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Michael Ihnat

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPharmaceutical Sciences
AddressCPB 319
1110 N Stonewall Ave
Oklahoma City OK 73117
Phone405/271-8000 ext 47965
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    Collapse Research 
    Collapse research activities and funding
    R03ES031358     (IHNAT, MICHAEL A)Jan 8, 2020 - Dec 31, 2021
    Nephrotoxic mechanisms of f low-rank coal (lignite) leachates in drinking water
    Role: Principal Investigator

    R44CA135867     (IHNAT, MICHAEL A)Sep 1, 2008 - Aug 31, 2015
    Drugs Targeting Dormant Tumors as Anti-Metastatic Agents
    Role: Principal Investigator

    R43CA135867     (IHNAT, MICHAEL A)Sep 1, 2008 - Nov 30, 2009
    Drugs Targeting Dormant Tumors as Anti-Metastatic Agents
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ding H, Jambunathan K, Jiang G, Margolis DM, Leng I, Ihnat M, Ma JX, Mirsalis J, Zhang Y. 3D Spheroids of Human Primary Urine-Derived Stem Cells in the Assessment of Drug-Induced Mitochondrial Toxicity. Pharmaceutics. 2022 May 11; 14(5). PMID: 35631624.
      Citations: 2     
    2. Dib P, Zhang Y, Ihnat MA, Gallucci RM, Standifer KM. TNF-Alpha as an Initiator of Allodynia and Anxiety-Like Behaviors in a Preclinical Model of PTSD and Comorbid Pain. Front Psychiatry. 2021; 12:721999. PMID: 34512420.
      Citations: 4     
    3. Sauer S, Reed DR, Ihnat M, Hurst RE, Warshawsky D, Barkan D. Innovative Approaches in the Battle Against Cancer Recurrence: Novel Strategies to Combat Dormant Disseminated Tumor Cells. Front Oncol. 2021; 11:659963. PMID: 33987095.
      Citations: 17     
    4. Islam F, Quadery TM, Bai R, Luckett-Chastain LR, Hamel E, Ihnat MA, Gangjee A. Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents. Bioorg Med Chem Lett. 2021 06 01; 41:127923. PMID: 33705908.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    5. Choudhary S, Doshi A, Luckett-Chastain L, Ihnat M, Hamel E, Mooberry SL, Gangjee A. Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer. Bioorg Med Chem. 2021 04 01; 35:116061. PMID: 33647840.
      Citations: 1     Fields:    Translation:HumansCells
    6. Xiang W, Quadery TM, Hamel E, Luckett-Chastain LR, Ihnat MA, Mooberry SL, Gangjee A. The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity. Bioorg Med Chem. 2021 01 01; 29:115887. PMID: 33310545.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    7. Ojeda AS, Ford SD, Gallucci RM, Ihnat MA, Philp RP. Geochemical characterization and renal cell toxicity of water-soluble extracts from U.S. Gulf Coast lignite. Environ Geochem Health. 2019 Apr; 41(2):1037-1053. PMID: 30276587.
      Citations: 1     Fields:    Translation:HumansCells
    8. Devambatla RKV, Choudhary S, Ihnat M, Hamel E, Mooberry SL, Gangjee A. Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential. Bioorg Med Chem Lett. 2018 10 01; 28(18):3085-3093. PMID: 30098869.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. Xia D, Lai DV, Wu W, Webb ZD, Yang Q, Zhao L, Yu Z, Thorpe JE, Disch BC, Ihnat MA, Jayaraman M, Dhanasekaran DN, Stratton KL, Cookson MS, Fung KM, Lin HK. Transition from androgenic to neurosteroidal action of 5a-androstane-3a, 17ß-diol through the type A ?-aminobutyric acid receptor in prostate cancer progression. J Steroid Biochem Mol Biol. 2018 04; 178:89-98. PMID: 29155210.
      Citations: 6     Fields:    Translation:HumansCells
    10. Eckert J, Scott B, Lawrence SM, Ihnat M, Chaaban H. FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis. J Inflamm Res. 2017; 10:75-81. PMID: 28652797.
