Leukemia Inhibitory Factor Receptor alpha Subunit
"Leukemia Inhibitory Factor Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
Below are MeSH descriptors whose meaning is more general than "Leukemia Inhibitory Factor Receptor alpha Subunit".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Cytokine [D12.776.543.750.705.852]
- Receptors, OSM-LIF [D12.776.543.750.705.852.583]
- Leukemia Inhibitory Factor Receptor alpha Subunit [D12.776.543.750.705.852.583.750]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Growth Factor [D12.776.543.750.750.400]
- Receptors, Nerve Growth Factor [D12.776.543.750.750.400.550]
- Receptor, Ciliary Neurotrophic Factor [D12.776.543.750.750.400.550.250]
- Leukemia Inhibitory Factor Receptor alpha Subunit [D12.776.543.750.750.400.550.250.750]
Below are MeSH descriptors whose meaning is more specific than "Leukemia Inhibitory Factor Receptor alpha Subunit".
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Below are the most recent publications written about "Leukemia Inhibitory Factor Receptor alpha Subunit" by people in Profiles.
HSV-1 targets lymphatic vessels in the eye and draining lymph node of mice leading to edema in the absence of a functional type I interferon response. Am J Pathol. 2013 Oct; 183(4):1233-1242.
Microglia and a functional type I IFN pathway are required to counter HSV-1-driven brain lateral ventricle enlargement and encephalitis. J Immunol. 2013 Mar 15; 190(6):2807-17.
A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor. J Biol Chem. 2012 Sep 21; 287(39):32848-59.
Loss of the type I interferon pathway increases vulnerability of mice to genital herpes simplex virus 2 infection. J Virol. 2011 Feb; 85(4):1625-33.
Loss of mandibular lymph node integrity is associated with an increase in sensitivity to HSV-1 infection in CD118-deficient mice. J Immunol. 2009 Mar 15; 182(6):3678-87.
Oligoadenylate synthetase/protein kinase R pathways and alphabeta TCR+ T cells are required for adenovirus vector: IFN-gamma inhibition of herpes simplex virus-1 in cornea. J Immunol. 2007 Apr 15; 178(8):5166-72.