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Paul L DeAngelis

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
AddressBMSB 842A
940 Stanton L Young Blvd
Oklahoma City OK 73104
Phone405/271-2227
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    Collapse Research 
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    R01GM056497     (DEANGELIS, PAUL L)Jul 1, 1997 - Jun 30, 2003
    NIH
    EUKARYOTIC HYALURONAN SYNTHASES
    Role: Principal Investigator

    R01HL062244     (LINHARDT, ROBERT J)Dec 15, 2000 - Dec 31, 2017
    NIH
    Synthetic Heparan Sulfate: Probing Biosynthesis to Prepare Defined Drugs
    Role: Co-Principal Investigator

    R43CA159494     (JING, WEI)Aug 1, 2011 - Jul 31, 2014
    NIH
    HEPylated G-CSF: Drug with Safer, Enhanced Delivery for Neutropenia Treatment
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. DeAngelis PL. A Primer for Initiation of Commercialization of Glycobiological Discoveries. Glycobiology. 2021 Apr 01. PMID: 33822046.
      Citations:    Fields:    
    2. Giubertoni G, Pérez de Alba Ortíz A, Bano F, Zhang X, Linhardt RJ, Green DE, DeAngelis PL, Koenderink GH, Richter RP, Ensing B, Bakker HJ. Strong Reduction of the Chain Rigidity of Hyaluronan by Selective Binding of Ca2+ Ions. Macromolecules. 2021 Feb 09; 54(3):1137-1146. PMID: 33583956.
      Citations:    Fields:    
    3. Yang W, Wang L, Mettenbrink EM, DeAngelis PL, Wilhelm S. Nanoparticle Toxicology. Annu Rev Pharmacol Toxicol. 2021 01 06; 61:269-289. PMID: 32841092.
      Citations: 2     Fields:    
    4. Rivas F, Zahid OK, Reesink HL, Peal BT, Nixon AJ, DeAngelis PL, Skardal A, Rahbar E, Hall AR. Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor. Nat Commun. 2018 03 12; 9(1):1037. PMID: 29531292.
      Citations: 9     Fields:    Translation:HumansAnimals
    5. Jing W, Roberts JW, Green DE, Almond A, DeAngelis PL. Synthesis and characterization of heparosan-granulocyte-colony stimulating factor conjugates: a natural sugar-based drug delivery system to treat neutropenia. Glycobiology. 2017 11 01; 27(11):1052-1061. PMID: 28973394.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    6. Lane RS, Haller FM, Chavaroche AAE, Almond A, DeAngelis PL. Heparosan-coated liposomes for drug delivery. Glycobiology. 2017 11 01; 27(11):1062-1074. PMID: 29044377.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    7. Zhang X, Green DE, Schultz VL, Lin L, Han X, Wang R, Yaksic A, Kim SY, DeAngelis PL, Linhardt RJ. Synthesis of 4-Azido-N-acetylhexosamine Uridine Diphosphate Donors: Clickable Glycosaminoglycans. J Org Chem. 2017 09 15; 82(18):9910-9915. PMID: 28813597.
      Citations: 3     Fields:    Translation:Cells
    8. Lane RS, St Ange K, Zolghadr B, Liu X, Schäffer C, Linhardt RJ, DeAngelis PL. Expanding glycosaminoglycan chemical space: towards the creation of sulfated analogs, novel polymers and chimeric constructs. Glycobiology. 2017 07 01; 27(7):646-656. PMID: 28334971.
      Citations: 2     Fields:    
    9. Green DE, DeAngelis PL. Identification of a chondroitin synthase from an unexpected source, the green sulfur bacterium Chlorobium phaeobacteroides. Glycobiology. 2017 05 01; 27(5):469-476. PMID: 28104786.