      Citations: 4     
    11. Ziegler J, Bastian A, Lerner M, Bailey-Downs L, Saunders D, Smith N, Sutton J, Battiste JD, Ihnat MA, Gangjee A, Towner RA. AG488 as a therapy against gliomas. Oncotarget. 2017 Sep 22; 8(42):71833-71844. PMID: 29069750.
      Citations: 2     Fields:    
    12. Luckett-Chastain LR, Cottrell ML, Kawar BM, Ihnat MA, Gallucci RM. Interleukin (IL)-6 modulates transforming growth factor-ß receptor I and II (TGF-ßRI and II) function in epidermal keratinocytes. Exp Dermatol. 2017 08; 26(8):697-704. PMID: 27892604.
      Citations: 4     Fields:    Translation:AnimalsCells
    13. Zaware N, Kisliuk R, Bastian A, Ihnat MA, Gangjee A. Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. Bioorg Med Chem Lett. 2017 04 01; 27(7):1602-1607. PMID: 28258797.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    14. Bastian A, Matsuzaki S, Humphries KM, Pharaoh GA, Doshi A, Zaware N, Gangjee A, Ihnat MA. AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1a stabilization. Cancer Lett. 2017 03 01; 388:149-157. PMID: 27939695.
      Citations: 17     Fields:    Translation:HumansAnimals
    15. Pavana RK, Choudhary S, Bastian A, Ihnat MA, Bai R, Hamel E, Gangjee A. Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents. Bioorg Med Chem. 2017 01 15; 25(2):545-556. PMID: 27894589.
      Citations: 4     Fields:    Translation:HumansCells
    16. Hurst RE, Bastian A, Bailey-Downs L, Ihnat MA. Targeting dormant micrometastases: rationale, evidence to date and clinical implications. Ther Adv Med Oncol. 2016 Mar; 8(2):126-37. PMID: 26929788.
      Citations: 14     
    17. Towner RA, Ihnat M, Saunders D, Bastian A, Smith N, Pavana RK, Gangjee A. A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model. BMC Cancer. 2015 Jul 17; 15:522. PMID: 26177924.
      Citations: 8     Fields:    Translation:AnimalsCells
    18. Crosby HA, Ihnat M, Spencer D, Miller KE. Expression of Glutaminase and Vesicular Glutamate Transporter Type 2 Immunoreactivity in Rat Sacral Dorsal Root Ganglia Following a Surgical Tail Incision. Pharm Pharmacol Int J. 2015; 2(3). PMID: 29888768.
    19. Hurst RE, Hauser PJ, You Y, Bailey-Downs LC, Bastian A, Matthews SM, Thorpe J, Earle C, Bourguignon LY, Ihnat MA. Identification of novel drugs to target dormant micrometastases. BMC Cancer. 2015 May 14; 15:404. PMID: 25971923.
      Citations: 7     Fields:    Translation:AnimalsCells
    20. Zhang X, Raghavan S, Ihnat M, Hamel E, Zammiello C, Bastian A, Mooberry SL, Gangjee A. The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents. Bioorg Med Chem. 2015 May 15; 23(10):2408-23. PMID: 25882519.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    21. Crosby HA, Ihnat M, Miller KE. Evaluating the Toxicity of the Analgesic Glutaminase Inhibitor 6-Diazo-5-Oxo-L-Norleucine in vitro and on Rat Dermal Skin Fibroblasts. MOJ Toxicol. 2015; 1(1). PMID: 29750203.
      Citations: 4     
    22. Bastian A, Thorpe JE, Disch BC, Bailey-Downs LC, Gangjee A, Devambatla RK, Henthorn J, Humphries KM, Vadvalkar SS, Ihnat MA. A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer. J Pharmacol Exp Ther. 2015 May; 353(2):392-404. PMID: 25720766.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    23. Bailey-Downs LC, Thorpe JE, Disch BC, Bastian A, Hauser PJ, Farasyn T, Berry WL, Hurst RE, Ihnat MA. Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression. PLoS One. 2014; 9(5):e98624. PMID: 24878664.
