citations: 62     Fields:    Translation:Cells
    74. Heuck AP, Hotze EM, Tweten RK, Johnson AE. Mechanism of membrane insertion of a multimeric beta-barrel protein: perfringolysin O creates a pore using ordered and coupled conformational changes. Mol Cell. 2000 Nov; 6(5):1233-42. PMID: 11106760.
      Citations: 75     Fields:    Translation:Cells
    75. Shatursky O, Bayles R, Rogers M, Jost BH, Songer JG, Tweten RK. Clostridium perfringens beta-toxin forms potential-dependent, cation-selective channels in lipid bilayers. Infect Immun. 2000 Oct; 68(10):5546-51. PMID: 10992452.
      Citations: 24     Fields:    Translation:AnimalsCells
    76. Shepard LA, Shatursky O, Johnson AE, Tweten RK. The mechanism of pore assembly for a cholesterol-dependent cytolysin: formation of a large prepore complex precedes the insertion of the transmembrane beta-hairpins. Biochemistry. 2000 Aug 22; 39(33):10284-93. PMID: 10956018.
      Citations: 84     Fields:    Translation:Cells
    77. Shatursky O, Heuck AP, Shepard LA, Rossjohn J, Parker MW, Johnson AE, Tweten RK. The mechanism of membrane insertion for a cholesterol-dependent cytolysin: a novel paradigm for pore-forming toxins. Cell. 1999 Oct 29; 99(3):293-9. PMID: 10555145.
      Citations: 143     Fields:    Translation:Cells
    78. Gordon VM, Nelson KL, Buckley JT, Stevens VL, Tweten RK, Elwood PC, Leppla SH. Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors. J Biol Chem. 1999 Sep 17; 274(38):27274-80. PMID: 10480947.
      Citations: 38     Fields:    Translation:AnimalsCells
    79. Diep DB, Nelson KL, Lawrence TS, Sellman BR, Tweten RK, Buckley JT. Expression and properties of an aerolysin--Clostridium septicum alpha toxin hybrid protein. Mol Microbiol. 1999 Feb; 31(3):785-94. PMID: 10048023.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    80. Gilbert RJ, Rossjohn J, Parker MW, Tweten RK, Morgan PJ, Mitchell TJ, Errington N, Rowe AJ, Andrew PW, Byron O. Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae. J Mol Biol. 1998 Dec 11; 284(4):1223-37. PMID: 9837740.
      Citations: 26     Fields:    Translation:Cells
    81. Rossjohn J, Gilbert RJ, Crane D, Morgan PJ, Mitchell TJ, Rowe AJ, Andrew PW, Paton JC, Tweten RK, Parker MW. The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae. J Mol Biol. 1998 Nov 27; 284(2):449-61. PMID: 9813129.
      Citations: 33     Fields:    Translation:Cells
    82. Shepard LA, Heuck AP, Hamman BD, Rossjohn J, Parker MW, Ryan KR, Johnson AE, Tweten RK. Identification of a membrane-spanning domain of the thiol-activated pore-forming toxin Clostridium perfringens perfringolysin O: an alpha-helical to beta-sheet transition identified by fluorescence spectroscopy. Biochemistry. 1998 Oct 13; 37(41):14563-74. PMID: 9772185.
      Citations: 148     Fields:    Translation:HumansCells
    83. Gordon VM, Benz R, Fujii K, Leppla SH, Tweten RK. Clostridium septicum alpha-toxin is proteolytically activated by furin. Infect Immun. 1997 Oct; 65(10):4130-4. PMID: 9317018.
      Citations: 14     Fields:    Translation:AnimalsCells
    84. Sellman BR, Tweten RK. The propeptide of Clostridium septicum alpha toxin functions as an intramolecular chaperone and is a potent inhibitor of alpha toxin-dependent cytolysis. Mol Microbiol. 1997 Aug; 25(3):429-40. PMID: 9302006.
