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Courtney T Griffin

InstitutionOklahoma Medical Research Foundation
DepartmentCardiovascular Biology Research Program
825 N.E. 13th Street
Oklahoma City OK 73104
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    R13HL158208     (GRIFFIN, COURTNEY T)Aug 6, 2021 - Jul 31, 2022
    Vascular Biology 2021: Annual meeting of the the North American Vascular Biology Organization (NAVBO)
    Role: Principal Investigator

    R35HL144605     (GRIFFIN, COURTNEY T)Mar 6, 2019 - Feb 28, 2026
    Protease-Mediated Vascular Instability in Development and Disease
    Role: Principal Investigator

    R01HL134778     (GRIFFIN, COURTNEY T)Dec 9, 2016 - Nov 30, 2020
    Epigenetic regulation of endothelial cell necroptosis impacts vascular integrity
    Role: Principal Investigator

    R01HL111178     (GRIFFIN, COURTNEY T)Jul 13, 2012 - May 31, 2018
    Regulation of Venous and Lymphatic Identity by Chromatin-Remodeling
    Role: Principal Investigator

    R00HL087621     (GRIFFIN, COURTNEY T)Sep 25, 2008 - Dec 31, 2011
    ATP-Dependent Chromatin-Remodeling Complexes and Vascular Development
    Role: Principal Investigator

    K99HL087621     (GRIFFIN, COURTNEY T)Dec 1, 2006 - Nov 30, 2008
    ATP-Dependent Chromatin-Remodeling Complexes and Vascular Development
    Role: Principal Investigator