      Citations: 38     Fields:    Translation:AnimalsCells
    24. Kim TD, Fuchs JR, Schwartz E, Abdelhamid D, Etter J, Berry WL, Li C, Ihnat MA, Li PK, Janknecht R. Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. Am J Transl Res. 2014; 6(3):236-47. PMID: 24936217.
      Citations: 36     
    25. Zhang X, Raghavan S, Ihnat M, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Dybdal-Hargreaves NF, Rohena CC, Hamel E, Mooberry SL, Gangjee A. The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents. Bioorg Med Chem. 2014 Jul 15; 22(14):3753-72. PMID: 24890652.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    26. Gangjee A, Pavana RK, Ihnat MA, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Hamel E, Bai R. Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential. ACS Med Chem Lett. 2014 May 08; 5(5):480-4. PMID: 24900865.
      Citations: 13     
    27. Pathuri G, Hedrick AF, Awasthi V, Ihnat MA, Gali H. Evaluation of 99mTc-probestin for imaging APN expressing tumors by SPECT. Bioorg Med Chem Lett. 2013 Sep 15; 23(18):5049-52. PMID: 23937983.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    28. Hurst RE, Hauser PJ, Kyker KD, Heinlen JE, Hodde JP, Hiles MC, Kosanke SD, Dozmorov M, Ihnat MA. Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: a model for tumor cell "dormancy". PLoS One. 2013; 8(5):e64181. PMID: 23717563.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    29. Pathuri G, Thorpe JE, Disch BC, Bailey-Downs LC, Ihnat MA, Gali H. Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor. Bioorg Med Chem Lett. 2013 Jun 15; 23(12):3561-4. PMID: 23664876.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    30. Gangjee A, Zaware N, Raghavan S, Disch BC, Thorpe JE, Bastian A, Ihnat MA. Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents. Bioorg Med Chem. 2013 Apr 01; 21(7):1857-64. PMID: 23434139.
      Citations: 4     Fields:    Translation:HumansCells
    31. Gangjee A, Namjoshi OA, Yu J, Ihnat MA, Thorpe JE, Bailey-Downs LC. N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents. Bioorg Med Chem. 2013 Mar 01; 21(5):1312-23. PMID: 23375090.
      Citations:    Fields:    Translation:HumansAnimalsCells
    32. Pathuri G, Hedrick AF, Disch BC, Ihnat MA, Awasthi V, Gali H. Synthesis and biodistribution studies of technetium-99m-labeled aminopeptidase N inhibitor conjugates. Bioorg Med Chem Lett. 2012 Jul 15; 22(14):4567-70. PMID: 22727671.
      Citations: 3     Fields:    Translation:AnimalsCells
    33. Gangjee A, Zhao Y, Ihnat MA, Thorpe JE, Bailey-Downs LC, Kisliuk RL. Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents. Bioorg Med Chem. 2012 Jul 15; 20(14):4217-25. PMID: 22739090.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    34. Luckett-Chastain LR, Ihnat MA, Mickle-Kawar BM, Gallucci RM. SOCS3 modulates interleukin-6R signaling preference in dermal fibroblasts. J Interferon Cytokine Res. 2012 May; 32(5):207-15. PMID: 22313262.
      Citations: 3     Fields:    Translation:AnimalsCells
    35. Gangjee A, Zaware N, Raghavan S, Yang J, Thorpe JE, Ihnat MA. N4-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation. Bioorg Med Chem. 2012 Apr 01; 20(7):2444-54. PMID: 22370340.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    36. Dandajena TC, Ihnat MA, Disch B, Thorpe J, Currier GF. Hypoxia triggers a HIF-mediated differentiation of peripheral blood mononuclear cells into osteoclasts. Orthod Craniofac Res. 2012 Feb; 15(1):1-9. PMID: 22264322.
      Citations: 17     Fields:    Translation:HumansCells
    37. Pathuri G, Hedrick AF, Disch BC, Doan JT, Ihnat MA, Awasthi V, Gali H. Synthesis and evaluation of novel Tc-99m labeled probestin conjugates for imaging APN/CD13 expression in vivo. Bioconjug Chem. 2012 Jan 18; 23(1):115-24. PMID: 22148582.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    38. Gangjee A, Kurup S, Ihnat MA, Thorpe JE, Disch B. N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors. Bioorg Med Chem. 2012 Jan 15; 20(2):910-4. PMID: 22204741.
