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Matlock Arizona Jeffries

TitleProf,Clin Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentRheumatology/Immunology/Allerg
AddressAAT 6468
800 Stanton L Young Blvd
Oklahoma City OK 73104
Phone405/271-8299
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    Collapse Research 
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    I01CX002494     (JEFFRIES, MATLOCK)Oct 1, 2022 - Sep 30, 2026
    NIH
    Cartilage Microbial Products as Novel Drivers of Knee Osteoarthritis Epigenetic Dysregulation
    Role: Principal Investigator
    R61AR078075     (JEFFRIES, MATLOCK)Sep 8, 2020 - Aug 31, 2022
    NIH
    Intraarticular microbial DNA as a novel mediator of osteoarthritis
    Role: Principal Investigator
    R01AR076440     (JEFFRIES, MATLOCK)Jun 16, 2020 - May 31, 2025
    NIH
    Peripheral blood mononuclear cell epigenetic associations in and biomarkers for knee osteoarthritis development and progression
    Role: Principal Investigator
    I01BX004882     (JEFFRIES, MATLOCK)Apr 1, 2020 - Sep 30, 2025
    NIH
    CMA: Cartilage Repair Strategies to Alleviate Arthritic Pain (CaRe AP): Optimizing the Host Environment for Intra-articular Osteoarthritis Therapies
    Role: Principal Investigator
    K08AR070891     (JEFFRIES, MATLOCK)Jun 1, 2017 - May 31, 2022
    NIH
    An integrative study of circulating leukocyte composition, epigenetic patterns, and functional consequences in knee osteoarthritis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Prinz E, Schlupp L, Dyson G, Barrett M, Szymczak A, Velasco C, Izda V, Dunn CM, Jeffries MA. OA susceptibility in mice is partially mediated by the gut microbiome, is transferrable via microbiome transplantation and is associated with immunophenotype changes. Ann Rheum Dis. 2023 Nov 18. PMID: 37979958.
      Citations:    Fields:    Translation:Animals
    2. Izda V, Schlupp L, Prinz E, Dyson G, Barrett M, Dunn CM, Nguyen E, Sturdy C, Jeffries MA. Murine cartilage microbial DNA deposition occurs rapidly following the introduction of a gut microbiome and changes with obesity, aging, and knee osteoarthritis. Geroscience. 2023 Nov 09. PMID: 37946009.
      Citations:    Fields:    Translation:HumansAnimals
    3. Schlupp L, Prinz E, Dyson G, Barrett M, Izda V, Dunn CM, Jeffries MA. Sex-linked discrepancies in C57BL6/J mouse osteoarthritis are associated with the gut microbiome and are transferrable by microbiome transplantation. Arthritis Rheumatol. 2023 Aug 31. PMID: 37651283.
      Citations:    Fields:    Translation:Animals
    4. Dunn CM, Sturdy C, Velasco C, Schlupp L, Prinz E, Izda V, Arbeeva L, Golightly YM, Nelson AE, Jeffries MA. Peripheral Blood DNA Methylation-Based Machine Learning Models for Prediction of Knee Osteoarthritis Progression: Biologic Specimens and Data From the Osteoarthritis Initiative and Johnston County Osteoarthritis Project. Arthritis Rheumatol. 2023 01; 75(1):28-40. PMID: 36411273; PMCID: PMC9797424.
      Citations: 2     Fields:    Translation:HumansCells
    5. Izda V, Dunn CM, Prinz E, Schlupp L, Nguyen E, Sturdy C, Jeffries MA. A Pilot Analysis of Genome-Wide DNA Methylation Patterns in Mouse Cartilage Reveals Overlapping Epigenetic Signatures of Aging and Osteoarthritis. ACR Open Rheumatol. 2022 Dec; 4(12):1004-1012. PMID: 36253145; PMCID: PMC9746664.
      Citations: 2     
    6. Dunn CM, Jeffries MA. The Microbiome in Osteoarthritis: a Narrative Review of Recent Human and Animal Model Literature. Curr Rheumatol Rep. 2022 05; 24(5):139-148. PMID: 35389162.
      Citations: 8     Fields:    Translation:HumansAnimals
    7. Izda V, Martin J, Sturdy C, Jeffries MA. DNA methylation and noncoding RNA in OA: Recent findings and methodological advances. Osteoarthr Cartil Open. 2021 Dec; 3(4). PMID: 35360044.
