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Arlan G. Richardson

TitleProf of Research
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
AddressBRC 1303
975 NE 10th St
Oklahoma City OK 73104
Phone405/456-3551
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    Collapse Research 
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    P30AG013319     (STRONG, RANDY)May 31, 2025
    NIH
    San Antonio Nathan Shock Center of Excellence in the Biology of Aging
    Role: Co-Principal Investigator

    R01AG001548     (RICHARDSON, ARLAN G.)Jul 1, 1979 - Mar 31, 1999
    NIH
    EFFECT OF DIETARY RESTRICTION ON GENE EXPRESSION
    Role: Principal Investigator

    R01AG004520     (RICHARDSON, ARLAN G.)Dec 1, 1984 - Nov 30, 1987
    NIH
    EFFECT OF AGING ON GENE EXPRESSION
    Role: Principal Investigator

    R13AG006362     (RICHARDSON, ARLAN G.)Sep 1, 1986 - Nov 30, 1986
    NIH
    AGING AND CANCER
    Role: Principal Investigator

    R01AG006819     (RICHARDSON, ARLAN G.)May 1, 1988 - Apr 30, 1991
    NIH
    ROLE OF GENE EXPRESSION IN GLUCONEOGENESIS
    Role: Principal Investigator

    R13AG009763     (RICHARDSON, ARLAN G.)Aug 1, 1991 - Jul 31, 1992
    NIH
    1991 GORDON RESEARCH CONFERENCE ON THE BIOLOGY OF AGING
    Role: Principal Investigator

    R01ES006277     (RICHARDSON, ARLAN G.)Jan 1, 1993 - Dec 31, 1996
    NIH
    ROLE OF METALLOTHIONEIN IN CELLULAR PROTECTION
    Role: Principal Investigator

    T35AG000230     (WARD, WALTER FREDERICK)May 1, 1993 - Apr 30, 2001
    NIH
    SHORT-TERM TRAINING STUDENTS IN HEALTH PROFESSIONAL SCHO
    Role: Co-Principal Investigator

    R13AG012917     (RICHARDSON, ARLAN G.)Apr 1, 1995 - May 31, 2018
    NIH
    Summer Training Course in Aging Research
    Role: Principal Investigator

    R01AG015134     (RICHARDSON, ARLAN G.)Apr 3, 1997 - Apr 30, 1998
    NIH
    TRANSGENIC MODELS TESTING ROLE OF DNA DAMAGE IN AGING
    Role: Principal Investigator

    P01AG014674     (RICHARDSON, ARLAN G.)May 1, 1998 - Apr 30, 2004
    NIH
    NUTRITIONAL PROBE OF THE AGING PROCESS
    Role: Principal Investigator

    R01AG015908     (RICHARDSON, ARLAN G.)Jul 15, 1998 - Jun 30, 2002
    NIH
    TRANSGENIC MICE, AGING, CANCER, AND OXIDATIVE DAMAGE
    Role: Principal Investigator

    R01AG023843     (RICHARDSON, ARLAN G.)Sep 15, 2003 - Aug 31, 2008
    NIH
    Role of Oxidative Damage to Specific Molecules in Aging
    Role: Principal Investigator

    R37AG026557     (RICHARDSON, ARLAN G.)Sep 15, 2005 - Aug 31, 2010
    NIH
    Protein Oxidation as a Factor in the Mechanism of Aging
    Role: Principal Investigator

    RC2AG036613     (RICHARDSON, ARLAN G.)Sep 30, 2009 - Aug 31, 2012
    NIH
    Can Rapamycin Retard Age-Related Diseases?
    Role: Principal Investigator

    I01BX000547     (RICHARDSON, ARLAN G.)Apr 1, 2011 - Mar 31, 2015
    NIH
    Does overexpressing Cu/Zn superoxide dismutase retard aging in rodents
    Role: Principal Investigator

    R01AG045693     (RICHARDSON, ARLAN G.)Aug 1, 2014 - Apr 30, 2021
    NIH
    Interaction of Genotype and Level of Dietary Restriction on Lifespan and Aging
    Role: Principal Investigator

    IS1BX003095     (RICHARDSON, ARLAN G.)Jan 1, 2015 - Sep 30, 2015
    NIH
    Multiplex Protein Quantification Core
    Role: Principal Investigator