      Citations: 3     Fields:    Translation:HumansCells
    39. Longeras R, Farjo K, Ihnat M, Ma JX. A PEDF-derived peptide inhibits retinal neovascularization and blocks mobilization of bone marrow-derived endothelial progenitor cells. Exp Diabetes Res. 2012; 2012:518426. PMID: 21754923.
      Citations: 26     Fields:    Translation:AnimalsCells
    40. Mondalek FG, Ashley RA, Roth CC, Kibar Y, Shakir N, Ihnat MA, Fung KM, Grady BP, Kropp BP, Lin HK. Enhanced angiogenesis of modified porcine small intestinal submucosa with hyaluronic acid-poly(lactide-co-glycolide) nanoparticles: from fabrication to preclinical validation. J Biomed Mater Res A. 2010 Sep 01; 94(3):712-9. PMID: 20213816.
      Citations: 18     Fields:    Translation:HumansAnimals
    41. Ceriello A, Ihnat MA. 'Glycaemic variability': a new therapeutic challenge in diabetes and the critical care setting. Diabet Med. 2010 Aug; 27(8):862-7. PMID: 20653741.
      Citations: 87     Fields:    Translation:Humans
    42. Ceriello A, Esposito K, Ihnat M, Thorpe J, Giugliano D. Effect of acute hyperglycaemia, long-term glycaemic control and insulin on endothelial dysfunction and inflammation in Type 1 diabetic patients with different characteristics. Diabet Med. 2010 Aug; 27(8):911-7. PMID: 20653749.
      Citations: 13     Fields:    Translation:Humans
    43. Ceriello A, Ihnat M. Oxidative stress is, convincingly, the mediator of the dangerous effects of glucose variability. Diabet Med. 2010 Aug; 27(8):968. PMID: 20653758.
      Citations: 4     Fields:    Translation:Humans
    44. Gangjee A, Zhao Y, Raghavan S, Ihnat MA, Disch BC. Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents. Bioorg Med Chem. 2010 Jul 15; 18(14):5261-73. PMID: 20558072.
      Citations: 4     Fields:    Translation:HumansCells
    45. Gangjee A, Kurup S, Ihnat MA, Thorpe JE, Shenoy SS. Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents. Bioorg Med Chem. 2010 May 15; 18(10):3575-87. PMID: 20403700.
      Citations: 6     Fields:    Translation:AnimalsCells
    46. Gangjee A, Namjoshi OA, Ihnat MA, Buchanan A. The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines. Bioorg Med Chem Lett. 2010 May 15; 20(10):3177-81. PMID: 20403693.
      Citations: 4     Fields:    Translation:HumansCells
    47. Lin L, Hutzen B, Zuo M, Ball S, Deangelis S, Foust E, Pandit B, Ihnat MA, Shenoy SS, Kulp S, Li PK, Li C, Fuchs J, Lin J. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res. 2010 Mar 15; 70(6):2445-54. PMID: 20215512.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    48. Pantazis P, Varman A, Simpson-Durand C, Thorpe J, Ramalingam S, Subramaniam D, Houchen C, Ihnat M, Anant S, Ramanujam RP. Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo. Altern Ther Health Med. 2010 Mar-Apr; 16(2):12-4. PMID: 20232614.
      Citations: 5     Fields:    Translation:HumansAnimals
    49. Gangjee A, Zaware N, Raghavan S, Ihnat M, Shenoy S, Kisliuk RL. Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. J Med Chem. 2010 Feb 25; 53(4):1563-78. PMID: 20092323.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    50. Gangjee A, Li W, Lin L, Zeng Y, Ihnat M, Warnke LA, Green DW, Cody V, Pace J, Queener SF. Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. Bioorg Med Chem. 2009 Oct 15; 17(20):7324-36. PMID: 19748785.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    51. Tuller ER, Beavers CT, Lou JR, Ihnat MA, Benbrook DM, Ding WQ. Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling. Mol Pharmacol. 2009 Sep; 76(3):588-95. PMID: 19528198.