      Citations: 4     
    8. Velasco C, Dunn C, Sturdy C, Izda V, Martin J, Rivas A, McNaughton J, Jeffries MA. Ear wound healing in MRL/MpJ mice is associated with gut microbiome composition and is transferable to non-healer mice via microbiome transplantation. PLoS One. 2021; 16(7):e0248322. PMID: 34283837.
      Citations: 5     Fields:    Translation:Animals
    9. Izda V, Jeffries MA, Sawalha AH. COVID-19: A review of therapeutic strategies and vaccine candidates. Clin Immunol. 2021 01; 222:108634. PMID: 33217545.
      Citations: 115     Fields:    Translation:HumansCells
    10. Dunn CM, Velasco C, Rivas A, Andrews M, Garman C, Jacob PB, Jeffries MA. Identification of Cartilage Microbial DNA Signatures and Associations With Knee and Hip Osteoarthritis. Arthritis Rheumatol. 2020 07; 72(7):1111-1122. PMID: 31961065.
      Citations: 29     Fields:    Translation:HumansAnimals
    11. Jeffries MA. The Development of Epigenetics in the Study of Disease Pathogenesis. Adv Exp Med Biol. 2020; 1253:57-94. PMID: 32445091.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    12. M Dunn C, Nevitt MC, Lynch JA, Jeffries MA. A pilot study of peripheral blood DNA methylation models as predictors of knee osteoarthritis radiographic progression: data from the Osteoarthritis Initiative (OAI). Sci Rep. 2019 11 14; 9(1):16880. PMID: 31727952.
      Citations: 8     Fields:    Translation:HumansCells
    13. Jeffries MA. Osteoarthritis year in review 2018: genetics and epigenetics. Osteoarthritis Cartilage. 2019 03; 27(3):371-377. PMID: 30808485.
      Citations: 21     Fields:    Translation:Humans
    14. Jeffries MA. Epigenetic editing: How cutting-edge targeted epigenetic modification might provide novel avenues for autoimmune disease therapy. Clin Immunol. 2018 11; 196:49-58. PMID: 29421443.
      Citations: 17     Fields:    Translation:HumansCells
    15. Husain A, Jeffries MA. Epigenetics and Bone Remodeling. Curr Osteoporos Rep. 2017 10; 15(5):450-458. PMID: 28808893.
      Citations: 34     Fields:    Translation:HumansCells
    16. Simon TC, Jeffries MA. The Epigenomic Landscape in Osteoarthritis. Curr Rheumatol Rep. 2017 Jun; 19(6):30. PMID: 28456906.
      Citations: 21     Fields:    Translation:HumansCells
    17. Jeffries MA, Donica M, Baker LW, Stevenson ME, Annan AC, Beth Humphrey M, James JA, Sawalha AH. Genome-Wide DNA Methylation Study Identifies Significant Epigenomic Changes in Osteoarthritic Subchondral Bone and Similarity to Overlying Cartilage. Arthritis Rheumatol. 2016 06; 68(6):1403-14. PMID: 26713865.
      Citations: 37     Fields:    Translation:HumansCells
    18. Renauer P, Coit P, Jeffries MA, Merrill JT, McCune WJ, Maksimowicz-McKinnon K, Sawalha AH. DNA methylation patterns in naïve CD4+ T cells identify epigenetic susceptibility loci for malar rash and discoid rash in systemic lupus erythematosus. Lupus Sci Med. 2015; 2(1):e000101. PMID: 26405558.
      Citations: 37     Fields:    
    19. Coit P, Renauer P, Jeffries MA, Merrill JT, McCune WJ, Maksimowicz-McKinnon K, Sawalha AH. Renal involvement in lupus is characterized by unique DNA methylation changes in naïve CD4+ T cells. J Autoimmun. 2015 Jul; 61:29-35. PMID: 26005050.
      Citations: 57     Fields:    Translation:HumansCells
    20. Jeffries MA, Sawalha AH. Autoimmune disease in the epigenetic era: how has epigenetics changed our understanding of disease and how can we expect the field to evolve? Expert Rev Clin Immunol. 2015 Jan; 11(1):45-58. PMID: 25534978.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    21. Jeffries MA, Donica M, Baker LW, Stevenson ME, Annan AC, Humphrey MB, James JA, Sawalha AH. Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage. Arthritis Rheumatol. 2014 Oct; 66(10):2804-15. PMID: 24980887.
      Citations: 83     Fields:    Translation:HumansCells
    22. Coit P, Jeffries M, Altorok N, Dozmorov MG, Koelsch KA, Wren JD, Merrill JT, McCune WJ, Sawalha AH. Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients. J Autoimmun. 2013 Jun; 43:78-84. PMID: 23623029.