      Citations:    Fields:    Translation:Cells
    10. Schultz VL, Zhang X, Linkens K, Rimel J, Green DE, DeAngelis PL, Linhardt RJ. Chemoenzymatic Synthesis of 4-Fluoro-N-Acetylhexosamine Uridine Diphosphate Donors: Chain Terminators in Glycosaminoglycan Synthesis. J Org Chem. 2017 02 17; 82(4):2243-2248. PMID: 28128958.
      Citations: 5     Fields:    Translation:Cells
    11. Schultz V, Suflita M, Liu X, Zhang X, Yu Y, Li L, Green DE, Xu Y, Zhang F, DeAngelis PL, Liu J, Linhardt RJ. Heparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c. J Biol Chem. 2017 02 10; 292(6):2495-2509. PMID: 28031461.
      Citations: 13     Fields:    Translation:AnimalsCells
    12. DeAngelis PL. Heparosan, a promising 'naturally good' polymeric conjugating vehicle for delivery of injectable therapeutics. Expert Opin Drug Deliv. 2015 Mar; 12(3):349-52. PMID: 25363378.
      Citations: 3     Fields:    
    13. Lauer ME, Hascall VC, Green DE, DeAngelis PL, Calabro A. Irreversible heavy chain transfer to chondroitin. J Biol Chem. 2014 Oct 17; 289(42):29171-9. PMID: 25135638.
      Citations: 2     Fields:    Translation:HumansCells
    14. Sterner E, Masuko S, Li G, Li L, Green DE, Otto NJ, Xu Y, DeAngelis PL, Liu J, Dordick JS, Linhardt RJ. Fibroblast growth factor-based signaling through synthetic heparan sulfate blocks copolymers studied using high cell density three-dimensional cell printing. J Biol Chem. 2014 Apr 04; 289(14):9754-65. PMID: 24563485.
      Citations: 11     Fields:    Translation:AnimalsCells
    15. Higman VA, Briggs DC, Mahoney DJ, Blundell CD, Sattelle BM, Dyer DP, Green DE, DeAngelis PL, Almond A, Milner CM, Day AJ. A refined model for the TSG-6 link module in complex with hyaluronan: use of defined oligosaccharides to probe structure and function. J Biol Chem. 2014 Feb 28; 289(9):5619-34. PMID: 24403066.
      Citations: 18     Fields:    Translation:HumansCells
    16. Li G, Masuko S, Green DE, Xu Y, Li L, Zhang F, Xue C, Liu J, DeAngelis PL, Linhardt RJ. N-sulfotestosteronan, a novel substrate for heparan sulfate 6-O-sulfotransferases and its analysis by oxidative degradation. Biopolymers. 2013 Oct; 99(10):675-85. PMID: 23606289.
      Citations: 4     Fields:    Translation:Cells
    17. DeAngelis PL, Liu J, Linhardt RJ. Chemoenzymatic synthesis of glycosaminoglycans: re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains. Glycobiology. 2013 Jul; 23(7):764-77. PMID: 23481097.
      Citations: 43     Fields:    Translation:AnimalsCells
    18. DeAngelis PL. Methods for the Pasteurella glycosaminoglycan synthases: enzymes that polymerize hyaluronan, chondroitin, or heparosan chains. Methods Mol Biol. 2013; 1022:215-27. PMID: 23765665.
      Citations: 2     Fields:    Translation:Cells
    19. Lauer ME, Glant TT, Mikecz K, DeAngelis PL, Haller FM, Husni ME, Hascall VC, Calabro A. Irreversible heavy chain transfer to hyaluronan oligosaccharides by tumor necrosis factor-stimulated gene-6. J Biol Chem. 2013 Jan 04; 288(1):205-14. PMID: 23166324.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    20. Siiskonen H, Rilla K, Kärnä R, Bart G, Jing W, Haller MF, DeAngelis PL, Tammi RH, Tammi MI. Hyaluronan in cytosol--microinjection-based probing of its existence and suggested functions. Glycobiology. 2013 Feb; 23(2):222-31. PMID: 23086746.