      Citations: 19     Fields:    Translation:HumansCells
    52. Ceriello A, Esposito K, Ihnat M, Thorpe J, Giugliano D. Long-term glycemic control influences the long-lasting effect of hyperglycemia on endothelial function in type 1 diabetes. J Clin Endocrinol Metab. 2009 Aug; 94(8):2751-6. PMID: 19491221.
      Citations: 30     Fields:    Translation:Humans
    53. Ceriello A, Esposito K, Ihnat M, Zhang J, Giugliano D. Simultaneous control of hyperglycemia and oxidative stress normalizes enhanced thrombin generation in type 1 diabetes. J Thromb Haemost. 2009 Jul; 7(7):1228-30. PMID: 19422461.
      Citations: 4     Fields:    Translation:Humans
    54. Kozul CD, Hampton TH, Davey JC, Gosse JA, Nomikos AP, Eisenhauer PL, Weiss DJ, Thorpe JE, Ihnat MA, Hamilton JW. Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung. Environ Health Perspect. 2009 Jul; 117(7):1108-15. PMID: 19654921.
      Citations: 56     Fields:    Translation:Animals
    55. Ceriello A, Ihnat MA, Thorpe JE. Clinical review 2: The "metabolic memory": is more than just tight glucose control necessary to prevent diabetic complications? J Clin Endocrinol Metab. 2009 Feb; 94(2):410-5. PMID: 19066300.
      Citations: 130     Fields:    Translation:Humans
    56. Ceriello A, Esposito K, Piconi L, Ihnat M, Thorpe J, Testa R, Bonfigli AR, Giugliano D. Glucose "peak" and glucose "spike": Impact on endothelial function and oxidative stress. Diabetes Res Clin Pract. 2008 Nov; 82(2):262-7. PMID: 18950890.
      Citations: 37     Fields:    Translation:Humans
    57. Corgnali M, Piconi L, Ihnat M, Ceriello A. Evaluation of gliclazide ability to attenuate the hyperglycaemic 'memory' induced by high glucose in isolated human endothelial cells. Diabetes Metab Res Rev. 2008 May-Jun; 24(4):301-9. PMID: 18088078.
      Citations: 13     Fields:    Translation:HumansCells
    58. Gangjee A, Namjoshi OA, Yu J, Ihnat MA, Thorpe JE, Warnke LA. Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents. Bioorg Med Chem. 2008 May 15; 16(10):5514-28. PMID: 18467105.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    59. Wu M, Chen Y, Wilson K, Chirindel A, Ihnat MA, Yu Y, Boulton ME, Szweda LI, Ma JX, Lyons TJ. Intraretinal leakage and oxidation of LDL in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2008 Jun; 49(6):2679-85. PMID: 18362112.
      Citations: 53     Fields:    Translation:HumansCells
    60. Kozul CD, Nomikos AP, Hampton TH, Warnke LA, Gosse JA, Davey JC, Thorpe JE, Jackson BP, Ihnat MA, Hamilton JW. Laboratory diet profoundly alters gene expression and confounds genomic analysis in mouse liver and lung. Chem Biol Interact. 2008 May 28; 173(2):129-40. PMID: 18396267.
      Citations: 47     Fields:    Translation:AnimalsPHPublic Health
    61. Ceriello A, Esposito K, Piconi L, Ihnat MA, Thorpe JE, Testa R, Boemi M, Giugliano D. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes. 2008 May; 57(5):1349-54. PMID: 18299315.
      Citations: 460     Fields:    Translation:Humans
    62. Saban MR, Hellmich HL, Simpson C, Davis CA, Lang ML, Ihnat MA, O'Donnell MA, Wu XR, Saban R. Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins. BMC Cancer. 2007 Nov 02; 7:204. PMID: 17980030.
      Citations: 9     Fields:    Translation:Animals
    63. Sarasam AR, Samli AI, Hess L, Ihnat MA, Madihally SV. Blending chitosan with polycaprolactone: porous scaffolds and toxicity. Macromol Biosci. 2007 Sep 11; 7(9-10):1160-7. PMID: 17703475.
