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Xi-Qin Ding

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCell Biology
AddressBMSB 553
940 Stanton L Young Blvd
Oklahoma City OK 73104
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    Collapse Research 
    Collapse research activities and funding
    R01EY033841     (DING, XI-QIN)Sep 1, 2022 - Apr 30, 2026
    NIH
    Thyroid Hormone Signaling and Cone Photoreceptor Degeneration
    Role: Principal Investigator
    R01EY027754     (DING, XI-QIN)Sep 1, 2017 - Jun 30, 2021
    NIH
    The Role of Endoplasmic Reticulum Calcium Channels in Cone Degeneration Resulting from CNG Channel Deficiency
    Role: Principal Investigator
    R21EY024583     (DING, XI-QIN)Sep 30, 2014 - Sep 29, 2017
    NIH
    Suppressing thyroid hormone signaling to protect cones in retinal degeneration
    Role: Principal Investigator
    R01EY019490     (DING, XI-QIN)Aug 1, 2010 - Jun 30, 2016
    NIH
    Mechanism of Cone Degeneration Resulting from CNG Channel Deficiency
    Role: Principal Investigator
    R21EY017031     (DING, XI-QIN)Aug 1, 2006 - Jul 31, 2009
    NIH
    Using Nanotechnology to Rescue Visual Loss in A Model of Human Blinding Disorder
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Li S, Ma H, Yang F, Ding XQ. Stimulation of Thyroid Hormone Signaling Induces Stress Responses in Mouse Retina. Adv Exp Med Biol. 2025; 1468:273-277. PMID: 39930208.
      Citations:    Fields:    Translation:AnimalsCells
    2. Ma H, Yang F, York LR, Li S, Ding XQ. Excessive Thyroid Hormone Signaling Induces Photoreceptor Degeneration in Mice. eNeuro. 2023 09; 10(9). PMID: 37596046; PMCID: PMC10481642.
      Citations: 11     Fields:    Translation:AnimalsCells
    3. Yang F, Ma H, Garg R, Lewin A, Ding XQ. Inhibition of Ryanodine Receptor 1 Reduces Endoplasmic Reticulum (ER) Stress and Promotes ER Protein Degradation in Cyclic Nucleotide-Gated Channel Deficiency. Adv Exp Med Biol. 2023; 1415:353-358. PMID: 37440056.
      Citations: 1     Fields:    Translation:AnimalsCells
    4. Ma H, Yang F, Ding XQ. Deficiency of thyroid hormone receptor protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration. Cell Death Dis. 2022 Mar 21; 13(3):255. PMID: 35314673.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    5. Ma H, Yang F, Ding XQ. Inhibition of thyroid hormone signaling protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration. Cell Death Dis. 2020 01 13; 11(1):24. PMID: 31932580.
      Citations: 35     Fields:    Translation:AnimalsCells
    6. Ma H, Yang F, Butler MR, Rapp J, Le YZ, Ding XQ. Ryanodine Receptor 2 Contributes to Impaired Protein Localization in Cyclic Nucleotide-Gated Channel Deficiency. eNeuro. 2019 May/Jun; 6(3). PMID: 31182474.
      Citations: 8     Fields:    Translation:AnimalsCells
    7. Yang F, Ma H, Boye SL, Hauswirth WW, Ding XQ. Overexpression of Type 3 Iodothyronine Deiodinase Reduces Cone Death in the Leber Congenital Amaurosis Model Mice. Adv Exp Med Biol. 2018; 1074:125-131. PMID: 29721936.
      Citations: 7     Fields:    Translation:AnimalsCells
    8. Yang F, Ma H, Ding XQ. Thyroid Hormone Signaling in Retinal Development, Survival, and Disease. Vitam Horm. 2018; 106:333-349. PMID: 29407441.
      Citations: 12     Fields:    Translation:HumansAnimals
    9. Butler MR, Ma H, Yang F, Belcher J, Le YZ, Mikoshiba K, Biel M, Michalakis S, Iuso A, Križaj D, Ding XQ. Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency. J Biol Chem. 2017 07 07; 292(27):11189-11205. PMID: 28495882.
      Citations: 24     Fields:    Translation:AnimalsCells
    10. Ma H, Yang F, Butler MR, Belcher J, Redmond TM, Placzek AT, Scanlan TS, Ding XQ. Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration. FASEB J. 2017 08; 31(8):3425-3438. PMID: 28428265.
      Citations: 11     Fields:    Translation:AnimalsCells
    11. Yang F, Ma H, Belcher J, Butler MR, Redmond TM, Boye SL, Hauswirth WW, Ding XQ. Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration. FASEB J. 2016 12; 30(12):4313-4325. PMID: 27623928.
      Citations: 19     Fields:    Translation:AnimalsCells
    12. Ding XQ, Thapa A, Ma H, Xu J, Elliott MH, Rodgers KK, Smith ML, Wang JS, Pittler SJ, Kefalov VJ. The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility. J Biol Chem. 2016 Apr 15; 291(16):8721-34. PMID: 26893377.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    13. Ma H, Ding XQ. Thyroid Hormone Signaling and Cone Photoreceptor Viability. Adv Exp Med Biol. 2016; 854:613-8. PMID: 26427466.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    14. Ma H, Butler MR, Thapa A, Belcher J, Yang F, Baehr W, Biel M, Michalakis S, Ding XQ. cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice. J Biol Chem. 2015 Aug 21; 290(34):20880-20892. PMID: 26124274.
      Citations: 31     Fields:    Translation:AnimalsCells
    15. Ding XQ, Matveev A, Singh A, Komori N, Matsumoto H. Exploration of cone cyclic nucleotide-gated channel-interacting proteins using affinity purification and mass spectrometry. Adv Exp Med Biol. 2014; 801:57-65. PMID: 24664681.
      Citations: 1     Fields:    Translation:AnimalsCells
    16. Ding XQ, Matveev A, Singh A, Komori N, Matsumoto H. Biochemical characterization of cone cyclic nucleotide-gated (CNG) channel using the infrared fluorescence detection system. Adv Exp Med Biol. 2012; 723:769-75. PMID: 22183405.
      Citations: 13     Fields:    Translation:AnimalsCells
    17. Ding XQ, Fitzgerald JB, Quiambao AB, Harry CS, Malykhina AP. Molecular pathogenesis of achromatopsia associated with mutations in the cone cyclic nucleotide-gated channel CNGA3 subunit. Adv Exp Med Biol. 2010; 664:245-53. PMID: 20238023.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    18. Ding XQ, Quiambao AB, Fitzgerald JB, Cooper MJ, Conley SM, Naash MI. Ocular delivery of compacted DNA-nanoparticles does not elicit toxicity in the mouse retina. PLoS One. 2009 Oct 12; 4(10):e7410. PMID: 19823583.
      Citations: 43     Fields:    Translation:Animals
    19. Ding XQ, Harry CS, Umino Y, Matveev AV, Fliesler SJ, Barlow RB. Impaired cone function and cone degeneration resulting from CNGB3 deficiency: down-regulation of CNGA3 biosynthesis as a potential mechanism. Hum Mol Genet. 2009 Dec 15; 18(24):4770-80. PMID: 19767295.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    20. Ding XQ, Fitzgerald JB, Matveev AV, McClellan ME, Elliott MH. Functional activity of photoreceptor cyclic nucleotide-gated channels is dependent on the integrity of cholesterol- and sphingolipid-enriched membrane domains. Biochemistry. 2008 Mar 25; 47(12):3677-87. PMID: 18303857.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
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