"Leukocyte Rolling" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Movement of tethered, spherical LEUKOCYTES along the endothelial surface of the microvasculature. The tethering and rolling involves interaction with SELECTINS and other adhesion molecules in both the ENDOTHELIUM and leukocyte. The rolling leukocyte then becomes activated by CHEMOKINES, flattens out, and firmly adheres to the endothelial surface in preparation for transmigration through the interendothelial cell junction. (From Abbas, Cellular and Molecular Immunology, 3rd ed)
| Descriptor ID |
D036904
|
| MeSH Number(s) |
G04.198.424.233.500
|
| Concept/Terms |
Leukocyte Rolling- Leukocyte Rolling
- Rolling, Leukocyte
- Leucocyte Rolling
- Rolling, Leucocyte
|
Below are MeSH descriptors whose meaning is more general than "Leukocyte Rolling".
Below are MeSH descriptors whose meaning is more specific than "Leukocyte Rolling".
This graph shows the total number of publications written about "Leukocyte Rolling" by people in this website by year, and whether "Leukocyte Rolling" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Leukocyte Rolling" by people in Profiles.
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Cytoplasmic domain of P-selectin glycoprotein ligand-1 facilitates dimerization and export from the endoplasmic reticulum. J Biol Chem. 2011 Mar 18; 286(11):9577-86.
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Differential regulation of human and murine P-selectin expression and function in vivo. J Exp Med. 2010 Dec 20; 207(13):2975-87.
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E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling. Blood. 2010 Jul 22; 116(3):485-94.
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Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow. Blood. 2008 Sep 01; 112(5):2035-45.
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CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2210-8.
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Surface fucosylation of human cord blood cells augments binding to P-selectin and E-selectin and enhances engraftment in bone marrow. Blood. 2004 Nov 15; 104(10):3091-6.