"DEAD Box Protein 58" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).
|DEAD Box Protein 58
- DEAD Box Protein 58
- DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58
- Probable ATP-Dependent RNA Helicase DDX58
- Probable ATP Dependent RNA Helicase DDX58
- RIG-I-like Receptor 1
- RIG I like Receptor 1
Below are MeSH descriptors whose meaning is more general than "DEAD Box Protein 58".
Below are MeSH descriptors whose meaning is more specific than "DEAD Box Protein 58".
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Below are the most recent publications written about "DEAD Box Protein 58" by people in Profiles.
RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo. Mediators Inflamm. 2018; 2018:6808934.
RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection. Respir Res. 2017 09 02; 18(1):166.
Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses. Respir Res. 2016 09 07; 17(1):111.
RIG-I and TLR3 are both required for maximum interferon induction by influenza virus in human lung alveolar epithelial cells. Virology. 2015 Aug; 482:181-8.
Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models. Am J Physiol Lung Cell Mol Physiol. 2014 Dec 01; 307(11):L848-58.
Influenza A(H1N1)pdm09 virus suppresses RIG-I initiated innate antiviral responses in the human lung. PLoS One. 2012; 7(11):e49856.
Cigarette smoke extract suppresses the RIG-I-initiated innate immune response to influenza virus in the human lung. Am J Physiol Lung Cell Mol Physiol. 2011 Jun; 300(6):L821-30.
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1. J Biol Chem. 2009 Apr 17; 284(16):10774-82.