    F32HD042938     (GRIFFIN, COURTNEY T)Aug 1, 2002 - Jul 31, 2005
    Genetic and Cellular Analysis of Retromer Components
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tong Y, Wu Y, Ma J, Ikeda M, Ide T, Griffin CT, Ding XQ, Wang S. Comparative mechanistic study of RPE cell death induced by different oxidative stresses. Redox Biol. 2023 09; 65:102840. PMID: 37566944; PMCID: PMC10440584.
      Citations: 2     Fields:    Translation:Humans
    2. Tsitsikov EN, Phan KP, Liu Y, Tsytsykova AV, Kinter M, Selland L, Garman L, Griffin C, Dunn IF. TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development. iScience. 2023 Aug 18; 26(8):107474. PMID: 37583551; PMCID: PMC10424150.
    3. Schafer CM, Martin-Almedina S, Kurylowicz K, Dufton N, Osuna-Almagro L, Wu ML, Johnson CF, Shah AV, Haskard DO, Buxton A, Willis E, Wheeler K, Turner S, Chlebicz M, Scott RP, Kovats S, Cleuren A, Birdsey GM, Randi AM, Griffin CT. Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge. Arterioscler Thromb Vasc Biol. 2023 08; 43(8):1412-1428. PMID: 37317853; PMCID: PMC10364964.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Schafer CM, Martin-Almedina S, Kurylowicz K, Dufton N, Osuna-Almagro L, Wu ML, Johnson CF, Shah AV, Haskard DO, Buxton A, Willis E, Wheeler K, Turner S, Chlebicz M, Scott RP, Kovats S, Cleuren A, Birdsey GM, Randi AM, Griffin CT. Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge. bioRxiv. 2023 Feb 11. PMID: 36798267; PMCID: PMC9934599.
    5. Kemp SS, Penn MR, Koller GM, Griffin CT, Davis GE. Proinflammatory mediators, TNFa, IFN?, and thrombin, directly induce lymphatic capillary tube regression. Front Cell Dev Biol. 2022; 10:937982. PMID: 35927983; PMCID: PMC9343954.
      Citations: 2     
    6. de Castro RO, Carbajal A, Previato de Almeida L, Goitea V, Griffin CT, Pezza RJ. Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development. Epigenetics Chromatin. 2022 05 14; 15(1):16. PMID: 35568926.
      Citations: 2     Fields:    Translation:AnimalsCells
    7. Menendez M, Drozd A, Borawska K, Chmielewska JJ, Wu ML, Griffin CT. IL-1ß Impacts Vascular Integrity and Lymphatic Function in the Embryonic Omentum. Circ Res. 2022 02 04; 130(3):366-383. PMID: 34986653.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Lin PK, Salvador J, Xie J, Aguera KN, Koller GM, Kemp SS, Griffin CT, Davis GE. Selective and Marked Blockade of Endothelial Sprouting Behavior Using Paclitaxel and Related Pharmacologic Agents. Am J Pathol. 2021 12; 191(12):2245-2264. PMID: 34563512.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    9. Gao S, Menendez M, Kurylowicz K, Griffin CT. Genomic locus proteomic screening identifies the NF-?B signaling pathway components NF?B1 and IKBKG as transcriptional regulators of Ripk3 in endothelial cells. PLoS One. 2021; 16(6):e0253519. PMID: 34153072.
      Citations: 3     Fields:    Translation:AnimalsCells
    10. Gao S, Griffin CT. RIPK3 modulates growth factor receptor expression in endothelial cells to support angiogenesis. Angiogenesis. 2021 08; 24(3):519-531. PMID: 33449298.
      Citations: 7     Fields:    Translation:AnimalsCells
    11. Schafer CM, Gurley JM, Kurylowicz K, Lin PK, Chen W, Elliott MH, Davis GE, Bhatti F, Griffin CT. An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regression. Proc Natl Acad Sci U S A. 2020 10 20; 117(42):26494-26502. PMID: 33020273.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    12. Xie J, Gao S, Schafer C, Colijn S, Muthukumar V, Griffin CT. The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development. PLoS One. 2020; 15(7):e0235799. PMID: 32658897.
      Citations: 3     Fields:    Translation:Animals
    13. Colijn S, Muthukumar V, Xie J, Gao S, Griffin CT. Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis. Dis Model Mech. 2020 01 24; 13(1). PMID: 31953345.
      Citations: 8     Fields:    Translation:AnimalsCells
    14. Koller GM, Schafer C, Kemp SS, Aguera KN, Lin PK, Forgy JC, Griffin CT, Davis GE. Proinflammatory Mediators, IL (Interleukin)-1ß, TNF (Tumor Necrosis Factor) a, and Thrombin Directly Induce Capillary Tube Regression. Arterioscler Thromb Vasc Biol. 2020 02; 40(2):365-377. PMID: 31852224.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    15. Colijn S, Gao S, Ingram KG, Menendez M, Muthukumar V, Silasi-Mansat R, Chmielewska JJ, Hinsdale M, Lupu F, Griffin CT. The NuRD chromatin-remodeling complex enzyme CHD4 prevents hypoxia-induced endothelial Ripk3 transcription and murine embryonic vascular rupture. Cell Death Differ. 2020 02; 27(2):618-631. PMID: 31235857.
      Citations: 11     Fields:    Translation:AnimalsCells
    16. Gao S, Silasi-Mansat R, Behar AR, Lupu F, Griffin CT. Excessive Plasmin Compromises Hepatic Sinusoidal Vascular Integrity After Acetaminophen Overdose. Hepatology. 2018 11; 68(5):1991-2003. PMID: 29729197.
      Citations: 5     Fields:    Translation:Animals
    17. Ungvari Z, Tarantini S, Kiss T, Wren JD, Giles CB, Griffin CT, Murfee WL, Pacher P, Csiszar A. Endothelial dysfunction and angiogenesis impairment in the ageing vasculature. Nat Rev Cardiol. 2018 09; 15(9):555-565. PMID: 29795441.
      Citations: 156     Fields:    Translation:HumansAnimals
    18. Kondo Y, Fu J, Wang H, Hoover C, McDaniel JM, Steet R, Patra D, Song J, Pollard L, Cathey S, Yago T, Wiley G, Macwana S, Guthridge J, McGee S, Li S, Griffin C, Furukawa K, James JA, Ruan C, McEver RP, Wierenga KJ, Gaffney PM, Xia L. Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking. JCI Insight. 2018 07 26; 3(14). PMID: 30046013.