      Citations: 6     Fields:    Translation:HumansCells
    21. DeAngelis PL. Glycosaminoglycan polysaccharide biosynthesis and production: today and tomorrow. Appl Microbiol Biotechnol. 2012 Apr; 94(2):295-305. PMID: 22391966.
      Citations: 24     Fields:    Translation:Cells
    22. Masuko S, Bera S, Green DE, Weïwer M, Liu J, DeAngelis PL, Linhardt RJ. Chemoenzymatic synthesis of uridine diphosphate-GlcNAc and uridine diphosphate-GalNAc analogs for the preparation of unnatural glycosaminoglycans. J Org Chem. 2012 Feb 03; 77(3):1449-56. PMID: 22239739.
      Citations: 19     Fields:    Translation:Cells
    23. Otto NJ, Green DE, Masuko S, Mayer A, Tanner ME, Linhardt RJ, DeAngelis PL. Structure/function analysis of Pasteurella multocida heparosan synthases: toward defining enzyme specificity and engineering novel catalysts. J Biol Chem. 2012 Mar 02; 287(10):7203-12. PMID: 22235128.
      Citations: 10     Fields:    Translation:Cells
    24. Otto NJ, Solakyildirim K, Linhardt RJ, DeAngelis PL. Comamonas testosteronan synthase, a bifunctional glycosyltransferase that produces a unique heparosan polysaccharide analog. Glycobiology. 2011 Oct; 21(10):1331-40. PMID: 21610195.
      Citations: 3     Fields:    Translation:Cells
    25. Alvarez-Barreto JF, Landy B, VanGordon S, Place L, DeAngelis PL, Sikavitsas VI. Enhanced osteoblastic differentiation of mesenchymal stem cells seeded in RGD-functionalized PLLA scaffolds and cultured in a flow perfusion bioreactor. J Tissue Eng Regen Med. 2011 Jun; 5(6):464-75. PMID: 20878644.
      Citations: 6     Fields:    Translation:AnimalsCells
    26. Liu R, Xu Y, Chen M, Weïwer M, Zhou X, Bridges AS, DeAngelis PL, Zhang Q, Linhardt RJ, Liu J. Chemoenzymatic design of heparan sulfate oligosaccharides. J Biol Chem. 2010 Oct 29; 285(44):34240-9. PMID: 20729556.
      Citations: 58     Fields:    Translation:HumansCells
    27. Weïwer M, Sherwood T, Green DE, Chen M, DeAngelis PL, Liu J, Linhardt RJ. Synthesis of uridine 5'-diphosphoiduronic acid: a potential substrate for the chemoenzymatic synthesis of heparin. J Org Chem. 2008 Oct 03; 73(19):7631-7. PMID: 18759479.
      Citations: 5     Fields:    
    28. DeAngelis PL. Hot topic: hyaluronan, a very useful sugar polymer. Curr Pharm Biotechnol. 2008 Aug; 9(4):235. PMID: 18691080.
      Citations:    Fields:    Translation:HumansAnimals
    29. DeAngelis PL. Monodisperse hyaluronan polymers: synthesis and potential applications. Curr Pharm Biotechnol. 2008 Aug; 9(4):246-8. PMID: 18691084.
      Citations: 6     Fields:    Translation:Cells
    30. Weigel PH, DeAngelis PL. Hyaluronan synthases: a decade-plus of novel glycosyltransferases. J Biol Chem. 2007 Dec 21; 282(51):36777-81. PMID: 17981795.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    31. Sismey-Ragatz AE, Green DE, Otto NJ, Rejzek M, Field RA, DeAngelis PL. Chemoenzymatic synthesis with distinct Pasteurella heparosan synthases: monodisperse polymers and unnatural structures. J Biol Chem. 2007 Sep 28; 282(39):28321-28327. PMID: 17627940.
      Citations: 35     Fields:    Translation:Cells
    32. Linhardt RJ, Dordick JS, Deangelis PL, Liu J. Enzymatic synthesis of glycosaminoglycan heparin. Semin Thromb Hemost. 2007 Jul; 33(5):453-65. PMID: 17629842.
