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Michael Hale Elliott

InstitutionUniversity of Oklahoma Health Sciences Center
AddressDMEI 419
608 Stanton L Young Blvd
Oklahoma City OK 73104
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    F32EY013674     (ELLIOTT, MICHAEL H)Sep 13, 2001
    Caveolin in Mammalian Photoreceptor Outer Segements
    Role: Principal Investigator

    R01EY019494     (ELLIOTT, MICHAEL H)Dec 1, 2009 - Jun 30, 2021
    Role of caveolin-1 in the maintenance of blood-retinal barrier integrity
    Role: Principal Investigator

    R01EY028608     (ELLIOTT, MICHAEL H)Sep 1, 2018 - Jun 30, 2022
    Caveolae-based mechanosensors for conventional outflow regulation
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Schafer CM, Gurley JM, Kurylowicz K, Lin PK, Chen W, Elliott MH, Davis GE, Bhatti F, Griffin CT. An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regression. Proc Natl Acad Sci U S A. 2020 10 20; 117(42):26494-26502. PMID: 33020273.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    2. Gurley JM, Gmyrek GB, McClellan ME, Hargis EA, Hauck SM, Dozmorov MG, Wren JD, Carr DJJ, Elliott MH. Neuroretinal-Derived Caveolin-1 Promotes Endotoxin-Induced Inflammation in the Murine Retina. Invest Ophthalmol Vis Sci. 2020 10 01; 61(12):19. PMID: 33079993.
      Citations:    Fields:    Translation:AnimalsCells
    3. De Ieso ML, Gurley JM, McClellan ME, Gu X, Navarro I, Li G, Gomez-Caraballo M, Enyong E, Stamer WD, Elliott MH. Physiologic Consequences of Caveolin-1 Ablation in Conventional Outflow Endothelia. Invest Ophthalmol Vis Sci. 2020 09 01; 61(11):32. PMID: 32940661.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Li G, Schmitt H, Johnson WM, Lee C, Navarro I, Cui J, Fleming T, Gomez-Caraballo M, Elliott MH, Sherwood JM, Hauser MA, Farsiu S, Ethier CR, Stamer WD. Integral role for lysyl oxidase-like-1 in conventional outflow tissue function and behavior. FASEB J. 2020 08; 34(8):10762-10777. PMID: 32623782.
      Citations: 4     Fields:    Translation:AnimalsCells
    5. Wilkerson JL, Stiles MA, Gurley JM, Grambergs RC, Gu X, Elliott MH, Proia RL, Mandal NA. Sphingosine Kinase-1 Is Essential for Maintaining External/Outer Limiting Membrane and Associated Adherens Junctions in the Aging Retina. Mol Neurobiol. 2019 Oct; 56(10):7188-7207. PMID: 30997640.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Gurley JM, Elliott MH. The Role of Caveolin-1 in Retinal Inflammation. Adv Exp Med Biol. 2019; 1185:169-173. PMID: 31884607.
      Citations: 1     Fields:    Translation:Humans
    7. Reagan AM, Gu X, Paudel S, Ashpole NM, Zalles M, Sonntag WE, Ungvari Z, Csiszar A, Otalora L, Freeman WM, Stout MB, Elliott MH. Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency. Neurobiol Aging. 2018 11; 71:1-12. PMID: 30059797.
      Citations: 2     Fields:    Translation:Animals
    8. Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, Gautam T, Zhang XA, Sonntag WE, de Cabo R, Farkas E, Elliott MH, Kinter MT, Deak F, Ungvari Z, Csiszar A. Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype. J Gerontol A Biol Sci Med Sci. 2018 06 14; 73(7):853-863. PMID: 29905772.
      Citations: 38     Fields:    Translation:Animals
    9. Keller KE, Bhattacharya SK, Borrás T, Brunner TM, Chansangpetch S, Clark AF, Dismuke WM, Du Y, Elliott MH, Ethier CR, Faralli JA, Freddo TF, Fuchshofer R, Giovingo M, Gong H, Gonzalez P, Huang A, Johnstone MA, Kaufman PL, Kelley MJ, Knepper PA, Kopczynski CC, Kuchtey JG, Kuchtey RW, Kuehn MH, Lieberman RL, Lin SC, Liton P, Liu Y, Lütjen-Drecoll E, Mao W, Masis-Solano M, McDonnell F, McDowell CM, Overby DR, Pattabiraman PP, Raghunathan VK, Rao PV, Rhee DJ, Chowdhury UR, Russell P, Samples JR, Schwartz D, Stubbs EB, Tamm ER, Tan JC, Toris CB, Torrejon KY, Vranka JA, Wirtz MK, Yorio T, Zhang J, Zode GS, Fautsch MP, Peters DM, Acott TS, Stamer WD. Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. Exp Eye Res. 2018 06; 171:164-173. PMID: 29526795.
