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Roberto J Pezza

TitleAssistant Member
InstitutionOklahoma Medical Research Foundation
DepartmentCell Cycle and Cancer Biology Research
Addressn/a
825 N.E. 13th Street
Oklahoma City OK 73104
Phone405/271-6467
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    Collapse Research 
    Collapse research activities and funding
    R01HD110990     (PEZZA, ROBERTO JOSE)Apr 10, 2023 - Feb 29, 2028
    NIH
    Development of a lacO/lacI based fluorescence reporter-operator system to study chromosome dynamics and double-strand break repair in mouse meiosis.
    Role: Principal Investigator
    R21HD103562     (PEZZA, ROBERTO JOSE)Apr 12, 2021 - Mar 31, 2023
    NIH
    Development of a lacO/lacI based flourescence reporter-operator system to study chromosome dynamics in mice
    Role: Principal Investigator
    R01GM125803     (PEZZA, ROBERTO JOSE)Jul 5, 2018 - Jun 30, 2022
    NIH
    Epigenetic control of meiotic recombination in mammals.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. de Castro RO, Previato de Almeida L, Carbajal A, Gryniuk I, Pezza RJ. PBAF chromatin remodeler complexes that mediate meiotic transitions in mouse. Development. 2022 09 15; 149(18). PMID: 36111709; PMCID: PMC9573785.
      Citations:    Fields:    Translation:AnimalsCells
    2. de Castro RO, Carbajal A, Previato de Almeida L, Goitea V, Griffin CT, Pezza RJ. Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development. Epigenetics Chromatin. 2022 05 14; 15(1):16. PMID: 35568926.
      Citations: 2     Fields:    Translation:AnimalsCells
    3. Lee CY, Bisig CG, Conrad MM, Ditamo Y, Previato de Almeida L, Dresser ME, Pezza RJ. Extranuclear Structural Components that Mediate Dynamic Chromosome Movements in Yeast Meiosis. Curr Biol. 2020 04 06; 30(7):1207-1216.e4. PMID: 32059771.
      Citations: 11     Fields:    Translation:AnimalsCells
    4. Lee CY, Bisig CG, Conrad MN, Ditamo Y, Previato de Almeida L, Dresser ME, Pezza RJ. Telomere-led meiotic chromosome movements: recent update in structure and function. Nucleus. 2020 01 01; 11(9):111-116. PMID: 32412326.
      Citations: 4     Fields:    Translation:AnimalsCells
    5. Eyster C, Chuong HH, Lee CY, Pezza RJ, Dawson D. The pericentromeric heterochromatin of homologous chromosomes remains associated after centromere pairing dissolves in mouse spermatocyte meiosis. Chromosoma. 2019 09; 128(3):355-367. PMID: 31165256.
      Citations: 5     Fields:    Translation:AnimalsCells
    6. Previato de Almeida L, Evatt JM, Chuong HH, Kurdzo EL, Eyster CA, Gladstone MN, Gómez-H L, Llano E, Meyer R, Pendas AM, Pezza RJ, Dawson DS. Shugoshin protects centromere pairing and promotes segregation of nonexchange partner chromosomes in meiosis. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9417-9422. PMID: 31019073.
      Citations: 9     Fields:    Translation:AnimalsCells
    7. Guiraldelli MF, Felberg A, Almeida LP, Parikh A, de Castro RO, Pezza RJ. SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis. PLoS Genet. 2018 05; 14(5):e1007381. PMID: 29742103.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    8. de Castro RO, Previato L, Goitea V, Felberg A, Guiraldelli MF, Filiberti A, Pezza RJ. The chromatin-remodeling subunit Baf200 promotes homology-directed DNA repair and regulates distinct chromatin-remodeling complexes. J Biol Chem. 2017 05 19; 292(20):8459-8471. PMID: 28381560.
      Citations: 14     Fields:    Translation:HumansCells
    9. Rao HB, Qiao H, Bhatt SK, Bailey LR, Tran HD, Bourne SL, Qiu W, Deshpande A, Sharma AN, Beebout CJ, Pezza RJ, Hunter N. A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination. Science. 2017 01 27; 355(6323):403-407. PMID: 28059716.