    P30AG050911     (RICHARDSON, ARLAN G.)Jul 15, 2015 - May 31, 2025
    NIH
    Oklahoma Nathan Shock Center of Excellence in Basic Biology of Aging
    Role: Co-Principal Investigator

    R01AG057424     (RICHARDSON, ARLAN G.)Sep 15, 2017 - May 31, 2022
    NIH
    TESTING THE ABILITY OF NOVEL ASSAYS OF RESILIENCE TO PREDICT LIFESPAN
    Role: Principal Investigator

    I01BX004538     (RICHARDSON, ARLAN G.)Apr 1, 2019 - Sep 30, 2023
    NIH
    Does Necroptosis Play a Role in Inflammation and Aging
    Role: Principal Investigator

    R21AG062894     (RICHARDSON, ARLAN G.)May 1, 2019 - Jan 31, 2022
    NIH
    Does Dietary Restriction Alter Stem Cell Function Through An Epigenetic Mechanism?
    Role: Principal Investigator

    IS1BX005032     (RICHARDSON, ARLAN G.)Sep 1, 2019 - Sep 30, 2020
    NIH
    ShEEP Request for Cell Sorter
    Role: Principal Investigator

    IK6BX005238     (RICHARDSON, ARLAN G.)Apr 1, 2020 - Mar 31, 2027
    NIH
    BLR&D Research Career Scientist Award Application
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Towner RA, Gulej R, Zalles M, Saunders D, Smith N, Lerner M, Morton KA, Richardson A. Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model. Geroscience. 2021 04; 43(2):563-578. PMID: 33846885.
      Citations:    Fields:    
    2. Kurup K, Matyi S, Giles CB, Wren JD, Jones K, Ericsson A, Raftery D, Wang L, Promislow D, Richardson A, Unnikrishnan A. Calorie restriction prevents age-related changes in the intestinal microbiota. Aging (Albany NY). 2021 03 10; 13(5):6298-6329. PMID: 33744869.
      Citations:    Fields:    
    3. Richardson A. You Have Come A Long Way Baby: Five Decades of Research on the Biology of Aging From the Perspective of a Researcher Studying Aging. J Gerontol A Biol Sci Med Sci. 2021 Jan 01; 76(1):57-63. PMID: 32840294.
      Citations:    Fields:    
    4. Chucair-Elliott AJ, Ocañas SR, Stanford DR, Ansere VA, Buettner KB, Porter H, Eliason NL, Reid JJ, Sharpe AL, Stout MB, Beckstead MJ, Miller BF, Richardson A, Freeman WM. Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia. Commun Biol. 2020 11 19; 3(1):693. PMID: 33214681.
      Citations:    
    5. Selvarani R, Mohammed S, Richardson A. Effect of rapamycin on aging and age-related diseases-past and future. Geroscience. 2021 Jun; 43(3):1135-1158. PMID: 33037985.
      Citations: 3     Fields:    
    6. Brown JL, Lawrence MM, Ahn B, Kneis P, Piekarz KM, Qaisar R, Ranjit R, Bian J, Pharaoh G, Brown C, Peelor FF, Kinter MT, Miller BF, Richardson A, Van Remmen H. Cancer cachexia in a mouse model of oxidative stress. J Cachexia Sarcopenia Muscle. 2020 12; 11(6):1688-1704. PMID: 32918528.
      Citations: 4     Fields:    
    7. Bhaskaran S, Pollock N, C Macpherson P, Ahn B, Piekarz KM, Staunton CA, Brown JL, Qaisar R, Vasilaki A, Richardson A, McArdle A, Jackson MJ, Brooks SV, Van Remmen H. Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell. 2020 10; 19(10):e13225. PMID: 32886862.
      Citations: 3     Fields:    
    8. Pharaoh G, Brown JL, Sataranatarajan K, Kneis P, Bian J, Ranjit R, Hadad N, Georgescu C, Rabinovitch P, Ran Q, Wren JD, Freeman W, Kinter M, Richardson A, Van Remmen H. Targeting cPLA2 derived lipid hydroperoxides as a potential intervention for sarcopenia. Sci Rep. 2020 08 18; 10(1):13968. PMID: 32811851.
      Citations: 1     Fields:    Translation:AnimalsCells
    9. Sataranatarajan K, Pharaoh G, Brown JL, Ranjit R, Piekarz KM, Street K, Wren JD, Georgescu C, Kinter C, Kinter M, Freeman WM, Richardson A, Van Remmen H. Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia. Geroscience. 2020 08; 42(4):1101-1118. PMID: 32394347.