      Citations: 12     Fields:    Translation:HumansCells
    85. Stevens DL, Tweten RK, Awad MM, Rood JI, Bryant AE. Clostridial gas gangrene: evidence that alpha and theta toxins differentially modulate the immune response and induce acute tissue necrosis. J Infect Dis. 1997 Jul; 176(1):189-95. PMID: 9207366.
      Citations: 38     Fields:    Translation:AnimalsCellsPHPublic Health
    86. Rossjohn J, Feil SC, McKinstry WJ, Tweten RK, Parker MW. Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form. Cell. 1997 May 30; 89(5):685-92. PMID: 9182756.
      Citations: 166     Fields:    Translation:Cells
    87. Sellman BR, Kagan BL, Tweten RK. Generation of a membrane-bound, oligomerized pre-pore complex is necessary for pore formation by Clostridium septicum alpha toxin. Mol Microbiol. 1997 Feb; 23(3):551-8. PMID: 9044288.
      Citations: 25     Fields:    Translation:HumansCells
    88. Feil SC, Rossjohn J, Rohde K, Tweten RK, Parker MW. Crystallization and preliminary X-ray analysis of a thiol-activated cytolysin. FEBS Lett. 1996 Nov 18; 397(2-3):290-2. PMID: 8955365.
      Citations: 9     Fields:    Translation:Cells
    89. Asmuth DM, Olson RD, Hackett SP, Bryant AE, Tweten RK, Tso JY, Zollman T, Stevens DL. Effects of Clostridium perfringens recombinant and crude phospholipase C and theta-toxin on rabbit hemodynamic parameters. J Infect Dis. 1995 Nov; 172(5):1317-23. PMID: 7594670.
      Citations: 8     Fields:    Translation:AnimalsCells
    90. Gottschalk S, Tweten RK, Smith LC, Woo SL. Efficient gene delivery and expression in mammalian cells using DNA coupled with perfringolysin O. Gene Ther. 1995 Sep; 2(7):498-503. PMID: 7584129.
      Citations: 1     Fields:    Translation:AnimalsCells
    91. Ballard J, Crabtree J, Roe BA, Tweten RK. The primary structure of Clostridium septicum alpha-toxin exhibits similarity with that of Aeromonas hydrophila aerolysin. Infect Immun. 1995 Jan; 63(1):340-4. PMID: 7806374.
      Citations: 18     Fields:    Translation:Cells
    92. Johnson S, Driks MR, Tweten RK, Ballard J, Stevens DL, Anderson DJ, Janoff EN. Clinical courses of seven survivors of Clostridium septicum infection and their immunologic responses to alpha toxin. Clin Infect Dis. 1994 Oct; 19(4):761-4. PMID: 7803645.
      Citations: 9     Fields:    Translation:HumansCells
    93. Bryant AE, Bergstrom R, Zimmerman GA, Salyer JL, Hill HR, Tweten RK, Sato H, Stevens DL. Clostridium perfringens invasiveness is enhanced by effects of theta toxin upon PMNL structure and function: the roles of leukocytotoxicity and expression of CD11/CD18 adherence glycoprotein. FEMS Immunol Med Microbiol. 1993 Dec; 7(4):321-36. PMID: 7907907.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    94. Ballard J, Sokolov Y, Yuan WL, Kagan BL, Tweten RK. Activation and mechanism of Clostridium septicum alpha toxin. Mol Microbiol. 1993 Nov; 10(3):627-34. PMID: 7968539.
      Citations: 23     Fields:    Translation:Cells
    95. Portnoy DA, Tweten RK, Kehoe M, Bielecki J. Capacity of listeriolysin O, streptolysin O, and perfringolysin O to mediate growth of Bacillus subtilis within mammalian cells. Infect Immun. 1992 Jul; 60(7):2710-7. PMID: 1612739.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    96. Ballard J, Bryant A, Stevens D, Tweten RK. Purification and characterization of the lethal toxin (alpha-toxin) of Clostridium septicum. Infect Immun. 1992 Mar; 60(3):784-90. PMID: 1541552.