      Citations: 82     Fields:    Translation:AnimalsCells
    10. Jordan PW, Eyster C, Chen J, Pezza RJ, Rankin S. Sororin is enriched at the central region of synapsed meiotic chromosomes. Chromosome Res. 2017 06; 25(2):115-128. PMID: 28050734.
      Citations: 6     Fields:    Translation:AnimalsCells
    11. Borgogno MV, Monti MR, Zhao W, Sung P, Argaraña CE, Pezza RJ. Tolerance of DNA Mismatches in Dmc1 Recombinase-mediated DNA Strand Exchange. J Biol Chem. 2016 Mar 04; 291(10):4928-38. PMID: 26709229.
      Citations: 12     Fields:    Translation:HumansCells
    12. Sansam CL, Pezza RJ. Connecting by breaking and repairing: mechanisms of DNA strand exchange in meiotic recombination. FEBS J. 2015 Jul; 282(13):2444-57. PMID: 25953379.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    13. Pezza RJ. Mechanisms of chromosome segregation in meiosis--new views on the old problem of aneuploidy. FEBS J. 2015 Jul; 282(13):2424-5. PMID: 25959513.
      Citations:    Fields:    Translation:Humans
    14. Lee CY, Horn HF, Stewart CL, Burke B, Bolcun-Filas E, Schimenti JC, Dresser ME, Pezza RJ. Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes. Cell Rep. 2015 Apr 28; 11(4):551-63. PMID: 25892231.
      Citations: 50     Fields:    Translation:AnimalsCells
    15. Bugreev DV, Huang F, Mazina OM, Pezza RJ, Voloshin ON, Camerini-Otero RD, Mazin AV. HOP2-MND1 modulates RAD51 binding to nucleotides and DNA. Nat Commun. 2014 Jun 19; 5:4198. PMID: 24943459.
      Citations: 33     Fields:    Translation:AnimalsCells
    16. Moktan H, Guiraldelli MF, Eyster CA, Zhao W, Lee CY, Mather T, Camerini-Otero RD, Sung P, Zhou DH, Pezza RJ. Solution structure and DNA-binding properties of the winged helix domain of the meiotic recombination HOP2 protein. J Biol Chem. 2014 May 23; 289(21):14682-91. PMID: 24711446.
      Citations: 9     Fields:    Translation:AnimalsCells
    17. Pezza RJ, Voloshin ON, Volodin AA, Boateng KA, Bellani MA, Mazin AV, Camerini-Otero RD. The dual role of HOP2 in mammalian meiotic homologous recombination. Nucleic Acids Res. 2014 Feb; 42(4):2346-57. PMID: 24304900.
      Citations: 29     Fields:    Translation:AnimalsCells
    18. Zhao W, Saro D, Hammel M, Kwon Y, Xu Y, Rambo RP, Williams GJ, Chi P, Lu L, Pezza RJ, Camerini-Otero RD, Tainer JA, Wang HW, Sung P. Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing. Nucleic Acids Res. 2014 Jan; 42(2):906-17. PMID: 24150939.
      Citations: 33     Fields:    Translation:AnimalsCells
    19. Obeso D, Pezza RJ, Dawson D. Couples, pairs, and clusters: mechanisms and implications of centromere associations in meiosis. Chromosoma. 2014 Mar; 123(1-2):43-55. PMID: 24126501.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    20. Guiraldelli MF, Eyster C, Pezza RJ. Genome instability and embryonic developmental defects in RMI1 deficient mice. DNA Repair (Amst). 2013 Oct; 12(10):835-43. PMID: 23900276.
      Citations: 6     Fields:    Translation:AnimalsCells
    21. Guiraldelli MF, Eyster C, Wilkerson JL, Dresser ME, Pezza RJ. Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis. PLoS Genet. 2013 Mar; 9(3):e1003383. PMID: 23555294.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    22. Bisig CG, Guiraldelli MF, Kouznetsova A, Scherthan H, Höög C, Dawson DS, Pezza RJ. Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes. PLoS Genet. 2012 Jun; 8(6):e1002701. PMID: 22761579.
