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Matlock Arizona Jeffries

TitleProf,Clin Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
AddressWP 1350
920 Stanton L Young Blvd
Oklahoma City OK 73104
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    K08AR070891     (JEFFRIES, MATLOCK)Jun 1, 2017 - May 31, 2022
    An integrative study of circulating leukocyte composition, epigenetic patterns, and functional consequences in knee osteoarthritis
    Role: Principal Investigator

    R01AR076440     (JEFFRIES, MATLOCK)Jun 16, 2020 - May 31, 2025
    Peripheral blood mononuclear cell epigenetic associations in and biomarkers for knee osteoarthritis development and progression
    Role: Principal Investigator

    R61AR078075     (JEFFRIES, MATLOCK)Sep 8, 2020 - Aug 31, 2022
    Intraarticular microbial DNA as a novel mediator of osteoarthritis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Izda V, Martin J, Sturdy C, Jeffries MA. DNA methylation and noncoding RNA in OA: Recent findings and methodological advances. Osteoarthr Cartil Open. 2021 Dec; 3(4). PMID: 35360044.
    2. Velasco C, Dunn C, Sturdy C, Izda V, Martin J, Rivas A, McNaughton J, Jeffries MA. Ear wound healing in MRL/MpJ mice is associated with gut microbiome composition and is transferable to non-healer mice via microbiome transplantation. PLoS One. 2021; 16(7):e0248322. PMID: 34283837.
      Citations: 1     Fields:    Translation:Animals
    3. Izda V, Jeffries MA, Sawalha AH. COVID-19: A review of therapeutic strategies and vaccine candidates. Clin Immunol. 2021 01; 222:108634. PMID: 33217545.
      Citations: 71     Fields:    Translation:HumansCells
    4. Dunn CM, Velasco C, Rivas A, Andrews M, Garman C, Jacob PB, Jeffries MA. Identification of Cartilage Microbial DNA Signatures and Associations With Knee and Hip Osteoarthritis. Arthritis Rheumatol. 2020 07; 72(7):1111-1122. PMID: 31961065.
      Citations: 13     Fields:    Translation:HumansAnimals
    5. Jeffries MA. The Development of Epigenetics in the Study of Disease Pathogenesis. Adv Exp Med Biol. 2020; 1253:57-94. PMID: 32445091.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    6. M Dunn C, Nevitt MC, Lynch JA, Jeffries MA. A pilot study of peripheral blood DNA methylation models as predictors of knee osteoarthritis radiographic progression: data from the Osteoarthritis Initiative (OAI). Sci Rep. 2019 11 14; 9(1):16880. PMID: 31727952.
      Citations: 5     Fields:    Translation:HumansCells
    7. Jeffries MA. Osteoarthritis year in review 2018: genetics and epigenetics. Osteoarthritis Cartilage. 2019 03; 27(3):371-377. PMID: 30808485.
      Citations: 17     Fields:    Translation:Humans
    8. Jeffries MA. Epigenetic editing: How cutting-edge targeted epigenetic modification might provide novel avenues for autoimmune disease therapy. Clin Immunol. 2018 11; 196:49-58. PMID: 29421443.
      Citations: 9     Fields:    Translation:HumansCells
    9. Husain A, Jeffries MA. Epigenetics and Bone Remodeling. Curr Osteoporos Rep. 2017 10; 15(5):450-458. PMID: 28808893.
      Citations: 28     Fields:    Translation:HumansCells
    10. Simon TC, Jeffries MA. The Epigenomic Landscape in Osteoarthritis. Curr Rheumatol Rep. 2017 Jun; 19(6):30. PMID: 28456906.
      Citations: 15     Fields:    Translation:HumansCells
    11. Jeffries MA, Donica M, Baker LW, Stevenson ME, Annan AC, Beth Humphrey M, James JA, Sawalha AH. Genome-Wide DNA Methylation Study Identifies Significant Epigenomic Changes in Osteoarthritic Subchondral Bone and Similarity to Overlying Cartilage. Arthritis Rheumatol. 2016 06; 68(6):1403-14. PMID: 26713865.
      Citations: 27     Fields:    Translation:HumansCells
    12. Renauer P, Coit P, Jeffries MA, Merrill JT, McCune WJ, Maksimowicz-McKinnon K, Sawalha AH. DNA methylation patterns in naïve CD4+ T cells identify epigenetic susceptibility loci for malar rash and discoid rash in systemic lupus erythematosus. Lupus Sci Med. 2015; 2(1):e000101. PMID: 26405558.
      Citations: 32     Fields:    
    13. Coit P, Renauer P, Jeffries MA, Merrill JT, McCune WJ, Maksimowicz-McKinnon K, Sawalha AH. Renal involvement in lupus is characterized by unique DNA methylation changes in naïve CD4+ T cells. J Autoimmun. 2015 Jul; 61:29-35. PMID: 26005050.
      Citations: 46     Fields:    Translation:HumansCells