      Citations: 53     Fields:    Translation:HumansAnimals
    10. Royer DJ, Elliott MH, Le YZ, Carr DJJ. Corneal Epithelial Cells Exhibit Myeloid Characteristics and Present Antigen via MHC Class II. Invest Ophthalmol Vis Sci. 2018 03 01; 59(3):1512-1522. PMID: 29625473.
      Citations: 5     Fields:    Translation:AnimalsCells
    11. Sudharsan R, Elliott MH, Dolgova N, Aguirre GD, Beltran WA. Photoreceptor Outer Segment Isolation from a Single Canine Retina for RPE Phagocytosis Assay. Adv Exp Med Biol. 2018; 1074:593-601. PMID: 29721992.
      Citations:    Fields:    Translation:AnimalsCells
    12. Masser DR, Otalora L, Clark NW, Kinter MT, Elliott MH, Freeman WM. Functional changes in the neural retina occur in the absence of mitochondrial dysfunction in a rodent model of diabetic retinopathy. J Neurochem. 2017 12; 143(5):595-608. PMID: 28902411.
      Citations: 9     Fields:    Translation:AnimalsCells
    13. Du M, Mangold CA, Bixler GV, Brucklacher RM, Masser DR, Stout MB, Elliott MH, Freeman WM. Retinal gene expression responses to aging are sexually divergent. Mol Vis. 2017; 23:707-717. PMID: 29062222.
      Citations: 10     Fields:    Translation:Animals
    14. Oliveira SDS, Castellon M, Chen J, Bonini MG, Gu X, Elliott MH, Machado RF, Minshall RD. Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-ß-driven pulmonary vascular remodeling. . 2017 05 01; 312(5):L760-L771. PMID: 28188225.
    15. McClellan ME, Elliott MH. Analysis of Fatty Acid and Cholesterol Content from Detergent-Resistant and Detergent-Free Membrane Microdomains. Methods Mol Biol. 2017; 1609:185-194. PMID: 28660583.
      Citations:    Fields:    Translation:Cells
    16. Elliott MH, Ashpole NE, Gu X, Herrnberger L, McClellan ME, Griffith GL, Reagan AM, Boyce TM, Tanito M, Tamm ER, Stamer WD. Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma. Sci Rep. 2016 11 14; 6:37127. PMID: 27841369.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    17. Gu X, Reagan AM, McClellan ME, Elliott MH. Caveolins and caveolae in ocular physiology and pathophysiology. Prog Retin Eye Res. 2017 01; 56:84-106. PMID: 27664379.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    18. Yu JY, Du M, Elliott MH, Wu M, Fu D, Yang S, Basu A, Gu X, Ma JX, Aston CE, Lyons TJ. Extravascular modified lipoproteins: a role in the propagation of diabetic retinopathy in a mouse model of type 1 diabetes. Diabetologia. 2016 09; 59(9):2026-35. PMID: 27306616.
      Citations: 6     Fields:    Translation:HumansAnimals
    19. Coburn PS, Wiskur BJ, Miller FC, LaGrow AL, Astley RA, Elliott MH, Callegan MC. Bloodstream-To-Eye Infections Are Facilitated by Outer Blood-Retinal Barrier Dysfunction. PLoS One. 2016; 11(5):e0154560. PMID: 27195776.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    20. Ding XQ, Thapa A, Ma H, Xu J, Elliott MH, Rodgers KK, Smith ML, Wang JS, Pittler SJ, Kefalov VJ. The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility. J Biol Chem. 2016 Apr 15; 291(16):8721-34. PMID: 26893377.
      Citations:    Fields:    Translation:HumansAnimalsCells
    21. Sethna S, Chamakkala T, Gu X, Thompson TC, Cao G, Elliott MH, Finnemann SC. Regulation of Phagolysosomal Digestion by Caveolin-1 of the Retinal Pigment Epithelium Is Essential for Vision. J Biol Chem. 2016 Mar 18; 291(12):6494-506. PMID: 26814131.
      Citations: 13     Fields:    Translation:AnimalsCells
    22. Reagan A, Gu X, Hauck SM, Ash JD, Cao G, Thompson TC, Elliott MH. Retinal Caveolin-1 Modulates Neuroprotective Signaling. Adv Exp Med Biol. 2016; 854:411-8. PMID: 26427439.
      Citations: 6     Fields:    Translation:AnimalsCells
    23. Li X, Gu X, Boyce TM, Zheng M, Reagan AM, Qi H, Mandal N, Cohen AW, Callegan MC, Carr DJ, Elliott MH. Caveolin-1 increases proinflammatory chemoattractants and blood-retinal barrier breakdown but decreases leukocyte recruitment in inflammation. Invest Ophthalmol Vis Sci. 2014 Aug 26; 55(10):6224-34. PMID: 25159208.