      Citations: 8     Fields:    Translation:Animals
    64. Saban R, Simpson C, Davis CA, Dozmorov I, Maier J, Fowler B, Ihnat MA, Hurst RE, Wershil BK, Saban MR. Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation. BMC Immunol. 2007 Aug 17; 8:17. PMID: 17705868.
      Citations: 10     Fields:    Translation:AnimalsCells
    65. Andrew AS, Bernardo V, Warnke LA, Davey JC, Hampton T, Mason RA, Thorpe JE, Ihnat MA, Hamilton JW. Exposure to arsenic at levels found inU.S. drinking water modifies expression in the mouse lung. Toxicol Sci. 2007 Nov; 100(1):75-87. PMID: 17682005.
      Citations: 28     Fields:    Translation:AnimalsCells
    66. Ihnat MA, Thorpe JE, Kamat CD, Szabó C, Green DE, Warnke LA, Lacza Z, Cselenyák A, Ross K, Shakir S, Piconi L, Kaltreider RC, Ceriello A. Reactive oxygen species mediate a cellular 'memory' of high glucose stress signalling. Diabetologia. 2007 Jul; 50(7):1523-31. PMID: 17508197.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    67. Ihnat MA, Thorpe JE, Ceriello A. Hypothesis: the 'metabolic memory', the new challenge of diabetes. Diabet Med. 2007 Jun; 24(6):582-6. PMID: 17490424.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    68. Saban R, D'Andrea MR, Andrade-Gordon P, Derian CK, Dozmorov I, Ihnat MA, Hurst RE, Simpson C, Saban MR. Regulatory network of inflammation downstream of proteinase-activated receptors. BMC Physiol. 2007 Mar 30; 7:3. PMID: 17397547.
      Citations: 18     Fields:    Translation:AnimalsCells
    69. Saban R, D'Andrea MR, Andrade-Gordon P, Derian CK, Dozmorov I, Ihnat MA, Hurst RE, Davis CA, Simpson C, Saban MR. Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation. BMC Physiol. 2007 Mar 30; 7:4. PMID: 17397548.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    70. Azzarello J, Ihnat MA, Kropp BP, Warnke LA, Lin HK. Assessment of angiogenic properties of biomaterials using the chicken embryo chorioallantoic membrane assay. Biomed Mater. 2007 Jun; 2(2):55-61. PMID: 18458436.
      Citations: 7     Fields:    Translation:Animals
    71. Kamat CD, Thorpe JE, Shenoy SS, Ceriello A, Green DE, Warnke LA, Ihnat MA. A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization. BMC Cardiovasc Disord. 2007 Jan 18; 7:4. PMID: 17233898.
      Citations: 6     Fields:    Translation:HumansCells
    72. Kamat CD, Green DE, Warnke L, Thorpe JE, Ceriello A, Ihnat MA. Mutant p53 facilitates pro-angiogenic, hyperproliferative phenotype in response to chronic relative hypoxia. Cancer Lett. 2007 May 08; 249(2):209-19. PMID: 16997458.
      Citations: 29     Fields:    Translation:HumansCells
    73. Gangjee A, Zeng Y, Ihnat M, Warnke LA, Green DW, Kisliuk RL, Lin FT. Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity. Bioorg Med Chem. 2005 Sep 15; 13(18):5475-91. PMID: 16039863.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    74. Kamat CD, Green DE, Curilla S, Warnke L, Hamilton JW, Sturup S, Clark C, Ihnat MA. Role of HIF signaling on tumorigenesis in response to chronic low-dose arsenic administration. Toxicol Sci. 2005 Aug; 86(2):248-57. PMID: 15888669.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    75. Hurst RE, Kamat CD, Kyker KD, Green DE, Ihnat MA. A novel multidrug resistance phenotype of bladder tumor cells grown on Matrigel or SIS gel. Cancer Lett. 2005 Jan 20; 217(2):171-80. PMID: 15617834.
      Citations: 8     Fields:    Translation:HumansCells
    76. Gangjee A, Yang J, Ihnat MA, Kamat S. Antiangiogenic and antitumor agents. Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases. Bioorg Med Chem. 2003 Nov 17; 11(23):5155-70. PMID: 14604679.
