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Luca Fornelli

TitleProf, Asst
InstitutionUniversity of Oklahoma, Norman
DepartmentDepartment of Biology
AddressRichards Hall 417
230 Van Vleet Oval
Norman OK 73019
Phone(405) 325-1483
Fax0
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ahsan N, Rao RSP, Wilson RS, Punyamurtula U, Salvato F, Petersen M, Ahmed MK, Abid MR, Verburgt JC, Kihara D, Yang Z, Fornelli L, Foster SB, Ramratnam B. Mass spectrometry-based proteomic platforms for better understanding of SARS-CoV-2 induced pathogenesis and potential diagnostic approaches. Proteomics. 2021 05; 21(10):e2000279. PMID: 33860983.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Kline JT, Mullen C, Durbin KR, Oates RN, Huguet R, Syka JEP, Fornelli L. Sequential Ion-Ion Reactions for Enhanced Gas-Phase Sequencing of Large Intact Proteins in a Tribrid Orbitrap Mass Spectrometer. J Am Soc Mass Spectrom. 2021 Apr 26. PMID: 33900069.
      Citations:    Fields:    
    3. Srzentic K, Fornelli L, Tsybin YO, Loo JA, Seckler H, Agar JN, Anderson LC, Bai DL, Beck A, Brodbelt JS, van der Burgt YEM, Chamot-Rooke J, Chatterjee S, Chen Y, Clarke DJ, Danis PO, Diedrich JK, D'Ippolito RA, Dupré M, Gasilova N, Ge Y, Goo YA, Goodlett DR, Greer S, Haselmann KF, He L, Hendrickson CL, Hinkle JD, Holt MV, Hughes S, Hunt DF, Kelleher NL, Kozhinov AN, Lin Z, Malosse C, Marshall AG, Menin L, Millikin RJ, Nagornov KO, Nicolardi S, Paša-Tolic L, Pengelley S, Quebbemann NR, Resemann A, Sandoval W, Sarin R, Schmitt ND, Shabanowitz J, Shaw JB, Shortreed MR, Smith LM, Sobott F, Suckau D, Toby T, Weisbrod CR, Wildburger NC, Yates JR, Yoon SH, Young NL, Zhou M. Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry. J Am Soc Mass Spectrom. 2020 Sep 02; 31(9):1783-1802. PMID: 32812765.
      Citations: 5     Fields:    
    4. Doubleday PF, Fornelli L, Kelleher NL. Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype. J Proteome Res. 2020 02 07; 19(2):938-948. PMID: 31940439.
      Citations:    Fields:    
    5. Fornelli L, Srzentic K, Toby TK, Doubleday PF, Huguet R, Mullen C, Melani RD, Dos Santos Seckler H, DeHart CJ, Weisbrod CR, Durbin KR, Greer JB, Early BP, Fellers RT, Zabrouskov V, Thomas PM, Compton PD, Kelleher NL. Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics. Mol Cell Proteomics. 2020 02; 19(2):405-420. PMID: 31888965.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    6. Huguet R, Mullen C, Srzentic K, Greer JB, Fellers RT, Zabrouskov V, Syka JEP, Kelleher NL, Fornelli L. Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms. Anal Chem. 2019 12 17; 91(24):15732-15739. PMID: 31714757.
      Citations: 4     Fields:    Translation:Cells
    7. Melani RD, Srzentic K, Gerbasi VR, McGee JP, Huguet R, Fornelli L, Kelleher NL. Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry. MAbs. 2019 Nov-Dec; 11(8):1351-1357. PMID: 31607219.
      Citations: 3     Fields:    
    8. Huang X, LeDuc RD, Fornelli L, Schunter AJ, Bennett RL, Kelleher NL, Licht JD. Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding. J Biol Chem. 2019 08 16; 294(33):12459-12471. PMID: 31248990.
      Citations: 5     Fields:    Translation:HumansCells
    9. Donnelly DP, Rawlins CM, DeHart CJ, Fornelli L, Schachner LF, Lin Z, Lippens JL, Aluri KC, Sarin R, Chen B, Lantz C, Jung W, Johnson KR, Koller A, Wolff JJ, Campuzano IDG, Auclair JR, Ivanov AR, Whitelegge JP, Paša-Tolic L, Chamot-Rooke J, Danis PO, Smith LM, Tsybin YO, Loo JA, Ge Y, Kelleher NL, Agar JN. Best practices and benchmarks for intact protein analysis for top-down mass spectrometry. Nat Methods. 2019 07; 16(7):587-594. PMID: 31249407.