      Citations: 26     Fields:    Translation:HumansCells
    19. Menendez MT, Griffin CT. Characterizing Epigenetic Changes in Endothelial Cells. Methods Mol Biol. 2018; 1846:335-344. PMID: 30242771.
      Citations: 2     Fields:    Translation:HumansCells
    20. Menendez MT, Ong EC, Shepherd BT, Muthukumar V, Silasi-Mansat R, Lupu F, Griffin CT. BRG1 (Brahma-Related Gene 1) Promotes Endothelial Mrtf Transcription to Establish Embryonic Capillary Integrity. Arterioscler Thromb Vasc Biol. 2017 09; 37(9):1674-1682. PMID: 28729363.
      Citations: 6     Fields:    Translation:AnimalsCells
    21. Griffin CT, Gao S. Building discontinuous liver sinusoidal vessels. J Clin Invest. 2017 Mar 01; 127(3):790-792. PMID: 28218626.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    22. Crosswhite PL, Podsiadlowska JJ, Curtis CD, Gao S, Xia L, Srinivasan RS, Griffin CT. CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity. J Clin Invest. 2016 06 01; 126(6):2254-66. PMID: 27140400.
      Citations: 19     Fields:    Translation:AnimalsCells
    23. Wiley MM, Muthukumar V, Griffin TM, Griffin CT. SWI/SNF chromatin-remodeling enzymes Brahma-related gene 1 (BRG1) and Brahma (BRM) are dispensable in multiple models of postnatal angiogenesis but are required for vascular integrity in infant mice. J Am Heart Assoc. 2015 Apr 22; 4(4). PMID: 25904594.
      Citations: 14     Fields:    Translation:Animals
    24. Liu X, Pasula S, Song H, Tessneer KL, Dong Y, Hahn S, Yago T, Brophy ML, Chang B, Cai X, Wu H, McManus J, Ichise H, Georgescu C, Wren JD, Griffin C, Xia L, Srinivasan RS, Chen H. Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function. Sci Signal. 2014 Oct 14; 7(347):ra97. PMID: 25314967.
      Citations: 32     Fields:    Translation:AnimalsCells
    25. Chen H, Griffin C, Xia L, Srinivasan RS. Molecular and cellular mechanisms of lymphatic vascular maturation. Microvasc Res. 2014 Nov; 96:16-22. PMID: 24928499.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    26. McBride JD, Jenkins AJ, Liu X, Zhang B, Lee K, Berry WL, Janknecht R, Griffin CT, Aston CE, Lyons TJ, Tomasek JJ, Ma JX. Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol. 2014 Jun; 134(6):1725-1734. PMID: 24463424.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    27. Ingram KG, Curtis CD, Silasi-Mansat R, Lupu F, Griffin CT. The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis. PLoS Genet. 2013; 9(12):e1004031. PMID: 24348274.
      Citations: 22     Fields:    Translation:AnimalsCells
    28. Tessneer KL, Pasula S, Cai X, Dong Y, McManus J, Liu X, Yu L, Hahn S, Chang B, Chen Y, Griffin C, Xia L, Adams RH, Chen H. Genetic reduction of vascular endothelial growth factor receptor 2 rescues aberrant angiogenesis caused by epsin deficiency. Arterioscler Thromb Vasc Biol. 2014 Feb; 34(2):331-337. PMID: 24311377.
      Citations: 30     Fields:    Translation:AnimalsCells
    29. Davis RB, Curtis CD, Griffin CT. BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. Development. 2013 Mar; 140(6):1272-81. PMID: 23406903.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    30. Curtis CD, Davis RB, Ingram KG, Griffin CT. Chromatin-remodeling complex specificity and embryonic vascular development. Cell Mol Life Sci. 2012 Dec; 69(23):3921-31. PMID: 22618247.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    31. Curtis CD, Griffin CT. The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. Mol Cell Biol. 2012 Apr; 32(7):1312-20. PMID: 22290435.
      Citations: 25     Fields:    Translation:AnimalsCells
    32. Griffin CT, Curtis CD, Davis RB, Muthukumar V, Magnuson T. The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2282-7. PMID: 21262838.
      Citations: 60     Fields:    Translation:AnimalsCells
    33. Webb CF, Bryant J, Popowski M, Allred L, Kim D, Harriss J, Schmidt C, Miner CA, Rose K, Cheng HL, Griffin C, Tucker PW. The ARID family transcription factor bright is required for both hematopoietic stem cell and B lineage development. Mol Cell Biol. 2011 Mar; 31(5):1041-53. PMID: 21199920.
      Citations: 45     Fields:    Translation:AnimalsCells
    34. Griffin CT, Brennan J, Magnuson T. The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. Development. 2008 Feb; 135(3):493-500. PMID: 18094026.
      Citations: 74     Fields:    Translation:AnimalsCells
    35. Gullapalli A, Wolfe BL, Griffin CT, Magnuson T, Trejo J. An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Mol Biol Cell. 2006 Mar; 17(3):1228-38. PMID: 16407403.
      Citations: 69     Fields:    Translation:HumansCells
    36. Griffin CT, Trejo J, Magnuson T. Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15173-7. PMID: 16214895.
      Citations: 37     Fields:    Translation:AnimalsCells
    37. Kikuchi S, Griffin CT, Wang SS, Bissell DM. Role of CD44 in epithelial wound repair: migration of rat hepatic stellate cells utilizes hyaluronic acid and CD44v6. J Biol Chem. 2005 Apr 15; 280(15):15398-404. PMID: 15691832.
      Citations: 20     Fields:    Translation:AnimalsCells
    38. Gullapalli A, Garrett TA, Paing MM, Griffin CT, Yang Y, Trejo J. A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Mol Biol Cell. 2004 May; 15(5):2143-55. PMID: 14978220.
      Citations: 49     Fields:    Translation:HumansCells
    39. Schwarz DG, Griffin CT, Schneider EA, Yee D, Magnuson T. Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice. Mol Biol Cell. 2002 Oct; 13(10):3588-600. PMID: 12388759.
      Citations: 30     Fields:    Translation:AnimalsCells
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