      Citations: 18     Fields:    Translation:HumansCells
    77. Soucy NV, Ihnat MA, Kamat CD, Hess L, Post MJ, Klei LR, Clark C, Barchowsky A. Arsenic stimulates angiogenesis and tumorigenesis in vivo. Toxicol Sci. 2003 Dec; 76(2):271-9. PMID: 12970581.
      Citations: 35     Fields:    Translation:Animals
    78. Shi J, Xiao Z, Ihnat MA, Kamat C, Pandit B, Hu Z, Li PK. Structure-activity relationships studies of the anti-angiogenic activities of linomide. Bioorg Med Chem Lett. 2003 Mar 24; 13(6):1187-9. PMID: 12643940.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    79. Marks MG, Shi J, Fry MO, Xiao Z, Trzyna M, Pokala V, Ihnat MA, Li PK. Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull. 2002 May; 25(5):597-604. PMID: 12033499.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    80. Kaltreider RC, Pesce CA, Ihnat MA, Lariviere JP, Hamilton JW. Differential effects of arsenic(III) and chromium(VI) on nuclear transcription factor binding. Mol Carcinog. 1999 Jul; 25(3):219-29. PMID: 10411148.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    81. Maurer BJ, Ihnat MA, Morgan C, Pullman J, O'Brien C, Johnson SW, Rasey JS, Cornwell MM. Growth of human tumor cells in macroporous microcarriers results in p53-independent, decreased cisplatin sensitivity relative to monolayers. Mol Pharmacol. 1999 May; 55(5):938-47. PMID: 10220573.
      Citations: 2     Fields:    Translation:HumansCells
    82. Ihnat MA, Nervi AM, Anthony SP, Kaltreider RC, Warren AJ, Pesce CA, Davis SA, Lariviere JP, Hamilton JW. Effects of mitomycin C and carboplatin pretreatment on multidrug resistance-associated P-glycoprotein expression and on subsequent suppression of tumor growth by doxorubicin and paclitaxel in human metastatic breast cancer xenografted nude mice. Oncol Res. 1999; 11(7):303-10. PMID: 10757444.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    83. Hamilton JW, Kaltreider RC, Bajenova OV, Ihnat MA, McCaffrey J, Turpie BW, Rowell EE, Oh J, Nemeth MJ, Pesce CA, Lariviere JP. Molecular basis for effects of carcinogenic heavy metals on inducible gene expression. Environ Health Perspect. 1998 Aug; 106 Suppl 4:1005-15. PMID: 9703486.
      Citations: 32     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    84. Bentivegna CS, Ihnat MA, Baptiste NS, Hamilton JW. Developmental regulation of the 3-methylcholanthrene- and dioxin-inducible CYP1A5 gene in chick embryo liver in vivo. Toxicol Appl Pharmacol. 1998 Jul; 151(1):166-73. PMID: 9705900.
      Citations: 1     Fields:    Translation:Animals
    85. Warren AJ, Ihnat MA, Ogdon SE, Rowell EE, Hamilton JW. Binding of nuclear proteins associated with mammalian DNA repair to the mitomycin C-DNA interstrand crosslink. Environ Mol Mutagen. 1998; 31(1):70-81. PMID: 9464318.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    86. Ihnat MA, Lariviere JP, Warren AJ, La Ronde N, Blaxall JR, Pierre KM, Turpie BW, Hamilton JW. Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents. Clin Cancer Res. 1997 Aug; 3(8):1339-46. PMID: 9815817.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    87. Abdel-Ghany YS, Ihnat MA, Miller DD, Kunin CM, Tong HH. Structure-activity relationship of glycine betaine analogs on osmotolerance of enteric bacteria. J Med Chem. 1993 Mar 19; 36(6):784-9. PMID: 8459406.
      Citations: 1     Fields:    Translation:Cells
    88. Kato G, Yung J, Ihnat M. Nuclear magnetic resonance studies on acetylcholinesterase. The use of atropine and eserine to probe binding sites. Mol Pharmacol. 1970 Nov; 6(6):588-96. PMID: 5497711.
      Citations: 1     Fields:    Translation:Cells
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