      Citations: 25     Fields:    Translation:Cells
    10. van der Burgt YEM, Kilgour DPA, Tsybin YO, Srzentic K, Fornelli L, Beck A, Wuhrer M, Nicolardi S. Structural Analysis of Monoclonal Antibodies by Ultrahigh Resolution MALDI In-Source Decay FT-ICR Mass Spectrometry. Anal Chem. 2019 02 05; 91(3):2079-2085. PMID: 30571088.
      Citations: 13     Fields:    Translation:Cells
    11. Toby TK, Fornelli L, Srzentic K, DeHart CJ, Levitsky J, Friedewald J, Kelleher NL. A comprehensive pipeline for translational top-down proteomics from a single blood draw. Nat Protoc. 2019 01; 14(1):119-152. PMID: 30518910.
      Citations: 16     Fields:    Translation:HumansCells
    12. Srzentic K, Nagornov KO, Fornelli L, Lobas AA, Ayoub D, Kozhinov AN, Gasilova N, Menin L, Beck A, Gorshkov MV, Aizikov K, Tsybin YO. Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody. Anal Chem. 2018 11 06; 90(21):12527-12535. PMID: 30252447.
      Citations: 9     Fields:    Translation:AnimalsCells
    13. Fornelli L, Srzentic K, Huguet R, Mullen C, Sharma S, Zabrouskov V, Fellers RT, Durbin KR, Compton PD, Kelleher NL. Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques. Anal Chem. 2018 07 17; 90(14):8421-8429. PMID: 29894161.
      Citations: 26     Fields:    Translation:Cells
    14. Srzentic K, Zhurov KO, Lobas AA, Nikitin G, Fornelli L, Gorshkov MV, Tsybin YO. Chemical-Mediated Digestion: An Alternative Realm for Middle-down Proteomics? J Proteome Res. 2018 06 01; 17(6):2005-2016. PMID: 29722266.
      Citations: 3     Fields:    Translation:Cells
    15. Seckler HDS, Fornelli L, Mutharasan RK, Thaxton CS, Fellers R, Daviglus M, Sniderman A, Rader D, Kelleher NL, Lloyd-Jones DM, Compton PD, Wilkins JT. A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity. J Proteome Res. 2018 06 01; 17(6):2156-2164. PMID: 29649363.
      Citations: 4     Fields:    Translation:HumansCells
    16. Ntai I, Fornelli L, DeHart CJ, Hutton JE, Doubleday PF, LeDuc RD, van Nispen AJ, Fellers RT, Whiteley G, Boja ES, Rodriguez H, Kelleher NL. Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):4140-4145. PMID: 29610327.
      Citations: 23     Fields:    Translation:HumansCells
    17. Skinner OS, Haverland NA, Fornelli L, Melani RD, Do Vale LHF, Seckler HS, Doubleday PF, Schachner LF, Srzentic K, Kelleher NL, Compton PD. Top-down characterization of endogenous protein complexes with native proteomics. Nat Chem Biol. 2018 Jan; 14(1):36-41. PMID: 29131144.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    18. Lyon YA, Riggs D, Fornelli L, Compton PD, Julian RR. The Ups and Downs of Repeated Cleavage and Internal Fragment Production in Top-Down Proteomics. J Am Soc Mass Spectrom. 2018 01; 29(1):150-157. PMID: 29038993.
      Citations: 7     Fields:    Translation:Humans
    19. Haverland NA, Skinner OS, Fellers RT, Tariq AA, Early BP, LeDuc RD, Fornelli L, Compton PD, Kelleher NL. Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry. J Am Soc Mass Spectrom. 2017 06; 28(6):1203-1215. PMID: 28374312.
      Citations: 18     Fields:    Translation:HumansCells
    20. Fornelli L, Ayoub D, Aizikov K, Liu X, Damoc E, Pevzner PA, Makarov A, Beck A, Tsybin YO. Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer. J Proteomics. 2017 04 21; 159:67-76. PMID: 28242452.
