Retinal Pigment Epithelium

"Retinal Pigment Epithelium" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The single layer of pigment-containing epithelial cells in the RETINA, situated closely to the tips (outer segments) of the RETINAL PHOTORECEPTOR CELLS. These epithelial cells are macroglia that perform essential functions for the photoreceptor cells, such as in nutrient transport, phagocytosis of the shed photoreceptor membranes, and ensuring retinal attachment.

Descriptor ID	D055213
MeSH Number(s)	A09.371.670.500 A09.371.729.887
Concept/Terms	Retinal Pigment Epithelium Retinal Pigment Epithelium Pigment Epithelium, Retinal Epithelium, Retinal Pigment

Below are MeSH descriptors whose meaning is more general than "Retinal Pigment Epithelium".

Anatomy [A]
Sense Organs [A09]
Eye [A09.371]
Pigment Epithelium of Eye [A09.371.670]
Retinal Pigment Epithelium [A09.371.670.500]
Retina [A09.371.729]
Retinal Pigment Epithelium [A09.371.729.887]

Below are MeSH descriptors whose meaning is related to "Retinal Pigment Epithelium".

Below are MeSH descriptors whose meaning is more specific than "Retinal Pigment Epithelium".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Retinal Pigment Epithelium" by people in this website by year, and whether "Retinal Pigment Epithelium" was a major or minor topic of these publications.

Bar chart showing 52 publications over 13 distinct years, with a maximum of 8 publications in 2012 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	2	0	2
2010	2	0	2
2011	2	2	4
2012	6	2	8
2013	4	1	5
2014	4	2	6
2015	3	0	3
2016	2	6	8
2017	1	1	2
2018	1	2	3
2019	1	2	3
2020	1	3	4
2021	2	0	2

Below are the most recent publications written about "Retinal Pigment Epithelium" by people in Profiles.

Tebbe L, Sakthivel H, Makia MS, Kakakhel M, Conley SM, Al-Ubaidi MR, Naash MI. Prph2 disease mutations lead to structural and functional defects in the RPE. FASEB J. 2022 May; 36(5):e22284.

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Ma H, Yang F, Ding XQ. Deficiency of thyroid hormone receptor protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration. Cell Death Dis. 2022 Mar 21; 13(3):255.

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Liu Y, Bell BA, Song Y, Zhang K, Anderson B, Axelsen PH, Bohannan W, Agbaga MP, Park HG, James G, Brenna JT, Schmidt K, Dunaief JL, Shchepinov MS. Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload. Aging Cell. 2022 Apr; 21(4):e13579.

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Ma X, Takahashi Y, Wu W, Chen J, Dehdarani M, Liang W, Shin YH, Benyajati S, Ma JX. Soluble very low-density lipoprotein receptor (sVLDLR) inhibits fibrosis in neovascular age-related macular degeneration. FASEB J. 2021 12; 35(12):e22058.

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Tsantilas KA, Cleghorn WM, Bisbach CM, Whitson JA, Hass DT, Robbings BM, Sadilek M, Linton JD, Rountree AM, Valencia AP, Sweetwyne MT, Campbell MD, Zhang H, Jankowski CSR, Sweet IR, Marcinek DJ, Rabinovitch PS, Hurley JB. An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice. Invest Ophthalmol Vis Sci. 2021 11 01; 62(14):20.

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Ma X, Takahashi Y, Wu W, Liang W, Chen J, Chakraborty D, Li Y, Du Y, Benyajati S, Ma JX. ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium. J Biol Chem. 2021 10; 297(4):101185.

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Shang P, Stepicheva N, Teel K, McCauley A, Fitting CS, Hose S, Grebe R, Yazdankhah M, Ghosh S, Liu H, Strizhakova A, Weiss J, Bhutto IA, Lutty GA, Jayagopal A, Qian J, Sahel JA, Samuel Zigler J, Handa JT, Sergeev Y, Rajala RVS, Watkins S, Sinha D. ßA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells. Commun Biol. 2021 07 08; 4(1):850.

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Singh HD, Ma JX, Takahashi Y. Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina. Biochem Biophys Res Commun. 2021 03 19; 545:8-13.

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Bullock J, Polato F, Abu-Asab M, Bernardo-Colón A, Aflaki E, Agbaga MP, Becerra SP. Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R). Invest Ophthalmol Vis Sci. 2021 02 01; 62(2):30.

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Cheng SY, Cipi J, Ma S, Hafler BP, Kanadia RN, Brush RS, Agbaga MP, Punzo C. Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies. Proc Natl Acad Sci U S A. 2020 06 09; 117(23):13094-13104.

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