      Citations: 2     Fields:    Translation:Animals
    10. Unnikrishnan A, Kurup K, Salmon AB, Richardson A. Is Rapamycin a Dietary Restriction Mimetic? J Gerontol A Biol Sci Med Sci. 2020 01 01; 75(1):4-13. PMID: 30854544.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    11. Valcarcel-Ares MN, Tucsek Z, Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Galvan V, Ballabh P, Richardson A, Freeman WM, Wren JD, Deak F, Ungvari Z, Csiszar A. Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline. J Gerontol A Biol Sci Med Sci. 2019 02 15; 74(3):290-298. PMID: 29893815.
      Citations: 18     Fields:    Translation:Animals
    12. Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H. Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching. J Cachexia Sarcopenia Muscle. 2019 04; 10(2):411-428. PMID: 30706998.
      Citations: 13     Fields:    
    13. Unnikrishnan A, Freeman WM, Jackson J, Wren JD, Porter H, Richardson A. The role of DNA methylation in epigenetics of aging. Pharmacol Ther. 2019 03; 195:172-185. PMID: 30419258.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    14. Qaisar R, Bhaskaran S, Premkumar P, Ranjit R, Natarajan KS, Ahn B, Riddle K, Claflin DR, Richardson A, Brooks SV, Van Remmen H. Oxidative stress-induced dysregulation of excitation-contraction coupling contributes to muscle weakness. J Cachexia Sarcopenia Muscle. 2018 10; 9(5):1003-1017. PMID: 30073804.
      Citations: 14     Fields:    Translation:AnimalsCells
    15. Deepa SS, Van Remmen H, Brooks SV, Faulkner JA, Larkin L, McArdle A, Jackson MJ, Vasilaki A, Richardson A. Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice. Free Radic Biol Med. 2019 02 20; 132:19-23. PMID: 30670156.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    16. Deepa SS, Unnikrishnan A, Matyi S, Hadad N, Richardson A. Necroptosis increases with age and is reduced by dietary restriction. Aging Cell. 2018 08; 17(4):e12770. PMID: 29696779.
      Citations: 10     Fields:    Translation:Animals
    17. Deepa SS, Pharaoh G, Kinter M, Diaz V, Fok WC, Riddle K, Pulliam D, Hill S, Fischer KE, Soto V, Georgescu C, Wren JD, Viscomi C, Richardson A, Van Remmen H. Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice. Aging Cell. 2018 08; 17(4):e12769. PMID: 29696791.
      Citations: 5     Fields:    Translation:AnimalsCells
    18. Logan S, Owen D, Chen S, Chen WJ, Ungvari Z, Farley J, Csiszar A, Sharpe A, Loos M, Koopmans B, Richardson A, Sonntag WE. Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice. Geroscience. 2018 04; 40(2):123-137. PMID: 29687240.
      Citations: 12     Fields:    Translation:Animals
    19. Hadad N, Unnikrishnan A, Jackson JA, Masser DR, Otalora L, Stanford DR, Richardson A, Freeman WM. Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylation. Neurobiol Aging. 2018 07; 67:53-66. PMID: 29631215.
      Citations: 7     Fields:    Translation:AnimalsCells
    20. Snider TA, Richardson A, Stoner JA, Deepa SS. The Geropathology Grading Platform demonstrates that mice null for Cu/Zn-superoxide dismutase show accelerated biological aging. Geroscience. 2018 04; 40(2):97-103. PMID: 29478190.
      Citations: 9     Fields:    Translation:Animals