      Citations: 12     Fields:    Translation:Humans
    21. Fornelli L, Toby TK, Schachner LF, Doubleday PF, Srzentic K, DeHart CJ, Kelleher NL. Top-down proteomics: Where we are, where we are going? J Proteomics. 2018 03 20; 175:3-4. PMID: 28188863.
      Citations: 16     Fields:    Translation:Cells
    22. DeHart CJ, Fellers RT, Fornelli L, Kelleher NL, Thomas PM. Bioinformatics Analysis of Top-Down Mass Spectrometry Data with ProSight Lite. Methods Mol Biol. 2017; 1558:381-394. PMID: 28150248.
      Citations: 5     Fields:    Translation:HumansAnimals
    23. Zhou Y, Zhang X, Fornelli L, Compton PD, Kelleher N, Wirth MJ. Chromatographic efficiency and selectivity in top-down proteomics of histones. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Feb 15; 1044-1045:47-53. PMID: 28076774.
      Citations: 2     Fields:    Translation:Animals
    24. Fornelli L, Durbin KR, Fellers RT, Early BP, Greer JB, LeDuc RD, Compton PD, Kelleher NL. Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer. J Proteome Res. 2017 02 03; 16(2):609-618. PMID: 28152595.
      Citations: 21     Fields:    Translation:HumansCells
    25. Toby TK, Fornelli L, Kelleher NL. Progress in Top-Down Proteomics and the Analysis of Proteoforms. Annu Rev Anal Chem (Palo Alto Calif). 2016 06 12; 9(1):499-519. PMID: 27306313.
      Citations: 120     Fields:    Translation:HumansAnimals
    26. Melani RD, Skinner OS, Fornelli L, Domont GB, Compton PD, Kelleher NL. Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics. Mol Cell Proteomics. 2016 07; 15(7):2423-34. PMID: 27178327.
      Citations: 10     Fields:    Translation:AnimalsCells
    27. Durbin KR, Fornelli L, Fellers RT, Doubleday PF, Narita M, Kelleher NL. Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa. J Proteome Res. 2016 Mar 04; 15(3):976-82. PMID: 26795204.
      Citations: 37     Fields:    Translation:HumansCells
    28. Skinner OS, Havugimana PC, Haverland NA, Fornelli L, Early BP, Greer JB, Fellers RT, Durbin KR, Do Vale LH, Melani RD, Seckler HS, Nelp MT, Belov ME, Horning SR, Makarov AA, LeDuc RD, Bandarian V, Compton PD, Kelleher NL. An informatic framework for decoding protein complexes by top-down mass spectrometry. Nat Methods. 2016 Mar; 13(3):237-40. PMID: 26780093.
      Citations: 27     Fields:    Translation:Cells
    29. Compton PD, Fornelli L, Kelleher NL, Skinner OS. Probing Asymmetric Charge Partitioning of Protein Oligomers during Tandem Mass Spectrometry. Int J Mass Spectrom. 2015 Nov 15; 390:132-136. PMID: 26692813.
      Citations:    
    30. Zheng Y, Fornelli L, Compton PD, Sharma S, Canterbury J, Mullen C, Zabrouskov V, Fellers RT, Thomas PM, Licht JD, Senko MW, Kelleher NL. Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression. Mol Cell Proteomics. 2016 Mar; 15(3):776-90. PMID: 26272979.
      Citations: 26     Fields:    Translation:HumansCells
    31. Savaryn JP, Skinner OS, Fornelli L, Fellers RT, Compton PD, Terhune SS, Abecassis MM, Kelleher NL. Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry. J Proteomics. 2016 Feb 16; 134:76-84. PMID: 25952688.
      Citations: 5     Fields:    Translation:HumansCells
    32. Tarasova IA, Surin AK, Fornelli L, Pridatchenko ML, Suvorina MY, Gorshkov MV. Ion coalescence in Fourier transform mass spectrometry: should we worry about this in shotgun proteomics? Eur J Mass Spectrom (Chichester). 2015; 21(3):459-70. PMID: 26307727.