      Citations: 11     Fields:    Translation:AnimalsCells
    24. Ding L, Cheng R, Hu Y, Takahashi Y, Jenkins AJ, Keech AC, Humphries KM, Gu X, Elliott MH, Xia X, Ma JX. Peroxisome proliferator-activated receptor a protects capillary pericytes in the retina. Am J Pathol. 2014 Oct; 184(10):2709-20. PMID: 25108226.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    25. Bennett LD, Brush RS, Chan M, Lydic TA, Reese K, Reid GE, Busik JV, Elliott MH, Anderson RE. Effect of reduced retinal VLC-PUFA on rod and cone photoreceptors. Invest Ophthalmol Vis Sci. 2014 Apr 10; 55(5):3150-7. PMID: 24722693.
      Citations: 11     Fields:    Translation:AnimalsCells
    26. Gu X, Reagan A, Yen A, Bhatti F, Cohen AW, Elliott MH. Spatial and temporal localization of caveolin-1 protein in the developing retina. Adv Exp Med Biol. 2014; 801:15-21. PMID: 24664676.
      Citations: 12     Fields:    Translation:AnimalsCells
    27. Gu X, Fliesler SJ, Zhao YY, Stallcup WB, Cohen AW, Elliott MH. Loss of caveolin-1 causes blood-retinal barrier breakdown, venous enlargement, and mural cell alteration. Am J Pathol. 2014 Feb; 184(2):541-55. PMID: 24326256.
      Citations: 17     Fields:    Translation:HumansAnimals
    28. Chen H, Tran JA, Eckerd A, Huynh TP, Elliott MH, Brush RS, Mandal NA. Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration. J Lipid Res. 2013 Jun; 54(6):1616-1629. PMID: 23468130.
      Citations: 16     Fields:    Translation:Animals
    29. Wu M, Yang S, Elliott MH, Fu D, Wilson K, Zhang J, Du M, Chen J, Lyons T. Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells. Invest Ophthalmol Vis Sci. 2012 Jul 09; 53(8):4595-604. PMID: 22678501.
      Citations: 26     Fields:    Translation:HumansCells
    30. Chucair-Elliott AJ, Elliott MH, Wang J, Moiseyev GP, Ma JX, Politi LE, Rotstein NP, Akira S, Uematsu S, Ash JD. Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium. J Biol Chem. 2012 Jul 13; 287(29):24092-102. PMID: 22645143.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    31. Li X, McClellan ME, Tanito M, Garteiser P, Towner R, Bissig D, Berkowitz BA, Fliesler SJ, Woodruff ML, Fain GL, Birch DG, Khan MS, Ash JD, Elliott MH. Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment. J Biol Chem. 2012 May 11; 287(20):16424-34. PMID: 22451674.
      Citations: 21     Fields:    Translation:AnimalsCells
    32. Mandal MN, Moiseyev GP, Elliott MH, Kasus-Jacobi A, Li X, Chen H, Zheng L, Nikolaeva O, Floyd RA, Ma JX, Anderson RE. Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity. J Biol Chem. 2011 Sep 16; 286(37):32491-501. PMID: 21785167.
      Citations: 33     Fields:    Translation:AnimalsCells
    33. Li F, Marchette LD, Brush RS, Elliott MH, Davis KR, Anderson AG, Anderson RE. High levels of retinal docosahexaenoic acid do not protect photoreceptor degeneration in VPP transgenic mice. Mol Vis. 2010 Aug 18; 16:1669-79. PMID: 20806040.
      Citations: 3     Fields:    Translation:AnimalsCells
    34. Wang J, Xu X, Elliott MH, Zhu M, Le YZ. Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage. Diabetes. 2010 Sep; 59(9):2297-305. PMID: 20530741.
      Citations: 123     Fields:    Translation:AnimalsCells
    35. Brush RS, Tran JT, Henry KR, McClellan ME, Elliott MH, Mandal MN. Retinal sphingolipids and their very-long-chain fatty acid-containing species. Invest Ophthalmol Vis Sci. 2010 Sep; 51(9):4422-31. PMID: 20393115.
      Citations: 23     Fields:    Translation:AnimalsCells
    36. Agbaga MP, Brush RS, Mandal MN, Elliott MH, Al-Ubaidi MR, Anderson RE. Role of Elovl4 protein in the biosynthesis of docosahexaenoic acid. Adv Exp Med Biol. 2010; 664:233-42. PMID: 20238022.
      Citations: 6     Fields:    Translation:AnimalsCells
    37. Tanito M, Brush RS, Elliott MH, Wicker LD, Henry KR, Anderson RE. Correlation between tissue docosahexaenoic acid levels and susceptibility to light-induced retinal degeneration. Adv Exp Med Biol. 2010; 664:567-73. PMID: 20238060.
