Interferon-Induced Helicase, IFIH1
"Interferon-Induced Helicase, IFIH1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.
| Descriptor ID |
D000072640
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| MeSH Number(s) |
D08.811.913.696.445.735.720.249.875
|
| Concept/Terms |
Interferon-Induced Helicase, IFIH1- Interferon-Induced Helicase, IFIH1
- Helicase, IFIH1 Interferon-Induced
- IFIH1 Interferon-Induced Helicase
- Interferon Induced Helicase, IFIH1
- Helicard
- Melanoma Differentiation-Associated Protein 5
- Melanoma Differentiation Associated Protein 5
- CADM-140 Autoantigen
- Autoantigen, CADM-140
- CADM 140 Autoantigen
- Interferon Induced with Helicase C Domain 1
- Interferon-Induced Helicase C Domain-Containing Protein 1
- Interferon Induced Helicase C Domain Containing Protein 1
- IFIH1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Interferon-Induced Helicase, IFIH1".
Below are MeSH descriptors whose meaning is more specific than "Interferon-Induced Helicase, IFIH1".
This graph shows the total number of publications written about "Interferon-Induced Helicase, IFIH1" by people in this website by year, and whether "Interferon-Induced Helicase, IFIH1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Interferon-Induced Helicase, IFIH1" by people in Profiles.
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The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner. Front Immunol. 2024; 15:1349601.
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Anti-MDA5 autoantibodies associated with juvenile dermatomyositis constitute a distinct phenotype in North America. Rheumatology (Oxford). 2021 04 06; 60(4):1839-1849.
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Features distinguishing clinically amyopathic juvenile dermatomyositis from juvenile dermatomyositis. Rheumatology (Oxford). 2018 11 01; 57(11):1956-1963.
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Describing and expanding the clinical phenotype of anti-MDA5-associated rapidly progressive interstitial lung disease: case series of nine Canadian patients and literature review. Scand J Rheumatol. 2018 05; 47(3):210-224.
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Association of IFIH1 and pro-inflammatory mediators: Potential new clues in SLE-associated pathogenesis. PLoS One. 2017; 12(2):e0171193.
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Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet. 2013; 9(2):e1003222.