      Citations: 14     Fields:    Translation:AnimalsCells
    33. Alvarez-Barreto JF, Shreve MC, Deangelis PL, Sikavitsas VI. Preparation of a functionally flexible, three-dimensional, biomimetic poly(L-lactic acid) scaffold with improved cell adhesion. Tissue Eng. 2007 Jun; 13(6):1205-17. PMID: 17518730.
      Citations: 2     Fields:    Translation:AnimalsCells
    34. Tracy BS, Avci FY, Linhardt RJ, DeAngelis PL. Acceptor specificity of the Pasteurella hyaluronan and chondroitin synthases and production of chimeric glycosaminoglycans. J Biol Chem. 2007 Jan 05; 282(1):337-44. PMID: 17099217.
      Citations: 10     Fields:    Translation:Cells
    35. Pummill PE, Kane TA, Kempner ES, DeAngelis PL. The functional molecular mass of the Pasteurella hyaluronan synthase is a monomer. Biochim Biophys Acta. 2007 Feb; 1770(2):286-90. PMID: 17095162.
      Citations: 1     Fields:    Translation:Cells
    36. Kane TA, White CL, DeAngelis PL. Functional characterization of PmHS1, a Pasteurella multocida heparosan synthase. J Biol Chem. 2006 Nov 03; 281(44):33192-7. PMID: 16959770.
      Citations: 17     Fields:    Translation:Cells
    37. Jing W, Haller FM, Almond A, DeAngelis PL. Defined megadalton hyaluronan polymer standards. Anal Biochem. 2006 Aug 15; 355(2):183-8. PMID: 16842731.
      Citations: 6     Fields:    Translation:Cells
    38. Blundell CD, Deangelis PL, Almond A. Hyaluronan: the absence of amide-carboxylate hydrogen bonds and the chain conformation in aqueous solution are incompatible with stable secondary and tertiary structure models. Biochem J. 2006 Jun 15; 396(3):487-98. PMID: 16506956.
      Citations: 10     Fields:    Translation:Cells
    39. Almond A, Deangelis PL, Blundell CD. Hyaluronan: the local solution conformation determined by NMR and computer modeling is close to a contracted left-handed 4-fold helix. J Mol Biol. 2006 May 19; 358(5):1256-69. PMID: 16584748.
      Citations: 22     Fields:    Translation:AnimalsCells
    40. Williams KJ, Halkes KM, Kamerling JP, DeAngelis PL. Critical elements of oligosaccharide acceptor substrates for the Pasteurella multocida hyaluronan synthase. J Biol Chem. 2006 Mar 03; 281(9):5391-7. PMID: 16361253.
      Citations: 14     Fields:    Translation:Cells
    41. Colebrooke SA, Blundell CD, DeAngelis PL, Campbell ID, Almond A. Exploiting the carboxylate chemical shift to resolve degenerate resonances in spectra of 13C-labelled glycosaminoglycans. Magn Reson Chem. 2005 Oct; 43(10):805-15. PMID: 15996005.
      Citations: 2     Fields:    Translation:Cells
    42. Widner B, Behr R, Von Dollen S, Tang M, Heu T, Sloma A, Sternberg D, Deangelis PL, Weigel PH, Brown S. Hyaluronic acid production in Bacillus subtilis. Appl Environ Microbiol. 2005 Jul; 71(7):3747-52. PMID: 16000785.
      Citations: 41     Fields:    Translation:Cells
    43. Blundell CD, Almond A, Mahoney DJ, DeAngelis PL, Campbell ID, Day AJ. Towards a structure for a TSG-6.hyaluronan complex by modeling and NMR spectroscopy: insights into other members of the link module superfamily. J Biol Chem. 2005 May 06; 280(18):18189-201. PMID: 15718240.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    44. Almond A, DeAngelis PL, Blundell CD. Dynamics of hyaluronan oligosaccharides revealed by 15N relaxation. J Am Chem Soc. 2005 Feb 02; 127(4):1086-7. PMID: 15669832.