      Citations: 152     Fields:    Translation:HumansCells
    23. Koelsch KA, Webb R, Jeffries M, Dozmorov MG, Frank MB, Guthridge JM, James JA, Wren JD, Sawalha AH. Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse. J Autoimmun. 2013 Mar; 41:168-74. PMID: 23428850.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    24. Jeffries MA, Sawalha AH. Epigenetics in systemic lupus erythematosus: leading the way for specific therapeutic agents. Int J Clin Rheumtol. 2011 Aug; 6(4):423-439. PMID: 22184503.
      Citations: 26     
    25. Jeffries MA, Dozmorov M, Tang Y, Merrill JT, Wren JD, Sawalha AH. Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus. Epigenetics. 2011 May; 6(5):593-601. PMID: 21436623.
      Citations: 107     Fields:    Translation:HumansCells
    26. Webb R, Wren JD, Jeffries M, Kelly JA, Kaufman KM, Tang Y, Frank MB, Merrill J, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Alarcón GS, Vilá LM, Alarcón-Riquelme ME, James JA, Vyse TJ, Moser KL, Gaffney PM, Gilkeson GS, Harley JB, Sawalha AH. Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus. Arthritis Rheum. 2009 Apr; 60(4):1076-84. PMID: 19333917.
      Citations: 51     Fields:    Translation:HumansCells
    27. Webb R, Jeffries M, Sawalha AH. Uric acid directly promotes human T-cell activation. Am J Med Sci. 2009 Jan; 337(1):23-7. PMID: 19057377.
      Citations: 20     Fields:    Translation:HumansCells
    28. Jeffries M, Hamadeh F, Aberle T, Glenn S, Kamen DL, Kelly JA, Reichlin M, Harley JB, Sawalha AH. Haemolytic anaemia in a multi-ethnic cohort of lupus patients: a clinical and serological perspective. Lupus. 2008 Aug; 17(8):739-43. PMID: 18625652.
      Citations: 13     Fields:    Translation:Humans
    29. Sawalha AH, Jeffries M, Webb R, Lu Q, Gorelik G, Ray D, Osban J, Knowlton N, Johnson K, Richardson B. Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun. 2008 Jun; 9(4):368-78. PMID: 18523434.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    30. Jeffries M, Bruner G, Glenn S, Sadanandan P, Carson CW, Harley JB, Sawalha AH. Sulpha allergy in lupus patients: a clinical perspective. Lupus. 2008 Mar; 17(3):202-5. PMID: 18372360.
      Citations: 5     Fields:    Translation:Humans
    31. Sawalha AH, Jeffries M. Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice. Eur J Immunol. 2007 May; 37(5):1407-13. PMID: 17429846.
      Citations: 25     Fields:    Translation:AnimalsCells
    32. Jeffries MA, Stern MA, Gunaratnam NT, Fontana RJ. Unsuspected infection is infrequent in asymptomatic outpatients with refractory ascites undergoing therapeutic paracentesis. Am J Gastroenterol. 1999 Oct; 94(10):2972-6. PMID: 10520854.
      Citations: 12     Fields:    Translation:Humans
    33. Shehab TM, Sonnad SS, Jeffries M, Gunaratnum N, Lok AS. Current practice patterns of primary care physicians in the management of patients with hepatitis C. Hepatology. 1999 Sep; 30(3):794-800. PMID: 10462388.
      Citations: 13     Fields:    Translation:Humans
    34. Jeffries MA, Kazanjian S, Wilson M, Punch J, Fontana RJ. Transjugular intrahepatic portosystemic shunts and liver transplantation in patients with refractory hepatic hydrothorax. Liver Transpl Surg. 1998 Sep; 4(5):416-23. PMID: 9724480.
      Citations: 17     Fields:    Translation:Humans
    35. Jeffries MA, Scheiman JM, Fendrick AM. Helicobacter pylori eradication: kill the bug and save the pill? Am J Gastroenterol. 1998 Jul; 93(7):1183-4. PMID: 9672364.
      Citations:    Fields:    Translation:HumansCellsCTClinical Trials
    36. Jeffries MA, McDonnell WM, Tworek JA, Merion RM, Moseley RH. Venoocclusive disease of the liver following renal transplantation. Dig Dis Sci. 1998 Feb; 43(2):229-34. PMID: 9512111.
      Citations:    Fields:    Translation:Humans
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