      Citations: 28     Fields:    Translation:AnimalsCellsPHPublic Health
    97. Tweten RK, Harris RW, Sims PJ. Isolation of a tryptic fragment from Clostridium perfringens theta-toxin that contains sites for membrane binding and self-aggregation. J Biol Chem. 1991 Jul 05; 266(19):12449-54. PMID: 2061320.
      Citations: 9     Fields:    Translation:Cells
    98. Harris RW, Sims PJ, Tweten RK. Evidence that Clostridium perfringens theta-toxin induces colloid-osmotic lysis of erythrocytes. Infect Immun. 1991 Jul; 59(7):2499-501. PMID: 2050414.
      Citations: 8     Fields:    Translation:HumansCells
    99. Harris RW, Sims PJ, Tweten RK. Kinetic aspects of the aggregation of Clostridium perfringens theta-toxin on erythrocyte membranes. A fluorescence energy transfer study. J Biol Chem. 1991 Apr 15; 266(11):6936-41. PMID: 2016307.
      Citations: 16     Fields:    Translation:HumansCells
    100. Tweten RK. Cloning and expression in Escherichia coli of the perfringolysin O (theta-toxin) gene from Clostridium perfringens and characterization of the gene product. Infect Immun. 1988 Dec; 56(12):3228-34. PMID: 2903127.
      Citations: 23     Fields:    Translation:Cells
    101. Tweten RK. Nucleotide sequence of the gene for perfringolysin O (theta-toxin) from Clostridium perfringens: significant homology with the genes for streptolysin O and pneumolysin. Infect Immun. 1988 Dec; 56(12):3235-40. PMID: 2903128.
      Citations: 46     Fields:    Translation:Cells
    102. Meador J, Tweten RK. Purification and characterization of toxin B from Clostridium difficile. Infect Immun. 1988 Jul; 56(7):1708-14. PMID: 3384474.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    103. Iandolo JJ, Tweten RK. Purification of staphylococcal enterotoxins. Methods Enzymol. 1988; 165:43-52. PMID: 3231117.
      Citations: 1     Fields:    Translation:Cells
    104. Tweten RK, Barbieri JT, Collier RJ. Diphtheria toxin. Effect of substituting aspartic acid for glutamic acid 148 on ADP-ribosyltransferase activity. J Biol Chem. 1985 Sep 05; 260(19):10392-4. PMID: 2863266.
      Citations: 28     Fields:    Translation:Cells
    105. Christianson KK, Tweten RK, Iandolo JJ. Transport and processing of staphylococcal enterotoxin A. Appl Environ Microbiol. 1985 Sep; 50(3):696-7. PMID: 4073896.
      Citations: 2     Fields:    Translation:Cells
    106. Tweten RK, Collier RJ. Molecular cloning and expression of gene fragments from corynebacteriophage beta encoding enzymatically active peptides of diphtheria toxin. J Bacteriol. 1983 Nov; 156(2):680-5. PMID: 6313613.
      Citations: 18     Fields:    Translation:Cells
    107. Tweten RK, Christianson KK, Iandolo JJ. Transport and processing of staphylococcal alpha-toxin. J Bacteriol. 1983 Nov; 156(2):524-8. PMID: 6630145.
      Citations: 10     Fields:    Translation:Cells
    108. Wen L, Tweten RK, Isackson PJ, Iandolo JJ, Reeck GR. Ionic interactions between proteins in nonequilibrium pH gradient electrophoresis: histones affect the migration of high mobility group nonhistone chromatin proteins. Anal Biochem. 1983 Jul 15; 132(2):294-304. PMID: 6226213.
      Citations: 1     Fields:    Translation:AnimalsCells
    109. Tweten RK, Iandolo JJ. Transport and processing of staphylococcal enterotoxin B. J Bacteriol. 1983 Jan; 153(1):297-303. PMID: 6848484.
      Citations: 20     Fields:    Translation:Cells
    110. Tweten RK, Iandolo JJ. Purification and partial characterization of a putative precursor to staphylococcal enterotoxin B. Infect Immun. 1981 Dec; 34(3):900-7. PMID: 7333675.
      Citations: 13     Fields:    Translation:Cells
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