      Citations: 7     Fields:    Translation:Cells
    45. Bodevin-Authelet S, Kusche-Gullberg M, Pummill PE, DeAngelis PL, Lindahl U. Biosynthesis of hyaluronan: direction of chain elongation. J Biol Chem. 2005 Mar 11; 280(10):8813-8. PMID: 15623518.
      Citations: 16     Fields:    Translation:AnimalsCells
    46. Deangelis PL, White CL. Identification of a distinct, cryptic heparosan synthase from Pasteurella multocida types A, D, and F. J Bacteriol. 2004 Dec; 186(24):8529-32. PMID: 15576804.
      Citations: 14     Fields:    Translation:Cells
    47. Jing W, DeAngelis PL. Synchronized chemoenzymatic synthesis of monodisperse hyaluronan polymers. J Biol Chem. 2004 Oct 01; 279(40):42345-9. PMID: 15299014.
      Citations: 35     Fields:    Translation:Cells
    48. Blundell CD, DeAngelis PL, Day AJ, Almond A. Use of 15N-NMR to resolve molecular details in isotopically-enriched carbohydrates: sequence-specific observations in hyaluronan oligomers up to decasaccharides. Glycobiology. 2004 Nov; 14(11):999-1009. PMID: 15215231.
      Citations: 17     Fields:    Translation:Cells
    49. Blundell CD, Mahoney DJ, Almond A, DeAngelis PL, Kahmann JD, Teriete P, Pickford AR, Campbell ID, Day AJ. The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding. J Biol Chem. 2003 Dec 05; 278(49):49261-70. PMID: 12972412.
      Citations: 22     Fields:    Translation:Cells
    50. DeAngelis PL, Oatman LC, Gay DF. Rapid chemoenzymatic synthesis of monodisperse hyaluronan oligosaccharides with immobilized enzyme reactors. J Biol Chem. 2003 Sep 12; 278(37):35199-203. PMID: 12840012.
      Citations: 22     Fields:    
    51. Jing W, DeAngelis PL. Analysis of the two active sites of the hyaluronan synthase and the chondroitin synthase of Pasteurella multocida. Glycobiology. 2003 Oct; 13(10):661-71. PMID: 12799342.
      Citations: 16     Fields:    Translation:Cells
    52. Pummill PE, DeAngelis PL. Alteration of polysaccharide size distribution of a vertebrate hyaluronan synthase by mutation. J Biol Chem. 2003 May 30; 278(22):19808-14. PMID: 12654925.
      Citations: 14     Fields:    Translation:Cells
    53. DeAngelis PL. Evolution of glycosaminoglycans and their glycosyltransferases: Implications for the extracellular matrices of animals and the capsules of pathogenic bacteria. Anat Rec. 2002 Nov 01; 268(3):317-26. PMID: 12382327.
      Citations: 27     Fields:    Translation:AnimalsCells
    54. DeAngelis PL, Gunay NS, Toida T, Mao WJ, Linhardt RJ. Identification of the capsular polysaccharides of Type D and F Pasteurella multocida as unmodified heparin and chondroitin, respectively. Carbohydr Res. 2002 Sep 27; 337(17):1547-52. PMID: 12350324.
      Citations: 28     Fields:    Translation:Cells
    55. Pummill PE, DeAngelis PL. Evaluation of critical structural elements of UDP-sugar substrates and certain cysteine residues of a vertebrate hyaluronan synthase. J Biol Chem. 2002 Jun 14; 277(24):21610-6. PMID: 11943783.
      Citations: 6     Fields:    Translation:AnimalsCells
    56. DeAngelis PL. Microbial glycosaminoglycan glycosyltransferases. Glycobiology. 2002 Jan; 12(1):9R-16R. PMID: 11825882.
      Citations: 31     Fields:    Translation:Cells
    57. DeAngelis PL, White CL. Identification and molecular cloning of a heparosan synthase from Pasteurella multocida type D. J Biol Chem. 2002 Mar 01; 277(9):7209-13. PMID: 11756462.