    14. Jeffries MA, Sawalha AH. Autoimmune disease in the epigenetic era: how has epigenetics changed our understanding of disease and how can we expect the field to evolve? Expert Rev Clin Immunol. 2015 Jan; 11(1):45-58. PMID: 25534978.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    15. Jeffries MA, Donica M, Baker LW, Stevenson ME, Annan AC, Humphrey MB, James JA, Sawalha AH. Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage. Arthritis Rheumatol. 2014 Oct; 66(10):2804-15. PMID: 24980887.
      Citations: 75     Fields:    Translation:HumansCells
    16. Coit P, Jeffries M, Altorok N, Dozmorov MG, Koelsch KA, Wren JD, Merrill JT, McCune WJ, Sawalha AH. Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients. J Autoimmun. 2013 Jun; 43:78-84. PMID: 23623029.
      Citations: 132     Fields:    Translation:HumansCells
    17. Koelsch KA, Webb R, Jeffries M, Dozmorov MG, Frank MB, Guthridge JM, James JA, Wren JD, Sawalha AH. Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse. J Autoimmun. 2013 Mar; 41:168-74. PMID: 23428850.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    18. Jeffries MA, Sawalha AH. Epigenetics in systemic lupus erythematosus: leading the way for specific therapeutic agents. Int J Clin Rheumtol. 2011 Aug; 6(4):423-439. PMID: 22184503.
    19. Jeffries MA, Dozmorov M, Tang Y, Merrill JT, Wren JD, Sawalha AH. Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus. Epigenetics. 2011 May; 6(5):593-601. PMID: 21436623.
      Citations: 99     Fields:    Translation:HumansCells
    20. Webb R, Wren JD, Jeffries M, Kelly JA, Kaufman KM, Tang Y, Frank MB, Merrill J, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Alarcón GS, Vilá LM, Alarcón-Riquelme ME, James JA, Vyse TJ, Moser KL, Gaffney PM, Gilkeson GS, Harley JB, Sawalha AH. Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus. Arthritis Rheum. 2009 Apr; 60(4):1076-84. PMID: 19333917.
      Citations: 49     Fields:    Translation:HumansCells
    21. Webb R, Jeffries M, Sawalha AH. Uric acid directly promotes human T-cell activation. Am J Med Sci. 2009 Jan; 337(1):23-7. PMID: 19057377.
      Citations: 16     Fields:    Translation:HumansCells
    22. Jeffries M, Hamadeh F, Aberle T, Glenn S, Kamen DL, Kelly JA, Reichlin M, Harley JB, Sawalha AH. Haemolytic anaemia in a multi-ethnic cohort of lupus patients: a clinical and serological perspective. Lupus. 2008 Aug; 17(8):739-43. PMID: 18625652.
      Citations: 12     Fields:    Translation:Humans
    23. Sawalha AH, Jeffries M, Webb R, Lu Q, Gorelik G, Ray D, Osban J, Knowlton N, Johnson K, Richardson B. Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun. 2008 Jun; 9(4):368-78. PMID: 18523434.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    24. Jeffries M, Bruner G, Glenn S, Sadanandan P, Carson CW, Harley JB, Sawalha AH. Sulpha allergy in lupus patients: a clinical perspective. Lupus. 2008 Mar; 17(3):202-5. PMID: 18372360.
      Citations: 4     Fields:    Translation:Humans
    25. Sawalha AH, Jeffries M. Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice. Eur J Immunol. 2007 May; 37(5):1407-13. PMID: 17429846.
      Citations: 24     Fields:    Translation:AnimalsCells
    26. Jeffries MA, Stern MA, Gunaratnam NT, Fontana RJ. Unsuspected infection is infrequent in asymptomatic outpatients with refractory ascites undergoing therapeutic paracentesis. Am J Gastroenterol. 1999 Oct; 94(10):2972-6. PMID: 10520854.
      Citations: 12     Fields:    Translation:Humans
    27. Shehab TM, Sonnad SS, Jeffries M, Gunaratnum N, Lok AS. Current practice patterns of primary care physicians in the management of patients with hepatitis C. Hepatology. 1999 Sep; 30(3):794-800. PMID: 10462388.
      Citations: 14     Fields:    Translation:Humans
    28. Jeffries MA, Kazanjian S, Wilson M, Punch J, Fontana RJ. Transjugular intrahepatic portosystemic shunts and liver transplantation in patients with refractory hepatic hydrothorax. Liver Transpl Surg. 1998 Sep; 4(5):416-23. PMID: 9724480.
      Citations: 14     Fields:    Translation:Humans
    29. Jeffries MA, Scheiman JM, Fendrick AM. Helicobacter pylori eradication: kill the bug and save the pill? Am J Gastroenterol. 1998 Jul; 93(7):1183-4. PMID: 9672364.
      Citations:    Fields:    Translation:HumansCellsCTClinical Trials
    30. Jeffries MA, McDonnell WM, Tworek JA, Merion RM, Moseley RH. Venoocclusive disease of the liver following renal transplantation. Dig Dis Sci. 1998 Feb; 43(2):229-34. PMID: 9512111.
      Citations:    Fields:    Translation:Humans
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