      Citations: 3     Fields:    Translation:Animals
    38. Li F, Marchette LD, Brush RS, Elliott MH, Le YZ, Henry KA, Anderson AG, Zhao C, Sun X, Zhang K, Anderson RE. DHA does not protect ELOVL4 transgenic mice from retinal degeneration. Mol Vis. 2009 Jun 13; 15:1185-93. PMID: 19536303.
      Citations: 19     Fields:    Translation:HumansAnimals
    39. Mandal MN, Patlolla JM, Zheng L, Agbaga MP, Tran JT, Wicker L, Kasus-Jacobi A, Elliott MH, Rao CV, Anderson RE. Curcumin protects retinal cells from light-and oxidant stress-induced cell death. Free Radic Biol Med. 2009 Mar 01; 46(5):672-9. PMID: 19121385.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    40. Tanito M, Brush RS, Elliott MH, Wicker LD, Henry KR, Anderson RE. High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration. J Lipid Res. 2009 May; 50(5):807-19. PMID: 19023138.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    41. Agbaga MP, Brush RS, Mandal MN, Henry K, Elliott MH, Anderson RE. Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12843-8. PMID: 18728184.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    42. Ding XQ, Fitzgerald JB, Matveev AV, McClellan ME, Elliott MH. Functional activity of photoreceptor cyclic nucleotide-gated channels is dependent on the integrity of cholesterol- and sphingolipid-enriched membrane domains. Biochemistry. 2008 Mar 25; 47(12):3677-87. PMID: 18303857.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    43. Elliott MH, Ghalayini AJ. Phosphorylation of caveolin-1 in bovine rod outer segments in vitro by an endogenous tyrosine kinase. Adv Exp Med Biol. 2008; 613:335-41. PMID: 18188962.
      Citations: 1     Fields:    Translation:AnimalsCells
    44. Elliott MH, Nash ZA, Takemori N, Fliesler SJ, McClellan ME, Naash MI. Differential distribution of proteins and lipids in detergent-resistant and detergent-soluble domains in rod outer segment plasma membranes and disks. J Neurochem. 2008 Jan; 104(2):336-52. PMID: 17944869.
      Citations: 16     Fields:    Translation:AnimalsCells
    45. Tanito M, Li F, Elliott MH, Dittmar M, Anderson RE. Protective effect of TEMPOL derivatives against light-induced retinal damage in rats. Invest Ophthalmol Vis Sci. 2007 Apr; 48(4):1900-5. PMID: 17389526.
      Citations: 26     Fields:    Translation:AnimalsCellsPHPublic Health
    46. Tanito M, Haniu H, Elliott MH, Singh AK, Matsumoto H, Anderson RE. Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration. Free Radic Biol Med. 2006 Dec 15; 41(12):1847-59. PMID: 17157187.
      Citations: 15     Fields:    Translation:AnimalsCells
    47. Rajala RV, Elliott MH, McClellan ME, Anderson RE. Localization of the insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments. Adv Exp Med Biol. 2006; 572:491-7. PMID: 17249614.
      Citations: 3     Fields:    Translation:AnimalsCells
    48. Tanito M, Elliott MH, Kotake Y, Anderson RE. Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina. Invest Ophthalmol Vis Sci. 2005 Oct; 46(10):3859-68. PMID: 16186375.
      Citations: 46     Fields:    Translation:AnimalsCellsPHPublic Health
    49. Martin RE, Elliott MH, Brush RS, Anderson RE. Detailed characterization of the lipid composition of detergent-resistant membranes from photoreceptor rod outer segment membranes. Invest Ophthalmol Vis Sci. 2005 Apr; 46(4):1147-54. PMID: 15790872.
      Citations: 46     Fields:    Translation:AnimalsCells
    50. Elliott MH, Fliesler SJ, Ghalayini AJ. Cholesterol-dependent association of caveolin-1 with the transducin alpha subunit in bovine photoreceptor rod outer segments: disruption by cyclodextrin and guanosine 5'-O-(3-thiotriphosphate). Biochemistry. 2003 Jul 08; 42(26):7892-903. PMID: 12834341.
      Citations: 17     Fields:    Translation:AnimalsCells
    51. Ghalayini AJ, Desai N, Smith KR, Holbrook RM, Elliott MH, Kawakatsu H. Light-dependent association of Src with photoreceptor rod outer segment membrane proteins in vivo. J Biol Chem. 2002 Jan 11; 277(2):1469-76. PMID: 11705988.
      Citations: 13     Fields:    Translation:AnimalsCells
    52. Davies S, Elliott MH, Floor E, Truscott TG, Zareba M, Sarna T, Shamsi FA, Boulton ME. Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells. Free Radic Biol Med. 2001 Jul 15; 31(2):256-65. PMID: 11440838.
      Citations: 43     Fields:    Translation:HumansCells
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