    21. Unnikrishnan A, Hadad N, Masser DR, Jackson J, Freeman WM, Richardson A. Revisiting the genomic hypomethylation hypothesis of aging. Ann N Y Acad Sci. 2018 04; 1418(1):69-79. PMID: 29363785.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    22. Masser DR, Hadad N, Porter HL, Mangold CA, Unnikrishnan A, Ford MM, Giles CB, Georgescu C, Dozmorov MG, Wren JD, Richardson A, Stanford DR, Freeman WM. Sexually divergent DNA methylation patterns with hippocampal aging. Aging Cell. 2017 12; 16(6):1342-1352. PMID: 28948711.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    23. Unnikrishnan A, Jackson J, Matyi SA, Hadad N, Wronowski B, Georgescu C, Garrett KP, Wren JD, Freeman WM, Richardson A. Role of DNA methylation in the dietary restriction mediated cellular memory. Geroscience. 2017 06; 39(3):331-345. PMID: 28477138.
      Citations: 8     Fields:    Translation:AnimalsCells
    24. Deepa SS, Bhaskaran S, Espinoza S, Brooks SV, McArdle A, Jackson MJ, Van Remmen H, Richardson A. A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse. Geroscience. 2017 04; 39(2):187-198. PMID: 28409332.
      Citations: 36     Fields:    Translation:Animals
    25. Hadad N, Masser DR, Logan S, Wronowski B, Mangold CA, Clark N, Otalora L, Unnikrishnan A, Ford MM, Giles CB, Wren JD, Richardson A, Sonntag WE, Stanford DR, Freeman W. Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice. Epigenetics Chromatin. 2016; 9:30. PMID: 27413395.
      Citations: 23     Fields:    
    26. Masser DR, Stanford DR, Hadad N, Giles CB, Wren JD, Sonntag WE, Richardson A, Freeman WM. Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation. Age (Dordr). 2016 Jun; 38(3):49. PMID: 27091453.
      Citations: 7     Fields:    Translation:AnimalsCells
    27. Richardson A, Austad SN, Ikeno Y, Unnikrishnan A, McCarter RJ. Significant life extension by ten percent dietary restriction. Ann N Y Acad Sci. 2016 Jan; 1363:11-7. PMID: 26695614.
      Citations: 4     Fields:    Translation:Animals
    28. Richardson A, Fischer KE, Speakman JR, de Cabo R, Mitchell SJ, Peterson CA, Rabinovitch P, Chiao YA, Taffet G, Miller RA, Rentería RC, Bower J, Ingram DK, Ladiges WC, Ikeno Y, Sierra F, Austad SN. Measures of Healthspan as Indices of Aging in Mice-A Recommendation. J Gerontol A Biol Sci Med Sci. 2016 Apr; 71(4):427-30. PMID: 26297941.
      Citations: 35     Fields:    Translation:HumansAnimals
    29. Sataranatarajan K, Qaisar R, Davis C, Sakellariou GK, Vasilaki A, Zhang Y, Liu Y, Bhaskaran S, McArdle A, Jackson M, Brooks SV, Richardson A, Van Remmen H. Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype. Redox Biol. 2015 Aug; 5:140-148. PMID: 25917273.
      Citations: 21     Fields:    Translation:AnimalsCells
    30. Richardson A, Galvan V, Lin AL, Oddo S. How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story. Exp Gerontol. 2015 Aug; 68:51-8. PMID: 25481271.
      Citations: 48     Fields:    Translation:AnimalsCells
    31. Richardson AG, Schadt EE. The role of macromolecular damage in aging and age-related disease. J Gerontol A Biol Sci Med Sci. 2014 Jun; 69 Suppl 1:S28-32. PMID: 24833583.
      Citations: 14     Fields:    Translation:Humans
    32. Han ES, Muller FL, Pérez VI, Qi W, Liang H, Xi L, Fu C, Doyle E, Hickey M, Cornell J, Epstein CJ, Roberts LJ, Van Remmen H, Richardson A. The in vivo gene expression signature of oxidative stress. Physiol Genomics. 2008 Jun 12; 34(1):112-26. PMID: 18445702.
      Citations: 79     Fields:    Translation:AnimalsCells
    33. Han ES, Wu Y, McCarter R, Nelson JF, Richardson A, Hilsenbeck SG. Reproducibility, sources of variability, pooling, and sample size: important considerations for the design of high-density oligonucleotide array experiments. J Gerontol A Biol Sci Med Sci. 2004 Apr; 59(4):306-15. PMID: 15071073.
      Citations: 18     Fields:    Translation:Animals
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