      Citations: 3     Fields:    
    33. Srzentic K, Fornelli L, Laskay ÜA, Monod M, Beck A, Ayoub D, Tsybin YO. Advantages of extended bottom-up proteomics using Sap9 for analysis of monoclonal antibodies. Anal Chem. 2014 Oct 07; 86(19):9945-53. PMID: 25207962.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    34. Zhurov KO, Kozhinov AN, Fornelli L, Tsybin YO. Distinguishing analyte from noise components in mass spectra of complex samples: where to cut the noise? Anal Chem. 2014 Apr 01; 86(7):3308-16. PMID: 24579830.
      Citations: 6     Fields:    
    35. Fornelli L, Ayoub D, Aizikov K, Beck A, Tsybin YO. Middle-down analysis of monoclonal antibodies with electron transfer dissociation orbitrap fourier transform mass spectrometry. Anal Chem. 2014 Mar 18; 86(6):3005-12. PMID: 24588056.
      Citations: 28     Fields:    Translation:Cells
    36. Fornelli L, Parra J, Hartmer R, Stoermer C, Lubeck M, Tsybin YO. Top-down analysis of 30-80 kDa proteins by electron transfer dissociation time-of-flight mass spectrometry. Anal Bioanal Chem. 2013 Oct; 405(26):8505-14. PMID: 23934349.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    37. Zhurov KO, Fornelli L, Wodrich MD, Laskay ÜA, Tsybin YO. Principles of electron capture and transfer dissociation mass spectrometry applied to peptide and protein structure analysis. Chem Soc Rev. 2013 Jun 21; 42(12):5014-30. PMID: 23450212.
      Citations: 48     Fields:    Translation:Cells
    38. Laskay UA, Srzentic K, Fornelli L, Upir O, Kozhinov AN, Monod M, Tsybin YO. Practical considerations for improving the productivity of mass spectrometry-based proteomics. Chimia (Aarau). 2013; 67(4):244-9. PMID: 23967698.
      Citations:    Fields:    Translation:Animals
    39. Fornelli L, Damoc E, Thomas PM, Kelleher NL, Aizikov K, Denisov E, Makarov A, Tsybin YO. Analysis of intact monoclonal antibody IgG1 by electron transfer dissociation Orbitrap FTMS. Mol Cell Proteomics. 2012 Dec; 11(12):1758-67. PMID: 22964222.
      Citations: 40     Fields:    Translation:HumansCells
    40. Gorshkov MV, Fornelli L, Tsybin YO. Observation of ion coalescence in Orbitrap Fourier transform mass spectrometry. Rapid Commun Mass Spectrom. 2012 Aug 15; 26(15):1711-7. PMID: 22730091.
      Citations: 12     Fields:    
    41. Miladinovic SM, Fornelli L, Lu Y, Piech KM, Girault HH, Tsybin YO. In-spray supercharging of peptides and proteins in electrospray ionization mass spectrometry. Anal Chem. 2012 Jun 05; 84(11):4647-51. PMID: 22571167.
      Citations: 17     Fields:    
    42. Nallet S, Fornelli L, Schmitt S, Parra J, Baldi L, Tsybin YO, Wurm FM. Glycan variability on a recombinant IgG antibody transiently produced in HEK-293E cells. N Biotechnol. 2012 May 15; 29(4):471-6. PMID: 22401955.
      Citations: 9     Fields:    Translation:HumansCells
    43. Tsybin YO, Fornelli L, Stoermer C, Luebeck M, Parra J, Nallet S, Wurm FM, Hartmer R. Structural analysis of intact monoclonal antibodies by electron transfer dissociation mass spectrometry. Anal Chem. 2011 Dec 01; 83(23):8919-27. PMID: 22017162.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    44. Tsybin YO, Fornelli L, Kozhinov AN, Vorobyev A, Miladinovic SM. High-resolution and tandem mass spectrometry--the indispensable tools of the XXI century. Chimia (Aarau). 2011; 65(9):641-5. PMID: 22026169.
      Citations:    Fields:    Translation:Cells
    45. Fornelli L, Schmid AW, Grasso L, Vogel H, Tsybin YO. Deamidation and transamidation of substance P by tissue transglutaminase revealed by electron-capture dissociation fourier transform mass spectrometry. Chemistry. 2011 Jan 10; 17(2):486-97. PMID: 21207565.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
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