Amyloid Precursor Protein Secretases

"Amyloid Precursor Protein Secretases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.

Descriptor ID	D053829
MeSH Number(s)	D08.811.277.656.300.032
Concept/Terms	Amyloid Precursor Protein Secretases Amyloid Precursor Protein Secretases Secretases Secretase Amyloid Precursor Protein Secretase APP Secretase Secretase, APP beta-Secretase beta-Secretase beta Secretase gamma-Secretase gamma-Secretase gamma Secretase alpha-Secretase alpha-Secretase alpha Secretase

Below are MeSH descriptors whose meaning is more general than "Amyloid Precursor Protein Secretases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Amyloid Precursor Protein Secretases [D08.811.277.656.300.032]

Below are MeSH descriptors whose meaning is related to "Amyloid Precursor Protein Secretases".

Below are MeSH descriptors whose meaning is more specific than "Amyloid Precursor Protein Secretases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Amyloid Precursor Protein Secretases" by people in this website by year, and whether "Amyloid Precursor Protein Secretases" was a major or minor topic of these publications.

Bar chart showing 15 publications over 10 distinct years, with a maximum of 4 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2003	0	1	1
2004	0	2	2
2005	0	1	1
2007	2	0	2
2011	0	1	1
2012	1	0	1
2013	0	4	4
2016	1	0	1
2019	1	0	1

Below are the most recent publications written about "Amyloid Precursor Protein Secretases" by people in Profiles.

Sharma D, Otto G, Warren EC, Beesley P, King JS, Williams RSB. Gamma secretase orthologs are required for lysosomal activity and autophagic degradation in Dictyostelium discoideum, independent of PSEN (presenilin) proteolytic function. Autophagy. 2019 08; 15(8):1407-1418.

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Ratnamala U, Jhala D, Jain NK, Saiyed NM, Raveendrababu M, Rao MV, Mehta TY, Al-Ali FM, Raval K, Nair S, Chandramohan NK, Kuracha MR, Nath SK, Radhakrishna U. Expanding the spectrum of ?-secretase gene mutation-associated phenotypes: two novel mutations segregating with familial hidradenitis suppurativa (acne inversa) and acne conglobata. Exp Dermatol. 2016 Apr; 25(4):314-6.

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Tucsek Z, Toth P, Sosnowska D, Gautam T, Mitschelen M, Koller A, Szalai G, Sonntag WE, Ungvari Z, Csiszar A. Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease. J Gerontol A Biol Sci Med Sci. 2014 Oct; 69(10):1212-26.

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Csiszar A, Tucsek Z, Toth P, Sosnowska D, Gautam T, Koller A, Deak F, Sonntag WE, Ungvari Z. Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in ß-amyloid generation and Alzheimer's disease. . 2013 Oct 15; 305(8):H1120-30.

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Weintraub MK, Bisson CM, Nouri JN, Vinson BT, Eimerbrink MJ, Kranjac D, Boehm GW, Chumley MJ. Imatinib methanesulfonate reduces hippocampal amyloid-ß and restores cognitive function following repeated endotoxin exposure. Brain Behav Immun. 2013 Oct; 33:24-8.

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Rice HC, Young-Pearse TL, Selkoe DJ. Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein. Biochemistry. 2013 May 14; 52(19):3264-77.

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Ghosh AK, Venkateswara Rao K, Yadav ND, Anderson DD, Gavande N, Huang X, Terzyan S, Tang J. Structure-based design of highly selective ß-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure. J Med Chem. 2012 Nov 08; 55(21):9195-207.

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Subramaniam D, Nicholes ND, Dhar A, Umar S, Awasthi V, Welch DR, Jensen RA, Anant S. 3,5-bis(2,4-difluorobenzylidene)-4-piperidone, a novel compound that affects pancreatic cancer growth and angiogenesis. . 2011 Nov; 10(11):2146-56.

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Chang WP, Downs D, Huang XP, Da H, Fung KM, Tang J. Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization. FASEB J. 2007 Oct; 21(12):3184-96.

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Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R. Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis. J Neurosci. 2007 Apr 04; 27(14):3639-49.

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