      Citations: 69     Fields:    Translation:AnimalsCells
    23. Bugreev DV, Pezza RJ, Mazina OM, Voloshin ON, Camerini-Otero RD, Mazin AV. The resistance of DMC1 D-loops to dissociation may account for the DMC1 requirement in meiosis. Nat Struct Mol Biol. 2011 Jan; 18(1):56-60. PMID: 21151113.
      Citations: 32     Fields:    Translation:HumansCells
    24. Pezza RJ, Camerini-Otero RD, Bianco PR. Hop2-Mnd1 condenses DNA to stimulate the synapsis phase of DNA strand exchange. Biophys J. 2010 Dec 01; 99(11):3763-72. PMID: 21112301.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    25. Pezza RJ, Voloshin ON, Vanevski F, Camerini-Otero RD. Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing. Genes Dev. 2007 Jul 15; 21(14):1758-66. PMID: 17639081.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    26. Miguel V, Pezza RJ, Argaraña CE. The C-terminal region of Escherichia coli MutS and protein oligomerization. Biochem Biophys Res Commun. 2007 Aug 24; 360(2):412-7. PMID: 17599803.
      Citations: 4     Fields:    Translation:Cells
    27. Bannister LA, Pezza RJ, Donaldson JR, de Rooij DG, Schimenti KJ, Camerini-Otero RD, Schimenti JC. A dominant, recombination-defective allele of Dmc1 causing male-specific sterility. PLoS Biol. 2007 May; 5(5):e105. PMID: 17425408.
      Citations: 38     Fields:    Translation:AnimalsCells
    28. Pezza RJ, Petukhova GV, Ghirlando R, Camerini-Otero RD. Molecular activities of meiosis-specific proteins Hop2, Mnd1, and the Hop2-Mnd1 complex. J Biol Chem. 2006 Jul 07; 281(27):18426-34. PMID: 16675459.
      Citations: 48     Fields:    Translation:AnimalsCells
    29. Petukhova GV, Pezza RJ, Vanevski F, Ploquin M, Masson JY, Camerini-Otero RD. The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination. Nat Struct Mol Biol. 2005 May; 12(5):449-53. PMID: 15834424.
      Citations: 97     Fields:    Translation:AnimalsCells
    30. Angaroni CJ, de Kremer RD, Argaraña CE, Paschini-Capra AE, Giner-Ayala AN, Pezza RJ, Pan CJ, Chou JY. Glycogen storage disease type Ia in Argentina: two novel glucose-6-phosphatase mutations affecting protein stability. Mol Genet Metab. 2004 Nov; 83(3):276-9. PMID: 15542400.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    31. Smania AM, Segura I, Pezza RJ, Becerra C, Albesa I, Argaraña CE. Emergence of phenotypic variants upon mismatch repair disruption in Pseudomonas aeruginosa. Microbiology (Reading). 2004 May; 150(Pt 5):1327-1338. PMID: 15133095.
      Citations: 20     Fields:    Translation:AnimalsCells
    32. Pezza RJ, Villarreal MA, Montich GG, Argaraña CE. Vanadate inhibits the ATPase activity and DNA binding capability of bacterial MutS. A structural model for the vanadate-MutS interaction at the Walker A motif. Nucleic Acids Res. 2002 Nov 01; 30(21):4700-8. PMID: 12409461.
      Citations: 27     Fields:    Translation:Cells
    33. Pezza RJ, Smania AM, Barra JL, Argaraña CE. Nucleotides and heteroduplex DNA preserve the active conformation of Pseudomonas aeruginosa MutS by preventing protein oligomerization. Biochem J. 2002 Jan 01; 361(Pt 1):87-95. PMID: 11742532.
      Citations: 5     Fields:    Translation:HumansCells
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