"Mice, Knockout" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Descriptor ID |
D018345
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MeSH Number(s) |
B01.050.050.136.500.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.150.900.649.313.992.635.505.500.800.500
|
Concept/Terms |
Mice, Knockout- Mice, Knockout
- Mice, Knock-out
- Knock-out Mice
- Mice, Knock out
- Mouse, Knockout
- Knockout Mouse
- Knockout Mice
|
Below are MeSH descriptors whose meaning is more general than "Mice, Knockout".
Below are MeSH descriptors whose meaning is more specific than "Mice, Knockout".
This graph shows the total number of publications written about "Mice, Knockout" by people in this website by year, and whether "Mice, Knockout" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1996 | 0 | 1 | 1 |
1998 | 0 | 2 | 2 |
1999 | 0 | 2 | 2 |
2000 | 0 | 4 | 4 |
2001 | 0 | 4 | 4 |
2002 | 0 | 8 | 8 |
2003 | 0 | 4 | 4 |
2004 | 0 | 17 | 17 |
2005 | 1 | 14 | 15 |
2006 | 1 | 20 | 21 |
2007 | 0 | 19 | 19 |
2008 | 0 | 29 | 29 |
2009 | 0 | 29 | 29 |
2010 | 0 | 27 | 27 |
2011 | 0 | 29 | 29 |
2012 | 0 | 37 | 37 |
2013 | 0 | 27 | 27 |
2014 | 0 | 42 | 42 |
2015 | 0 | 28 | 28 |
2016 | 0 | 37 | 37 |
2017 | 0 | 32 | 32 |
2018 | 0 | 31 | 31 |
2019 | 0 | 25 | 25 |
2020 | 0 | 22 | 22 |
2021 | 0 | 17 | 17 |
2022 | 0 | 4 | 4 |
2023 | 0 | 6 | 6 |
2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mice, Knockout" by people in Profiles.
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Reduced estrogen signaling contributes to bone loss and cardiac dysfunction in interleukin-10 knockout mice. Physiol Rep. 2024 Jan; 12(1):e15914.
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The Role of Sphingosine-1-Phosphate Receptor 2 in Mouse Retina Light Responses. Biomolecules. 2023 Nov 23; 13(12).
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ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims. Elife. 2023 Nov 22; 12.
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Glycine-?-Muricholic Acid Improves Liver Fibrosis and Gut Barrier Function by Reducing Bile Acid Pool Size and Hydrophobicity in Male Cyp2c70 Knockout Mice. Cells. 2023 05 12; 12(10).
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Peroxisome proliferator-activated receptor-a (PPARa) regulates wound healing and mitochondrial metabolism in the cornea. Proc Natl Acad Sci U S A. 2023 Mar 28; 120(13):e2217576120.
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The usherin mutation c.2299delG leads to its mislocalization and disrupts interactions with whirlin and VLGR1. Nat Commun. 2023 02 21; 14(1):972.
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Wheat Germ Supplementation Reduces Inflammation and Gut Epithelial Barrier Dysfunction in Female Interleukin-10 Knockout Mice Fed a Pro-Atherogenic Diet. J Nutr. 2023 03; 153(3):870-879.
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A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models. Dis Model Mech. 2023 01 01; 16(1).
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The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age-dependent manner. Geroscience. 2023 04; 45(2):983-999.
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Modulation of cGAS-STING signaling by PPARa in a mouse model of ischemia-induced retinopathy. Proc Natl Acad Sci U S A. 2022 11 29; 119(48):e2208934119.