      Citations: 22     Fields:    Translation:Cells
    58. Pummill PE, Kempner ES, DeAngelis PL. Functional molecular mass of a vertebrate hyaluronan synthase as determined by radiation inactivation analysis. J Biol Chem. 2001 Oct 26; 276(43):39832-5. PMID: 11517224.
      Citations: 8     Fields:    Translation:AnimalsCells
    59. Heldermon C, DeAngelis PL, Weigel PH. Topological organization of the hyaluronan synthase from Streptococcus pyogenes. J Biol Chem. 2001 Jan 19; 276(3):2037-46. PMID: 11024012.
      Citations: 26     Fields:    Translation:Cells
    60. Jing W, DeAngelis PL. Dissection of the two transferase activities of the Pasteurella multocida hyaluronan synthase: two active sites exist in one polypeptide. Glycobiology. 2000 Sep; 10(9):883-9. PMID: 10988250.
      Citations: 21     Fields:    Translation:Cells
    61. DeAngelis PL. Polysaccharide labeling with N-methylisatoic anhydride: generation of ultraviolet chromophores and blue fluorophores. Anal Biochem. 2000 Aug 15; 284(1):167-9. PMID: 10933873.
      Citations: 1     Fields:    
    62. DeAngelis PL, Padgett-McCue AJ. Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F. J Biol Chem. 2000 Aug 04; 275(31):24124-9. PMID: 10818104.
      Citations: 11     Fields:    Translation:Cells
    63. DeAngelis PL. Hyaluronan synthases: fascinating glycosyltransferases from vertebrates, bacterial pathogens, and algal viruses. Cell Mol Life Sci. 1999 Nov 15; 56(7-8):670-82. PMID: 11212314.
      Citations: 39     Fields:    Translation:AnimalsCells
    64. DeAngelis PL. Molecular directionality of polysaccharide polymerization by the Pasteurella multocida hyaluronan synthase. J Biol Chem. 1999 Sep 10; 274(37):26557-62. PMID: 10473619.
      Citations: 23     Fields:    Translation:Cells
    65. DeAngelis PL, Jing W, Drake RR, Achyuthan AM. Identification and molecular cloning of a unique hyaluronan synthase from Pasteurella multocida. J Biol Chem. 1998 Apr 03; 273(14):8454-8. PMID: 9525958.
      Citations: 21     Fields:    Translation:Cells
    66. DeAngelis PL. Transposon Tn916 insertional mutagenesis of Pasteurella multocida and direct sequencing of disruption site. Microb Pathog. 1998 Apr; 24(4):203-9. PMID: 9533892.
      Citations: 3     Fields:    Translation:Cells
    67. Pummill PE, Achyuthan AM, DeAngelis PL. Enzymological characterization of recombinant xenopus DG42, a vertebrate hyaluronan synthase. J Biol Chem. 1998 Feb 27; 273(9):4976-81. PMID: 9478944.
      Citations: 10     Fields:    Translation:Animals
    68. DeAngelis PL, Jing W, Graves MV, Burbank DE, Van Etten JL. Hyaluronan synthase of chlorella virus PBCV-1. Science. 1997 Dec 05; 278(5344):1800-3. PMID: 9388183.
      Citations: 35     Fields:    Translation:AnimalsCells
    69. DeAngelis PL, Achyuthan AM. Yeast-derived recombinant DG42 protein of Xenopus can synthesize hyaluronan in vitro. J Biol Chem. 1996 Sep 27; 271(39):23657-60. PMID: 8798586.
      Citations: 9     Fields:    Translation:AnimalsCells
    70. DeAngelis PL. Enzymological characterization of the Pasteurella multocida hyaluronic acid synthase. Biochemistry. 1996 Jul 30; 35(30):9768-71. PMID: 8703949.
      Citations: 6     Fields:    Translation:Cells
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